Motif ID: TEAD1.p2

Z-value: 4.430


Transcription factors associated with TEAD1.p2:

Gene SymbolEntrez IDGene Name
TEAD1 7003 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 8463 TEA domain family member 2
TEAD3 7005 TEAD3 TEA domain family member 3
TEAD4 7004 TEAD4 TEA domain family member 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TEAD1chr11_+_129173690.911.2e-06Click!
TEAD4chr12_+_29387030.853.3e-05Click!
TEAD2chr19_-_545574500.165.6e-01Click!
TEAD3chr6_-_355726940.078.0e-01Click!


Activity profile for motif TEAD1.p2.

activity profile for motif TEAD1.p2


Sorted Z-values histogram for motif TEAD1.p2

Sorted Z-values for motif TEAD1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_132314004 9.323 NM_001901
CTGF
connective tissue growth factor
chr19_+_39664706 8.956 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr1_-_212791597 8.621 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr3_-_135575925 8.551 NM_016201
AMOTL2
angiomotin like 2
chr1_-_212791467 7.842 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr15_+_37660568 6.117 NM_003246
THBS1
thrombospondin 1
chr4_+_184257337 5.285 NM_024949
WWC2
WW and C2 domain containing 2
chr6_-_75972286 4.878 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr10_-_125843092 4.519 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr5_-_39460687 4.481 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr1_-_1283770 4.148 NM_032348
MXRA8
matrix-remodelling associated 8
chr15_+_73728402 3.950 NM_153271
SNX33
sorting nexin 33
chr3_-_113841967 3.812 CCDC80
coiled-coil domain containing 80
chr14_-_88090641 3.721 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr1_-_16355013 3.698 NM_004431
EPHA2
EPH receptor A2
chr14_-_22516271 3.633 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_-_189752575 3.585 NM_000393
COL5A2
collagen, type V, alpha 2
chr14_-_22515725 3.572 JUB
jub, ajuba homolog (Xenopus laevis)
chr11_-_6298284 3.496 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_85819004 3.461 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr6_-_128883125 3.419 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr8_+_1759502 3.379 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr10_+_102782151 3.377 SFXN3
sideroflexin 3
chr9_+_136673534 3.341 COL5A1
collagen, type V, alpha 1
chr19_-_49523747 3.339 ZFP112
zinc finger protein 112 homolog (mouse)
chr3_-_113842133 3.326 CCDC80
coiled-coil domain containing 80
chr1_-_199613427 3.305 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr3_-_113841941 3.299 CCDC80
coiled-coil domain containing 80
chr3_+_9919295 3.241 NM_153483
IL17RE
interleukin 17 receptor E
chr15_-_39973566 3.201 NM_016642
SPTBN5
spectrin, beta, non-erythrocytic 5
chr7_+_134114912 3.195 CALD1
caldesmon 1
chr17_-_37828643 3.144 NM_012232
PTRF
polymerase I and transcript release factor
chr3_-_113842350 3.115 CCDC80
coiled-coil domain containing 80
chr3_-_113842255 3.053 CCDC80
coiled-coil domain containing 80
chr19_-_14467939 2.925 NM_005716
NM_202467
NM_202468
NM_202469
NM_202470
NM_202494
GIPC1





GIPC PDZ domain containing family, member 1





chr18_+_8707368 2.920 NM_015210
KIAA0802
KIAA0802
chr11_-_8789457 2.887 NM_139157
ST5
suppression of tumorigenicity 5
chr19_-_14467890 2.873 GIPC1
GIPC PDZ domain containing family, member 1
chr5_-_39460787 2.697 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_-_113842553 2.671 CCDC80
coiled-coil domain containing 80
chr4_-_152368492 2.635 SH3D19
SH3 domain containing 19
chr7_+_134114701 2.567 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr3_-_113842652 2.547 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr22_+_22907443 2.487 NM_019601
SUSD2
sushi domain containing 2
chr8_-_13018123 2.464 NM_001164271
DLC1
deleted in liver cancer 1
chr11_-_8788765 2.462 NM_213618
ST5
suppression of tumorigenicity 5
chr11_-_47427263 2.460 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr5_-_39461054 2.401 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_+_51728999 2.380 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr6_-_75972473 2.347 COL12A1
collagen, type XII, alpha 1
chr2_+_102125616 2.343 IL1R1
interleukin 1 receptor, type I
chr22_+_40286957 2.329 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr8_+_70541412 2.287 NM_001128204
NM_015170
SULF1

sulfatase 1

chr6_-_42218692 2.275 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr3_+_9919511 2.274 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr10_+_102782156 2.242 SFXN3
sideroflexin 3
chr6_+_134251957 2.229 TCF21
transcription factor 21
chr15_+_61121806 2.225 NM_000366
NM_001018004
NM_001018005
NM_001018006
NM_001018007
NM_001018020
TPM1





tropomyosin 1 (alpha)





chr6_+_134251940 2.221 NM_198392
NM_003206
TCF21

transcription factor 21

chr1_+_181421796 2.198 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr21_-_26345294 2.193


chr17_-_24973940 2.185 CORO6
coronin 6
chr1_+_181422016 2.175 LAMC2
laminin, gamma 2
chr6_+_83130220 2.163 TPBG
trophoblast glycoprotein
chr1_-_207892420 2.138 NM_000228
LAMB3
laminin, beta 3
chr1_+_181421984 2.131 LAMC2
laminin, gamma 2
chr1_-_199704773 2.090 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr5_-_151046680 2.076 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_-_151046638 2.049 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chrX_-_106129854 2.024 MORC4
MORC family CW-type zinc finger 4
chr17_+_71229151 2.015 ITGB4
integrin, beta 4
chr13_+_109936080 1.988 COL4A2
collagen, type IV, alpha 2
chr15_-_67494412 1.987 LOC145694
hypothetical LOC145694
chr2_-_192420168 1.955 NM_004657
SDPR
serum deprivation response
chr5_-_37871349 1.945 NM_199231
GDNF
glial cell derived neurotrophic factor
chr12_-_119172339 1.938 NM_025157
PXN
paxillin
chr5_-_37871685 1.935 NM_001190468
NM_001190469
GDNF

glial cell derived neurotrophic factor

chr3_-_113842237 1.917 CCDC80
coiled-coil domain containing 80
chr2_-_192419896 1.910 SDPR
serum deprivation response
chr7_+_134114957 1.890 CALD1
caldesmon 1
chr1_-_207892296 1.890 NM_001127641
LAMB3
laminin, beta 3
chr11_-_46896484 1.878 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr19_+_58239802 1.871 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr22_+_22907417 1.862 SUSD2
sushi domain containing 2
chr2_-_160972606 1.857 RBMS1
RNA binding motif, single stranded interacting protein 1
chr10_+_123862430 1.842 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_115952279 1.833 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr2_-_215955206 1.830 FN1
fibronectin 1
chr12_-_47464143 1.812 NM_015270
ADCY6
adenylate cyclase 6
chr11_-_85107569 1.810 NM_206929
SYTL2
synaptotagmin-like 2
chr5_-_58918031 1.801 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_7136147 1.780 NM_001733
C1R
complement component 1, r subcomponent
chr9_+_115970599 1.778 COL27A1
collagen, type XXVII, alpha 1
chrX_-_10548458 1.764 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr19_+_50041424 1.744 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr9_+_34980715 1.717 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr3_+_148609841 1.700 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr15_+_61122139 1.675 TPM1
tropomyosin 1 (alpha)
chr17_+_71229191 1.670 ITGB4
integrin, beta 4
chr12_-_13044448 1.656 HEBP1
heme binding protein 1
chr5_+_34723420 1.644 NM_001145523
RAI14
retinoic acid induced 14
chr12_-_7136189 1.642 C1R
complement component 1, r subcomponent
chr6_-_134538762 1.638 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr12_+_27568311 1.631 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr11_-_2127368 1.628 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_95303947 1.626 PROM2
prominin 2
chr5_-_148422799 1.621 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr1_-_148175383 1.616 NM_001145862
MTMR11
myotubularin related protein 11
chr12_-_53099277 1.615 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chrX_-_53327473 1.610 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr16_-_62573 1.594 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr1_-_153272859 1.583 NM_144622
DCST2
DC-STAMP domain containing 2
chr6_+_83129641 1.575 NM_006670
TPBG
trophoblast glycoprotein
chr2_-_217248967 1.568 IGFBP5
insulin-like growth factor binding protein 5
chr3_-_10522267 1.562 NM_001001331
NM_001683
ATP2B2

ATPase, Ca++ transporting, plasma membrane 2

chr3_-_129023850 1.553 NM_007283
MGLL
monoglyceride lipase
chr1_+_216585298 1.552 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr10_-_17699309 1.516 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr20_+_34603311 1.488 MYL9
myosin, light chain 9, regulatory
chr5_+_176446425 1.464 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr12_-_53099269 1.460 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr9_+_112470871 1.457 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chrX_+_106050261 1.454 NM_020384
CLDN2
claudin 2
chr14_+_54102518 1.449 LOC644925
hypothetical LOC644925
chr2_-_220116062 1.441 NM_001195731
CHPF
chondroitin polymerizing factor
chrX_-_152794592 1.427 NM_000425
NM_001143963
NM_024003
L1CAM


L1 cell adhesion molecule


chr12_-_15706340 1.410 EPS8
epidermal growth factor receptor pathway substrate 8
chr3_-_115825742 1.406 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_53099203 1.385 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr14_-_22521544 1.376 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_-_94708641 1.363 NM_021229
NTN4
netrin 4
chr3_+_125586241 1.362 KALRN
kalirin, RhoGEF kinase
chr1_+_238321794 1.335 NM_020066
FMN2
formin 2
chr3_-_150533948 1.330 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr4_-_89837951 1.328 NM_153757
NAP1L5
nucleosome assembly protein 1-like 5
chr11_+_46323495 1.316 DGKZ
diacylglycerol kinase, zeta
chr1_-_151848039 1.282 S100A16
S100 calcium binding protein A16
chr17_+_3486510 1.273 NM_001031681
NM_004937
CTNS

cystinosis, nephropathic

chr17_+_71229110 1.272 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr3_+_50281309 1.265 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr20_+_34603290 1.263 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chrX_-_83644054 1.258 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr7_+_115952074 1.256 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr2_+_95303922 1.243 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr11_+_19328846 1.241 NM_001111018
NAV2
neuron navigator 2
chr11_+_124294355 1.241 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr6_+_131508153 1.228 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr18_-_19496590 1.226 NM_173505
ANKRD29
ankyrin repeat domain 29
chr12_-_13044314 1.222 HEBP1
heme binding protein 1
chr8_-_38444398 1.216 NM_001174065
NM_001174066
NM_001174067
FGFR1


fibroblast growth factor receptor 1


chr19_-_41514390 1.212


chr12_-_54387934 1.212 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr11_+_113671744 1.211 NM_006169
NNMT
nicotinamide N-methyltransferase
chr6_-_134538526 1.210 SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_54387732 1.208 ITGA7
integrin, alpha 7
chr18_+_13815542 1.177 NM_005913
MC5R
melanocortin 5 receptor
chr12_-_13044467 1.175 NM_015987
HEBP1
heme binding protein 1
chr15_-_93671314 1.175 LOC400456
hypothetical LOC400456
chr1_-_201411533 1.170 NM_004997
MYBPH
myosin binding protein H
chr3_+_113061218 1.156 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr11_-_124311512 1.153 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr19_+_41980248 1.151 LOC284408
hypothetical LOC284408
chr5_+_140848905 1.148 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr2_-_75641587 1.121 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr2_-_75641535 1.118 FAM176A
family with sequence similarity 176, member A
chr12_+_77782579 1.108 NM_005639
SYT1
synaptotagmin I
chr1_-_17179694 1.105 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr6_-_167491305 1.102 NM_005299
GPR31
G protein-coupled receptor 31
chr11_+_66580861 1.094 NM_014578
RHOD
ras homolog gene family, member D
chr5_+_38882017 1.089 OSMR
oncostatin M receptor
chr5_+_76150637 1.086 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr5_+_150138489 1.082 C5orf62
chromosome 5 open reading frame 62
chr6_+_158322875 1.080 NM_003898
SYNJ2
synaptojanin 2
chr19_-_54063522 1.075 NM_001161354
NM_020904
PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chr9_+_88953378 1.069 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr11_+_66580884 1.061 RHOD
ras homolog gene family, member D
chr14_-_22974707 1.058 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr12_+_77782648 1.048 SYT1
synaptotagmin I
chr1_-_148175345 1.045 MTMR11
myotubularin related protein 11
chr9_+_111927601 1.036 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr5_-_38631263 1.022 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr19_-_13909877 1.014 PODNL1
podocan-like 1
chr1_-_24311212 1.013 NM_152372
MYOM3
myomesin family, member 3
chr11_+_57123927 1.011 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr8_-_146173531 1.011 ZNF252
zinc finger protein 252
chr8_-_38444675 1.011 FGFR1
fibroblast growth factor receptor 1
chr12_+_2938703 1.007 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr6_-_3102690 1.005 NM_001069
TUBB2A
tubulin, beta 2A
chr3_-_48446405 1.003 NM_001130082
PLXNB1
plexin B1
chr9_+_90339835 0.996 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr9_-_106705780 0.987 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_158098962 0.980 NM_001013661
VSIG8
V-set and immunoglobulin domain containing 8
chr11_-_10630408 0.980 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr9_-_16717887 0.979 BNC2
basonuclin 2
chr4_-_171247757 0.978 NM_016228
AADAT
aminoadipate aminotransferase
chr4_-_184480572 0.977 NM_001185149
CLDN24
claudin 24
chr11_-_126375895 0.969 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr16_+_2461500 0.965 NM_006181
NTN3
netrin 3
chr7_+_115952325 0.963 CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_114323552 0.956 NM_020190
OLFML3
olfactomedin-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.97 6.53e-05 GO:0007155 cell adhesion
1.97 6.53e-05 GO:0022610 biological adhesion
1.77 1.63e-03 GO:0048468 cell development
1.34 2.79e-03 GO:0007275 multicellular organismal development
1.31 4.05e-03 GO:0032502 developmental process
1.38 4.84e-03 GO:0048731 system development
1.55 5.61e-03 GO:0009653 anatomical structure morphogenesis
1.35 5.65e-03 GO:0048856 anatomical structure development
2.03 8.62e-03 GO:0072358 cardiovascular system development
2.03 8.62e-03 GO:0072359 circulatory system development
2.35 1.05e-02 GO:0001944 vasculature development
1.24 1.20e-02 GO:0032501 multicellular organismal process
2.37 1.61e-02 GO:0001568 blood vessel development
1.45 1.83e-02 GO:0048513 organ development
2.52 2.01e-02 GO:0048514 blood vessel morphogenesis
3.07 2.65e-02 GO:0014706 striated muscle tissue development
2.25 3.46e-02 GO:0030029 actin filament-based process
2.28 3.57e-02 GO:0061061 muscle structure development
2.21 3.85e-02 GO:0022603 regulation of anatomical structure morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 5.52e-06 GO:0005576 extracellular region
3.71 2.78e-05 GO:0044420 extracellular matrix part
2.32 5.66e-05 GO:0031012 extracellular matrix
1.31 1.02e-04 GO:0071944 cell periphery
1.46 1.27e-04 GO:0044459 plasma membrane part
1.30 3.04e-04 GO:0005886 plasma membrane
2.40 3.46e-04 GO:0015629 actin cytoskeleton
1.68 4.64e-04 GO:0044421 extracellular region part
2.31 6.04e-04 GO:0005578 proteinaceous extracellular matrix
4.08 8.98e-04 GO:0005604 basement membrane
2.45 2.17e-02 GO:0031252 cell leading edge
5.44 2.25e-02 GO:0001725 stress fiber
12.70 3.45e-02 GO:0001527 microfibril
5.08 3.86e-02 GO:0032432 actin filament bundle

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.41 1.17e-04 GO:0003779 actin binding
3.38 1.39e-03 GO:0019838 growth factor binding
3.81 1.70e-03 GO:0005201 extracellular matrix structural constituent
2.83 4.87e-03 GO:0005539 glycosaminoglycan binding
2.74 5.42e-03 GO:0001871 pattern binding
2.74 5.42e-03 GO:0030247 polysaccharide binding
1.88 5.68e-03 GO:0008092 cytoskeletal protein binding
1.76 9.92e-03 GO:0005509 calcium ion binding
6.10 1.39e-02 GO:0050840 extracellular matrix binding
4.43 3.05e-02 GO:0008307 structural constituent of muscle
7.62 3.50e-02 GO:0043236 laminin binding
2.89 3.74e-02 GO:0008201 heparin binding