Motif ID: TLX2.p2

Z-value: 1.906


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX2chr2_+_745950730.312.4e-01Click!


Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_8571988 1.209 NM_030906
STK33
serine/threonine kinase 33
chr4_-_75938710 1.148 NM_001729
BTC
betacellulin
chr13_-_46368968 1.117 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr9_+_70509925 1.111 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr1_-_245237977 1.019 NM_020394
ZNF695
zinc finger protein 695
chrX_+_38305634 0.991 NM_004615
TSPAN7
tetraspanin 7
chr7_-_22363036 0.940 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_+_167445284 0.917 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_-_68688219 0.910 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr6_-_26038817 0.887 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr1_-_245237925 0.883 ZNF695
zinc finger protein 695
chr3_+_123279439 0.864 NM_006889
CD86
CD86 molecule
chr12_-_97562532 0.864 NM_153687
NM_201612
NM_201613
IKBIP


IKBKB interacting protein


chr11_-_22807842 0.860 NM_148893
SVIP
small VCP/p97-interacting protein
chr2_+_43919606 0.807 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr14_-_35859545 0.799 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr20_+_42463350 0.796 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_42463387 0.771 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_+_56318415 0.754 RAB22A
RAB22A, member RAS oncogene family
chr18_+_27332024 0.742 NM_001943
DSG2
desmoglein 2
chr1_+_16203317 0.734 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr10_+_82163568 0.727 C10orf58
chromosome 10 open reading frame 58
chr20_+_42463419 0.722 HNF4A
hepatocyte nuclear factor 4, alpha
chr10_-_59697636 0.720 NM_152230
IPMK
inositol polyphosphate multikinase
chr18_-_26935883 0.719 NM_004949
NM_024422
DSC2

desmocollin 2

chr1_-_74971276 0.717 CRYZ
crystallin, zeta (quinone reductase)
chr10_-_12125028 0.716 NM_080599
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr16_+_49139694 0.700 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr2_-_160277083 0.696 BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr1_+_159817752 0.694 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_-_8572321 0.690 STK33
serine/threonine kinase 33
chrX_-_77281764 0.681 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr2_+_172252194 0.671 NM_001378
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr3_+_153469421 0.671 MBNL1
muscleblind-like (Drosophila)
chr12_-_32940931 0.664 NM_001005242
NM_004572
PKP2

plakophilin 2

chr6_-_127706204 0.660 ECHDC1
enoyl CoA hydratase domain containing 1
chr6_-_35804337 0.646 NM_001145775
FKBP5
FK506 binding protein 5
chr2_-_210798232 0.646 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr11_-_8572277 0.644 STK33
serine/threonine kinase 33
chr10_-_12124778 0.643 NM_015542
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chrX_-_30817329 0.641 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr7_+_72913424 0.640 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr2_+_169367345 0.637 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr7_-_112545840 0.637 LOC401397
hypothetical LOC401397
chr11_+_59979857 0.636 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr1_-_114925734 0.632 NM_005872
BCAS2
breast carcinoma amplified sequence 2
chr2_+_60962279 0.628 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr20_-_13713509 0.627 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr17_+_51585834 0.625 NM_153228
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr17_-_57497380 0.623 NM_005121
MED13
mediator complex subunit 13
chr4_-_155753249 0.622 FGG
fibrinogen gamma chain
chr8_-_91726915 0.622 TMEM64
transmembrane protein 64
chr20_+_47328585 0.614 NCRNA00275
non-protein coding RNA 275
chr17_+_55269974 0.614


chr7_-_112545847 0.609 LOC401397
hypothetical LOC401397
chr1_-_114215768 0.604 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr7_-_33047042 0.603 NM_001166118
NM_016489
NT5C3

5'-nucleotidase, cytosolic III

chr3_-_180805104 0.592 NM_020409
NM_177988
MRPL47

mitochondrial ribosomal protein L47

chr2_-_174537021 0.589 NM_001017371
SP3
Sp3 transcription factor
chr11_+_113435640 0.585 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr1_-_92537087 0.584 NM_053274
GLMN
glomulin, FKBP associated protein
chr20_+_42417502 0.580 HNF4A
hepatocyte nuclear factor 4, alpha
chr15_+_24799174 0.577 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr18_+_31488530 0.574 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr8_+_76614757 0.574 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr12_+_15955549 0.571 DERA
deoxyribose-phosphate aldolase (putative)
chr19_-_6671585 0.566 NM_000064
C3
complement component 3
chr1_-_151549790 0.563 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr14_+_23008742 0.561 NGDN
neuroguidin, EIF4E binding protein
chr1_-_116915163 0.555 NM_001144822
NM_001779
CD58

CD58 molecule

chr1_+_111573855 0.553 NM_001025199
CHI3L2
chitinase 3-like 2
chr4_-_147662318 0.551 NM_001029998
NM_032128
SLC10A7

solute carrier family 10 (sodium/bile acid cotransporter family), member 7

chr2_+_160277219 0.551 NM_022826
MARCH7
membrane-associated ring finger (C3HC4) 7
chr12_+_26982571 0.550 NM_001171887
NM_001171888
NM_015633
FGFR1OP2


FGFR1 oncogene partner 2


chr1_-_159257486 0.547 F11R
F11 receptor
chr1_-_1840564 0.544 NM_178545
TMEM52
transmembrane protein 52
chr9_-_114520118 0.543 C9orf80
chromosome 9 open reading frame 80
chr14_-_34168911 0.541 SNX6
sorting nexin 6
chr16_+_29581783 0.541 NM_001030288
SPN
sialophorin
chr18_+_58006154 0.541


chr15_-_32289561 0.540 NM_024713
C15orf29
chromosome 15 open reading frame 29
chr20_+_45564007 0.539 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr8_+_17874128 0.539 PCM1
pericentriolar material 1
chr2_+_60962228 0.538 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chrX_+_24393264 0.537 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr20_+_36867708 0.537 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr2_-_153282104 0.535 NM_017892
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr9_-_14683459 0.535 NM_178566
ZDHHC21
zinc finger, DHHC-type containing 21
chr1_+_205561709 0.533 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr18_+_17575275 0.530 MIB1
mindbomb homolog 1 (Drosophila)
chr3_-_156904690 0.529 NM_014996
PLCH1
phospholipase C, eta 1
chr10_+_76541351 0.529 NM_001174156
NM_144660
SAMD8

sterile alpha motif domain containing 8

chr2_-_104834344 0.525 LOC100506421
hypothetical LOC100506421
chr19_+_2818332 0.525 NM_024967
ZNF556
zinc finger protein 556
chr6_-_127706384 0.518 NM_001002030
NM_001105544
NM_001105545
NM_018479
ECHDC1



enoyl CoA hydratase domain containing 1



chr16_+_29582065 0.518 SPN
sialophorin
chr12_+_32003553 0.516 NM_018169
C12orf35
chromosome 12 open reading frame 35
chr20_-_39199936 0.514


chr2_-_55413253 0.514 CCDC88A
coiled-coil domain containing 88A
chr20_+_45564063 0.514 NCOA3
nuclear receptor coactivator 3
chr1_-_151333624 0.513 NM_001024209
SPRR2E
small proline-rich protein 2E
chr2_+_113479919 0.510 NM_014440
IL1F6
interleukin 1 family, member 6 (epsilon)
chr8_+_32905027 0.510


chr8_-_27171814 0.507 NM_030795
STMN4
stathmin-like 4
chr14_+_23008723 0.505 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr21_+_29593098 0.504 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr19_-_6621078 0.504 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr21_+_29593088 0.504 NM_001186
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr7_+_130445394 0.502 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr4_-_68093829 0.501 NM_001812
CENPC1
centromere protein C 1
chr12_+_32003648 0.501 C12orf35
chromosome 12 open reading frame 35
chr6_-_119297851 0.497 MCM9
minichromosome maintenance complex component 9
chr16_+_55963899 0.497 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr16_+_64958025 0.496 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr8_+_86538307 0.492 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr1_+_195055483 0.489 NM_002113
CFHR1
complement factor H-related 1
chr4_-_68093784 0.487 CENPC1
centromere protein C 1
chrX_-_118711144 0.487 SEPT6
septin 6
chr1_+_26744929 0.486 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_-_32665409 0.486 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr7_+_150065594 0.484 GIMAP5
GTPase, IMAP family member 5
chr5_+_75414994 0.484 NM_014979
SV2C
synaptic vesicle glycoprotein 2C
chr14_+_30098079 0.482 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr2_+_63669596 0.480 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr4_+_41632125 0.479 TMEM33
transmembrane protein 33
chr16_+_51722285 0.477 CHD9
chromodomain helicase DNA binding protein 9
chr12_+_67426225 0.476 SLC35E3
solute carrier family 35, member E3
chr10_+_96295511 0.473 NM_018063
HELLS
helicase, lymphoid-specific
chr21_+_29592984 0.472 BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr2_+_60962206 0.472 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr1_+_160002746 0.472 ATF6
activating transcription factor 6
chrX_+_115481774 0.470 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr16_-_16224791 0.470 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr10_-_82039158 0.469 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chrX_-_31194867 0.468 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr20_+_56318245 0.468 RAB22A
RAB22A, member RAS oncogene family
chr13_+_59869427 0.468 NM_001146070
TDRD3
tudor domain containing 3
chr6_+_32713160 0.467 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr20_+_44180355 0.466 CD40
CD40 molecule, TNF receptor superfamily member 5
chr2_+_187163232 0.465 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr20_+_42463279 0.463 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chrX_+_144707022 0.463 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr17_-_6958282 0.461 NM_080914
ASGR2
asialoglycoprotein receptor 2
chrX_-_55037235 0.461 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr14_+_34521854 0.461 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr6_+_160068135 0.458 NM_004906
NM_152858
WTAP

Wilms tumor 1 associated protein

chr20_+_5679032 0.455 NM_152504
C20orf196
chromosome 20 open reading frame 196
chr9_-_74735669 0.455 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr20_+_56318155 0.454 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr10_-_120928266 0.454 PRDX3
peroxiredoxin 3
chr5_-_60031695 0.451 NM_001145208
NM_018369
DEPDC1B

DEP domain containing 1B

chr9_-_27563444 0.450 NM_018325
C9orf72
chromosome 9 open reading frame 72
chr20_+_47328575 0.449 NCRNA00275
non-protein coding RNA 275
chrX_+_15428820 0.449 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr10_-_32384914 0.449


chr6_-_127705244 0.449 NM_001139510
ECHDC1
enoyl CoA hydratase domain containing 1
chr13_+_25726755 0.448 NM_001260
CDK8
cyclin-dependent kinase 8
chr1_-_245308649 0.448 ZNF670-ZNF695
ZNF670
ZNF670-ZNF695 read-through transcript
zinc finger protein 670
chr2_+_219141761 0.448 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr14_+_34521945 0.447 SRP54
signal recognition particle 54kDa
chr6_+_11202251 0.447 NM_001135575
LOC221710
hypothetical protein LOC221710
chr7_-_104949787 0.445 NM_019042
PUS7
pseudouridylate synthase 7 homolog (S. cerevisiae)
chr18_+_17575542 0.444 NM_020774
MIB1
mindbomb homolog 1 (Drosophila)
chr4_+_38722593 0.444 NM_001007075
NM_001171654
KLHL5

kelch-like 5 (Drosophila)

chr2_+_160277273 0.443 MARCH7
membrane-associated ring finger (C3HC4) 7
chr6_-_165995510 0.442 NM_001130690
NM_006661
PDE10A

phosphodiesterase 10A

chr6_-_149847718 0.442 ZC3H12D
zinc finger CCCH-type containing 12D
chr20_+_52258023 0.442 PFDN4
prefoldin subunit 4
chr14_+_64040979 0.441 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr12_-_97562836 0.440 IKBIP
IKBKB interacting protein
chr6_+_116528663 0.440 NM_152729
NT5DC1
5'-nucleotidase domain containing 1
chr12_+_30970625 0.438


chr8_-_143820825 0.438 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr1_-_31003181 0.437 LAPTM5
lysosomal protein transmembrane 5
chr2_+_32244406 0.437 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr6_+_131190237 0.436 NM_001195597
LOC285733
hypothetical LOC285733
chr9_-_88087192 0.433 NM_030940
ISCA1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr2_+_208103001 0.432 CREB1
cAMP responsive element binding protein 1
chr4_-_35922288 0.432 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_74963246 0.431 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr1_+_205561632 0.431 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr22_+_23153529 0.430 NM_000675
ADORA2A
adenosine A2a receptor
chr15_+_39839866 0.429 MGA
MAX gene associated
chr2_-_238776932 0.429 ILKAP
integrin-linked kinase-associated serine/threonine phosphatase
chr8_+_22266256 0.428 PIWIL2
piwi-like 2 (Drosophila)
chr4_+_57468847 0.426 REST
RE1-silencing transcription factor
chr5_-_60031654 0.426 DEPDC1B
DEP domain containing 1B
chr21_-_15358996 0.425 NM_003489
NRIP1
nuclear receptor interacting protein 1
chrX_-_118711088 0.424 SEPT6
septin 6
chr3_+_194793691 0.423 OPA1
optic atrophy 1 (autosomal dominant)
chr11_-_107234733 0.423 SLC35F2
solute carrier family 35, member F2
chr8_-_117837240 0.422 NM_003756
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr5_+_96297529 0.422 LNPEP
leucyl/cystinyl aminopeptidase
chr2_+_187162969 0.420 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr20_+_52257800 0.420 NM_002623
PFDN4
prefoldin subunit 4
chr10_-_120928327 0.420 NM_006793
NM_014098
PRDX3

peroxiredoxin 3

chr1_+_26744893 0.420 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr9_-_15500209 0.420 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr8_-_33450172 0.418 NM_032664
FUT10
fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
chr19_+_56990222 0.418 NM_002030
FPR3
formyl peptide receptor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 4.09e-03 GO:0009987 cellular process
1.63 4.16e-03 GO:0000278 mitotic cell cycle
1.54 1.35e-02 GO:0022403 cell cycle phase
1.54 1.41e-02 GO:0002682 regulation of immune system process
1.12 2.14e-02 GO:0065007 biological regulation
1.12 3.18e-02 GO:0008152 metabolic process
1.12 3.82e-02 GO:0050789 regulation of biological process
1.37 4.01e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 5.67e-07 GO:0005737 cytoplasm
1.20 1.72e-06 GO:0044422 organelle part
1.20 1.95e-06 GO:0044446 intracellular organelle part
1.32 2.39e-05 GO:0031974 membrane-enclosed lumen
1.32 3.10e-05 GO:0043233 organelle lumen
1.09 6.54e-05 GO:0044424 intracellular part
1.24 7.05e-05 GO:0032991 macromolecular complex
1.09 7.34e-05 GO:0005622 intracellular
1.31 1.29e-04 GO:0070013 intracellular organelle lumen
1.11 1.40e-04 GO:0043229 intracellular organelle
1.10 1.69e-04 GO:0043226 organelle
1.16 2.02e-04 GO:0044444 cytoplasmic part
1.32 2.27e-04 GO:0005829 cytosol
1.25 6.78e-04 GO:0043234 protein complex
1.38 1.57e-03 GO:0005654 nucleoplasm
1.11 1.59e-03 GO:0043227 membrane-bounded organelle
1.11 1.60e-03 GO:0043231 intracellular membrane-bounded organelle
1.31 2.00e-03 GO:0031981 nuclear lumen
1.27 5.10e-03 GO:0044428 nuclear part
5.25 1.58e-02 GO:0042613 MHC class II protein complex
1.21 3.10e-02 GO:0043228 non-membrane-bounded organelle
1.21 3.10e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 2.84e-03 GO:0005515 protein binding