Motif ID: TP53.p2

Z-value: 0.504


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_75314560.332.1e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_11824361 0.745 NM_024693
 ECHDC3
enoyl CoA hydratase domain containing 3
chr7_-_74705276 0.468 NM_001145064
 GATSL2
GATS protein-like 2
chr8_-_10625352 0.438 NM_031439
 SOX7
SRY (sex determining region Y)-box 7
chr1_-_38185291 0.400 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr8_-_23138517 0.363 TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr19_+_44379440 0.362 NM_001001414
 NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr17_+_73721924 0.324 BIRC5
baculoviral IAP repeat containing 5
chr8_-_22982351 0.289 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr8_-_22982435 0.285 NM_003842
NM_147187
 TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr3_-_44494108 0.263 ZNF445
zinc finger protein 445
chr19_-_5741913 0.256 DUS3L
dihydrouridine synthase 3-like (S. cerevisiae)
chr9_+_80101810 0.248 NM_021154
NM_058179
 PSAT1

phosphoserine aminotransferase 1

chr1_-_10455190 0.240 NM_004401
NM_213566
 DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr16_-_31013626 0.234 NM_024006
NM_206824
 VKORC1

vitamin K epoxide reductase complex, subunit 1

chr6_+_36206239 0.227 NM_002754
 MAPK13
mitogen-activated protein kinase 13
chr1_-_45578193 0.224 NM_001048174
NM_001048172
NM_001048173
NM_001048171
NM_001128425
NM_012222
 MUTYH





mutY homolog (E. coli)





chr8_-_10734700 0.221 NM_017884
 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr1_-_38185312 0.213 NM_005540
 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_207892420 0.210 NM_000228
 LAMB3
laminin, beta 3
chr15_+_89300995 0.202 RCCD1
RCC1 domain containing 1
chr9_+_129962292 0.202 NM_024112
 C9orf16
chromosome 9 open reading frame 16
chr15_+_38319326 0.201 NM_020168
 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr20_-_33007243 0.197 NM_000178
 GSS
glutathione synthetase
chr22_-_18687511 0.194 NM_033257
 DGCR6L
DiGeorge syndrome critical region gene 6-like
chr22_-_22422951 0.193 NM_021916
 ZNF70
zinc finger protein 70
chr11_-_47356562 0.192 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr19_+_61344501 0.191 ZNF444
zinc finger protein 444
chr1_-_10455100 0.191 DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
chr20_+_4077409 0.188 NM_175839
NM_175840
NM_175841
NM_175842
 SMOX



spermine oxidase



chr8_-_10734792 0.188 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr19_-_47438583 0.188 GSK3A
glycogen synthase kinase 3 alpha
chr2_-_26058941 0.183 NM_002254
 KIF3C
kinesin family member 3C
chr2_-_26058831 0.183 KIF3C
kinesin family member 3C
chr11_+_45783216 0.182 NM_018389
 SLC35C1
solute carrier family 35, member C1
chr19_+_13090101 0.180 NM_052876
 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr17_-_59304729 0.179 NM_020991
NM_022644
NM_022645
 CSH2


chorionic somatomammotropin hormone 2


chr4_+_103641585 0.176 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_+_17766609 0.174 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr7_+_100792841 0.172 NM_133457
 EMID2
EMI domain containing 2
chr14_-_30959487 0.170 HEATR5A
HEAT repeat containing 5A
chr22_+_39096509 0.169 NM_015705
 SGSM3
small G protein signaling modulator 3
chr1_+_45578256 0.169 TOE1
target of EGR1, member 1 (nuclear)
chr11_-_3035172 0.167 NM_001014437
NM_001194997
NM_001751
NM_139273
 CARS



cysteinyl-tRNA synthetase



chr1_-_38185307 0.165 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr10_-_73281056 0.165 NM_001042465
NM_001042466
NM_002778
 PSAP


prosaposin


chr15_+_89300973 0.165 RCCD1
RCC1 domain containing 1
chr16_-_15057328 0.162 NM_173474
 NTAN1
N-terminal asparagine amidase
chr19_-_47438563 0.162 NM_019884
 GSK3A
glycogen synthase kinase 3 alpha
chr15_+_86965526 0.160 NM_022767
 AEN
apoptosis enhancing nuclease
chr19_+_17766935 0.160 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr1_+_45578370 0.159 TOE1
target of EGR1, member 1 (nuclear)
chr14_+_77336172 0.158 NM_001142545
NM_020421
 ADCK1

aarF domain containing kinase 1

chr1_+_114249549 0.158 DCLRE1B
DNA cross-link repair 1B
chr19_+_17766907 0.157 NM_014256
 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr22_+_35777561 0.155 NM_024681
 KCTD17
potassium channel tetramerisation domain containing 17
chr19_-_47438548 0.155 GSK3A
glycogen synthase kinase 3 alpha
chr9_-_137992967 0.153 NM_016172
 UBAC1
UBA domain containing 1
chr11_-_72986738 0.151 NM_015159
 FAM168A
family with sequence similarity 168, member A
chr1_-_52936611 0.150 NM_023077
 C1orf163
chromosome 1 open reading frame 163
chr19_-_47438518 0.150 GSK3A
glycogen synthase kinase 3 alpha
chr22_-_38045555 0.149 NM_000967
NM_001033853
 RPL3

ribosomal protein L3

chr1_-_52936602 0.148 C1orf163
chromosome 1 open reading frame 163
chr19_-_8670054 0.148 NM_178525
 ACTL9
actin-like 9
chr19_+_61344341 0.147 NM_018337
 ZNF444
zinc finger protein 444
chr17_+_18027538 0.147 NM_017758
 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr22_-_16637238 0.147 NM_001196
NM_197967
 BID

BH3 interacting domain death agonist

chr1_+_43084846 0.145 NM_015911
 ZNF691
zinc finger protein 691
chr1_+_3597092 0.143 NM_001126240
NM_001126241
NM_001126242
 TP73


tumor protein p73


chr22_-_16491503 0.142 ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
chr17_+_12633504 0.141 NM_014859
 ARHGAP44
Rho GTPase activating protein 44
chr1_-_154977479 0.141 MRPL24
mitochondrial ribosomal protein L24
chr1_+_45578464 0.141 TOE1
target of EGR1, member 1 (nuclear)
chr19_-_6542012 0.140 CD70
CD70 molecule
chr1_+_114249429 0.139 NM_022836
 DCLRE1B
DNA cross-link repair 1B
chr19_-_2407954 0.138 NM_032737
 LMNB2
lamin B2
chr12_+_54784614 0.136 PA2G4
proliferation-associated 2G4, 38kDa
chr16_-_31013594 0.135 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr20_-_33007209 0.135 GSS
glutathione synthetase
chr4_-_40211324 0.135 RBM47
RNA binding motif protein 47
chr22_+_23753940 0.135 NM_001145206
 KIAA1671
KIAA1671
chr12_-_53328402 0.135 NM_053283
 DCD
dermcidin
chr1_+_153799637 0.134 LOC645676
hypothetical LOC645676
chr10_+_133850325 0.134 NM_006426
 DPYSL4
dihydropyrimidinase-like 4
chr12_-_112257283 0.132 NM_024959
 SLC24A6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
chr4_+_103641511 0.131 NM_001165412
NM_003998
 NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr1_-_154977526 0.130 NM_024540
NM_145729
 MRPL24

mitochondrial ribosomal protein L24

chr22_+_36632242 0.130 NM_033386
 MICALL1
MICAL-like 1
chr17_-_4879423 0.128 NM_001104577
NM_017986
 GPR172B

G protein-coupled receptor 172B

chr5_+_141328876 0.126 RNF14
ring finger protein 14
chr16_-_31013550 0.126 VKORC1
vitamin K epoxide reductase complex, subunit 1
chr20_-_43022286 0.126 NM_006809
 TOMM34
translocase of outer mitochondrial membrane 34
chr1_+_42920946 0.126 YBX1
Y box binding protein 1
chr19_-_47413642 0.126 NM_133328
 DEDD2
death effector domain containing 2
chr22_+_34266837 0.124


chr20_-_62151216 0.123 NM_018419
 SOX18
SRY (sex determining region Y)-box 18
chr4_-_48603501 0.122 NM_001014446
NM_152398
 OCIAD2

OCIA domain containing 2

chrX_+_151837064 0.121 NM_001178113
 ZNF185
zinc finger protein 185 (LIM domain)
chr1_-_1198920 0.121 UBE2J2
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
chr3_+_13496714 0.120 NM_024827
NM_001136041
 HDAC11

histone deacetylase 11

chr20_+_4077466 0.120 SMOX
spermine oxidase
chr12_+_54784591 0.120 PA2G4
proliferation-associated 2G4, 38kDa
chr1_-_2447848 0.119 NM_018216
 PANK4
pantothenate kinase 4
chr15_-_62242243 0.118 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr1_-_52936573 0.118 C1orf163
chromosome 1 open reading frame 163
chr12_+_54784625 0.117 PA2G4
proliferation-associated 2G4, 38kDa
chr17_+_18027816 0.116 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr11_-_226833 0.116 SIRT3
sirtuin 3
chr19_-_4768502 0.116 TICAM1
toll-like receptor adaptor molecule 1
chr10_-_104252394 0.113 NM_005736
 ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr1_+_11718798 0.112 AGTRAP
angiotensin II receptor-associated protein
chr18_+_75760434 0.112


chr6_-_166502119 0.112 NM_003181
 T
T, brachyury homolog (mouse)
chr19_-_47413733 0.110 DEDD2
death effector domain containing 2
chr21_+_45649429 0.110 NM_130445
 COL18A1
collagen, type XVIII, alpha 1
chr2_-_242096673 0.110 NM_006374
 STK25
serine/threonine kinase 25
chr3_-_46012303 0.109 NM_024513
 FYCO1
FYVE and coiled-coil domain containing 1
chr12_+_108822447 0.109 NM_001143852
 TCHP
trichoplein, keratin filament binding
chr4_-_9727394 0.108 WDR1
WD repeat domain 1
chr3_+_129253816 0.108 NM_013336
 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr5_+_141328805 0.108 NM_004290
NM_183398
NM_183400
 RNF14


ring finger protein 14


chr3_-_44494160 0.108 NM_181489
 ZNF445
zinc finger protein 445
chr9_+_114953087 0.107 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr8_-_124322764 0.107 NM_032847
 C8orf76
chromosome 8 open reading frame 76
chr1_+_11718764 0.106 AGTRAP
angiotensin II receptor-associated protein
chr19_-_2407921 0.106 LMNB2
lamin B2
chr8_+_55533047 0.105 NM_022454
 SOX17
SRY (sex determining region Y)-box 17
chr22_-_16637160 0.105 BID
BH3 interacting domain death agonist
chr12_+_54784632 0.104 PA2G4
proliferation-associated 2G4, 38kDa
chr21_+_42807052 0.104 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr5_-_175721320 0.104 NM_001079684
NM_001079685
NM_020444
 KIAA1191


KIAA1191


chr19_+_7859380 0.104 NM_025061
 LRRC8E
leucine rich repeat containing 8 family, member E
chr2_+_11213053 0.104 PQLC3
PQ loop repeat containing 3
chr3_-_24511456 0.103 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr3_+_129253997 0.103 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr10_-_105202012 0.103 CALHM2
calcium homeostasis modulator 2
chr8_+_42315132 0.103 NM_002690
 POLB
polymerase (DNA directed), beta
chr20_+_34667566 0.102 NM_018840
NM_199483
 C20orf24

chromosome 20 open reading frame 24

chr12_-_52356375 0.101 NM_005176
 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr19_+_47056162 0.101 RPS19
ribosomal protein S19
chr1_+_154318954 0.100 LMNA
lamin A/C
chr11_+_124944580 0.100 EI24
etoposide induced 2.4 mRNA
chr11_-_47356650 0.100 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr12_+_122652572 0.099 NM_020936
 DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr15_-_62242145 0.099 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr22_-_16491400 0.099 ATP6V1E1
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
chr11_-_74337798 0.099 XRRA1
X-ray radiation resistance associated 1
chr1_-_27802947 0.098 AHDC1
AT hook, DNA binding motif, containing 1
chr12_+_131577229 0.098 NM_001142641
 FBRSL1
fibrosin-like 1
chr2_-_96311367 0.097 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_+_33486750 0.096 NM_002636
NM_024165
 PHF1

PHD finger protein 1

chr19_+_2736464 0.096 NM_003249
 THOP1
thimet oligopeptidase 1
chr9_+_137107187 0.095 OLFM1
olfactomedin 1
chrX_-_152938456 0.095 IRAK1
interleukin-1 receptor-associated kinase 1
chr11_-_47356642 0.094 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr12_+_54784600 0.093 PA2G4
proliferation-associated 2G4, 38kDa
chr19_+_54299686 0.093 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr12_+_54784681 0.093 PA2G4
proliferation-associated 2G4, 38kDa
chr4_-_9727476 0.093 WDR1
WD repeat domain 1
chr19_+_5855842 0.092 NM_001017921
 VMAC
vimentin-type intermediate filament associated coiled-coil protein
chrX_-_70390704 0.091 NM_201599
 ZMYM3
zinc finger, MYM-type 3
chr15_-_62242259 0.091 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr12_+_6807831 0.090 NM_014262
 LEPREL2
leprecan-like 2
chr12_+_103375116 0.089 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr15_+_89279542 0.089 UNC45A
unc-45 homolog A (C. elegans)
chr20_-_32354736 0.088 NM_000687
 AHCY
adenosylhomocysteinase
chr15_-_62242352 0.088 NM_000942
 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr2_-_55413253 0.088 CCDC88A
coiled-coil domain containing 88A
chr16_+_66438337 0.088 NUTF2
nuclear transport factor 2
chr16_+_387176 0.088 NM_005009
 NME4
non-metastatic cells 4, protein expressed in
chr12_+_103374892 0.087 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr22_+_16491598 0.086 BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr16_-_66558197 0.086 NM_001145964
 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr22_+_39096563 0.086 SGSM3
small G protein signaling modulator 3
chr18_+_44319365 0.086 NM_001142397
NM_014772
 CTIF

CBP80/20-dependent translation initiation factor

chr22_+_36575396 0.086 EIF3L
eukaryotic translation initiation factor 3, subunit L
chr10_-_105202139 0.085 NM_015916
 CALHM2
calcium homeostasis modulator 2
chr18_+_75540786 0.085 NM_004715
NM_048368
 CTDP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

chr20_-_1321702 0.085 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 read-through transcript
FK506 binding protein 1A, 12kDa
chr1_+_232107170 0.085 NM_173508
 SLC35F3
solute carrier family 35, member F3
chr2_+_74610751 0.085 HTRA2
HtrA serine peptidase 2
chr10_-_118755077 0.085 NM_001127211
NM_018330
 KIAA1598

KIAA1598

chr1_+_110329224 0.085 AHCYL1
adenosylhomocysteinase-like 1
chr1_-_201202956 0.085 NM_016243
 CYB5R1
cytochrome b5 reductase 1
chr1_+_41217555 0.084 NM_001905
 CTPS
CTP synthase
chr12_+_51932136 0.084 NM_032889
 MFSD5
major facilitator superfamily domain containing 5
chr15_-_62242237 0.084 PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr19_+_40183169 0.083 GRAMD1A
GRAM domain containing 1A
chr16_-_66555449 0.083 NM_001145963
 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr1_-_114249158 0.082 NM_006594
 AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr12_+_51932252 0.082 MFSD5
major facilitator superfamily domain containing 5
chr1_+_1199203 0.082


chr19_+_17831670 0.082 NM_000980
 RPL18A
ribosomal protein L18a
chr6_-_30820264 0.082 NM_003897
 IER3
immediate early response 3
chr22_-_16491519 0.082 NM_001039366
NM_001039367
NM_001696
 ATP6V1E1


ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1


chr4_-_9727456 0.081 WDR1
WD repeat domain 1
chr11_-_66993211 0.081 NM_001078650
NM_001078651
NM_025124
 TMEM134


transmembrane protein 134


chr19_-_47438384 0.081 GSK3A
glycogen synthase kinase 3 alpha
chr8_+_23016271 0.081 NM_003841
 TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr1_+_15957832 0.080 NM_017556
 FBLIM1
filamin binding LIM protein 1
chr9_+_115077776 0.078 NM_004697
 PRPF4
PRP4 pre-mRNA processing factor 4 homolog (yeast)

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 3.12e-07 GO:0044444 cytoplasmic part
1.22 3.57e-06 GO:0005737 cytoplasm
1.26 8.50e-04 GO:0044446 intracellular organelle part
1.25 1.44e-03 GO:0044422 organelle part
1.44 7.35e-03 GO:0005829 cytosol
1.13 1.01e-02 GO:0043226 organelle
1.11 1.12e-02 GO:0044424 intracellular part
1.13 1.12e-02 GO:0043229 intracellular organelle
1.42 1.27e-02 GO:0031090 organelle membrane
1.49 1.59e-02 GO:0012505 endomembrane system
1.10 1.79e-02 GO:0005622 intracellular
1.14 3.39e-02 GO:0043227 membrane-bounded organelle
1.14 4.07e-02 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
23.36 1.48e-03 GO:0045569 TRAIL binding