Motif ID: bHLH_family.p2

Z-value: 2.159


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ID1chr20_+_296567440.629.7e-03Click!
MLXIPLchr7_-_726767500.621.0e-02Click!
MITFchr3_+_69895651-0.572.0e-02Click!
ARNTLchr11_+_13255905-0.533.6e-02Click!
HES6chr2_-_2388133650.448.9e-02Click!
MXD4chr4_-_2233504-0.449.0e-02Click!
HEYLchr1_-_39877928-0.371.5e-01Click!
NPAS2chr2_+_1008029230.361.7e-01Click!
ARNTL2chr12_+_27377034-0.332.1e-01Click!
CLOCKchr4_-_56107725-0.292.8e-01Click!
TFE3chrX_-_48787876-0.263.3e-01Click!
HEY2chr6_+_1261125880.263.3e-01Click!
MNTchr17_-_2250967-0.214.2e-01Click!
HEY1chr8_-_80842452-0.194.8e-01Click!
OLIG2chr21_+_333200800.165.6e-01Click!
MXI1chr10_+_111959978-0.116.8e-01Click!
OLIG1chr21_+_33364420-0.107.2e-01Click!
MXD3chr5_-_1766714370.077.9e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_120289735 2.091 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr17_-_73636362 2.013 TMC6
transmembrane channel-like 6
chr6_-_47385313 1.553 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_56432385 1.488 NM_000075
CDK4
cyclin-dependent kinase 4
chr1_-_12599934 1.463 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr11_+_384199 1.435 NM_007183
PKP3
plakophilin 3
chr6_-_33493792 1.418 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr19_+_10626106 1.344 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_+_218992053 1.309 NM_007127
VIL1
villin 1
chr12_-_61614930 1.305 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_+_384238 1.302 PKP3
plakophilin 3
chr5_-_133734616 1.269 CDKL3
cyclin-dependent kinase-like 3
chr16_-_5023934 1.266 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_-_208342296 1.266 NM_003468
FZD5
frizzled homolog 5 (Drosophila)
chr8_+_95722448 1.250 ESRP1
epithelial splicing regulatory protein 1
chr6_+_143423656 1.244 NM_016108
AIG1
androgen-induced 1
chrX_+_152562013 1.240 DUSP9
dual specificity phosphatase 9
chr12_-_61615124 1.221 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_+_76171780 1.206 NM_015516
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr1_+_3360880 1.187 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
3.16 9.00e-03 GO:0015682 ferric iron transport
3.16 9.00e-03 GO:0033572 transferrin transport
1.33 5.55e-07 GO:0010467 gene expression
1.32 3.79e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 1.18e-04 GO:0016070 RNA metabolic process
1.25 1.07e-02 GO:0034645 cellular macromolecule biosynthetic process
1.24 3.26e-02 GO:0009059 macromolecule biosynthetic process
1.23 1.91e-03 GO:0090304 nucleic acid metabolic process
1.22 2.69e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 3.77e-05 GO:0034641 cellular nitrogen compound metabolic process
1.21 5.36e-05 GO:0006807 nitrogen compound metabolic process
1.21 2.77e-03 GO:0044249 cellular biosynthetic process
1.20 8.93e-08 GO:0044260 cellular macromolecule metabolic process
1.20 1.08e-02 GO:0009058 biosynthetic process
1.19 4.29e-08 GO:0043170 macromolecule metabolic process
1.18 3.86e-11 GO:0044238 primary metabolic process
1.18 3.00e-10 GO:0044237 cellular metabolic process
1.17 1.05e-02 GO:0048856 anatomical structure development
1.16 2.13e-11 GO:0008152 metabolic process
1.11 1.67e-13 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
3.12 1.24e-02 GO:0044452 nucleolar part
2.00 2.37e-02 GO:0042470 melanosome
2.00 2.37e-02 GO:0048770 pigment granule
1.57 1.01e-05 GO:0005730 nucleolus
1.53 1.16e-02 GO:0005773 vacuole
1.40 2.33e-02 GO:0030529 ribonucleoprotein complex
1.29 3.27e-06 GO:0031981 nuclear lumen
1.27 2.36e-07 GO:0031974 membrane-enclosed lumen
1.27 6.89e-07 GO:0043233 organelle lumen
1.27 1.22e-06 GO:0070013 intracellular organelle lumen
1.27 1.63e-06 GO:0044428 nuclear part
1.27 2.24e-03 GO:0005654 nucleoplasm
1.20 8.81e-03 GO:0005829 cytosol
1.18 3.40e-03 GO:0043228 non-membrane-bounded organelle
1.18 3.40e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.16 1.73e-07 GO:0044422 organelle part
1.16 2.24e-07 GO:0044446 intracellular organelle part
1.15 5.97e-03 GO:0032991 macromolecular complex
1.14 4.60e-06 GO:0044444 cytoplasmic part
1.13 7.85e-10 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.38 8.54e-03 GO:0043565 sequence-specific DNA binding
1.33 1.33e-03 GO:0030528 transcription regulator activity
1.19 9.70e-03 GO:0000166 nucleotide binding
1.15 2.16e-10 GO:0005515 protein binding
1.06 5.87e-05 GO:0005488 binding