Motif ID: SPIB.p2

Z-value: 2.329


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.312.4e-01Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_44643067 2.713 ABI3
ABI family, member 3
chr18_-_51219880 2.548 TCF4
transcription factor 4
chr12_-_15005761 2.477 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_175207521 2.274 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr4_+_91035025 2.207 NM_007351
 MMRN1
multimerin 1
chr6_-_32742265 1.662 NM_002123
 HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr18_-_59137488 1.632 NM_000633
NM_000657
 BCL2

B-cell CLL/lymphoma 2

chr21_-_38792173 1.630 NM_001136155
NM_182918
 ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_+_263025 1.593 NM_001190458
NM_001193536
 DOCK8

dedicator of cytokinesis 8

chr7_+_149778869 1.519 NM_175571
 GIMAP8
GTPase, IMAP family member 8
chr12_+_25096755 1.498 LRMP
lymphoid-restricted membrane protein
chr3_-_113701073 1.468 NM_001085357
NM_181780
 BTLA

B and T lymphocyte associated

chr6_-_159386007 1.376 NM_054114
NM_138810
NM_152133
 TAGAP


T-cell activation RhoGTPase activating protein


chr18_-_16945763 1.367 NM_005406
 ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr7_+_149778815 1.365 GIMAP8
GTPase, IMAP family member 8
chr17_+_64922420 1.359 NM_002758
 MAP2K6
mitogen-activated protein kinase kinase 6
chr4_-_174557191 1.343 NM_007281
 SCRG1
stimulator of chondrogenesis 1
chr10_-_64246129 1.281 NM_000399
NM_001136177
NM_001136179
 EGR2


early growth response 2


chr2_-_225519974 1.274 DOCK10
dedicator of cytokinesis 10
chr19_+_14554895 1.252 NM_207390
 CLEC17A
C-type lectin domain family 17, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
2.13 4.55e-03 GO:0031294 lymphocyte costimulation
2.13 4.55e-03 GO:0031295 T cell costimulation
1.84 2.63e-02 GO:0050851 antigen receptor-mediated signaling pathway
1.80 9.94e-04 GO:0050870 positive regulation of T cell activation
1.75 2.58e-04 GO:0051251 positive regulation of lymphocyte activation
1.69 7.00e-04 GO:0050867 positive regulation of cell activation
1.68 1.56e-03 GO:0002696 positive regulation of leukocyte activation
1.68 2.56e-03 GO:0050863 regulation of T cell activation
1.67 1.57e-02 GO:0050900 leukocyte migration
1.58 9.02e-03 GO:0051249 regulation of lymphocyte activation
1.56 3.85e-03 GO:0050865 regulation of cell activation
1.53 1.57e-02 GO:0002694 regulation of leukocyte activation
1.49 3.15e-03 GO:0070647 protein modification by small protein conjugation or removal
1.49 2.20e-02 GO:0032446 protein modification by small protein conjugation
1.41 9.26e-04 GO:0044265 cellular macromolecule catabolic process
1.38 3.17e-10 GO:0002376 immune system process
1.38 1.88e-05 GO:0006955 immune response
1.38 8.87e-03 GO:0007599 hemostasis
1.38 9.27e-03 GO:0007596 blood coagulation
1.38 9.27e-03 GO:0050817 coagulation

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.66 2.49e-02 GO:0016607 nuclear speck
1.47 3.98e-02 GO:0016604 nuclear body
1.17 9.77e-03 GO:0031981 nuclear lumen
1.16 4.89e-03 GO:0044428 nuclear part
1.11 6.52e-06 GO:0005634 nucleus
1.06 1.51e-03 GO:0043227 membrane-bounded organelle
1.06 1.70e-03 GO:0043231 intracellular membrane-bounded organelle
1.05 2.05e-02 GO:0043229 intracellular organelle
1.05 2.81e-02 GO:0043226 organelle
1.04 6.51e-03 GO:0005622 intracellular
1.04 9.27e-03 GO:0044424 intracellular part
1.03 1.01e-06 GO:0044464 cell part
1.03 1.09e-06 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.31 4.08e-04 GO:0003723 RNA binding
1.12 6.09e-03 GO:0003676 nucleic acid binding
1.07 9.67e-03 GO:0005515 protein binding
1.04 4.17e-02 GO:0005488 binding