Motif ID: SP1.p2

Z-value: 1.224


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_520601910.048.7e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_+_46226072 4.825 NM_001848
 COL6A1
collagen, type VI, alpha 1
chr4_+_3264509 4.411 RGS12
regulator of G-protein signaling 12
chr7_+_5289079 4.319 NM_001040661
NM_153247
 SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr13_-_113066366 3.776 NM_024719
 GRTP1
growth hormone regulated TBC protein 1
chr2_+_42128521 3.489 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr2_+_235525355 3.337 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr17_-_829655 3.265 NM_022463
 NXN
nucleoredoxin
chr19_+_59064795 3.250 MYADM
myeloid-associated differentiation marker
chr1_-_158335241 3.125 IGSF8
immunoglobulin superfamily, member 8
chr14_-_20636337 3.041 ZNF219
zinc finger protein 219
chr14_-_20636568 3.012 NM_016423
 ZNF219
zinc finger protein 219
chr2_-_227372574 2.944 IRS1
insulin receptor substrate 1
chr19_+_59064471 2.906 NM_001020821
NM_001020818
 MYADM

myeloid-associated differentiation marker

chr15_+_78232194 2.868 FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr1_-_158334983 2.756 NM_052868
 IGSF8
immunoglobulin superfamily, member 8
chr15_+_97009194 2.702 IGF1R
insulin-like growth factor 1 receptor
chr3_-_125085834 2.679 NM_053025
NM_053026
NM_053027
NM_053028
 MYLK



myosin light chain kinase



chr7_+_55054152 2.536 NM_005228
NM_201282
NM_201283
NM_201284
 EGFR



epidermal growth factor receptor



chr18_+_11971421 2.474 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr15_+_71131877 2.470 NM_001172623
NM_001172624
NM_002499
 NEO1


neogenin 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 113 entries
enrichment   p-value GO term description
1.38 1.06e-02 GO:0051493 regulation of cytoskeleton organization
1.38 1.33e-02 GO:0006417 regulation of translation
1.35 9.00e-04 GO:0051248 negative regulation of protein metabolic process
1.35 1.40e-03 GO:0046578 regulation of Ras protein signal transduction
1.34 2.36e-03 GO:0032269 negative regulation of cellular protein metabolic process
1.33 1.21e-02 GO:0051129 negative regulation of cellular component organization
1.31 1.76e-04 GO:0051056 regulation of small GTPase mediated signal transduction
1.30 2.17e-04 GO:0016568 chromatin modification
1.28 1.46e-02 GO:0033043 regulation of organelle organization
1.28 1.60e-02 GO:0048285 organelle fission
1.27 2.68e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.24 1.04e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.24 9.98e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.24 1.19e-03 GO:0051253 negative regulation of RNA metabolic process
1.24 5.14e-03 GO:0007010 cytoskeleton organization
1.23 2.60e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.23 1.08e-03 GO:0000278 mitotic cell cycle
1.22 1.64e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.22 1.86e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.22 2.11e-03 GO:0010629 negative regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
1.48 6.70e-03 GO:0016585 chromatin remodeling complex
1.37 9.93e-04 GO:0005819 spindle
1.37 8.26e-03 GO:0005912 adherens junction
1.35 3.90e-03 GO:0031252 cell leading edge
1.33 3.41e-02 GO:0070161 anchoring junction
1.29 3.15e-02 GO:0000228 nuclear chromosome
1.27 1.35e-03 GO:0005815 microtubule organizing center
1.27 7.25e-03 GO:0005874 microtubule
1.25 1.80e-07 GO:0015630 microtubule cytoskeleton
1.23 1.99e-06 GO:0044451 nucleoplasm part
1.22 1.71e-02 GO:0043005 neuron projection
1.21 2.24e-03 GO:0005694 chromosome
1.20 1.60e-15 GO:0005829 cytosol
1.20 3.78e-09 GO:0005654 nucleoplasm
1.19 1.88e-05 GO:0005794 Golgi apparatus
1.19 1.23e-02 GO:0044431 Golgi apparatus part
1.19 4.95e-02 GO:0000139 Golgi membrane
1.18 8.77e-11 GO:0031981 nuclear lumen
1.17 1.31e-12 GO:0044428 nuclear part
1.17 1.18e-03 GO:0042995 cell projection

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
1.46 2.48e-03 GO:0015631 tubulin binding
1.29 3.59e-07 GO:0008092 cytoskeletal protein binding
1.27 8.63e-05 GO:0019904 protein domain specific binding
1.25 1.33e-03 GO:0004674 protein serine/threonine kinase activity
1.24 4.81e-02 GO:0003779 actin binding
1.22 1.51e-05 GO:0019899 enzyme binding
1.19 3.38e-05 GO:0001071 nucleic acid binding transcription factor activity
1.19 3.38e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.18 3.93e-05 GO:0030528 transcription regulator activity
1.18 2.78e-03 GO:0016301 kinase activity
1.18 4.33e-02 GO:0004672 protein kinase activity
1.17 8.06e-03 GO:0042802 identical protein binding
1.17 1.64e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.15 2.17e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.13 1.49e-06 GO:0000166 nucleotide binding
1.13 1.33e-04 GO:0016740 transferase activity
1.13 1.87e-03 GO:0030554 adenyl nucleotide binding
1.12 2.16e-30 GO:0005515 protein binding
1.12 1.08e-05 GO:0003677 DNA binding
1.12 2.79e-04 GO:0017076 purine nucleotide binding