Motif ID: SRF.p3

Z-value: 2.379


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432468970.322.3e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_34603311 4.209 MYL9
myosin, light chain 9, regulatory
chr5_+_137829065 4.197 EGR1
early growth response 1
chr20_+_34603290 4.015 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr2_+_73973640 3.370 ACTG2
actin, gamma 2, smooth muscle, enteric
chr5_-_33928049 2.963 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr9_-_78710698 2.930 NM_015225
 PRUNE2
prune homolog 2 (Drosophila)
chr5_-_33927724 2.540 NM_030955
 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr2_+_73973600 2.534 NM_001615
 ACTG2
actin, gamma 2, smooth muscle, enteric
chr5_+_137829077 2.461 NM_001964
 EGR1
early growth response 1
chr1_-_89303478 2.254 NM_002053
 GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr9_+_36126667 2.048 GLIPR2
GLI pathogenesis-related 2
chr15_-_32875040 1.957 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr1_-_166373434 1.822 GPR161
G protein-coupled receptor 161
chr17_-_44026042 1.772 NM_002147
 HOXB5
homeobox B5
chr12_+_50731457 1.715 NM_002135
NM_173157
 NR4A1

nuclear receptor subfamily 4, group A, member 1

chr17_+_39990124 1.617 NM_001466
 FZD2
frizzled homolog 2 (Drosophila)
chr5_+_60663842 1.612 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr1_-_166373351 1.601 GPR161
G protein-coupled receptor 161
chr9_+_91409746 1.526 NM_006705
 GADD45G
growth arrest and DNA-damage-inducible, gamma
chr1_-_166373159 1.509 GPR161
G protein-coupled receptor 161

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
11.18 1.36e-02 GO:0030049 muscle filament sliding
11.18 1.36e-02 GO:0033275 actin-myosin filament sliding
10.89 1.60e-02 GO:0070252 actin-mediated cell contraction
10.82 6.33e-04 GO:0030048 actin filament-based movement
8.29 1.49e-09 GO:0006936 muscle contraction
8.05 2.43e-02 GO:0008360 regulation of cell shape
8.02 7.13e-10 GO:0003012 muscle system process
5.97 2.35e-03 GO:0034329 cell junction assembly
5.38 6.51e-03 GO:0034330 cell junction organization
5.25 4.83e-04 GO:0007517 muscle organ development
4.84 1.60e-05 GO:0030029 actin filament-based process
4.26 1.22e-03 GO:0061061 muscle structure development
4.13 8.23e-03 GO:0030036 actin cytoskeleton organization
3.17 7.14e-05 GO:0010628 positive regulation of gene expression
2.90 3.36e-02 GO:0007010 cytoskeleton organization
2.82 7.55e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.82 7.84e-03 GO:0045893 positive regulation of transcription, DNA-dependent
2.77 1.72e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
2.74 1.37e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
2.63 2.40e-02 GO:0051254 positive regulation of RNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
21.21 5.11e-03 GO:0031672 A band
19.15 8.29e-04 GO:0005859 muscle myosin complex
17.24 2.07e-05 GO:0001725 stress fiber
17.24 1.46e-03 GO:0016460 myosin II complex
16.71 3.24e-06 GO:0042641 actomyosin
16.09 3.47e-05 GO:0032432 actin filament bundle
10.77 4.77e-06 GO:0016459 myosin complex
10.14 2.23e-02 GO:0005884 actin filament
9.76 1.35e-09 GO:0044449 contractile fiber part
9.53 4.40e-10 GO:0043292 contractile fiber
9.51 2.04e-09 GO:0030016 myofibril
9.15 3.00e-07 GO:0030017 sarcomere
8.62 1.18e-02 GO:0031674 I band
7.66 3.57e-05 GO:0005925 focal adhesion
7.29 5.93e-05 GO:0005924 cell-substrate adherens junction
7.02 8.71e-05 GO:0030055 cell-substrate junction
6.99 2.82e-14 GO:0015629 actin cytoskeleton
5.56 3.31e-04 GO:0005912 adherens junction
5.02 9.62e-04 GO:0070161 anchoring junction
3.62 2.44e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
13.79 5.17e-03 GO:0017022 myosin binding
11.22 5.11e-04 GO:0008307 structural constituent of muscle
6.13 9.71e-03 GO:0003704 specific RNA polymerase II transcription factor activity
4.96 7.10e-03 GO:0005516 calmodulin binding
4.58 1.44e-06 GO:0003779 actin binding
4.44 4.12e-02 GO:0003774 motor activity
3.20 1.09e-04 GO:0008092 cytoskeletal protein binding
2.68 2.42e-03 GO:0046983 protein dimerization activity
2.39 5.99e-04 GO:0030528 transcription regulator activity
2.34 3.93e-02 GO:0043565 sequence-specific DNA binding
2.29 2.91e-03 GO:0001071 nucleic acid binding transcription factor activity
2.29 2.91e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.28 4.11e-02 GO:0005515 protein binding