Motif ID: TGIF1.p2

Z-value: 1.613


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TGIF1chr18_+_3443771-0.381.4e-01Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_129024665 1.717 NM_001003794
MGLL
monoglyceride lipase
chr1_+_66230977 1.668 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_+_140848905 1.631 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr2_-_188021117 1.603 NM_005795
CALCRL
calcitonin receptor-like
chr3_-_129023850 1.507 NM_007283
MGLL
monoglyceride lipase
chr5_-_88235624 1.493 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr4_+_54790190 1.435 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_-_46725087 1.431 NM_000138
FBN1
fibrillin 1
chr11_+_6368213 1.412 NM_000543
NM_001007593
SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr16_+_27320983 1.368 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr17_+_65677255 1.367 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr12_-_107551783 1.344 NM_003006
SELPLG
selectin P ligand
chr4_+_71713324 1.332 NM_031889
ENAM
enamelin
chr8_+_28230567 1.315 NM_006228
PNOC
prepronociceptin
chr4_+_54790020 1.307 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_+_114733907 1.295 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr1_+_78858675 1.285 NM_006820
IFI44L
interferon-induced protein 44-like
chr20_+_42007949 1.269 NM_001098798
TOX2
TOX high mobility group box family member 2
chr11_-_76059435 1.261 NM_001128922
LRRC32
leucine rich repeat containing 32
chrX_-_128616594 1.252 NM_017413
APLN
apelin
chr3_-_184756101 1.247 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr11_-_127962662 1.237 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr14_+_23590939 1.210 NM_138360
LRRC16B
leucine rich repeat containing 16B
chr14_-_72430545 1.177 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr10_-_73203202 1.158 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr12_-_107551744 1.122 SELPLG
selectin P ligand
chr12_-_107551694 1.116 SELPLG
selectin P ligand
chr5_+_32824701 1.094 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr9_+_124173049 1.035 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr20_-_9767406 1.033 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr9_+_18464090 1.032 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr9_-_129580732 1.019 NM_170600
SH2D3C
SH2 domain containing 3C
chr2_+_234333653 1.015 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr18_+_64616296 0.985 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr8_+_67201684 0.980 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_+_96566190 0.972 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr11_-_110755112 0.964 POU2AF1
POU class 2 associating factor 1
chr11_-_10630408 0.939 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr12_+_54612055 0.932 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr22_+_42726423 0.930 NM_001003828
PARVB
parvin, beta
chr1_+_243384868 0.927 NM_018012
KIF26B
kinesin family member 26B
chr6_-_119137923 0.921 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr3_+_171112053 0.899 NM_182610
SAMD7
sterile alpha motif domain containing 7
chr1_+_101475149 0.883 S1PR1
sphingosine-1-phosphate receptor 1
chr5_+_43228083 0.881 NM_153361
MGC42105
serine/threonine-protein kinase NIM1
chr21_-_33107813 0.876 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr7_+_156496360 0.869 LOC645249
hypothetical LOC645249
chr4_+_42094612 0.853 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr3_-_39209075 0.851 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr2_-_225519974 0.851 DOCK10
dedicator of cytokinesis 10
chr10_+_85994788 0.847 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr4_-_83702123 0.843 NM_001080506
TMEM150C
transmembrane protein 150C
chrX_+_38096679 0.842 NM_000531
OTC
ornithine carbamoyltransferase
chr17_-_23244499 0.837 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr11_-_76058542 0.836 NM_005512
LRRC32
leucine rich repeat containing 32
chr5_+_180190542 0.822


chr9_-_16717887 0.820 BNC2
basonuclin 2
chr7_+_119700924 0.816 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr7_+_101715110 0.815 NM_020979
SH2B2
SH2B adaptor protein 2
chr12_+_76749199 0.813 NM_014903
NAV3
neuron navigator 3
chr13_+_113577228 0.810 NM_001143946
GAS6
growth arrest-specific 6
chr9_+_101623957 0.808 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr3_+_120495906 0.807 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr9_+_35032222 0.806 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr12_-_21649019 0.805 NM_021957
GYS2
glycogen synthase 2 (liver)
chr7_+_101715137 0.800 SH2B2
SH2B adaptor protein 2
chr1_+_148020869 0.799 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr22_-_36212160 0.785 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr20_+_54420574 0.779 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr8_+_42671718 0.775 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr5_-_54317102 0.760 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr9_+_124173143 0.755 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_-_7672978 0.755 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr1_+_22909916 0.749 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr11_+_63808858 0.730 NM_001177358
NM_001170881
GPR137

G protein-coupled receptor 137

chr1_+_101474892 0.730 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr5_+_40877053 0.726 NM_032587
CARD6
caspase recruitment domain family, member 6
chr1_+_161305019 0.721 NM_001102445
RGS4
regulator of G-protein signaling 4
chr1_-_158948176 0.718 NM_001778
CD48
CD48 molecule
chr14_+_104462260 0.718 PLD4
phospholipase D family, member 4
chr8_+_134272463 0.717 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr5_+_110587546 0.713 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr1_+_149309703 0.706 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr12_+_6768960 0.706 CD4
CD4 molecule
chr2_-_197883739 0.704 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr10_-_14412813 0.702 NM_018027
FRMD4A
FERM domain containing 4A
chr2_-_179623030 0.702 NM_173648
CCDC141
coiled-coil domain containing 141
chr1_-_42157077 0.696 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr10_+_90629880 0.686 NM_020799
STAMBPL1
STAM binding protein-like 1
chr7_+_39839337 0.685


chr7_-_42243142 0.681 NM_000168
GLI3
GLI family zinc finger 3
chr3_+_35697432 0.677 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_+_136203938 0.676 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr1_-_42156957 0.675 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr11_+_128751044 0.672 NM_003658
BARX2
BARX homeobox 2
chr18_+_52965290 0.669 BOD1P
biorientation of chromosomes in cell division 1 pseudogene
chr2_+_33514896 0.668 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_133120587 0.662 NM_004665
VNN2
vanin 2
chr3_-_130807865 0.658 NM_015103
PLXND1
plexin D1
chr5_-_169657395 0.649 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_46439127 0.649 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr11_-_74119833 0.647 NM_015424
CHRDL2
chordin-like 2
chr12_+_51728999 0.641 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr15_-_41346346 0.638 NM_004245
NM_201631
TGM5

transglutaminase 5

chr1_-_246525502 0.636 NM_001004692
OR2T12
olfactory receptor, family 2, subfamily T, member 12
chr18_+_29412538 0.635 NM_030632
ASXL3
additional sex combs like 3 (Drosophila)
chr18_+_52469559 0.628 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr11_-_7941617 0.623 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr12_+_6768966 0.615 CD4
CD4 molecule
chr12_+_6768934 0.614 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr11_-_73397929 0.611 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr13_-_69580459 0.610 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr4_+_91035025 0.610 NM_007351
MMRN1
multimerin 1
chr12_-_46438447 0.605 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr6_-_33822659 0.601 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr4_+_120167770 0.599 SYNPO2
synaptopodin 2
chr4_+_187227302 0.595 NM_003265
TLR3
toll-like receptor 3
chr19_-_14089362 0.594 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr12_-_25239298 0.594 NM_001082972
NM_001082973
NM_018272
CASC1


cancer susceptibility candidate 1


chr1_-_199348316 0.590 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr8_-_93099040 0.582 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_12958129 0.579 NM_001100631
PRAMEF22
PRAME family member 22
chr14_+_23907065 0.578 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr6_+_32515596 0.575 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_-_43963270 0.571 NM_002144
HOXB1
homeobox B1
chr11_+_832821 0.571 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr1_+_161305188 0.567 NM_005613
RGS4
regulator of G-protein signaling 4
chr9_+_18464138 0.562 ADAMTSL1
ADAMTS-like 1
chr2_-_71307705 0.562 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr9_+_124172606 0.558 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chrX_+_129133234 0.556 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr11_-_110755366 0.554 NM_006235
POU2AF1
POU class 2 associating factor 1
chr12_+_119562737 0.550 NM_001033677
CABP1
calcium binding protein 1
chr13_-_37070862 0.545 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr1_+_196874759 0.544 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr14_+_99912481 0.544 NM_001161476
NM_024515
WDR25

WD repeat domain 25

chr11_+_130745580 0.544 NM_001048209
NTM
neurotrimin
chr12_+_6768866 0.543 NM_000616
CD4
CD4 molecule
chr15_+_42815851 0.537 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr1_-_197173159 0.535 LOC100131234
familial acute myelogenous leukemia related factor
chr20_+_2224612 0.535 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr12_+_48630790 0.533 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr12_+_118100977 0.531 NM_014365
HSPB8
heat shock 22kDa protein 8
chr22_-_16060485 0.530 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr4_+_120168002 0.530 SYNPO2
synaptopodin 2
chr9_-_71476917 0.528 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr11_-_100505667 0.526 NM_000926
PGR
progesterone receptor
chr14_+_62740878 0.525 NM_020663
RHOJ
ras homolog gene family, member J
chr1_-_184916044 0.524 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_169171235 0.523 NM_001163629
NM_025063
C1orf129

chromosome 1 open reading frame 129

chr6_+_31059463 0.521 NM_001010909
MUC21
mucin 21, cell surface associated
chr5_-_169657312 0.517 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_167865973 0.514 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr7_+_123036312 0.506 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr8_-_134184491 0.506 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr3_-_145049853 0.504 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr16_-_2330712 0.500 ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr10_-_73167586 0.497 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr6_-_69401639 0.495


chr15_+_41597097 0.495 NM_002373
MAP1A
microtubule-associated protein 1A
chr14_+_37746937 0.494 NM_001049
SSTR1
somatostatin receptor 1
chr6_+_73133152 0.494 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr16_-_2330594 0.492 ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr1_+_168381811 0.492 NM_001136107
METTL11B
methyltransferase like 11B
chr5_+_140790365 0.490 PCDHGA12
protocadherin gamma subfamily A, 12
chr10_-_49483002 0.489 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr7_+_69869099 0.487 AUTS2
autism susceptibility candidate 2
chr11_+_120478584 0.487 NM_005422
TECTA
tectorin alpha
chr4_+_120167721 0.486 SYNPO2
synaptopodin 2
chr8_+_38363150 0.484 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr21_-_44795769 0.484 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr11_+_67532592 0.482 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr10_-_48010879 0.478 NM_002900
RBP3
retinol binding protein 3, interstitial
chr4_-_122357104 0.477 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chrX_-_48818585 0.475 NM_007213
PRAF2
PRA1 domain family, member 2
chr9_-_35640852 0.474 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr11_+_2279812 0.473 NM_139022
TSPAN32
tetraspanin 32
chr18_+_57308754 0.472 NM_031891
CDH20
cadherin 20, type 2
chr4_-_114902285 0.472 NM_001221
NM_172114
NM_172115
NM_172127
NM_172128
NM_172129
CAMK2D





calcium/calmodulin-dependent protein kinase II delta





chr4_+_120167950 0.472 SYNPO2
synaptopodin 2
chr9_-_129537372 0.466 NM_001085347
NM_001134430
NM_001134431
NM_130459
TOR2A



torsin family 2, member A



chrX_+_154650590 0.466 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr6_-_41781655 0.463 TFEB
transcription factor EB
chr12_-_15005761 0.463 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_231498184 0.462 NM_005683
GPR55
G protein-coupled receptor 55
chr19_-_14089560 0.462 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr7_-_131483925 0.461 PLXNA4
plexin A4
chr9_+_34980266 0.460 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr15_+_36776090 0.458 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr7_-_130021845 0.457 NM_052933
TSGA13
testis specific, 13
chr3_-_9570412 0.454 NM_198560
LHFPL4
lipoma HMGIC fusion partner-like 4
chr1_-_35223489 0.452 LOC100506144
hypothetical protein LOC100506144
chr5_-_157011949 0.451 NM_007017
NM_178424
SOX30

SRY (sex determining region Y)-box 30

chr3_+_101381002 0.450


chr11_+_73339011 0.450 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr1_+_205068844 0.447 NM_013371
IL19
interleukin 19
chr17_-_64462976 0.446 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr5_-_88155360 0.446 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr13_+_27392136 0.446 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr1_-_231498081 0.445 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 3.73e-08 GO:0032501 multicellular organismal process
1.55 9.29e-07 GO:0003008 system process
1.22 1.30e-05 GO:0050896 response to stimulus
1.30 5.73e-05 GO:0023052 signaling
1.30 4.11e-04 GO:0007165 signal transduction
1.51 6.15e-04 GO:0050877 neurological system process
1.33 8.37e-04 GO:0048731 system development
1.47 1.14e-03 GO:0007399 nervous system development
1.69 1.24e-03 GO:0007267 cell-cell signaling
1.41 2.31e-03 GO:0007166 cell surface receptor linked signaling pathway
1.56 3.41e-03 GO:0007154 cell communication
2.02 4.84e-03 GO:0015672 monovalent inorganic cation transport
1.26 1.16e-02 GO:0007275 multicellular organismal development
1.27 1.35e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 5.27e-15 GO:0005886 plasma membrane
1.42 5.33e-15 GO:0071944 cell periphery
1.45 6.40e-07 GO:0044459 plasma membrane part
1.18 2.71e-06 GO:0016020 membrane
1.20 8.72e-06 GO:0044425 membrane part
1.56 1.27e-05 GO:0031226 intrinsic to plasma membrane
1.56 2.02e-05 GO:0005887 integral to plasma membrane
2.07 2.65e-04 GO:0005578 proteinaceous extracellular matrix
1.20 3.15e-04 GO:0031224 intrinsic to membrane
1.18 2.26e-03 GO:0016021 integral to membrane
1.85 3.66e-03 GO:0031012 extracellular matrix
3.00 4.48e-03 GO:0045095 keratin filament
1.32 6.42e-03 GO:0005576 extracellular region
1.45 1.59e-02 GO:0044421 extracellular region part
2.06 1.63e-02 GO:0034702 ion channel complex
1.72 4.28e-02 GO:0009986 cell surface

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.39 1.92e-04 GO:0004871 signal transducer activity
1.39 1.92e-04 GO:0060089 molecular transducer activity
1.43 2.21e-04 GO:0004872 receptor activity
1.73 2.43e-04 GO:0005509 calcium ion binding
1.50 3.00e-04 GO:0004888 transmembrane receptor activity
1.60 1.03e-03 GO:0004930 G-protein coupled receptor activity
1.50 1.03e-02 GO:0022857 transmembrane transporter activity
1.42 2.04e-02 GO:0005215 transporter activity