Motif ID: TFAP2{A,C}.p2

Z-value: 3.674


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10520264-0.485.8e-02Click!
TFAP2Cchr20_+_54637714-0.411.2e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_115958051 6.883 NM_032888
 COL27A1
collagen, type XXVII, alpha 1
chr9_+_136673534 5.801 COL5A1
collagen, type V, alpha 1
chr2_+_236068029 5.442 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_+_92946348 5.349 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_33494745 4.954 NM_152493
 ZNF362
zinc finger protein 362
chr9_+_136673464 4.634 NM_000093
 COL5A1
collagen, type V, alpha 1
chr17_+_56832255 4.396 TBX2
T-box 2
chr3_-_126257425 4.183 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr3_-_130807865 4.058 NM_015103
 PLXND1
plexin D1
chr17_+_56831951 3.984 NM_005994
 TBX2
T-box 2
chr8_-_38444982 3.881 FGFR1
fibroblast growth factor receptor 1
chr2_+_235525355 3.869 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr8_+_37672427 3.742 NM_025069
 ZNF703
zinc finger protein 703
chr5_-_159672060 3.610 NM_024565
 CCNJL
cyclin J-like
chr2_+_236067687 3.585 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_-_187025501 3.412 NM_001007225
NM_006548
 IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr19_+_15079141 3.307 NM_033025
 SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr19_+_38377329 3.290 NM_002333
 LRP3
low density lipoprotein receptor-related protein 3
chr3_+_185580554 3.230 NM_003741
 CHRD
chordin
chr22_+_49459935 3.209 NM_001080420
 SHANK3
SH3 and multiple ankyrin repeat domains 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 106 entries
enrichment   p-value GO term description
1.41 2.28e-04 GO:0030036 actin cytoskeleton organization
1.39 1.53e-02 GO:0044087 regulation of cellular component biogenesis
1.36 2.47e-02 GO:0051129 negative regulation of cellular component organization
1.36 4.50e-02 GO:0045786 negative regulation of cell cycle
1.35 3.11e-03 GO:0030029 actin filament-based process
1.35 1.36e-02 GO:0046578 regulation of Ras protein signal transduction
1.34 4.66e-02 GO:0001558 regulation of cell growth
1.32 1.85e-02 GO:0051329 interphase of mitotic cell cycle
1.31 5.80e-05 GO:0007010 cytoskeleton organization
1.31 5.26e-03 GO:0044419 interspecies interaction between organisms
1.31 9.83e-03 GO:0009894 regulation of catabolic process
1.31 2.41e-02 GO:0051325 interphase
1.30 2.45e-06 GO:0051726 regulation of cell cycle
1.30 2.45e-04 GO:0072358 cardiovascular system development
1.30 2.45e-04 GO:0072359 circulatory system development
1.27 8.52e-07 GO:0051128 regulation of cellular component organization
1.26 4.26e-07 GO:0048468 cell development
1.26 5.99e-03 GO:0031175 neuron projection development
1.26 4.95e-02 GO:0007409 axonogenesis
1.25 8.55e-04 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.63 3.61e-04 GO:0030027 lamellipodium
1.60 2.47e-02 GO:0030426 growth cone
1.57 2.28e-08 GO:0031252 cell leading edge
1.53 3.16e-02 GO:0014069 postsynaptic density
1.50 2.95e-02 GO:0016585 chromatin remodeling complex
1.49 4.47e-02 GO:0001726 ruffle
1.30 6.13e-03 GO:0015629 actin cytoskeleton
1.18 3.97e-10 GO:0044428 nuclear part
1.17 4.40e-09 GO:0005829 cytosol
1.17 6.15e-07 GO:0031981 nuclear lumen
1.17 9.96e-05 GO:0005654 nucleoplasm
1.16 7.42e-08 GO:0070013 intracellular organelle lumen
1.16 2.70e-02 GO:0042995 cell projection
1.15 1.99e-07 GO:0031974 membrane-enclosed lumen
1.15 2.66e-07 GO:0043233 organelle lumen
1.13 5.90e-03 GO:0012505 endomembrane system
1.12 5.24e-15 GO:0005634 nucleus
1.10 6.05e-23 GO:0043227 membrane-bounded organelle
1.10 7.74e-23 GO:0005737 cytoplasm
1.10 2.31e-22 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
1.38 6.30e-03 GO:0010843 promoter binding
1.37 6.61e-03 GO:0000975 regulatory region DNA binding
1.37 6.61e-03 GO:0001067 regulatory region nucleic acid binding
1.37 6.61e-03 GO:0044212 transcription regulatory region DNA binding
1.33 4.19e-06 GO:0019904 protein domain specific binding
1.31 2.10e-03 GO:0003779 actin binding
1.30 2.98e-02 GO:0032403 protein complex binding
1.29 9.70e-06 GO:0008092 cytoskeletal protein binding
1.29 2.69e-02 GO:0005083 small GTPase regulator activity
1.27 2.15e-03 GO:0004674 protein serine/threonine kinase activity
1.25 7.05e-03 GO:0030695 GTPase regulator activity
1.24 9.91e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.22 4.81e-04 GO:0019899 enzyme binding
1.22 8.75e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.21 7.58e-04 GO:0016301 kinase activity
1.21 1.30e-02 GO:0004672 protein kinase activity
1.20 7.51e-03 GO:0043565 sequence-specific DNA binding
1.19 6.54e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 1.14e-03 GO:0001071 nucleic acid binding transcription factor activity
1.18 1.14e-03 GO:0003700 sequence-specific DNA binding transcription factor activity