Motif ID: TFAP2{A,C}.p2

Z-value: 3.674


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10520264-0.485.8e-02Click!
TFAP2Cchr20_+_54637714-0.411.2e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_115958051 6.883 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr9_+_136673534 5.801 COL5A1
collagen, type V, alpha 1
chr2_+_236068029 5.442 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_+_92946348 5.349 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_33494745 4.954 NM_152493
ZNF362
zinc finger protein 362
chr9_+_136673464 4.634 NM_000093
COL5A1
collagen, type V, alpha 1
chr17_+_56832255 4.396 TBX2
T-box 2
chr3_-_126257425 4.183 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr3_-_130807865 4.058 NM_015103
PLXND1
plexin D1
chr17_+_56831951 3.984 NM_005994
TBX2
T-box 2
chr8_-_38444982 3.881 FGFR1
fibroblast growth factor receptor 1
chr2_+_235525355 3.869 NM_014521
SH3BP4
SH3-domain binding protein 4
chr8_+_37672427 3.742 NM_025069
ZNF703
zinc finger protein 703
chr5_-_159672060 3.610 NM_024565
CCNJL
cyclin J-like
chr2_+_236067687 3.585 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr3_-_187025501 3.412 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr19_+_15079141 3.307 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr19_+_38377329 3.290 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr3_+_185580554 3.230 NM_003741
CHRD
chordin
chr22_+_49459935 3.209 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr20_+_4077466 3.196 SMOX
spermine oxidase
chr3_+_50217692 3.188 NM_006841
SLC38A3
solute carrier family 38, member 3
chr19_+_39664706 3.174 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr2_+_42128521 3.151 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr22_-_32646325 3.138 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr17_+_56832492 3.114 TBX2
T-box 2
chr19_+_40213431 3.091 NM_001037
NM_199037
SCN1B

sodium channel, voltage-gated, type I, beta

chr9_+_115957537 3.039 COL27A1
collagen, type XXVII, alpha 1
chr2_+_36436316 3.021 CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr3_-_187025438 2.992 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_+_22909916 2.938 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr19_+_50004134 2.906 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr19_-_15172773 2.800 NM_000435
NOTCH3
notch 3
chr2_+_241023908 2.785 GPC1
glypican 1
chr10_+_104394185 2.749 NM_030912
TRIM8
tripartite motif containing 8
chr12_-_123023312 2.721 CCDC92
coiled-coil domain containing 92
chr9_+_134026836 2.627 NTNG2
netrin G2
chr4_-_22126437 2.565 NM_145290
GPR125
G protein-coupled receptor 125
chr17_-_71385651 2.560 TRIM47
tripartite motif containing 47
chr2_+_85834111 2.550 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr20_+_44771532 2.522 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr9_-_83493415 2.503 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_+_61204392 2.359 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr2_+_236067424 2.350 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr11_-_60819110 2.341 VWCE
von Willebrand factor C and EGF domains
chr11_-_60819273 2.307 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr22_-_19122107 2.295 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr14_-_29466562 2.238 NM_002742
PRKD1
protein kinase D1
chr11_-_65082208 2.233 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr8_-_38444675 2.215 FGFR1
fibroblast growth factor receptor 1
chr17_+_70495318 2.204 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr17_-_71386229 2.197 NM_033452
TRIM47
tripartite motif containing 47
chr11_-_65081967 2.182 LTBP3
latent transforming growth factor beta binding protein 3
chr6_+_107917965 2.171 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr9_+_136358145 2.161 RXRA
retinoid X receptor, alpha
chr1_+_9275542 2.153 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr14_+_104957298 2.142 MTA1
metastasis associated 1
chr16_-_4106022 2.139 ADCY9
adenylate cyclase 9
chr1_+_9275518 2.123 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr16_-_4106186 2.110 NM_001116
ADCY9
adenylate cyclase 9
chr14_-_76856776 2.053 NM_013382
POMT2
protein-O-mannosyltransferase 2
chr2_-_73193566 2.049 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr22_-_29113301 2.047 NM_001017981
RNF215
ring finger protein 215
chr17_-_76064842 2.040 NM_002522
NPTX1
neuronal pentraxin I
chr7_-_45927263 2.033 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr10_+_134060681 2.023 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr5_+_72957736 1.995 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr9_+_128128913 1.995 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr3_+_112273464 1.992 NM_015480
PVRL3
poliovirus receptor-related 3
chr15_+_94674849 1.984 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr14_+_92049396 1.978 NM_024832
RIN3
Ras and Rab interactor 3
chr12_+_6907646 1.974 NM_001940
ATN1
atrophin 1
chr11_+_12652427 1.972 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr16_+_88517187 1.969 NM_006086
TUBB3
tubulin, beta 3
chr2_-_220116508 1.967 NM_024536
CHPF
chondroitin polymerizing factor
chr5_-_172594691 1.964 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chr14_+_64240902 1.952 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_-_16355013 1.944 NM_004431
EPHA2
EPH receptor A2
chr4_+_4912272 1.942 NM_002448
MSX1
msh homeobox 1
chr14_-_102593264 1.937


chr5_-_178704934 1.934 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr14_+_64240996 1.930 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr13_+_97593711 1.929 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_-_73193581 1.923 NM_015470
RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr12_-_105056577 1.899 NUAK1
NUAK family, SNF1-like kinase, 1
chr9_-_139060285 1.884 NPDC1
neural proliferation, differentiation and control, 1
chr2_+_241023703 1.873 NM_002081
GPC1
glypican 1
chr20_+_4077409 1.860 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr2_+_159533329 1.858 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr3_-_51976428 1.839 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr6_+_148705646 1.838 SASH1
SAM and SH3 domain containing 1
chr3_+_30623376 1.809 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr14_-_102045849 1.797 NM_152326
ANKRD9
ankyrin repeat domain 9
chr10_-_76829857 1.781 ZNF503
zinc finger protein 503
chr16_-_71639670 1.773 NM_006885
ZFHX3
zinc finger homeobox 3
chr1_+_176330254 1.762 RASAL2
RAS protein activator like 2
chr2_-_73193419 1.761 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr2_+_42129440 1.760


chr10_+_104253716 1.751 SUFU
suppressor of fused homolog (Drosophila)
chr16_-_69277355 1.743 NM_138383
MTSS1L
metastasis suppressor 1-like
chr8_+_22492586 1.736 PDLIM2
PDZ and LIM domain 2 (mystique)
chr14_-_102593384 1.721 NM_006035
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like)
chr3_+_50167851 1.718 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr7_+_99919485 1.713 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr22_-_34754343 1.709 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr17_+_7252225 1.694 NM_020795
NLGN2
neuroligin 2
chr12_-_15833617 1.693 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr1_-_120413542 1.688 NOTCH2
notch 2
chr9_-_135847106 1.686 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr16_-_49742651 1.682 NM_002968
SALL1
sal-like 1 (Drosophila)
chr16_+_85158357 1.674 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr13_+_26029799 1.663 NM_006646
WASF3
WAS protein family, member 3
chr4_+_995609 1.663 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr7_-_130069399 1.658 NM_138693
KLF14
Kruppel-like factor 14
chr12_-_49897743 1.657 POU6F1
POU class 6 homeobox 1
chr19_+_7486987 1.652 NM_018083
ZNF358
zinc finger protein 358
chr2_-_128792515 1.651 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr5_-_57791544 1.637 NM_006622
PLK2
polo-like kinase 2
chr14_-_24588916 1.632 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr9_-_38059082 1.628 SHB
Src homology 2 domain containing adaptor protein B
chr10_+_124124196 1.612 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_36436873 1.611 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr12_-_105165805 1.602 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr6_+_35335278 1.602 ZNF76
zinc finger protein 76
chr2_-_96899326 1.602 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr10_+_123912930 1.599 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_+_1822943 1.588 SIRPA
signal-regulatory protein alpha
chr1_-_120413783 1.585 NOTCH2
notch 2
chr1_-_120413698 1.583 NOTCH2
notch 2
chr8_+_25098296 1.581 DOCK5
dedicator of cytokinesis 5
chr16_-_69277194 1.580 MTSS1L
metastasis suppressor 1-like
chr22_-_19122047 1.575 SCARF2
scavenger receptor class F, member 2
chr11_+_19691397 1.574 NM_145117
NM_182964
NAV2

neuron navigator 2

chr22_+_27609889 1.567 NM_032173
ZNRF3
zinc and ring finger 3
chr13_+_26029879 1.567 WASF3
WAS protein family, member 3
chr10_-_76831430 1.552 NM_032772
ZNF503
zinc finger protein 503
chr18_-_53621277 1.551 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr3_-_129689394 1.545 NM_001145662
GATA2
GATA binding protein 2
chr16_-_52877467 1.544 IRX3
iroquois homeobox 3
chr19_-_54557450 1.540 NM_003598
TEAD2
TEA domain family member 2
chr2_+_173000590 1.538 ITGA6
integrin, alpha 6
chr16_-_71650034 1.534 NM_001164766
ZFHX3
zinc finger homeobox 3
chrX_-_54538591 1.532 FGD1
FYVE, RhoGEF and PH domain containing 1
chr1_-_212791467 1.532 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr19_-_50963942 1.531


chr1_-_85703198 1.524 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr20_+_1823825 1.523 NM_001040023
SIRPA
signal-regulatory protein alpha
chr10_-_76831142 1.522 ZNF503
zinc finger protein 503
chr6_+_151603346 1.521 AKAP12
A kinase (PRKA) anchor protein 12
chr20_-_49818268 1.511 ATP9A
ATPase, class II, type 9A
chr7_+_55054416 1.507 EGFR
epidermal growth factor receptor
chr16_-_4105703 1.504 ADCY9
adenylate cyclase 9
chr11_+_119586879 1.501 NM_178507
OAF
OAF homolog (Drosophila)
chr7_-_27120015 1.497 HOXA3
homeobox A3
chr12_-_47468985 1.495 NM_020983
ADCY6
adenylate cyclase 6
chr1_+_19843261 1.495 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr14_+_54102518 1.489 LOC644925
hypothetical LOC644925
chr6_-_128883125 1.487 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr11_-_6633427 1.486 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr9_-_139060377 1.486 NPDC1
neural proliferation, differentiation and control, 1
chr14_-_102045749 1.481 ANKRD9
ankyrin repeat domain 9
chr19_+_49943773 1.477 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr9_-_139060416 1.472 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr2_-_218551786 1.470 TNS1
tensin 1
chr6_-_132314004 1.468 NM_001901
CTGF
connective tissue growth factor
chr9_-_138126917 1.467 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr10_-_15453060 1.465 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr22_-_28972683 1.465 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr1_-_120413798 1.454 NM_024408
NOTCH2
notch 2
chr5_-_16989371 1.451 NM_012334
MYO10
myosin X
chr6_+_5030718 1.437 NM_001145115
PPP1R3G
protein phosphatase 1, regulatory (inhibitor) subunit 3G
chr3_+_189354167 1.437 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_51403760 1.435 NM_013286
RBM15B
RNA binding motif protein 15B
chr7_+_3307445 1.434 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr8_-_18915443 1.431 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr3_+_148610516 1.430 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr10_+_101079099 1.429 CNNM1
cyclin M1
chr2_+_231610438 1.426 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr15_+_64782468 1.425 SMAD6
SMAD family member 6
chr15_+_65145215 1.419 SMAD3
SMAD family member 3
chr10_-_99084254 1.411 FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr5_-_178705036 1.409 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr4_-_5945596 1.408 NM_001014809
CRMP1
collapsin response mediator protein 1
chr20_+_11819364 1.391 NM_181443
BTBD3
BTB (POZ) domain containing 3
chrX_+_46963107 1.390 CDK16
cyclin-dependent kinase 16
chr6_+_157722467 1.389 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr11_+_72697310 1.387 NM_014786
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr18_-_33399601 1.384 CELF4
CUGBP, Elav-like family member 4
chr10_+_104253706 1.370 NM_001178133
NM_016169
SUFU

suppressor of fused homolog (Drosophila)

chr7_-_27136876 1.368 NM_002141
HOXA4
homeobox A4
chr5_+_14196287 1.358 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr20_+_2621193 1.353 NM_001110514
EBF4
early B-cell factor 4
chr10_-_118491971 1.350 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr10_+_59942874 1.346 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr7_-_5429702 1.342 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr19_+_38979502 1.340 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr19_-_60320592 1.338 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr22_+_22445035 1.332 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr12_+_6363482 1.332 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr20_+_1822779 1.329 NM_001040022
SIRPA
signal-regulatory protein alpha

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.56e-25 GO:0009987 cellular process
1.17 1.30e-20 GO:0044260 cellular macromolecule metabolic process
1.12 1.81e-18 GO:0044237 cellular metabolic process
1.11 1.12e-16 GO:0050794 regulation of cellular process
1.10 1.67e-15 GO:0050789 regulation of biological process
1.09 5.83e-15 GO:0065007 biological regulation
1.13 1.20e-14 GO:0043170 macromolecule metabolic process
1.10 1.87e-13 GO:0008152 metabolic process
1.10 7.11e-13 GO:0044238 primary metabolic process
1.15 9.32e-12 GO:0016043 cellular component organization
1.15 3.93e-11 GO:0071840 cellular component organization or biogenesis
1.17 9.08e-11 GO:0071842 cellular component organization at cellular level
1.16 3.55e-10 GO:0071841 cellular component organization or biogenesis at cellular level
1.17 4.00e-10 GO:0044267 cellular protein metabolic process
1.21 9.44e-09 GO:0006996 organelle organization
1.17 1.97e-08 GO:0048519 negative regulation of biological process
1.17 2.95e-08 GO:0048523 negative regulation of cellular process
1.15 7.76e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.13 2.23e-07 GO:0034641 cellular nitrogen compound metabolic process
1.18 3.34e-07 GO:0006464 protein modification process
1.20 3.77e-07 GO:0007399 nervous system development
1.26 4.26e-07 GO:0048468 cell development
1.12 4.75e-07 GO:0032502 developmental process
1.17 7.10e-07 GO:0043412 macromolecule modification
1.27 8.52e-07 GO:0051128 regulation of cellular component organization
1.12 1.06e-06 GO:0031323 regulation of cellular metabolic process
1.12 1.36e-06 GO:0006807 nitrogen compound metabolic process
1.18 1.77e-06 GO:0009059 macromolecule biosynthetic process
1.18 2.19e-06 GO:0034645 cellular macromolecule biosynthetic process
1.30 2.45e-06 GO:0051726 regulation of cell cycle
1.13 2.58e-06 GO:0019538 protein metabolic process
1.15 3.58e-06 GO:0090304 nucleic acid metabolic process
1.14 5.13e-06 GO:0044249 cellular biosynthetic process
1.11 9.29e-06 GO:0019222 regulation of metabolic process
1.12 1.02e-05 GO:0048856 anatomical structure development
1.15 1.13e-05 GO:0048869 cellular developmental process
1.15 1.18e-05 GO:0030154 cell differentiation
1.22 1.33e-05 GO:0007049 cell cycle
1.11 2.21e-05 GO:0060255 regulation of macromolecule metabolic process
1.11 4.20e-05 GO:0080090 regulation of primary metabolic process
1.31 5.80e-05 GO:0007010 cytoskeleton organization
1.11 7.78e-05 GO:0007275 multicellular organismal development
1.13 8.15e-05 GO:0048522 positive regulation of cellular process
1.23 9.34e-05 GO:0048699 generation of neurons
1.22 1.09e-04 GO:0022008 neurogenesis
1.13 1.74e-04 GO:0009058 biosynthetic process
1.15 1.81e-04 GO:0010467 gene expression
1.16 1.91e-04 GO:0016070 RNA metabolic process
1.41 2.28e-04 GO:0030036 actin cytoskeleton organization
1.30 2.45e-04 GO:0072358 cardiovascular system development
1.30 2.45e-04 GO:0072359 circulatory system development
1.09 4.79e-04 GO:0051716 cellular response to stimulus
1.16 4.98e-04 GO:0009653 anatomical structure morphogenesis
1.11 5.33e-04 GO:0048731 system development
1.10 5.68e-04 GO:0051179 localization
1.21 6.05e-04 GO:0006351 transcription, DNA-dependent
1.23 8.24e-04 GO:2000026 regulation of multicellular organismal development
1.25 8.55e-04 GO:0030030 cell projection organization
1.24 9.74e-04 GO:0045595 regulation of cell differentiation
1.15 1.13e-03 GO:0023051 regulation of signaling
1.11 1.40e-03 GO:0048518 positive regulation of biological process
1.19 1.80e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.20 1.98e-03 GO:0050793 regulation of developmental process
1.20 2.02e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.10 2.66e-03 GO:0007165 signal transduction
1.25 2.74e-03 GO:0048666 neuron development
1.21 2.82e-03 GO:0022402 cell cycle process
1.35 3.11e-03 GO:0030029 actin filament-based process
1.25 3.14e-03 GO:0000278 mitotic cell cycle
1.16 3.19e-03 GO:0009966 regulation of signal transduction
1.19 4.58e-03 GO:0032774 RNA biosynthetic process
1.22 4.59e-03 GO:0030182 neuron differentiation
1.11 5.23e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.31 5.26e-03 GO:0044419 interspecies interaction between organisms
1.16 5.66e-03 GO:0051239 regulation of multicellular organismal process
1.21 5.78e-03 GO:0006468 protein phosphorylation
1.26 5.99e-03 GO:0031175 neuron projection development
1.17 6.17e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.18 8.70e-03 GO:0006793 phosphorus metabolic process
1.18 8.70e-03 GO:0006796 phosphate metabolic process
1.31 9.83e-03 GO:0009894 regulation of catabolic process
1.09 1.00e-02 GO:0023052 signaling
1.10 1.16e-02 GO:0051234 establishment of localization
1.21 1.26e-02 GO:0009790 embryo development
1.35 1.36e-02 GO:0046578 regulation of Ras protein signal transduction
1.22 1.52e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.39 1.53e-02 GO:0044087 regulation of cellular component biogenesis
1.10 1.62e-02 GO:0006810 transport
1.22 1.82e-02 GO:0032989 cellular component morphogenesis
1.25 1.83e-02 GO:0000904 cell morphogenesis involved in differentiation
1.18 1.84e-02 GO:0009892 negative regulation of metabolic process
1.32 1.85e-02 GO:0051329 interphase of mitotic cell cycle
1.11 1.96e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.10 1.96e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.11 2.00e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.19 2.06e-02 GO:0016310 phosphorylation
1.31 2.41e-02 GO:0051325 interphase
1.36 2.47e-02 GO:0051129 negative regulation of cellular component organization
1.24 3.28e-02 GO:0007417 central nervous system development
1.17 3.35e-02 GO:0032268 regulation of cellular protein metabolic process
1.15 4.29e-02 GO:0044248 cellular catabolic process
1.17 4.38e-02 GO:0042127 regulation of cell proliferation
1.36 4.50e-02 GO:0045786 negative regulation of cell cycle
1.34 4.66e-02 GO:0001558 regulation of cell growth
1.20 4.79e-02 GO:0009890 negative regulation of biosynthetic process
1.26 4.95e-02 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 1.44e-35 GO:0005622 intracellular
1.09 7.48e-35 GO:0044424 intracellular part
1.09 8.76e-25 GO:0043226 organelle
1.09 3.63e-24 GO:0043229 intracellular organelle
1.10 6.05e-23 GO:0043227 membrane-bounded organelle
1.10 7.74e-23 GO:0005737 cytoplasm
1.10 2.31e-22 GO:0043231 intracellular membrane-bounded organelle
1.12 5.24e-15 GO:0005634 nucleus
1.10 4.55e-13 GO:0044444 cytoplasmic part
1.10 3.55e-10 GO:0044446 intracellular organelle part
1.10 3.71e-10 GO:0044422 organelle part
1.18 3.97e-10 GO:0044428 nuclear part
1.17 4.40e-09 GO:0005829 cytosol
1.57 2.28e-08 GO:0031252 cell leading edge
1.03 2.93e-08 GO:0005623 cell
1.03 3.52e-08 GO:0044464 cell part
1.16 7.42e-08 GO:0070013 intracellular organelle lumen
1.15 1.99e-07 GO:0031974 membrane-enclosed lumen
1.15 2.66e-07 GO:0043233 organelle lumen
1.17 6.15e-07 GO:0031981 nuclear lumen
1.17 9.96e-05 GO:0005654 nucleoplasm
1.10 1.83e-04 GO:0032991 macromolecular complex
1.63 3.61e-04 GO:0030027 lamellipodium
1.10 9.29e-04 GO:0043228 non-membrane-bounded organelle
1.10 9.29e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.10 1.59e-03 GO:0043234 protein complex
1.13 5.90e-03 GO:0012505 endomembrane system
1.30 6.13e-03 GO:0015629 actin cytoskeleton
1.60 2.47e-02 GO:0030426 growth cone
1.16 2.70e-02 GO:0042995 cell projection
1.50 2.95e-02 GO:0016585 chromatin remodeling complex
1.53 3.16e-02 GO:0014069 postsynaptic density
1.49 4.47e-02 GO:0001726 ruffle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 2.02e-22 GO:0005515 protein binding
1.05 2.46e-14 GO:0005488 binding
1.33 4.19e-06 GO:0019904 protein domain specific binding
1.29 9.70e-06 GO:0008092 cytoskeletal protein binding
1.13 1.10e-04 GO:0000166 nucleotide binding
1.22 4.81e-04 GO:0019899 enzyme binding
1.19 6.54e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.21 7.58e-04 GO:0016301 kinase activity
1.22 8.75e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.18 1.14e-03 GO:0001071 nucleic acid binding transcription factor activity
1.18 1.14e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.14 1.25e-03 GO:0030554 adenyl nucleotide binding
1.13 1.59e-03 GO:0017076 purine nucleotide binding
1.31 2.10e-03 GO:0003779 actin binding
1.27 2.15e-03 GO:0004674 protein serine/threonine kinase activity
1.14 2.36e-03 GO:0032559 adenyl ribonucleotide binding
1.12 2.90e-03 GO:0032553 ribonucleotide binding
1.12 2.90e-03 GO:0032555 purine ribonucleotide binding
1.13 3.11e-03 GO:0016740 transferase activity
1.07 3.22e-03 GO:0003824 catalytic activity
1.14 3.95e-03 GO:0005524 ATP binding
1.12 4.53e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.17 4.78e-03 GO:0030528 transcription regulator activity
1.38 6.30e-03 GO:0010843 promoter binding
1.37 6.61e-03 GO:0000975 regulatory region DNA binding
1.37 6.61e-03 GO:0001067 regulatory region nucleic acid binding
1.37 6.61e-03 GO:0044212 transcription regulatory region DNA binding
1.25 7.05e-03 GO:0030695 GTPase regulator activity
1.20 7.51e-03 GO:0043565 sequence-specific DNA binding
1.24 9.91e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.10 1.07e-02 GO:0003677 DNA binding
1.21 1.30e-02 GO:0004672 protein kinase activity
1.29 2.69e-02 GO:0005083 small GTPase regulator activity
1.30 2.98e-02 GO:0032403 protein complex binding