Motif ID: TFAP2B.p2

Z-value: 0.805


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.165.6e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_39664706 1.730 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr10_-_99175685 1.077


chr17_-_24940728 0.917 NM_001085454
NM_014030
 GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr17_-_24940521 0.849 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr10_+_134060681 0.735 NM_001098637
NM_138499
 PWWP2B

PWWP domain containing 2B

chr17_-_24940746 0.713 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr19_-_1518875 0.694 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)

chr9_+_123501186 0.677 DAB2IP
DAB2 interacting protein
chrX_+_9943793 0.647 NM_015691
 WWC3
WWC family member 3
chr22_+_48951286 0.641 NM_001160300
NM_052839
 PANX2

pannexin 2

chr5_-_176833197 0.619 DBN1
drebrin 1
chr2_+_241023908 0.599 GPC1
glypican 1
chr9_+_136358145 0.581 RXRA
retinoid X receptor, alpha
chr5_-_176833259 0.573 NM_004395
 DBN1
drebrin 1
chr9_+_131974506 0.571 NM_014286
 NCS1
neuronal calcium sensor 1
chr9_+_137511448 0.555 NM_014811
 KIAA0649
KIAA0649
chr5_-_2804768 0.555 NM_001134222
NM_033267
 IRX2

iroquois homeobox 2

chr9_+_136358134 0.550 NM_002957
 RXRA
retinoid X receptor, alpha
chr1_+_22909916 0.546 NM_004442
NM_017449
 EPHB2

EPH receptor B2

chr9_+_95378492 0.515 NM_005392
 PHF2
PHD finger protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 126 entries
enrichment   p-value GO term description
1.75 1.19e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.62 7.81e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.49 1.79e-09 GO:0000904 cell morphogenesis involved in differentiation
1.47 4.10e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.47 4.98e-07 GO:0007409 axonogenesis
1.46 3.30e-08 GO:0032990 cell part morphogenesis
1.46 4.23e-08 GO:0048858 cell projection morphogenesis
1.46 3.71e-07 GO:0048812 neuron projection morphogenesis
1.46 1.21e-04 GO:0007411 axon guidance
1.46 1.20e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.45 2.05e-05 GO:0007264 small GTPase mediated signal transduction
1.44 4.36e-02 GO:0045786 negative regulation of cell cycle
1.43 4.65e-09 GO:0032989 cellular component morphogenesis
1.43 1.59e-08 GO:0000902 cell morphogenesis
1.43 1.31e-06 GO:0031175 neuron projection development
1.41 4.47e-03 GO:0060284 regulation of cell development
1.40 1.02e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.39 1.86e-07 GO:0030030 cell projection organization
1.39 2.72e-06 GO:0048666 neuron development
1.39 4.32e-02 GO:0032446 protein modification by small protein conjugation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
1.61 2.13e-02 GO:0005925 focal adhesion
1.58 1.88e-02 GO:0030055 cell-substrate junction
1.55 2.26e-03 GO:0005912 adherens junction
1.53 7.61e-04 GO:0031252 cell leading edge
1.49 7.79e-03 GO:0070161 anchoring junction
1.34 9.23e-06 GO:0044431 Golgi apparatus part
1.34 2.17e-04 GO:0000139 Golgi membrane
1.28 1.26e-03 GO:0030054 cell junction
1.25 2.84e-05 GO:0005794 Golgi apparatus
1.21 9.69e-09 GO:0005829 cytosol
1.18 9.18e-07 GO:0031090 organelle membrane
1.18 2.97e-04 GO:0012505 endomembrane system
1.18 3.62e-03 GO:0005654 nucleoplasm
1.15 5.66e-03 GO:0031981 nuclear lumen
1.14 2.65e-30 GO:0005737 cytoplasm
1.14 4.02e-16 GO:0044444 cytoplasmic part
1.14 1.99e-13 GO:0005634 nucleus
1.14 1.20e-03 GO:0044428 nuclear part
1.13 8.97e-03 GO:0070013 intracellular organelle lumen
1.12 7.00e-22 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
1.59 4.67e-04 GO:0004721 phosphoprotein phosphatase activity
1.51 6.52e-05 GO:0016791 phosphatase activity
1.51 1.05e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.36 4.58e-02 GO:0016881 acid-amino acid ligase activity
1.34 4.56e-03 GO:0008047 enzyme activator activity
1.33 1.10e-03 GO:0030695 GTPase regulator activity
1.32 2.39e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.31 7.18e-03 GO:0019904 protein domain specific binding
1.29 2.73e-03 GO:0008092 cytoskeletal protein binding
1.29 3.23e-02 GO:0004674 protein serine/threonine kinase activity
1.27 3.68e-03 GO:0004672 protein kinase activity
1.26 6.12e-04 GO:0016301 kinase activity
1.25 3.62e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 8.62e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.23 4.35e-04 GO:0001071 nucleic acid binding transcription factor activity
1.23 4.35e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.22 1.54e-03 GO:0030528 transcription regulator activity
1.21 9.18e-03 GO:0030234 enzyme regulator activity
1.16 1.40e-03 GO:0016740 transferase activity
1.14 1.31e-22 GO:0005515 protein binding