Motif ID: ZEB1.p2

Z-value: 1.673


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZEB1chr10_+_31648103-0.665.1e-03Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_38720881 3.404 NM_138435
FAM83F
family with sequence similarity 83, member F
chr19_+_43446937 3.198 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr8_+_120289735 3.075 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_+_43447078 2.990 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_-_27159462 2.431 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr19_+_43447262 2.422 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr20_+_42463279 2.411 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_3360880 2.053 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_+_6415259 2.049 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr21_-_42060266 2.040 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr11_-_64368616 1.995 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr19_+_7566698 1.987 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr21_-_42060334 1.927 RIPK4
receptor-interacting serine-threonine kinase 4
chr17_+_71033339 1.879 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr3_+_10832867 1.841 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr8_-_127639647 1.747 FAM84B
family with sequence similarity 84, member B
chr16_+_76690664 1.630 NM_016373
NM_130791
NM_130844
WWOX


WW domain containing oxidoreductase


chr16_+_67236730 1.623 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr16_+_67328693 1.608 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr5_+_76150588 1.590 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_71229151 1.585 ITGB4
integrin, beta 4
chr1_-_158182006 1.567 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr20_-_6051562 1.555 FERMT1
fermitin family member 1
chr5_+_76150637 1.551 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr5_+_167651063 1.545 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr1_+_152644471 1.544 IL6R
interleukin 6 receptor
chr4_+_2390469 1.519 NM_001193282
LOC402160
hypothetical protein LOC402160
chr16_+_67328715 1.499 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr17_+_71229110 1.465 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr20_+_42463350 1.400 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_-_22363036 1.400 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr3_-_48446405 1.394 NM_001130082
PLXNB1
plexin B1
chr20_+_60918836 1.382 NM_001853
COL9A3
collagen, type IX, alpha 3
chr17_+_71229191 1.380 ITGB4
integrin, beta 4
chr16_+_67328737 1.359 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr8_+_95722448 1.359 ESRP1
epithelial splicing regulatory protein 1
chr8_-_144887876 1.356 NM_198488
FAM83H
family with sequence similarity 83, member H
chr21_+_42807052 1.354 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr17_+_35147738 1.348 GRB7
growth factor receptor-bound protein 7
chr4_+_75529716 1.303 NM_001657
AREG
amphiregulin
chr15_-_98902394 1.296 NM_178842
LASS3
LAG1 homolog, ceramide synthase 3
chr19_-_60587414 1.291 NM_001190764
LOC388564
hypothetical protein LOC388564
chr14_-_70345485 1.290 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr16_+_67328805 1.287 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr20_+_25176698 1.283 NM_002862
PYGB
phosphorylase, glycogen; brain
chr12_-_51086330 1.268 NM_033033
KRT82
keratin 82
chr22_+_40107878 1.258 NM_003216
TEF
thyrotrophic embryonic factor
chr20_+_42463387 1.229 HNF4A
hepatocyte nuclear factor 4, alpha
chr12_-_32940931 1.220 NM_001005242
NM_004572
PKP2

plakophilin 2

chr6_-_10527772 1.205 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_+_7486836 1.194 DSP
desmoplakin
chr1_-_208046011 1.192 NM_006147
IRF6
interferon regulatory factor 6
chr6_+_7486862 1.185 NM_001008844
NM_004415
DSP

desmoplakin

chr1_+_152644292 1.160 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr7_+_26298018 1.153 NM_013322
SNX10
sorting nexin 10
chr2_-_121759237 1.152 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr2_-_166358951 1.128 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_-_142695392 1.124


chr17_-_6887965 1.116 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr3_+_30623376 1.102 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr17_+_35147697 1.102 NM_005310
GRB7
growth factor receptor-bound protein 7
chr3_-_48445719 1.099 NM_002673
PLXNB1
plexin B1
chr10_+_115988999 1.098 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr8_-_144862266 1.094 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr1_+_61980679 1.084 NM_176877
INADL
InaD-like (Drosophila)
chr11_+_696103 1.076 NM_022772
EPS8L2
EPS8-like 2
chr5_-_168660293 1.057 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr20_-_6051860 1.053 FERMT1
fermitin family member 1
chr18_+_45342398 1.050 NM_006033
LIPG
lipase, endothelial
chr11_+_75157450 1.041 DGAT2
diacylglycerol O-acyltransferase 2
chr15_+_63156206 1.029 NM_001101362
KBTBD13
kelch repeat and BTB (POZ) domain containing 13
chr11_+_75157414 1.027 NM_032564
DGAT2
diacylglycerol O-acyltransferase 2
chr19_-_2734313 1.022 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr12_+_54760211 1.015 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr20_+_13150417 1.011 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr19_-_2734225 1.011 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr6_+_7486891 1.007 DSP
desmoplakin
chr8_+_86563382 1.002 NM_000067
CA2
carbonic anhydrase II
chr1_+_152644668 0.999 IL6R
interleukin 6 receptor
chr20_-_10602429 0.997 NM_000214
JAG1
jagged 1
chr21_-_41140908 0.974 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr19_-_40693176 0.971 NM_001126059
DMKN
dermokine
chr14_+_64240902 0.966 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_+_40431618 0.962 LSR
lipolysis stimulated lipoprotein receptor
chr3_-_45162783 0.962


chr8_-_143482433 0.953 NM_145003
TSNARE1
t-SNARE domain containing 1
chrX_-_13866451 0.952 GPM6B
glycoprotein M6B
chr19_+_40431359 0.951 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr2_-_241408296 0.949 NM_004321
KIF1A
kinesin family member 1A
chrX_-_20044936 0.946 NM_001168465
NM_001168466
NM_152780
MAP7D2


MAP7 domain containing 2


chr8_-_484834 0.946 C8orf42
chromosome 8 open reading frame 42
chr18_+_27332024 0.945 NM_001943
DSG2
desmoglein 2
chr19_-_2734324 0.933 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr19_-_2734332 0.931 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr17_-_37196463 0.920 NM_002230
NM_021991
JUP

junction plakoglobin

chr3_-_45162847 0.919 CDCP1
CUB domain containing protein 1
chr3_-_45162901 0.915 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr3_-_45162865 0.907 CDCP1
CUB domain containing protein 1
chr16_-_11588257 0.888 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr2_-_216586488 0.872 NM_018000
MREG
melanoregulin
chr11_+_69602055 0.865 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr7_+_45580704 0.861 ADCY1
adenylate cyclase 1 (brain)
chr17_-_77602493 0.859 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_-_11588525 0.855 LITAF
lipopolysaccharide-induced TNF factor
chr20_-_10602139 0.852 JAG1
jagged 1
chr2_+_241279934 0.850 NM_198998
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr4_-_35922288 0.845 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_68746694 0.828 NM_001038603
MARVELD2
MARVEL domain containing 2
chr11_+_45900731 0.815 GYLTL1B
glycosyltransferase-like 1B
chr7_+_26298136 0.814 SNX10
sorting nexin 10
chrX_-_20044670 0.812 NM_001168467
MAP7D2
MAP7 domain containing 2
chr11_-_124871258 0.812 NM_005103
NM_022549
FEZ1

fasciculation and elongation protein zeta 1 (zygin I)

chr20_+_9963696 0.810 NM_022096
NM_198798
ANKRD5

ankyrin repeat domain 5

chr1_+_60053050 0.808 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr16_+_67236699 0.808 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr12_-_51200347 0.806 NM_000424
KRT5
keratin 5
chr12_+_6179736 0.803 NM_001769
CD9
CD9 molecule
chr1_+_26376560 0.802 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr19_+_40431122 0.799 LSR
lipolysis stimulated lipoprotein receptor
chr8_-_75396016 0.797 NM_020647
JPH1
junctophilin 1
chr1_+_1971762 0.793 NM_002744
PRKCZ
protein kinase C, zeta
chr2_-_224410544 0.791 NM_001039569
AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr11_+_1287553 0.790 LOC255512
hypothetical LOC255512
chr20_+_48781457 0.788 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_-_36384 0.788 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr4_+_89519004 0.786 HERC6
hect domain and RLD 6
chr17_+_26839143 0.785 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr2_+_46378405 0.783 EPAS1
endothelial PAS domain protein 1
chr1_+_149750485 0.777 NM_020770
CGN
cingulin
chr14_-_105851580 0.776 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_-_61874934 0.776 ZNF835
zinc finger protein 835
chr17_+_7883076 0.773 NM_001039130
NM_001039131
NM_001141
ALOX15B


arachidonate 15-lipoxygenase, type B


chr4_+_89518898 0.766 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr11_+_712282 0.764 EPS8L2
EPS8-like 2
chr1_-_27212035 0.759 FAM46B
family with sequence similarity 46, member B
chr3_-_191321367 0.756 LEPREL1
leprecan-like 1
chr1_+_203740391 0.753 CDK18
cyclin-dependent kinase 18
chr12_+_54760153 0.745 NM_001005915
NM_001982
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr8_-_144731498 0.730 NAPRT1
nicotinate phosphoribosyltransferase domain containing 1
chrX_-_152592450 0.730 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr1_-_44269719 0.725 NM_001024845
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_135229035 0.723 NM_001143763
NM_001143764
SYCE1

synaptonemal complex central element protein 1

chr17_+_32368611 0.717 NM_005568
LHX1
LIM homeobox 1
chr2_-_224410444 0.716 AP1S3
adaptor-related protein complex 1, sigma 3 subunit
chr21_+_33364316 0.714 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr1_-_44269615 0.711 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_+_73775927 0.708 NM_182894
VSX2
visual system homeobox 2
chr9_-_139455611 0.707 NM_001033113
NM_198585
ENTPD8

ectonucleoside triphosphate diphosphohydrolase 8

chr1_+_109594163 0.706 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr14_-_20636337 0.700 ZNF219
zinc finger protein 219
chr20_-_60375695 0.699 NM_005560
LAMA5
laminin, alpha 5
chr19_+_40431678 0.699 LSR
lipolysis stimulated lipoprotein receptor
chr1_-_3556420 0.698 NM_017818
WDR8
WD repeat domain 8
chr12_-_46585032 0.696 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr19_-_56214765 0.694 NM_145888
KLK10
kallikrein-related peptidase 10
chr11_+_72607040 0.692 NM_176071
P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr12_+_7174230 0.692 NM_014718
CLSTN3
calsyntenin 3
chr6_+_143423738 0.692 AIG1
androgen-induced 1
chr1_+_24518398 0.688 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chrX_+_153428755 0.687 NM_001099857
NM_001145255
IKBKG

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

chr16_+_751050 0.685 NM_013404
MSLN
mesothelin
chr17_+_35148084 0.679 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr4_+_89519134 0.675 HERC6
hect domain and RLD 6
chrX_+_152562013 0.672 DUSP9
dual specificity phosphatase 9
chr8_-_28299850 0.667 NM_018660
ZNF395
zinc finger protein 395
chr3_+_50167424 0.666 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr11_-_431995 0.665 NM_001012302
ANO9
anoctamin 9
chr14_+_104402626 0.664 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr17_-_28644118 0.663 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr2_-_166358792 0.662 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_-_56178882 0.661 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr2_+_171280944 0.660 SP5
Sp5 transcription factor
chr4_+_155884600 0.657 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr11_-_431956 0.657 ANO9
anoctamin 9
chr9_-_139060377 0.652 NPDC1
neural proliferation, differentiation and control, 1
chr9_-_115901157 0.651 NM_138424
KIF12
kinesin family member 12
chr1_-_32002222 0.649 NM_001703
BAI2
brain-specific angiogenesis inhibitor 2
chr2_-_20288647 0.643 NM_001006946
SDC1
syndecan 1
chr3_+_30622905 0.640 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr19_-_60461732 0.638 NM_014931
PPP6R1
protein phosphatase 6, regulatory subunit 1
chr15_-_38332401 0.637 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr11_+_72606950 0.633 NM_002564
NM_176072
P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr15_-_50375143 0.631 NM_018728
MYO5C
myosin VC
chr6_+_54819527 0.629 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr10_+_103338030 0.629 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr9_+_138900760 0.628 NM_021138
TRAF2
TNF receptor-associated factor 2
chr18_+_59295123 0.628 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr8_-_28299508 0.620 ZNF395
zinc finger protein 395
chr2_-_20288108 0.620 NM_002997
SDC1
syndecan 1
chr11_-_1287459 0.619 TOLLIP
toll interacting protein
chr9_-_139060416 0.619 NM_015392
NPDC1
neural proliferation, differentiation and control, 1
chr2_+_222997456 0.619 SGPP2
sphingosine-1-phosphate phosphatase 2
chr16_+_1524162 0.614 NM_024600
TMEM204
transmembrane protein 204
chr21_-_41140457 0.612 DSCAM
Down syndrome cell adhesion molecule
chr1_+_204390905 0.602 NM_000707
AVPR1B
arginine vasopressin receptor 1B
chr11_-_1287467 0.597 NM_019009
TOLLIP
toll interacting protein
chr17_-_2561676 0.597 NM_015229
KIAA0664
KIAA0664
chr17_-_3518568 0.596 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr19_+_45799060 0.594 NM_001042545
LTBP4
latent transforming growth factor beta binding protein 4
chr14_+_64240996 0.588 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 3.74e-03 GO:0048583 regulation of response to stimulus
1.19 4.41e-03 GO:0048518 positive regulation of biological process
1.25 6.91e-03 GO:0023051 regulation of signaling
1.72 9.69e-03 GO:0048011 nerve growth factor receptor signaling pathway
3.29 3.29e-02 GO:0046626 regulation of insulin receptor signaling pathway
1.31 4.22e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 4.34e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.75e-02 GO:0005794 Golgi apparatus
1.07 4.23e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 5.31e-06 GO:0005515 protein binding
2.70 6.94e-03 GO:0003823 antigen binding