Motif ID: TBX4,5.p2

Z-value: 0.882


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX4chr17_+_568845600.273.1e-01Click!
TBX5chr12_-_113330574-0.116.8e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_61204392 1.046 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr17_+_4621924 0.889 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr12_+_130004404 0.717 NM_198827
GPR133
G protein-coupled receptor 133
chr14_+_94148466 0.681 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr20_-_24987615 0.656 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr15_+_88120592 0.605 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr3_+_187813553 0.579 AHSG
alpha-2-HS-glycoprotein
chr17_-_6958282 0.522 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr12_+_56435042 0.518 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr12_-_26877189 0.506 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr6_+_26476384 0.486 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr22_-_49363711 0.483 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr14_+_92188546 0.482 RIN3
Ras and Rab interactor 3
chr17_-_16816113 0.476 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr2_+_219453487 0.468 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr20_+_61963009 0.451 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr17_+_64922420 0.450 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr3_+_168936125 0.442 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr6_+_31651319 0.439 NM_000594
TNF
tumor necrosis factor
chr2_+_171280046 0.438 NM_001003845
SP5
Sp5 transcription factor
chr11_-_2138984 0.432 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr19_+_482688 0.426 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr16_-_49272617 0.421 SNX20
sorting nexin 20
chr20_+_42463279 0.420 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr17_-_2943039 0.420 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr19_+_14501403 0.413 TECR
trans-2,3-enoyl-CoA reductase
chr19_+_482737 0.413 CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr18_-_42490993 0.409 NM_144612
LOXHD1
lipoxygenase homology domains 1
chr11_-_124137260 0.403 NM_138961
ESAM
endothelial cell adhesion molecule
chr1_+_152644668 0.398 IL6R
interleukin 6 receptor
chr22_-_31732648 0.396 NM_003490
NM_133633
SYN3

synapsin III

chr17_+_31455332 0.395 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr10_-_99521701 0.395 NM_003015
SFRP5
secreted frizzled-related protein 5
chr14_-_53491019 0.392 NM_130851
BMP4
bone morphogenetic protein 4
chrX_+_75564449 0.392 NM_020932
MAGEE1
melanoma antigen family E, 1
chr17_+_52689372 0.391 NM_170721
MSI2
musashi homolog 2 (Drosophila)
chr20_+_8060762 0.391 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr19_-_4509471 0.387 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr16_-_87460514 0.383 NM_001080487
PABPN1L
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr14_+_20537253 0.376 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr11_-_128242342 0.374 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr15_+_72209039 0.373 NM_001130137
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr21_-_41801950 0.368 NM_005656
TMPRSS2
transmembrane protease, serine 2
chr22_+_23153529 0.367 NM_000675
ADORA2A
adenosine A2a receptor
chr9_-_34387786 0.365 NM_032596
C9orf24
chromosome 9 open reading frame 24
chr2_+_29057667 0.363 NM_199280
FAM179A
family with sequence similarity 179, member A
chr16_-_49272741 0.362 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr15_+_72208751 0.362 NM_001130136
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr11_+_48303047 0.359 NM_001004702
OR4C3
olfactory receptor, family 4, subfamily C, member 3
chr2_-_152664056 0.358 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr3_-_49701085 0.356 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_152644471 0.355 IL6R
interleukin 6 receptor
chr19_+_7734034 0.355 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr21_+_44856423 0.354 NM_198695
KRTAP10-8
keratin associated protein 10-8
chr13_-_33148899 0.353 STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_176761552 0.350 NM_024501
HOXD1
homeobox D1
chr1_+_157441133 0.350 NM_002036
DARC
Duffy blood group, chemokine receptor
chr5_+_133889584 0.349 NM_015288
PHF15
PHD finger protein 15
chr16_+_56134037 0.341 GPR114
G protein-coupled receptor 114
chr19_+_14501406 0.339 TECR
trans-2,3-enoyl-CoA reductase
chr2_+_171280944 0.339 SP5
Sp5 transcription factor
chr16_+_3055640 0.337 IL32
interleukin 32
chr10_+_120957084 0.337 NM_005308
GRK5
G protein-coupled receptor kinase 5
chrX_+_153325643 0.337 NM_004699
FAM50A
family with sequence similarity 50, member A
chr1_-_35143570 0.337 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr14_-_106270497 0.337 IGHG3
immunoglobulin heavy constant gamma 3 (G3m marker)
chr16_-_2521359 0.332 NM_001048212
CEMP1
cementum protein 1
chr20_-_4752067 0.327 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr10_+_114125003 0.326 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_-_22513050 0.325 NM_021784
FOXA2
forkhead box A2
chr7_+_29200850 0.325 CHN2
chimerin (chimaerin) 2
chr1_+_149750485 0.324 NM_020770
CGN
cingulin
chr2_+_219244963 0.324 NM_015690
STK36
serine/threonine kinase 36
chr7_-_99864220 0.323 NM_017984
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr16_+_55963883 0.321 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr9_-_103237851 0.318 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr19_+_14501363 0.317 NM_138501
TECR
trans-2,3-enoyl-CoA reductase
chrX_-_130251068 0.316 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr6_+_167445284 0.316 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr17_+_77529070 0.314 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_141568210 0.314 NM_001130675
NM_004362
CLGN

calmegin

chr3_+_10832867 0.313 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr21_-_41801778 0.313 NM_001135099
TMPRSS2
transmembrane protease, serine 2
chr1_-_10964680 0.311 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr3_+_135996990 0.309 EPHB1
EPH receptor B1
chr5_+_81636921 0.308 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr15_-_88095363 0.304 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr19_+_40213431 0.302 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr5_+_142130475 0.300 NM_001135608
NM_015071
ARHGAP26

Rho GTPase activating protein 26

chr11_+_66547391 0.300 NM_177963
SYT12
synaptotagmin XII
chr21_-_41801946 0.297 TMPRSS2
transmembrane protease, serine 2
chr17_+_56831951 0.294 NM_005994
TBX2
T-box 2
chr6_-_32268615 0.292 GPSM3
G-protein signaling modulator 3
chrX_-_130250880 0.291 IGSF1
immunoglobulin superfamily, member 1
chr9_-_116196505 0.291 NM_030767
AKNA
AT-hook transcription factor
chr6_+_43135606 0.290 NM_201523
KLC4
kinesin light chain 4
chr14_-_106084519 0.289 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_35818728 0.289 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr14_+_22581215 0.289 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chr17_+_77442909 0.288 ANAPC11
anaphase promoting complex subunit 11
chr3_+_120983620 0.287 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr3_+_120983556 0.285 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_-_8118367 0.283 NM_032447
FBN3
fibrillin 3
chr2_+_218992053 0.282 NM_007127
VIL1
villin 1
chr16_+_56134077 0.281 NM_153837
GPR114
G protein-coupled receptor 114
chr3_+_114414064 0.281 NM_033254
BOC
Boc homolog (mouse)
chr20_-_3133286 0.280 NM_023935
DDRGK1
DDRGK domain containing 1
chr7_-_44331544 0.276 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_28797309 0.275 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr2_-_218843088 0.275 AAMP
angio-associated, migratory cell protein
chr17_-_33178987 0.274 HNF1B
HNF1 homeobox B
chrX_-_19598912 0.274 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr4_-_105631915 0.273 NM_025212
CXXC4
CXXC finger protein 4
chrX_-_130250715 0.273 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr1_-_205161821 0.272 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr3_+_187813538 0.271 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr11_-_605998 0.270 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr14_-_23734433 0.268 TM9SF1
transmembrane 9 superfamily member 1
chr3_+_135996734 0.268 NM_004441
EPHB1
EPH receptor B1
chr14_+_74964672 0.268 NM_001135048
NM_130469
JDP2

Jun dimerization protein 2

chr11_-_605649 0.267 NM_004031
IRF7
interferon regulatory factor 7
chr14_+_23175383 0.266 NM_005794
NM_182908
DHRS2

dehydrogenase/reductase (SDR family) member 2

chr8_-_81155564 0.266 NM_001025252
TPD52
tumor protein D52
chr22_-_49240594 0.265 SBF1
SET binding factor 1
chr9_+_136912474 0.263 NM_004108
NM_015837
FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

chr11_-_605920 0.263 IRF7
interferon regulatory factor 7
chr11_+_59979857 0.262 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_+_127892489 0.262 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr11_+_70926718 0.262 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr16_-_20271530 0.261 NM_001008389
NM_003361
UMOD

uromodulin

chr19_+_40716153 0.261 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr3_+_187813405 0.260 AHSG
alpha-2-HS-glycoprotein
chr9_+_115151632 0.259 NM_017688
BSPRY
B-box and SPRY domain containing
chr6_+_167456230 0.258 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr17_-_40858775 0.258 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr20_-_1298493 0.258 FKBP1A
FK506 binding protein 1A, 12kDa
chr15_+_86983038 0.257 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr5_+_167651063 0.257 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr9_+_114288899 0.257 NM_133465
KIAA1958
KIAA1958
chr22_+_40816850 0.256 LOC100132273
hypothetical LOC100132273
chr3_-_198767202 0.255 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr2_-_70167569 0.254 LOC400960
hypothetical LOC400960
chr14_-_19973640 0.254 NM_001109997
KLHL33
kelch-like 33 (Drosophila)
chr9_-_34366831 0.249 NM_020702
KIAA1161
KIAA1161
chr11_+_68614059 0.248


chr14_-_23734446 0.248 TM9SF1
transmembrane 9 superfamily member 1
chr22_-_49363209 0.246 NM_001145137
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr22_-_35835548 0.246 TMPRSS6
transmembrane protease, serine 6
chr5_+_133870175 0.245


chr3_-_52419086 0.243 BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr18_+_65219114 0.242 NM_152721
DOK6
docking protein 6
chr13_+_23742846 0.242 SPATA13
spermatogenesis associated 13
chr14_+_23670514 0.241 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr15_-_72288362 0.241 NM_001142617
NM_001142619
NM_001142620
STRA6


stimulated by retinoic acid gene 6 homolog (mouse)


chr13_+_34414390 0.240 NM_015678
NBEA
neurobeachin
chr16_+_55963899 0.240 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_6668880 0.240 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr12_+_53241365 0.239 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr9_-_122877231 0.239 C5
complement component 5
chr19_+_46762872 0.237 CEACAM21
carcinoembryonic antigen-related cell adhesion molecule 21
chr6_+_43135346 0.236 NM_138343
NM_201521
KLC4

kinesin light chain 4

chr10_-_101831579 0.236 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_+_171280182 0.234


chr8_+_145700272 0.234 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr14_+_23675233 0.233 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_241408296 0.233 NM_004321
KIF1A
kinesin family member 1A
chr16_-_66523255 0.233 NM_001907
CTRL
chymotrypsin-like
chr3_+_52803823 0.231 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr7_+_74017015 0.231 NM_001145063
GATSL1
GATSL2
GATS protein-like 1
GATS protein-like 2
chr22_+_29974314 0.231 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr2_+_96355661 0.230 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr12_+_54396118 0.230 BLOC1S1
biogenesis of lysosomal organelles complex-1, subunit 1
chr17_-_37222349 0.230 LEPREL4
leprecan-like 4
chr12_-_47545816 0.229 NM_014470
RND1
Rho family GTPase 1
chr4_+_3285671 0.229 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chr17_+_77442892 0.229 NM_001002244
NM_001002245
NM_001002246
NM_001002247
NM_001002248
NM_016476
ANAPC11





anaphase promoting complex subunit 11





chrX_-_2428963 0.229 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr1_-_154215558 0.228 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr6_-_71069347 0.227 NM_001851
COL9A1
collagen, type IX, alpha 1
chr19_+_55398680 0.226 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr10_+_63331401 0.226 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_+_89870707 0.225 CLDN12
claudin 12
chr2_-_100088760 0.225 AFF3
AF4/FMR2 family, member 3
chr6_+_43553233 0.225 NM_001146016
NM_001146018
NM_001146019
NM_001146020
NM_080604
TJAP1




tight junction associated protein 1 (peripheral)




chr11_-_1576057 0.224 NM_001004325
KRTAP5-2
keratin associated protein 5-2
chr2_+_65070030 0.223 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr1_-_172153087 0.222 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_80626456 0.221 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_-_36346240 0.221 KRT23
keratin 23 (histone deacetylase inducible)
chr7_-_22363036 0.220 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_53587492 0.219 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr14_+_23675206 0.218 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr2_+_74610039 0.218 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr6_+_29902734 0.218 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr12_+_52665196 0.218 NM_017409
HOXC10
homeobox C10
chr5_+_176786279 0.216 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr7_-_44547382 0.216 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr2_-_60634271 0.216 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr19_-_51820133 0.216 NM_000960
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr15_-_38886937 0.216 DNAJC17
DnaJ (Hsp40) homolog, subfamily C, member 17

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 6.93e-06 GO:0050896 response to stimulus
1.24 1.68e-05 GO:0023052 signaling
1.51 4.36e-05 GO:0009605 response to external stimulus
1.52 2.18e-04 GO:0040011 locomotion
1.13 2.50e-04 GO:0065007 biological regulation
1.20 9.06e-04 GO:0051716 cellular response to stimulus
1.70 1.47e-03 GO:0032583 regulation of gene-specific transcription
1.38 1.58e-03 GO:0051239 regulation of multicellular organismal process
1.61 3.76e-03 GO:0006935 chemotaxis
1.61 3.76e-03 GO:0042330 taxis
1.21 4.01e-03 GO:0007165 signal transduction
1.12 4.03e-03 GO:0050789 regulation of biological process
1.30 5.08e-03 GO:0048583 regulation of response to stimulus
1.12 6.27e-03 GO:0050794 regulation of cellular process
2.00 7.17e-03 GO:0032582 negative regulation of gene-specific transcription
3.36 1.73e-02 GO:0001708 cell fate specification
1.15 1.80e-02 GO:0032501 multicellular organismal process
2.02 3.78e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.25 4.08e-02 GO:0065008 regulation of biological quality
1.07 4.24e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.93 2.41e-02 GO:0005912 adherens junction
1.21 3.32e-02 GO:0044459 plasma membrane part
2.43 4.63e-02 GO:0030426 growth cone

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.60 1.70e-05 GO:0043565 sequence-specific DNA binding
1.40 2.68e-03 GO:0001071 nucleic acid binding transcription factor activity
1.40 2.68e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
3.30 2.83e-03 GO:0003823 antigen binding
1.11 5.87e-03 GO:0005515 protein binding
1.34 4.17e-02 GO:0005102 receptor binding