• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: bHLH_family.p2

Z-value: 2.159

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_120289735	2.091	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr17_-_73636362	2.013		TMC6	transmembrane channel-like 6
chr6_-_47385313	1.553		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr12_-_56432385	1.488	NM_000075	CDK4	cyclin-dependent kinase 4
chr1_-_12599934	1.463	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr11_+_384199	1.435	NM_007183	PKP3	plakophilin 3
chr6_-_33493792	1.418		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr19_+_10626106	1.344		ILF3	interleukin enhancer binding factor 3, 90kDa
chr2_+_218992053	1.309	NM_007127	VIL1	villin 1
chr12_-_61614930	1.305	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_+_384238	1.302		PKP3	plakophilin 3
chr5_-_133734616	1.269		CDKL3	cyclin-dependent kinase-like 3
chr16_-_5023934	1.266	NM_016256	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_-_208342296	1.266	NM_003468	FZD5	frizzled homolog 5 (Drosophila)
chr8_+_95722448	1.250		ESRP1	epithelial splicing regulatory protein 1
chr6_+_143423656	1.244	NM_016108	AIG1	androgen-induced 1
chrX_+_152562013	1.240		DUSP9	dual specificity phosphatase 9
chr12_-_61615124	1.221		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_+_76171780	1.206	NM_015516	TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr1_+_3360880	1.187	NM_014448	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16
chr17_+_35148084	1.172	NM_001030002	GRB7	growth factor receptor-bound protein 7
chr2_+_10101081	1.168	NM_003597 NM_001177716	KLF11	Kruppel-like factor 11
chr17_-_35510431	1.158	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr17_+_77478858	1.147		LOC92659	hypothetical LOC92659
chr17_-_35510074	1.144		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr17_+_44429748	1.143	NM_001160423 NM_006546	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1
chr6_-_47385599	1.138		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr17_+_9489578	1.135	NM_153210	USP43	ubiquitin specific peptidase 43
chr4_-_15694407	1.127		PROM1	prominin 1
chr19_+_54149941	1.125		BAX	BCL2-associated X protein
chr6_+_37245860	1.123	NM_002648	PIM1	pim-1 oncogene
chr14_-_23106372	1.119		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr6_-_47385205	1.099		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr19_-_10625449	1.099		LOC147727	hypothetical LOC147727
chr6_-_47385604	1.091		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr1_+_17954394	1.084	NM_030812	ACTL8	actin-like 8
chr20_-_43953036	1.071	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr11_-_118757477	1.071		USP2	ubiquitin specific peptidase 2
chr6_+_143423738	1.060		AIG1	androgen-induced 1
chr11_-_116168316	1.047	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr17_-_73636386	1.031	NM_001127198	TMC6	transmembrane channel-like 6
chr16_+_65471881	1.031	NM_020786	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr2_-_101134146	1.028	NM_001102426	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr16_-_66827449	1.027	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chr6_-_47385470	1.020		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr16_-_5023914	1.019		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr6_-_47385605	1.018	NM_014452	TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr9_+_696744	1.015	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr8_+_98857190	1.012		LAPTM4B	lysosomal protein transmembrane 4 beta
chr16_+_67236699	0.989		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr2_-_172675873	0.988		DLX2	distal-less homeobox 2
chr17_+_35147697	0.986	NM_005310	GRB7	growth factor receptor-bound protein 7
chr6_-_33493640	0.975		CUTA	cutA divalent cation tolerance homolog (E. coli)
chr16_-_23068010	0.975	NM_020718	USP31	ubiquitin specific peptidase 31
chr15_+_48261649	0.968	NM_001159629 NM_003645	SLC27A2	solute carrier family 27 (fatty acid transporter), member 2
chr1_-_159459999	0.967	NM_001643	APOA2	apolipoprotein A-II
chr17_-_38979178	0.961	NM_001079675	ETV4	ets variant 4
chr17_+_35147738	0.958		GRB7	growth factor receptor-bound protein 7
chr8_+_95722575	0.948		ESRP1	epithelial splicing regulatory protein 1
chr1_-_113300138	0.939	NM_001166496	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr8_+_95722516	0.937	NM_001034915 NM_001122825 NM_001122826 NM_001122827 NM_017697	ESRP1	epithelial splicing regulatory protein 1
chr17_+_52518098	0.913		AKAP1	A kinase (PRKA) anchor protein 1
chr10_+_101079099	0.911		CNNM1	cyclin M1
chr6_+_32230172	0.890		PPT2	palmitoyl-protein thioesterase 2
chr20_+_43953428	0.889		CTSA	cathepsin A
chr1_-_21868380	0.885	NM_001145657 NM_002885	RAP1GAP	RAP1 GTPase activating protein
chr19_+_10625987	0.884		ILF3	interleukin enhancer binding factor 3, 90kDa
chr6_+_80397690	0.876	NM_031469	SH3BGRL2	SH3 domain binding glutamic acid-rich protein like 2
chrX_+_117992603	0.872		LONRF3	LON peptidase N-terminal domain and ring finger 3
chr20_-_13567529	0.869	NM_017714	TASP1	taspase, threonine aspartase, 1
chr22_-_39923412	0.867
chr1_+_29113589	0.853	NM_001166006	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_+_152459918	0.853	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr1_-_1840564	0.846	NM_178545	TMEM52	transmembrane protein 52
chr5_+_78568094	0.833
chr1_-_152459697	0.832	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr20_+_43953606	0.828		CTSA	cathepsin A
chr20_-_60484420	0.826	NM_080473	GATA5	GATA binding protein 5
chr17_+_43374021	0.821		PNPO	pyridoxamine 5'-phosphate oxidase
chr20_+_47986335	0.820		RNF114	ring finger protein 114
chr16_+_1341937	0.817		GNPTG	N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr19_-_45132372	0.802	NM_003890	FCGBP	Fc fragment of IgG binding protein
chr17_+_36636404	0.800	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr4_+_54660954	0.798	NM_133267	GSX2	GS homeobox 2
chr11_-_118757574	0.797	NM_004205	USP2	ubiquitin specific peptidase 2
chr9_-_99994704	0.795	NM_052820	CORO2A	coronin, actin binding protein, 2A
chr20_+_43953331	0.795		CTSA	cathepsin A
chr12_-_56432375	0.794		CDK4	cyclin-dependent kinase 4
chr7_-_22363036	0.788	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr16_-_5023562	0.786		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr6_+_32229771	0.786		PPT2-EGFL8 PPT2	PPT2-EGFL8 read-through transcript palmitoyl-protein thioesterase 2
chr20_+_43953372	0.786		CTSA	cathepsin A
chr7_-_150847624	0.784		RHEB	Ras homolog enriched in brain
chr1_-_113300351	0.783	NM_003051	SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr9_-_126309510	0.782	NM_004959	NR5A1	nuclear receptor subfamily 5, group A, member 1
chr7_-_72380020	0.772	NM_178125	TRIM50	tripartite motif containing 50
chr2_+_176680251	0.762	NM_021192	HOXD11	homeobox D11
chr19_+_38979502	0.760	NM_001129994 NM_001129995 NM_024076	KCTD15	potassium channel tetramerisation domain containing 15
chr17_+_2627099	0.756		RAP1GAP2	RAP1 GTPase activating protein 2
chr1_-_152459667	0.750		C1orf43	chromosome 1 open reading frame 43
chr1_-_31485320	0.750	NM_024522	NKAIN1	Na+/K+ transporting ATPase interacting 1
chr17_-_42250961	0.747	NM_030753	WNT3	wingless-type MMTV integration site family, member 3
chr2_+_74594093	0.743		TLX2	T-cell leukemia homeobox 2
chr6_+_7486836	0.733		DSP	desmoplakin
chrX_-_132947141	0.729		GPC3	glypican 3
chr5_+_150807380	0.727		SLC36A1	solute carrier family 36 (proton/amino acid symporter), member 1
chr11_+_45900731	0.726		GYLTL1B	glycosyltransferase-like 1B
chr6_+_7486862	0.725	NM_001008844 NM_004415	DSP	desmoplakin
chr10_+_101078784	0.723	NM_020348	CNNM1	cyclin M1
chr4_+_186176988	0.717	NM_001029887	HELT	HES/HEY-like transcription factor
chr6_+_41622267	0.715		FOXP4	forkhead box P4
chr11_-_71492019	0.714	NM_017907	LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr12_+_94861201	0.714	NM_152435	AMDHD1	amidohydrolase domain containing 1
chr6_+_36346214	0.709	NM_001145717	PNPLA1	patatin-like phospholipase domain containing 1
chr17_-_36507900	0.705	NM_031960	KRTAP4-8	keratin associated protein 4-8
chr3_-_188945921	0.701		BCL6	B-cell CLL/lymphoma 6
chr2_+_219751207	0.697		FAM134A	family with sequence similarity 134, member A
chr12_+_54760211	0.697		ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr4_-_15694691	0.696	NM_001145847 NM_001145848	PROM1	prominin 1
chr6_+_160310118	0.693	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr14_-_54438913	0.692	NM_000161 NM_001024024 NM_001024070 NM_001024071	GCH1	GTP cyclohydrolase 1
chr20_-_2769120	0.692		FAM113A	family with sequence similarity 113, member A
chr11_-_66482366	0.688	NM_000920 NM_001040716	PC	pyruvate carboxylase
chr6_+_138230045	0.688	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr1_+_61320213	0.685	NM_001134673 NM_005595	NFIA	nuclear factor I/A
chr2_-_239988269	0.683		HDAC4	histone deacetylase 4
chr19_-_2734324	0.681		SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr19_-_5291700	0.681	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr14_-_93919305	0.679		SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_82039158	0.678	NM_000429	MAT1A	methionine adenosyltransferase I, alpha
chr2_-_220116508	0.678	NM_024536	CHPF	chondroitin polymerizing factor
chr10_-_120504445	0.677		C10orf46	chromosome 10 open reading frame 46
chr11_+_18300370	0.673	NM_001142307 NM_005316	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr6_+_143423723	0.672		AIG1	androgen-induced 1
chr20_+_13924263	0.672		MACROD2	MACRO domain containing 2
chr1_+_61315516	0.669	NM_001145511	NFIA	nuclear factor I/A
chr9_-_130749604	0.663	NM_014908	DOLK	dolichol kinase
chr11_-_71491942	0.660		LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chrX_+_130985316	0.659	NM_001042452	MST4	serine/threonine protein kinase MST4
chr6_+_31903374	0.657	NM_005346	HSPA1A HSPA1B	heat shock 70kDa protein 1A heat shock 70kDa protein 1B
chrX_-_107866262	0.654	NM_003604	IRS4	insulin receptor substrate 4
chr20_+_48781457	0.654	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr20_+_37024383	0.652	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr17_+_73676219	0.650	NM_004710	SYNGR2	synaptogyrin 2
chr17_+_75689955	0.648		GAA	glucosidase, alpha; acid
chr16_+_56616782	0.647	NM_002428	MMP15	matrix metallopeptidase 15 (membrane-inserted)
chr15_+_57696200	0.647		GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_-_188946168	0.645	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr2_-_172675480	0.643	NM_004405	DLX2	distal-less homeobox 2
chr2_-_39859689	0.640		THUMPD2	THUMP domain containing 2
chr21_+_32167175	0.637	NM_014586	HUNK	hormonally up-regulated Neu-associated kinase
chr4_+_164484540	0.634	NM_006174	NPY5R	neuropeptide Y receptor Y5
chr2_-_11727705	0.633	NM_012344	NTSR2	neurotensin receptor 2
chr1_-_109742020	0.631	NM_002959	SORT1	sortilin 1
chr2_-_85683268	0.628	NM_001031738	TMEM150A	transmembrane protein 150A
chr4_-_100069303	0.625		EIF4E	eukaryotic translation initiation factor 4E
chr17_+_77528782	0.625		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr7_-_103417198	0.620	NM_005045 NM_173054	RELN	reelin
chrX_-_131919896	0.620		HS6ST2	heparan sulfate 6-O-sulfotransferase 2
chr6_+_105511615	0.620	NM_001004317	LIN28B	lin-28 homolog B (C. elegans)
chr1_-_152459506	0.620		C1orf43	chromosome 1 open reading frame 43
chr16_-_69277355	0.614	NM_138383	MTSS1L	metastasis suppressor 1-like
chr22_-_35233032	0.611	NM_024955 NM_001102371	FOXRED2	FAD-dependent oxidoreductase domain containing 2
chr6_+_41622111	0.609	NM_001012426 NM_001012427 NM_138457	FOXP4	forkhead box P4
chr6_-_44333002	0.607	NM_178148	SLC35B2	solute carrier family 35, member B2
chr8_-_145609737	0.606		SLC39A4	solute carrier family 39 (zinc transporter), member 4
chr17_-_35140307	0.606	NM_032339	C17orf37	chromosome 17 open reading frame 37
chr18_+_9698299	0.605		RAB31	RAB31, member RAS oncogene family
chrX_+_117992623	0.603	NM_001031855 NM_024778	LONRF3	LON peptidase N-terminal domain and ring finger 3
chr19_-_8292273	0.600	NM_005001	NDUFA7	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr22_-_17798998	0.598		HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr19_+_38376980	0.597		LRP3	low density lipoprotein receptor-related protein 3
chr16_-_23429295	0.597		GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr11_-_16992524	0.595	NM_175058	PLEKHA7	pleckstrin homology domain containing, family A member 7
chr1_-_24307514	0.590		MYOM3	myomesin family, member 3
chr6_-_151814861	0.590	NM_017909	RMND1	required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr7_+_55054416	0.588		EGFR	epidermal growth factor receptor
chr19_-_8292245	0.585		NDUFA7	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr1_+_160306093	0.581	NM_001164757 NM_014697	NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein
chr8_+_123863169	0.579		ZHX2	zinc fingers and homeoboxes 2
chr2_-_39859912	0.578	NM_025264	THUMPD2	THUMP domain containing 2
chr8_+_123863075	0.578	NM_014943	ZHX2	zinc fingers and homeoboxes 2
chr1_-_26105954	0.575	NM_203399	STMN1	stathmin 1
chr12_-_101835183	0.570		PAH	phenylalanine hydroxylase
chr1_-_27113018	0.568	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2
chr14_-_23981493	0.566	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr6_-_43305156	0.562	NM_006443 NM_199184	C6orf108	chromosome 6 open reading frame 108
chr11_+_118443738	0.559		VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_-_18848713	0.559	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr17_-_37586716	0.557	NM_012285	KCNH4	potassium voltage-gated channel, subfamily H (eag-related), member 4
chr3_-_4483952	0.555		SUMF1	sulfatase modifying factor 1
chr14_-_93859394	0.553	NM_001756	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr16_+_29726195	0.553		MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr8_+_11599119	0.552	NM_002052	GATA4	GATA binding protein 4
chr16_+_23597691	0.551		PLK1	polo-like kinase 1
chr1_+_237616457	0.551		CHRM3	cholinergic receptor, muscarinic 3
chr20_-_2769245	0.550	NM_022760	FAM113A	family with sequence similarity 113, member A
chr12_-_115660227	0.550		C12orf49	chromosome 12 open reading frame 49
chr7_+_1050704	0.549
chr17_-_74487527	0.549	NM_005567	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.11	1.67e-13	GO:0009987	cellular process
1.16	2.13e-11	GO:0008152	metabolic process
1.18	3.86e-11	GO:0044238	primary metabolic process
1.18	3.00e-10	GO:0044237	cellular metabolic process
1.19	4.29e-08	GO:0043170	macromolecule metabolic process
1.20	8.93e-08	GO:0044260	cellular macromolecule metabolic process
1.33	5.55e-07	GO:0010467	gene expression
1.21	3.77e-05	GO:0034641	cellular nitrogen compound metabolic process
1.21	5.36e-05	GO:0006807	nitrogen compound metabolic process
1.29	1.18e-04	GO:0016070	RNA metabolic process
1.22	2.69e-04	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23	1.91e-03	GO:0090304	nucleic acid metabolic process
1.21	2.77e-03	GO:0044249	cellular biosynthetic process
3.16	9.00e-03	GO:0015682	ferric iron transport
3.16	9.00e-03	GO:0033572	transferrin transport
1.17	1.05e-02	GO:0048856	anatomical structure development
1.25	1.07e-02	GO:0034645	cellular macromolecule biosynthetic process
1.20	1.08e-02	GO:0009058	biosynthetic process
1.24	3.26e-02	GO:0009059	macromolecule biosynthetic process
1.32	3.79e-02	GO:0006357	regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.09	7.83e-12	GO:0005622	intracellular
1.09	2.79e-11	GO:0044424	intracellular part
1.13	7.85e-10	GO:0005737	cytoplasm
1.10	8.37e-09	GO:0043226	organelle
1.10	1.51e-08	GO:0043229	intracellular organelle
1.16	1.73e-07	GO:0044422	organelle part
1.16	2.24e-07	GO:0044446	intracellular organelle part
1.27	2.36e-07	GO:0031974	membrane-enclosed lumen
1.10	4.11e-07	GO:0043227	membrane-bounded organelle
1.10	5.79e-07	GO:0043231	intracellular membrane-bounded organelle
1.27	6.89e-07	GO:0043233	organelle lumen
1.27	1.22e-06	GO:0070013	intracellular organelle lumen
1.27	1.63e-06	GO:0044428	nuclear part
1.29	3.27e-06	GO:0031981	nuclear lumen
1.14	4.60e-06	GO:0044444	cytoplasmic part
1.57	1.01e-05	GO:0005730	nucleolus
1.27	2.24e-03	GO:0005654	nucleoplasm
1.18	3.40e-03	GO:0043228	non-membrane-bounded organelle
1.18	3.40e-03	GO:0043232	intracellular non-membrane-bounded organelle
1.15	5.97e-03	GO:0032991	macromolecular complex
1.20	8.81e-03	GO:0005829	cytosol
1.11	9.61e-03	GO:0005634	nucleus
1.53	1.16e-02	GO:0005773	vacuole
3.12	1.24e-02	GO:0044452	nucleolar part
1.40	2.33e-02	GO:0030529	ribonucleoprotein complex
2.00	2.37e-02	GO:0042470	melanosome
2.00	2.37e-02	GO:0048770	pigment granule

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.15	2.16e-10	GO:0005515	protein binding
1.06	5.87e-05	GO:0005488	binding
1.33	1.33e-03	GO:0030528	transcription regulator activity
1.38	8.54e-03	GO:0043565	sequence-specific DNA binding
1.19	9.70e-03	GO:0000166	nucleotide binding