Motif ID: STAT5{A,B}.p2

Z-value: 0.704


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Achr17_+_37693090-0.457.8e-02Click!
STAT5Bchr17_-_37681917-0.058.5e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_49552638 1.634 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_49248003 1.539 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_39860398 1.456 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr6_-_27548438 1.389 NM_007149
 ZNF184
zinc finger protein 184
chr19_-_49309102 1.358 LOC100379224
hypothetical LOC100379224
chr19_+_42099073 1.317 NM_198539
 ZNF568
zinc finger protein 568
chr19_+_49290319 1.291 NM_013398
 ZNF224
zinc finger protein 224
chr19_+_49180171 1.273 NM_003445
NM_198089
 ZNF155

zinc finger protein 155

chr10_-_121345968 1.204 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr19_+_49361054 1.184 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chr19_+_42033106 1.149 NM_003419
 ZNF345
zinc finger protein 345
chr19_-_42098758 1.144 NM_001171979
 ZNF829
zinc finger protein 829
chr10_-_98315090 1.142 TM9SF3
transmembrane 9 superfamily member 3
chr19_+_42400908 1.135 ZNF383
zinc finger protein 383
chr19_-_49131250 1.125 NM_003425
 ZNF45
zinc finger protein 45
chr19_+_49198916 1.102 NM_006300
 ZNF230
zinc finger protein 230
chr5_+_178219519 1.081 NM_058230
 ZNF354B
zinc finger protein 354B
chr1_-_219977424 1.079 NM_144728
 DUSP10
dual specificity phosphatase 10
chr19_+_49309350 1.078 NM_013362
 ZNF225
zinc finger protein 225
chr19_-_62781883 1.036 NM_017879
 ZNF416
zinc finger protein 416
chr19_+_62972861 1.008 ZNF586
zinc finger protein 586
chr19_-_62680703 1.005 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr19_+_49221333 0.998 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_+_62949972 0.959 NM_173632
 ZNF776
zinc finger protein 776
chr19_-_62782066 0.946 ZNF416
zinc finger protein 416
chr17_+_15543771 0.946 ZNF286A
zinc finger protein 286A
chr19_+_45194782 0.931 NM_178544
 ZNF546
zinc finger protein 546
chr12_-_44670475 0.929 SCAF11
SR-related CTD-associated factor 11
chr19_+_49408523 0.928 NM_182490
 ZNF227
zinc finger protein 227
chr17_-_18526296 0.920 NM_001145045
 ZNF286B
zinc finger protein 286B
chr19_+_49337548 0.907 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr19_+_62950001 0.891 ZNF776
zinc finger protein 776
chr11_+_65024889 0.889 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr19_-_41672598 0.883 ZNF566
zinc finger protein 566
chr18_-_45241014 0.856 NM_017653
 DYM
dymeclin
chr19_+_49337568 0.848 ZNF234
zinc finger protein 234
chr9_-_103200697 0.839 NM_019051
 MRPL50
mitochondrial ribosomal protein L50
chr19_+_42033564 0.831 ZNF345
zinc finger protein 345
chr3_+_171422908 0.809 NM_002740
 PRKCI
protein kinase C, iota
chr1_+_40769877 0.802 ZNF684
zinc finger protein 684
chr19_-_41672176 0.763 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr19_+_49023283 0.763 NM_181845
 ZNF283
zinc finger protein 283
chr19_+_62972808 0.728 NM_017652
 ZNF586
zinc finger protein 586
chr19_-_49500966 0.726 NM_004234
 ZNF235
zinc finger protein 235
chr19_-_62912347 0.717 NM_001085384
 ZNF154
zinc finger protein 154
chr19_+_39916935 0.692 ZNF181
zinc finger protein 181
chr14_-_67232172 0.691 NM_016026
 RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr12_-_47250069 0.681 NM_002289
 LALBA
lactalbumin, alpha-
chr12_+_132167551 0.681 ZNF140
zinc finger protein 140
chr3_-_52839727 0.678 NM_001166449
NM_002218
 ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr6_+_139136349 0.663 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr19_-_49696322 0.660 NM_013256
 ZNF180
zinc finger protein 180
chr19_-_61596681 0.660 NM_144690
 ZNF582
zinc finger protein 582
chr19_+_61798434 0.639 NM_021216
 ZNF71
zinc finger protein 71
chr5_-_178090203 0.638 NM_005649
 ZNF354A
zinc finger protein 354A
chr16_+_52295545 0.635 FTO
fat mass and obesity associated
chr9_+_103200939 0.626 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chr8_-_66708948 0.625 ARMC1
armadillo repeat containing 1
chr7_-_93471463 0.622 NM_005868
 BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr1_-_33275015 0.611 AK2
adenylate kinase 2
chr5_+_32621361 0.609 NM_006713
 SUB1
SUB1 homolog (S. cerevisiae)
chr12_+_132167512 0.609 ZNF140
zinc finger protein 140
chr9_-_98656206 0.607 NM_001001662
 ZNF782
zinc finger protein 782
chr3_-_185218311 0.601 NM_001023587
NM_005688
 ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr19_+_39916964 0.599 ZNF181
zinc finger protein 181
chr16_-_52295214 0.595 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr19_+_62638474 0.594 NM_001023561
 ZNF749
zinc finger protein 749
chr20_-_18425811 0.589 NM_006606
 RBBP9
retinoblastoma binding protein 9
chr19_+_49147219 0.567 NM_013359
 ZNF221
zinc finger protein 221
chr19_+_62836322 0.566 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr7_+_89870707 0.563 CLDN12
claudin 12
chr6_-_83960351 0.562 PGM3
phosphoglucomutase 3
chr11_-_125278296 0.552 NM_031307
 PUS3
pseudouridylate synthase 3
chr2_+_161873031 0.551 NM_005805
 PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
chr5_+_178383381 0.549 NM_001136116
 ZNF879
zinc finger protein 879
chr8_-_56848423 0.547 NM_152417
 TMEM68
transmembrane protein 68
chr9_+_129226473 0.538 NM_007135
 ZNF79
zinc finger protein 79
chr19_-_41849558 0.534 NM_153257
 ZNF461
zinc finger protein 461
chr9_-_133944877 0.531 MED27
mediator complex subunit 27
chr16_-_219111 0.531


chr19_-_41711009 0.526 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr10_+_124903874 0.525 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr7_+_89870647 0.523 NM_001185072
NM_001185073
NM_012129
 CLDN12


claudin 12


chr17_-_5263594 0.523 NUP88
nucleoporin 88kDa
chr19_+_63053031 0.519 NM_032828
 ZNF587
zinc finger protein 587
chr18_-_41938196 0.510 NM_001001937
 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr1_+_40769819 0.504 NM_152373
 ZNF684
zinc finger protein 684
chr8_-_66708967 0.500 NM_018120
 ARMC1
armadillo repeat containing 1
chr11_-_82675024 0.498 NM_021825
 CCDC90B
coiled-coil domain containing 90B
chr9_-_103185621 0.498 NM_001127610
 BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr12_-_44670632 0.493 NM_004719
 SCAF11
SR-related CTD-associated factor 11
chr19_+_49455872 0.492 NM_181756
 ZNF233
zinc finger protein 233
chr1_-_33275071 0.489 NM_013411
 AK2
adenylate kinase 2
chr17_+_15543615 0.482 NM_001130842
NM_020652
 ZNF286A

zinc finger protein 286A

chr7_+_98940537 0.480 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr1_+_151897768 0.480 NM_012437
 SNAPIN
SNAP-associated protein
chr2_+_95194903 0.478 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr19_-_42098919 0.466 NM_001037232
 ZNF829
zinc finger protein 829
chr3_+_66094324 0.463 NM_173471
 SLC25A26
solute carrier family 25, member 26
chr17_+_5264195 0.462 RPAIN
RPA interacting protein
chr19_-_63018092 0.460 NM_024762
 ZNF552
zinc finger protein 552
chr1_+_38250953 0.459 NM_016037
 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr1_+_38250995 0.458 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr8_-_109330116 0.451 NM_001568
 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr15_+_20384835 0.450 NM_001102610
NM_052903
 TUBGCP5

tubulin, gamma complex associated protein 5

chr11_-_133628348 0.447 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
 THYN1




thymocyte nuclear protein 1




chr12_+_132167057 0.445 NM_003440
 ZNF140
zinc finger protein 140
chr2_+_95195260 0.439 ZNF2
zinc finger protein 2
chr18_+_41938295 0.439 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr19_-_42777486 0.433 NM_016536
 ZNF571
zinc finger protein 571
chr3_+_140545528 0.420 NM_020191
 MRPS22
mitochondrial ribosomal protein S22
chr2_+_43854681 0.418 NM_001193464
NM_015522
NM_016008
 DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr8_-_109330101 0.418 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr5_+_150008030 0.417 SYNPO
synaptopodin
chr19_+_63611819 0.413 NM_173548
 ZNF584
zinc finger protein 584
chr19_+_63611930 0.410 ZNF584
zinc finger protein 584
chr14_-_81069865 0.407 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr3_+_132228383 0.407 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr1_-_54291378 0.404 TMEM59
transmembrane protein 59
chr9_-_133945064 0.402 NM_004269
 CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr19_-_63205948 0.398 ZNF606
zinc finger protein 606
chr5_-_145542407 0.396 LARS
leucyl-tRNA synthetase
chr14_+_96333434 0.395 NM_003384
 VRK1
vaccinia related kinase 1
chr7_+_98940508 0.393 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr8_-_101384633 0.392 NM_015435
 RNF19A
ring finger protein 19A
chr3_-_158695832 0.392 NM_001167917
 VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr2_+_88772281 0.378 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr22_-_37232261 0.377 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr11_-_82674546 0.375 CCDC90B
coiled-coil domain containing 90B
chr22_-_37232290 0.373 NM_001098504
NM_006386
 DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr2_+_171999042 0.367 DCAF17
DDB1 and CUL4 associated factor 17
chr1_+_40715465 0.365 ZNF642
zinc finger protein 642
chr2_-_84540096 0.365 NM_003849
 SUCLG1
succinate-CoA ligase, alpha subunit
chr19_+_50601708 0.364 CD3EAP
CD3e molecule, epsilon associated protein
chr4_+_174528602 0.358 NM_003864
 SAP30
Sin3A-associated protein, 30kDa
chr12_-_44670613 0.356 SCAF11
SR-related CTD-associated factor 11
chr3_+_197951121 0.356 NM_002577
 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr5_-_111120817 0.356 NM_004772
 C5orf13
chromosome 5 open reading frame 13
chr19_+_9112052 0.354 NM_001190791
NM_020933
 ZNF317

zinc finger protein 317

chr2_+_63669596 0.343 NM_005917
 MDH1
malate dehydrogenase 1, NAD (soluble)
chr20_+_35266581 0.341 RPN2
ribophorin II
chr20_-_25625173 0.336 NM_015655
 ZNF337
zinc finger protein 337
chr7_-_112545840 0.335 LOC401397
hypothetical LOC401397
chr14_-_19951417 0.334 NM_007110
 TEP1
telomerase-associated protein 1
chrX_+_105932536 0.328 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr12_+_12857516 0.328 NM_016355
NM_201224
 DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr13_-_24395054 0.321 NM_018451
 CENPJ
centromere protein J
chr9_+_15412875 0.318 SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr9_-_114814286 0.316 NM_001101338
 ZNF883
zinc finger protein 883
chr3_-_120861959 0.315 NM_022135
 POPDC2
popeye domain containing 2
chr15_-_72540518 0.315 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr1_-_233734403 0.313 NM_152490
 B3GALNT2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr14_+_22305570 0.310 NM_005015
 OXA1L
oxidase (cytochrome c) assembly 1-like
chr9_+_129226535 0.310 ZNF79
zinc finger protein 79
chr6_-_159160355 0.308 EZR
ezrin
chr14_-_81069951 0.306 NM_005065
 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr6_+_88239423 0.305 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr19_+_58733144 0.305 NM_001079906
 ZNF331
zinc finger protein 331
chr22_-_37232246 0.304 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr13_+_24844084 0.302 NM_016529
 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr15_-_81744469 0.299 NM_001717
 BNC1
basonuclin 1
chr1_+_53165545 0.293 SCP2
sterol carrier protein 2
chr15_-_81527109 0.292 NM_001011885
NM_025238
 BTBD1

BTB (POZ) domain containing 1

chr14_+_23700261 0.291 NM_006084
 IRF9
interferon regulatory factor 9
chr6_-_159160421 0.290 NM_001111077
 EZR
ezrin
chr8_+_124154117 0.287 WDR67
WD repeat domain 67
chr3_-_132228273 0.287 NM_014065
 ASTE1
asteroid homolog 1 (Drosophila)
chr6_+_84626113 0.282 CYB5R4
cytochrome b5 reductase 4
chr15_-_81526896 0.281 BTBD1
BTB (POZ) domain containing 1
chr4_+_174528675 0.279 SAP30
Sin3A-associated protein, 30kDa
chr7_+_98940208 0.278 NM_145102
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr5_+_178300799 0.277 NM_001178089
NM_001178090
NM_182594
 ZNF454


zinc finger protein 454


chr8_-_66708954 0.275 ARMC1
armadillo repeat containing 1
chr3_+_123882355 0.274 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr19_+_55221088 0.273 ZNF473
zinc finger protein 473
chr4_+_2853434 0.270 ADD1
adducin 1 (alpha)
chr20_-_42713663 0.269 ADA
adenosine deaminase
chr5_-_95184121 0.264 GLRX
glutaredoxin (thioltransferase)
chr6_+_84626083 0.263 NM_016230
 CYB5R4
cytochrome b5 reductase 4
chr19_-_41955493 0.262 NM_001193552
 ZNF850
zinc finger protein 850
chr19_+_55221106 0.262 ZNF473
zinc finger protein 473
chr1_-_233734088 0.255 B3GALNT2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr4_+_70831387 0.252 NM_001025104
NM_001890
 CSN1S1

casein alpha s1

chrX_+_149487677 0.251 NM_000252
 MTM1
myotubularin 1
chr16_+_52025891 0.250 RBL2
retinoblastoma-like 2 (p130)
chr5_-_145542261 0.248 LARS
leucyl-tRNA synthetase
chr1_-_233734311 0.248 B3GALNT2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr6_+_20642665 0.246 NM_017774
 CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr5_-_145542428 0.243 NM_020117
 LARS
leucyl-tRNA synthetase
chr7_-_132417374 0.241 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr1_-_206125877 0.240


chr10_+_43421889 0.238 ZNF485
zinc finger protein 485
chr19_+_49268106 0.237 NM_001037813
 ZNF284
zinc finger protein 284
chr1_-_33275057 0.236 NM_001625
 AK2
adenylate kinase 2
chr7_-_133652289 0.235 NM_032826
 SLC35B4
solute carrier family 35, member B4
chr19_+_63022879 0.235 LOC100293516
zinc finger protein
chr14_-_69953433 0.234 NM_018373
 SYNJ2BP
synaptojanin 2 binding protein
chr21_-_35174742 0.231 RUNX1
runt-related transcription factor 1
chr6_-_159160386 0.231 EZR
ezrin
chr8_+_124154079 0.231 NM_001145088
NM_145647
 WDR67

WD repeat domain 67


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 3.64e-11 GO:0006355 regulation of transcription, DNA-dependent
2.13 3.27e-10 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.18 3.42e-10 GO:0051252 regulation of RNA metabolic process
2.10 6.06e-10 GO:0010556 regulation of macromolecule biosynthetic process
2.04 3.60e-09 GO:0010468 regulation of gene expression
1.97 7.28e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.97 1.42e-08 GO:0009889 regulation of biosynthetic process
1.97 1.79e-08 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.97 1.79e-08 GO:0031326 regulation of cellular biosynthetic process
1.80 1.22e-07 GO:0060255 regulation of macromolecule metabolic process
1.73 6.94e-07 GO:0031323 regulation of cellular metabolic process
1.72 1.36e-06 GO:0080090 regulation of primary metabolic process
1.65 3.47e-06 GO:0019222 regulation of metabolic process
1.33 3.42e-03 GO:0050794 regulation of cellular process
1.29 4.95e-03 GO:0065007 biological regulation
1.28 2.61e-02 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 8.02e-16 GO:0043229 intracellular organelle
1.41 1.08e-15 GO:0043226 organelle
1.45 8.04e-15 GO:0043231 intracellular membrane-bounded organelle
1.45 9.51e-15 GO:0043227 membrane-bounded organelle
1.67 4.55e-13 GO:0005634 nucleus
1.29 6.52e-12 GO:0044424 intracellular part
1.27 9.43e-11 GO:0005622 intracellular
1.09 9.72e-03 GO:0044464 cell part
1.09 9.84e-03 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.52 2.94e-16 GO:0008270 zinc ion binding
2.39 3.31e-16 GO:0046914 transition metal ion binding
2.30 2.54e-14 GO:0003677 DNA binding
1.89 9.59e-11 GO:0003676 nucleic acid binding
1.77 3.74e-10 GO:0046872 metal ion binding
1.75 8.65e-10 GO:0043169 cation binding
1.74 1.04e-09 GO:0043167 ion binding