Motif ID: TFAP4.p2

Z-value: 1.108


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_4262696-0.155.7e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_36436979 1.880 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr17_-_36451189 1.867 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr3_-_87122936 1.237 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr3_-_87122958 1.145 VGLL3
vestigial like 3 (Drosophila)
chr17_-_27210330 1.064 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr5_+_94981735 0.993 NM_199243
GPR150
G protein-coupled receptor 150
chr17_-_36444626 0.955 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr6_-_132764257 0.906 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr1_-_199704773 0.901 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr17_-_36577949 0.897 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr11_+_60391590 0.887 NM_207341
ZP1
zona pellucida glycoprotein 1 (sperm receptor)
chr22_-_32646325 0.822 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr16_-_4106186 0.791 NM_001116
ADCY9
adenylate cyclase 9
chr12_-_50871953 0.772 NM_001081492
NM_182507
KRT80

keratin 80

chr1_+_43769065 0.756 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr8_+_144711619 0.745 NM_024736
GSDMD
gasdermin D
chr19_-_18912112 0.743 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr16_-_4106022 0.738 ADCY9
adenylate cyclase 9
chr1_-_6502655 0.724 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_+_43502301 0.723 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr11_-_47427263 0.684 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr1_-_159325709 0.673 PVRL4
poliovirus receptor-related 4
chr4_-_7095566 0.670 NM_153376
CCDC96
coiled-coil domain containing 96
chr7_-_27136876 0.667 NM_002141
HOXA4
homeobox A4
chr20_-_61669550 0.657 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr11_-_35503720 0.655 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr19_+_43502360 0.635 KCNK6
potassium channel, subfamily K, member 6
chr7_+_73341640 0.633 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr9_-_128924782 0.626 ANGPTL2
angiopoietin-like 2
chr6_-_75972286 0.610 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr1_-_93919789 0.609 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr11_+_74629597 0.595 NM_001195528
LOC441617
hypothetical LOC441617
chr17_+_67628772 0.594 SOX9
SRY (sex determining region Y)-box 9
chr17_-_36528113 0.582 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr15_-_68933481 0.579 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr10_+_103338030 0.573 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr16_+_2461500 0.563 NM_006181
NTN3
netrin 3
chr17_-_19711580 0.562 NM_001142610
NM_014683
ULK2

unc-51-like kinase 2 (C. elegans)

chr22_+_49333327 0.560 NM_138433
KLHDC7B
kelch domain containing 7B
chr11_+_832821 0.559 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr21_+_36429079 0.557 NM_001236
CBR3
carbonyl reductase 3
chr1_-_56817717 0.554 PPAP2B
phosphatidic acid phosphatase type 2B
chr17_+_14145051 0.553 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chrX_-_106846253 0.552 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr17_-_77602938 0.549 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_-_65860450 0.546 NM_004292
RIN1
Ras and Rab interactor 1
chr9_-_128924819 0.544 NM_012098
ANGPTL2
angiopoietin-like 2
chr17_+_77780177 0.540 NM_004207
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr1_+_26220852 0.533 NM_004455
EXTL1
exostoses (multiple)-like 1
chr1_-_6474346 0.532 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr5_+_135392482 0.532 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr10_+_99322187 0.522 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr1_-_22136263 0.510 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr17_+_67628763 0.509 SOX9
SRY (sex determining region Y)-box 9
chr1_+_1256585 0.504 NM_152228
TAS1R3
taste receptor, type 1, member 3
chr16_+_2226468 0.504 NM_001374
DNASE1L2
deoxyribonuclease I-like 2
chr19_+_13090101 0.499 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr18_-_42798364 0.496 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr2_+_220007943 0.496 NM_005876
SPEG
SPEG complex locus
chr5_-_178704934 0.495 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr3_-_197120276 0.489 NM_005781
TNK2
tyrosine kinase, non-receptor, 2
chr2_+_3620296 0.486 NM_024027
NM_199235
COLEC11

collectin sub-family member 11

chr9_-_128924706 0.485 ANGPTL2
angiopoietin-like 2
chr9_+_133154896 0.485 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr11_-_123319754 0.485 NM_001005187
OR6T1
olfactory receptor, family 6, subfamily T, member 1
chr10_+_134060681 0.484 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr16_-_4105703 0.481 ADCY9
adenylate cyclase 9
chr2_-_233060774 0.481 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr14_+_20608179 0.477 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr2_+_26768894 0.471 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr1_-_56817568 0.471 PPAP2B
phosphatidic acid phosphatase type 2B
chrX_+_152682772 0.471 NM_001163257
NM_005393
PLXNB3

plexin B3

chr9_-_139042416 0.470 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr12_-_51528983 0.467 NM_173352
KRT78
keratin 78
chr5_-_178705036 0.466 NM_014244
NM_021599
ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

chr9_+_115265827 0.466 NM_017790
RGS3
regulator of G-protein signaling 3
chr16_-_31013423 0.462


chr6_-_75972473 0.460 COL12A1
collagen, type XII, alpha 1
chr10_-_88720908 0.459 LOC100133190
hypothetical LOC100133190
chr1_+_154297588 0.452 NM_020387
RAB25
RAB25, member RAS oncogene family
chr19_-_9982041 0.451 NM_015719
COL5A3
collagen, type V, alpha 3
chr7_+_2525922 0.445 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr17_+_38256710 0.445 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr15_+_69626594 0.444 THSD4
thrombospondin, type I, domain containing 4
chr18_-_42804291 0.444 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr11_+_67534364 0.444 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr12_+_13240868 0.442 NM_001423
EMP1
epithelial membrane protein 1
chr2_-_216944911 0.441 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr5_+_135392624 0.435 TGFBI
transforming growth factor, beta-induced, 68kDa
chr20_+_61796731 0.434 NM_032945
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_+_26220895 0.434 EXTL1
exostoses (multiple)-like 1
chr5_-_139992621 0.434 NM_000591
CD14
CD14 molecule
chr17_+_67628749 0.433 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr11_+_58696115 0.433 NM_015177
DTX4
deltex homolog 4 (Drosophila)
chr14_-_64948998 0.432 LOC645431
hypothetical LOC645431
chr2_+_132890616 0.431 NM_001508
GPR39
G protein-coupled receptor 39
chr9_-_139047112 0.431 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr14_+_104462260 0.429 PLD4
phospholipase D family, member 4
chr1_+_178390646 0.428 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr17_+_36515166 0.426 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr9_-_138958889 0.424 FBXW5
F-box and WD repeat domain containing 5
chr19_+_18543613 0.421 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr10_+_134108643 0.421 NM_173541
C10orf91
chromosome 10 open reading frame 91
chr7_+_39839337 0.417


chr20_-_23534512 0.417 NM_001008693
CST9
cystatin 9 (testatin)
chr8_-_145090892 0.416 NM_201381
PLEC
plectin
chr5_+_140160966 0.411 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr17_-_8034217 0.410 NM_017622
C17orf59
chromosome 17 open reading frame 59
chr19_-_15204194 0.409 NM_024794
EPHX3
epoxide hydrolase 3
chr15_+_72005839 0.408 NM_005576
LOXL1
lysyl oxidase-like 1
chr10_+_88404285 0.408 NM_001030015
NM_033282
OPN4

opsin 4

chr10_-_76831430 0.408 NM_032772
ZNF503
zinc finger protein 503
chr2_+_95303947 0.406 PROM2
prominin 2
chr22_+_20068039 0.404 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr16_-_31013626 0.403 NM_024006
NM_206824
VKORC1

vitamin K epoxide reductase complex, subunit 1

chr19_-_45424403 0.401 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr19_+_44266784 0.401 NM_001004318
PAPL
iron/zinc purple acid phosphatase-like protein
chr6_+_42991704 0.401 NM_138296
PTCRA
pre T-cell antigen receptor alpha
chr1_+_20788027 0.401 NM_001785
CDA
cytidine deaminase
chr15_+_72005864 0.399 LOXL1
lysyl oxidase-like 1
chr11_-_78829342 0.399 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr10_-_105202012 0.399 CALHM2
calcium homeostasis modulator 2
chr3_-_48607596 0.396 NM_000094
COL7A1
collagen, type VII, alpha 1
chr12_+_13240987 0.396 EMP1
epithelial membrane protein 1
chr20_+_19818209 0.395 NM_018993
RIN2
Ras and Rab interactor 2
chr11_+_47386621 0.395 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr9_+_123544884 0.394 NM_138709
DAB2IP
DAB2 interacting protein
chr15_+_72005875 0.394 LOXL1
lysyl oxidase-like 1
chr17_-_40594652 0.393


chr11_+_67534371 0.390 ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr18_-_63334902 0.389 NM_032160
DSEL
dermatan sulfate epimerase-like
chr12_-_50971516 0.389 NM_002281
KRT81
keratin 81
chr16_-_11270619 0.388 NM_005425
TNP2
transition protein 2 (during histone to protamine replacement)
chr14_+_92049396 0.388 NM_024832
RIN3
Ras and Rab interactor 3
chr17_+_25910709 0.386 NM_015594
TBC1D29
TBC1 domain family, member 29
chr19_+_3473953 0.385 NM_001136197
NM_001136198
FZR1

fizzy/cell division cycle 20 related 1 (Drosophila)

chr19_-_51690989 0.384 NM_020709
PNMAL2
PNMA-like 2
chr19_+_43502591 0.381 KCNK6
potassium channel, subfamily K, member 6
chr15_+_90738108 0.381 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr16_-_1215254 0.381 NM_012467
TPSG1
tryptase gamma 1
chr22_-_17303654 0.380 PRODH
proline dehydrogenase (oxidase) 1
chr19_+_60691671 0.379 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr1_-_120413798 0.379 NM_024408
NOTCH2
notch 2
chr1_+_152806924 0.376 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr9_-_83493415 0.376 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr13_-_76358370 0.374 KCTD12
potassium channel tetramerisation domain containing 12
chr15_+_72006015 0.373 LOXL1
lysyl oxidase-like 1
chr17_+_70495318 0.373 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chrX_-_70755023 0.372 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_+_17817397 0.372 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr20_+_31783426 0.372 NM_032819
ZNF341
zinc finger protein 341
chr1_-_120413542 0.367 NOTCH2
notch 2
chr4_+_8251818 0.366 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_+_47021816 0.365 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr2_+_233029076 0.365 NM_001631
ALPI
alkaline phosphatase, intestinal
chr17_+_71095733 0.364 MYO15B
myosin XVB pseudogene
chr9_-_71476917 0.362 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr1_+_1360765 0.361 NM_022834
NM_199121
VWA1

von Willebrand factor A domain containing 1

chr11_+_696607 0.361 EPS8L2
EPS8-like 2
chr8_+_22078622 0.361 BMP1
bone morphogenetic protein 1
chr3_-_51971915 0.360 NM_033010
PCBP4
poly(rC) binding protein 4
chr6_+_43151922 0.358 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr22_+_44277354 0.358 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr1_+_178390660 0.357 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr11_+_128266460 0.355 NM_000890
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr11_-_66945190 0.354 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr11_-_65395248 0.354 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr11_+_124240491 0.353 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr9_+_129588135 0.351 CDK9
cyclin-dependent kinase 9
chr10_+_102495327 0.350 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr2_-_74498351 0.349 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chr1_+_178390654 0.348 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr17_-_69151821 0.347 NM_001144952
SDK2
sidekick homolog 2 (chicken)
chr6_-_167195987 0.347 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr6_+_45498354 0.347 RUNX2
runt-related transcription factor 2
chr12_+_106236281 0.346 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr14_+_102636233 0.344 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr8_-_28299508 0.344 ZNF395
zinc finger protein 395
chr1_+_149750485 0.344 NM_020770
CGN
cingulin
chr10_+_124210980 0.344 NM_002775
HTRA1
HtrA serine peptidase 1
chr4_-_957269 0.342 DGKQ
diacylglycerol kinase, theta 110kDa
chr11_+_47386707 0.341 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr7_-_97719372 0.339 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr16_+_87021379 0.338 NM_001127464
ZNF469
zinc finger protein 469
chr19_+_482688 0.338 NM_004359
CDC34
cell division cycle 34 homolog (S. cerevisiae)
chr2_+_234286376 0.336 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr6_-_109883525 0.334 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr8_-_23768242 0.334 NM_003155
STC1
stanniocalcin 1
chr20_-_3635774 0.332 NM_023068
SIGLEC1
sialic acid binding Ig-like lectin 1, sialoadhesin
chr1_-_150079656 0.332 NM_001136003
C2CD4D
C2 calcium-dependent domain containing 4D
chr1_-_6243621 0.330 NM_207370
GPR153
G protein-coupled receptor 153
chr17_+_23735637 0.329 SARM1
sterile alpha and TIR motif containing 1
chr22_+_22907443 0.327 NM_019601
SUSD2
sushi domain containing 2
chr21_+_44844924 0.325 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr1_-_41722883 0.324 NM_001956
EDN2
endothelin 2
chr12_+_112344529 0.324 NM_138432
SDSL
serine dehydratase-like
chr3_+_123385870 0.324 NM_001178065
CASR
calcium-sensing receptor
chr9_-_138958922 0.323 NM_018998
FBXW5
F-box and WD repeat domain containing 5
chr15_+_72005847 0.322 LOXL1
lysyl oxidase-like 1
chr5_-_157011665 0.322



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.20e-06 GO:0023052 signaling
1.23 1.29e-05 GO:0007165 signal transduction
1.33 2.14e-05 GO:0007166 cell surface receptor linked signaling pathway
1.31 2.04e-03 GO:0007399 nervous system development
1.21 3.26e-03 GO:0048731 system development
1.40 4.26e-03 GO:0022008 neurogenesis
1.18 6.57e-03 GO:0007275 multicellular organismal development
1.17 1.10e-02 GO:0032502 developmental process
1.39 1.21e-02 GO:0048699 generation of neurons
1.45 1.35e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.72 1.77e-02 GO:0030334 regulation of cell migration
1.67 2.26e-02 GO:0040012 regulation of locomotion
1.70 2.75e-02 GO:2000145 regulation of cell motility
1.50 2.98e-02 GO:0000904 cell morphogenesis involved in differentiation
1.15 3.25e-02 GO:0051716 cellular response to stimulus
1.43 4.12e-02 GO:0030030 cell projection organization
1.17 4.54e-02 GO:0048856 anatomical structure development
1.53 4.84e-02 GO:0007409 axonogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.12 2.02e-09 GO:0045095 keratin filament
1.77 1.41e-06 GO:0031012 extracellular matrix
1.85 1.49e-06 GO:0005578 proteinaceous extracellular matrix
1.30 3.21e-06 GO:0005576 extracellular region
1.42 8.21e-06 GO:0044421 extracellular region part
2.02 1.04e-05 GO:0045111 intermediate filament cytoskeleton
2.11 1.05e-05 GO:0005882 intermediate filament
1.25 1.64e-04 GO:0044459 plasma membrane part
1.17 2.87e-04 GO:0005886 plasma membrane
1.16 4.97e-04 GO:0071944 cell periphery
2.47 1.42e-03 GO:0005604 basement membrane
1.09 2.99e-03 GO:0016020 membrane
2.04 6.35e-03 GO:0044420 extracellular matrix part
1.25 1.11e-02 GO:0005856 cytoskeleton
1.35 1.50e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.03 2.23e-02 GO:0019838 growth factor binding
1.40 3.34e-02 GO:0005198 structural molecule activity
2.16 4.65e-02 GO:0005201 extracellular matrix structural constituent