Motif ID: STAT2,4,6.p2

Z-value: 1.275


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT2chr12_-_550401230.458.2e-02Click!
STAT6chr12_-_557913880.411.2e-01Click!
STAT4chr2_-_1917239780.136.2e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_49552638 2.343 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr3_-_188945921 1.994 BCL6
B-cell CLL/lymphoma 6
chr3_-_188946168 1.588 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr19_+_49248003 1.286 NM_013361
ZNF223
zinc finger protein 223
chr12_-_7136147 1.093 NM_001733
C1R
complement component 1, r subcomponent
chr17_+_35425139 0.994 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr12_-_7136189 0.911 C1R
complement component 1, r subcomponent
chr19_+_42099073 0.908 NM_198539
ZNF568
zinc finger protein 568
chr19_+_49147219 0.901 NM_013359
ZNF221
zinc finger protein 221
chr9_+_96806235 0.885 C9orf3
chromosome 9 open reading frame 3
chr1_+_148137778 0.883 NM_016074
BOLA1
bolA homolog 1 (E. coli)
chr17_+_45617676 0.841


chr10_-_95231933 0.839 NM_013451
NM_133337
MYOF

myoferlin

chr9_-_116920232 0.833 NM_002160
TNC
tenascin C
chr10_+_75343352 0.831 PLAU
plasminogen activator, urokinase
chr8_-_8276598 0.830 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr14_+_94148466 0.813 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_-_41164010 0.809 PRICKLE1
prickle homolog 1 (Drosophila)
chr12_+_51730101 0.805 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_+_15079141 0.795 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_-_27565923 0.785 NM_004672
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr12_-_41164052 0.783 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr11_-_85115105 0.775 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr3_-_135575925 0.763 NM_016201
AMOTL2
angiomotin like 2
chr8_-_127639892 0.752 NM_174911
FAM84B
family with sequence similarity 84, member B
chr14_+_95792299 0.739 NM_000710
BDKRB1
bradykinin receptor B1
chr19_+_61798434 0.729 NM_021216
ZNF71
zinc finger protein 71
chr3_-_64186151 0.718 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_-_106130098 0.706 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr1_+_17779528 0.701 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr8_+_70567581 0.699 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr8_+_70567634 0.697 SULF1
sulfatase 1
chr2_-_218516950 0.693 NM_022648
TNS1
tensin 1
chr6_-_152681171 0.688 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr19_+_43502380 0.688 KCNK6
potassium channel, subfamily K, member 6
chr8_+_32698892 0.687 NM_001159996
NRG1
neuregulin 1
chr3_+_189353502 0.679 LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_27637771 0.678 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr10_-_126706442 0.670 NM_022802
CTBP2
C-terminal binding protein 2
chr3_+_114414064 0.647 NM_033254
BOC
Boc homolog (mouse)
chr5_+_145296313 0.642 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr12_-_119172339 0.639 NM_025157
PXN
paxillin
chr5_+_172193826 0.631 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr7_-_41709191 0.630 NM_002192
INHBA
inhibin, beta A
chr17_-_8215577 0.628 NM_213597
KRBA2
KRAB-A domain containing 2
chr1_-_68071635 0.624 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr19_-_42098919 0.623 NM_001037232
ZNF829
zinc finger protein 829
chr19_-_54031725 0.608 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr12_+_7038240 0.589 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr12_+_13088412 0.588 KIAA1467
KIAA1467
chr2_+_235525355 0.585 NM_014521
SH3BP4
SH3-domain binding protein 4
chr2_-_56266408 0.576 LOC100129434
hypothetical LOC100129434
chr5_-_138238877 0.574 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr19_-_49644470 0.566 NM_014518
ZNF229
zinc finger protein 229
chr11_-_11986704 0.564 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr2_-_151052391 0.558 NM_005168
RND3
Rho family GTPase 3
chr14_-_79748273 0.557 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr11_+_61204392 0.555 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr2_-_218843109 0.553 NM_001087
AAMP
angio-associated, migratory cell protein
chr3_+_189354167 0.552 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_-_52487022 0.545 FERMT2
fermitin family member 2
chr3_-_71376919 0.541 FOXP1
forkhead box P1
chr19_+_39860398 0.537 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr11_+_10283171 0.530 NM_001124
ADM
adrenomedullin
chr21_-_27139563 0.529 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr20_+_35406497 0.526 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr2_-_218843088 0.525 AAMP
angio-associated, migratory cell protein
chr19_+_43502301 0.525 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr11_-_104399104 0.525 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr14_+_20608179 0.520 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr19_-_42098758 0.518 NM_001171979
ZNF829
zinc finger protein 829
chr8_-_130868315 0.513 NM_031415
GSDMC
gasdermin C
chr9_-_4142182 0.512 NM_152629
GLIS3
GLIS family zinc finger 3
chr9_+_88086932 0.510


chr12_-_83830710 0.508 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr8_-_120720200 0.500 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr11_+_129823667 0.499 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr7_+_134114912 0.499 CALD1
caldesmon 1
chr20_-_14266200 0.497 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_+_201158824 0.494 AOX1
aldehyde oxidase 1
chr14_-_53493198 0.491 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr8_-_27525084 0.487 NM_001171138
CLU
clusterin
chr12_+_51729239 0.485 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr9_-_106730157 0.485 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_-_189752575 0.485 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_38881719 0.483 NM_003999
OSMR
oncostatin M receptor
chr8_-_127639647 0.482 FAM84B
family with sequence similarity 84, member B
chr3_-_48607596 0.482 NM_000094
COL7A1
collagen, type VII, alpha 1
chr3_-_48456439 0.481 NM_024661
CCDC51
coiled-coil domain containing 51
chr1_-_27565412 0.479 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr19_-_54031479 0.476 HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chrX_-_106129854 0.475 MORC4
MORC family CW-type zinc finger 4
chr5_+_73145098 0.475 RGNEF
190 kDa guanine nucleotide exchange factor
chr17_+_6288457 0.470 NM_001195228
NM_019013
FAM64A

family with sequence similarity 64, member A

chr14_-_68515791 0.468 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr12_+_11693993 0.467 NM_001987
ETV6
ets variant 6
chr2_-_43919392 0.465 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr19_+_49361054 0.464 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr19_+_54669629 0.462 FLT3LG
fms-related tyrosine kinase 3 ligand
chr1_+_158063130 0.462 SLAMF8
SLAM family member 8
chr11_+_55174953 0.462 NM_001004059
OR4S2
olfactory receptor, family 4, subfamily S, member 2
chr22_-_29866339 0.461 NM_015715
PLA2G3
phospholipase A2, group III
chr17_-_77884926 0.458 SECTM1
secreted and transmembrane 1
chr14_-_68515727 0.457 ACTN1
actinin, alpha 1
chr5_+_38882017 0.456 OSMR
oncostatin M receptor
chr6_+_43507466 0.454 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr15_-_86600658 0.454 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr3_-_48516486 0.451 NM_016479
SHISA5
shisa homolog 5 (Xenopus laevis)
chr9_-_106730256 0.451 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr15_+_92700167 0.448 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr2_+_201158975 0.446 NM_001159
AOX1
aldehyde oxidase 1
chr11_-_11987198 0.445 NM_015881
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr17_-_77885192 0.442 NM_003004
SECTM1
secreted and transmembrane 1
chr9_-_21999270 0.441 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr4_+_169654742 0.439 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr19_+_39916935 0.439 ZNF181
zinc finger protein 181
chr14_-_68515731 0.438 ACTN1
actinin, alpha 1
chr8_-_26427304 0.437 NM_007257
PNMA2
paraneoplastic antigen MA2
chr7_+_134114957 0.437 CALD1
caldesmon 1
chr12_+_13088551 0.433 NM_020853
KIAA1467
KIAA1467
chr17_-_77884899 0.433 SECTM1
secreted and transmembrane 1
chr20_+_19903778 0.430 RIN2
Ras and Rab interactor 2
chr4_-_140696740 0.429 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr15_+_60838053 0.429 TLN2
talin 2
chr9_-_112841300 0.428 LPAR1
lysophosphatidic acid receptor 1
chr14_-_68515525 0.427 ACTN1
actinin, alpha 1
chr14_-_68515761 0.427 ACTN1
actinin, alpha 1
chr14_+_75521806 0.427 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr11_+_124539814 0.424 PKNOX2
PBX/knotted 1 homeobox 2
chr9_+_22103542 0.422 CDKN2B-AS1
CDKN2B antisense RNA 1 (non-protein coding)
chr5_+_150008030 0.421 SYNPO
synaptopodin
chr1_+_158063102 0.419 NM_020125
SLAMF8
SLAM family member 8
chr11_+_57122153 0.419 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr11_+_4522993 0.418 NM_001004137
OR52M1
olfactory receptor, family 52, subfamily M, member 1
chr5_+_38881716 0.418 NM_001168355
OSMR
oncostatin M receptor
chr14_-_68515742 0.415 ACTN1
actinin, alpha 1
chr13_-_32678142 0.414 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr15_-_68971665 0.413 NM_020147
THAP10
THAP domain containing 10
chr7_+_27102197 0.411


chr14_-_59020795 0.410 NM_144581
C14orf149
chromosome 14 open reading frame 149
chr19_+_2427122 0.409 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chrX_+_152682772 0.409 NM_001163257
NM_005393
PLXNB3

plexin B3

chr1_+_161305558 0.408 NM_001113381
RGS4
regulator of G-protein signaling 4
chr9_+_5440455 0.407 NM_014143
CD274
CD274 molecule
chr19_+_58715988 0.407 NM_018555
ZNF331
zinc finger protein 331
chr8_-_48813256 0.407 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr10_-_90601655 0.406 NM_144590
ANKRD22
ankyrin repeat domain 22
chr19_-_39859997 0.405


chr6_-_152744143 0.405 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_-_11987115 0.405 DKK3
dickkopf homolog 3 (Xenopus laevis)
chr16_+_52295545 0.403 FTO
fat mass and obesity associated
chr19_-_12028126 0.401 NM_001080404
ZNF878
zinc finger protein 878
chr4_-_5881271 0.400 CRMP1
collapsin response mediator protein 1
chr15_+_84021271 0.398 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr21_-_27139143 0.398 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr14_+_73775927 0.397 NM_182894
VSX2
visual system homeobox 2
chr11_-_2881750 0.397 NM_007105
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr9_-_139060285 0.396 NPDC1
neural proliferation, differentiation and control, 1
chr8_-_27524744 0.396 NM_203339
CLU
clusterin
chr8_-_95343716 0.396 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr8_+_26491507 0.395 DPYSL2
dihydropyrimidinase-like 2
chr8_-_95343696 0.395 GEM
GTP binding protein overexpressed in skeletal muscle
chr1_+_153413675 0.395 TRIM46
tripartite motif containing 46
chr5_-_151046638 0.395 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr13_-_35603513 0.392 NM_004734
DCLK1
doublecortin-like kinase 1
chr5_-_151046680 0.391 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr16_-_28457825 0.389 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr17_+_1592879 0.387 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr9_+_18464138 0.387 ADAMTSL1
ADAMTS-like 1
chr3_+_14141553 0.385 TMEM43
transmembrane protein 43
chr11_-_8788765 0.384 NM_213618
ST5
suppression of tumorigenicity 5
chr16_-_3025542 0.383 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr16_+_52295375 0.381 NM_001080432
FTO
fat mass and obesity associated
chrX_-_106846253 0.381 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr1_-_51560469 0.379 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr3_-_125085834 0.379 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr1_-_6502655 0.379 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_68070573 0.379


chr14_+_74968589 0.377 NM_001135049
JDP2
Jun dimerization protein 2
chrX_+_106030049 0.376 NM_001171092
CLDN2
claudin 2
chr15_-_73447997 0.375 MAN2C1
mannosidase, alpha, class 2C, member 1
chr10_+_90740364 0.374 FAS
Fas (TNF receptor superfamily, member 6)
chr16_+_54072969 0.373 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chrX_+_106057984 0.373 CLDN2
claudin 2
chr14_-_68515701 0.371 ACTN1
actinin, alpha 1
chr20_+_58004811 0.371 NM_021810
CDH26
cadherin 26
chr3_-_50335113 0.370 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr9_-_21325239 0.368 NM_018847
KLHL9
kelch-like 9 (Drosophila)
chr5_-_138238953 0.368 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr12_-_9159789 0.368 NM_000014
A2M
alpha-2-macroglobulin
chr16_-_28457728 0.368 NUPR1
nuclear protein, transcriptional regulator, 1
chr18_+_2896178 0.364 EMILIN2
elastin microfibril interfacer 2
chr5_+_178383381 0.361 NM_001136116
ZNF879
zinc finger protein 879
chr2_-_74498351 0.361 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chrX_-_10504852 0.361 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_171441234 0.361 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_+_154178103 0.360 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr9_+_116943917 0.358 NM_017418
DEC1
deleted in esophageal cancer 1
chr11_+_4571844 0.358 NM_001005169
OR52I1
olfactory receptor, family 52, subfamily I, member 1
chr15_-_69194854 0.355 NM_001102658
CT62
cancer/testis antigen 62

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.40 5.54e-04 GO:0005925 focal adhesion
2.09 8.19e-04 GO:0005912 adherens junction
2.27 1.54e-03 GO:0030055 cell-substrate junction
2.29 1.84e-03 GO:0005924 cell-substrate adherens junction
1.24 2.83e-03 GO:0044459 plasma membrane part
1.94 5.62e-03 GO:0070161 anchoring junction
1.14 4.10e-02 GO:0005886 plasma membrane
1.69 4.40e-02 GO:0016323 basolateral plasma membrane
1.14 4.93e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.65 1.20e-02 GO:0003779 actin binding