Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.040

Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3

Network of associatons between targets according to the STRING database.

First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:

Promoter Score Refseq Gene Symbol Gene Name
chr15_+_72620570 3.332 NM_006465
AT rich interactive domain 3B (BRIGHT-like)
chr22_+_20350272 3.041 NM_014337

peptidylprolyl isomerase (cyclophilin)-like 2

chr17_+_4784524 2.807 RNF167
ring finger protein 167
chr16_+_65783571 2.592 E2F4
E2F transcription factor 4, p107/p130-binding
chr16_+_65783528 2.562 NM_001950
E2F transcription factor 4, p107/p130-binding
chr19_-_17349096 2.545 NM_031310
plasmalemma vesicle associated protein
chr12_+_118590039 2.229 NM_006253
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr16_-_48960186 2.207 NM_001173984

bromodomain containing 7

chr12_-_47698781 2.158 NM_002733

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

chr16_+_65783599 2.148 E2F4
E2F transcription factor 4, p107/p130-binding
chr17_-_71017509 2.107 NM_001142643
CASK interacting protein 2
chr2_+_169367345 1.999 NM_001039724

nitric oxide synthase trafficker

chr22_-_17798998 1.991 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_+_33514896 1.951 NM_170672
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_36169260 1.932 NM_024852

eukaryotic translation initiation factor 2C, 3

chr16_-_1999760 1.930 NM_178167
zinc finger protein 598
chr2_-_74915722 1.873

chr9_-_122595475 1.860 NM_012164
F-box and WD repeat domain containing 2
chr2_+_128565269 1.765 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_-_168219380 1.734 NM_001122841
FERM domain containing 1
chr20_+_21231921 1.714 NM_012255
5'-3' exoribonuclease 2
chr2_+_65308332 1.701 NM_001005386

ARP2 actin-related protein 2 homolog (yeast)

chr17_+_72596349 1.680 SEC14L1
SEC14-like 1 (S. cerevisiae)
chromosome 17 open reading frame 86
chr7_-_107997132 1.661 NM_182529

THAP domain containing 5

chr4_-_76658606 1.634 NM_001008925

ring finger and CHY zinc finger domain containing 1

chr11_-_67795903 1.620 C11orf24
chromosome 11 open reading frame 24
chr4_+_76658677 1.616 NM_144721
THAP domain containing 6
chr1_-_32888677 1.615 NM_178547
zinc finger and BTB domain containing 8 opposite strand
chr3_-_184756101 1.598 NM_130446
kelch-like 6 (Drosophila)
chr9_-_133141726 1.593 NM_033387
family with sequence similarity 78, member A
chr4_-_76658503 1.577 RCHY1
ring finger and CHY zinc finger domain containing 1
chr6_+_170705345 1.574 NM_001172085

TATA box binding protein

chr21_+_46530654 1.557 NM_001006114

ybeY metallopeptidase (putative)

chr19_+_45914755 1.552 NM_025194
inositol 1,4,5-trisphosphate 3-kinase C
chr20_-_44426407 1.546 NM_015945

solute carrier family 35, member C2

chr2_-_65308220 1.534 LOC729324
chr1_-_170679830 1.520 PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr3_-_168935287 1.511 NM_007217

programmed cell death 10

chr5_+_147743734 1.509 NM_030793

F-box protein 38

chr1_-_170679794 1.497 PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr1_-_170679833 1.486 NM_002642

phosphatidylinositol glycan anchor biosynthesis, class C

chr6_+_111409933 1.482 NM_032194
ribosome production factor 2 homolog (S. cerevisiae)
chr8_+_145553016 1.479 NM_024531
G protein-coupled receptor 172A
chr9_-_122595349 1.475 FBXW2
F-box and WD repeat domain containing 2
chr9_+_35722629 1.472 CREB3
cAMP responsive element binding protein 3
chr6_-_166675980 1.471 NM_145169
SFT2 domain containing 1
chr5_+_147743753 1.467 FBXO38
F-box protein 38
chr6_-_166676016 1.457 SFT2D1
SFT2 domain containing 1
chr16_+_67931178 1.453 NIP7
nuclear import 7 homolog (S. cerevisiae)
chr2_+_101235782 1.435 C2orf29
chromosome 2 open reading frame 29
chr16_-_1999796 1.433 ZNF598
zinc finger protein 598
chr3_+_32701663 1.431 NM_015442
CCR4-NOT transcription complex, subunit 10
chr10_+_112247614 1.431 NM_004419
dual specificity phosphatase 5
chr15_-_63596656 1.426 NM_197960
dipeptidyl-peptidase 8
chr3_+_133861894 1.422 UBA5
ubiquitin-like modifier activating enzyme 5
chr4_-_159863889 1.418 NM_005038
peptidylprolyl isomerase D
chr12_-_48248132 1.412 NM_006337
microspherule protein 1
chr3_+_9809776 1.411 NM_001198780
actin related protein 2/3 complex, subunit 4, 20kDa
chr7_-_99355051 1.397 TRIM4
tripartite motif containing 4
chr9_+_131605270 1.389 TOR1B
torsin family 1, member B (torsin B)
chr6_+_30693464 1.387 NM_014046
mitochondrial ribosomal protein S18B
chr15_-_62435267 1.373 CSNK1G1
casein kinase 1, gamma 1
chr16_-_70400393 1.371 NM_001030007

adaptor-related protein complex 1, gamma 1 subunit

chr16_-_70400232 1.368 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr4_-_153675602 1.348 NM_033632
F-box and WD repeat domain containing 7
chr6_-_32268267 1.348 GPSM3
G-protein signaling modulator 3
chr6_-_151754337 1.333 NM_020861
zinc finger and BTB domain containing 2
chr19_-_45914618 1.329 NM_024876
aarF domain containing kinase 4
chr21_-_37561463 1.328 DSCR3
Down syndrome critical region gene 3
chr1_-_85497903 1.328 NM_198077
chromosome 1 open reading frame 52
chr1_-_52272020 1.317 NM_138417
KTI12 homolog, chromatin associated (S. cerevisiae)
chr7_-_99536214 1.301 NM_182776
minichromosome maintenance complex component 7
chr17_-_53282376 1.286 NM_016070
mitochondrial ribosomal protein S23
chr2_+_98591516 1.286 UNC50
unc-50 homolog (C. elegans)
chr3_+_198153865 1.283 LOC152217
hypothetical LOC152217
chr12_-_122415327 1.274 SBNO1
strawberry notch homolog 1 (Drosophila)
chr6_-_28475478 1.272 NM_001163391
zinc finger and SCAN domain containing 12
chr7_+_104959767 1.271 NM_021930
RAD50 interactor 1
chr16_+_87811585 1.271 NM_182531
zinc finger protein 778
chr2_-_152740387 1.268 NM_005843
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr20_+_43028533 1.268 NM_006282
serine/threonine kinase 4
chr15_-_62435412 1.262 NM_022048
casein kinase 1, gamma 1
chr1_+_37712767 1.258 ZC3H12A
zinc finger CCCH-type containing 12A
chr7_+_106292932 1.256 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_220170804 1.251 NM_052902
serine/threonine kinase 11 interacting protein
chr5_+_148705169 1.243 NM_152407
GrpE-like 2, mitochondrial (E. coli)
chr6_-_36950520 1.243 PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr11_-_67796022 1.240 NM_022338
chromosome 11 open reading frame 24
chr2_+_98591473 1.234 NM_014044
unc-50 homolog (C. elegans)
chr5_+_34692124 1.223 NM_001145522

retinoic acid induced 14

chr16_+_21926939 1.222 NM_001164579
chromosome 16 open reading frame 52
chr7_+_106292975 1.217 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_-_99355065 1.197 TRIM4
tripartite motif containing 4
chr4_-_915868 1.189 GAK
cyclin G associated kinase
chr7_-_128482059 1.181 TNPO3
transportin 3
chr1_+_27521333 1.181 LOC644961
actin, gamma 1 pseudogene
transmembrane protein 222
chr12_-_104153920 1.180 NM_018171
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr6_-_125664913 1.179 NM_016063
HD domain containing 2
chr4_+_2906403 1.178 C4orf10
chromosome 4 open reading frame 10
chr2_-_54051290 1.173 NM_014614
proteasome (prosome, macropain) activator subunit 4
chr20_+_43028590 1.169 STK4
serine/threonine kinase 4
chr10_+_75174151 1.167 SEC24C
SEC24 family, member C (S. cerevisiae)
chr12_+_50592379 1.147 NM_001077401
activin A receptor type II-like 1
chr8_-_68136881 1.144 COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
chr1_-_27159462 1.140 NM_152365
chromosome 1 open reading frame 172
chr1_+_229731021 1.139 NM_005999
TSNAX-DISC1 read-through gene
translin-associated factor X
chr4_-_140224794 1.138 ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_-_33398656 1.136 NM_001141969

death-domain associated protein

chr12_+_8958397 1.136 NM_004426
polyhomeotic homolog 1 (Drosophila)
chr16_-_30301357 1.136 SEPT1
septin 1
chr5_-_60493903 1.135 C5orf43
chromosome 5 open reading frame 43
chr7_-_44891471 1.126 NM_033224
purine-rich element binding protein B
chr6_+_33347833 1.121 RPS18
ribosomal protein S18
chr21_+_46530725 1.120 YBEY
ybeY metallopeptidase (putative)
chr11_-_60885928 1.118 CYBASC3
cytochrome b, ascorbate dependent 3
chr22_-_17799177 1.116 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr11_+_65485735 1.115 NM_005146
squamous cell carcinoma antigen recognized by T cells
chr2_-_27147995 1.115 NM_001134693
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr16_+_68353738 1.112 NM_007014

WW domain containing E3 ubiquitin protein ligase 2

chr12_-_119116848 1.112 NM_006836
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr9_-_130124820 1.109 TRUB2
TruB pseudouridine (psi) synthase homolog 2 (E. coli)
chr12_-_46786107 1.103 SENP1
SUMO1/sentrin specific peptidase 1
chr11_+_123997983 1.102 TBRG1
transforming growth factor beta regulator 1
chr10_-_88707299 1.100 NM_024756
multimerin 2
chr7_+_106293112 1.098 NM_002649
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr9_+_130124873 1.095 COQ4
coenzyme Q4 homolog (S. cerevisiae)
chr11_+_65164767 1.093 SIPA1
signal-induced proliferation-associated 1
chr7_-_91995684 1.090 NM_000466
peroxisomal biogenesis factor 1
chr1_-_1580266 1.090 CDK11A
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr20_+_28225511 1.089 LOC283788
FSHD region gene 1 pseudogene
FSHD region gene 1 family, member B
chr10_+_114144512 1.089 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_32380287 1.088 NM_012138
apoptosis antagonizing transcription factor
chr1_+_61642287 1.085 NFIA
nuclear factor I/A
chr11_-_60953848 1.085 NM_024811
cleavage and polyadenylation specific factor 7, 59kDa
chr3_-_20202622 1.083 NM_001012409

shugoshin-like 1 (S. pombe)

chr2_+_64604940 1.082 NM_001002243


chr2_-_201461945 1.082 NM_032472

peptidylprolyl isomerase (cyclophilin)-like 3

chr21_+_44256601 1.079 TRAPPC10
trafficking protein particle complex 10
chr10_+_75174125 1.077 NM_004922

SEC24 family, member C (S. cerevisiae)

chr17_-_24013013 1.077 NM_006923
stromal cell-derived factor 2
chr11_-_95296903 1.077 NM_016156

myotubularin related protein 2

chr10_+_1092295 1.076 WDR37
WD repeat domain 37
chr3_+_20056527 1.074 NM_003884
K(lysine) acetyltransferase 2B
chr17_+_6858815 1.072 C17orf49
chromosome 17 open reading frame 49
chr1_+_164004789 1.070 LOC100147773
hypothetical LOC100147773
chr15_+_62921134 1.063 NM_001195059

pleckstrin homology domain containing, family O member 2

chr20_+_43478120 1.063 NM_001184728

phosphatidylinositol glycan anchor biosynthesis, class T

chr1_+_148305965 1.062 NM_007259
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr9_+_131605215 1.056 NM_014506
torsin family 1, member B (torsin B)
chr2_-_46697689 1.055 NM_002643

phosphatidylinositol glycan anchor biosynthesis, class F

chr19_+_55918405 1.053 NM_002975
C-type lectin domain family 11, member A
chr7_-_99355085 1.053 NM_033017

tripartite motif containing 4

chr22_-_19543069 1.049 NM_058004
phosphatidylinositol 4-kinase, catalytic, alpha
chr3_+_198153953 1.044 LOC152217
hypothetical LOC152217
chr1_+_37712716 1.043 ZC3H12A
zinc finger CCCH-type containing 12A
chr9_+_35739321 1.043 RGP1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr17_-_76883656 1.042 SLC38A10
solute carrier family 38, member 10
chr9_-_37775064 1.033 NM_016042

exosome component 3

chr9_+_130173458 1.033 URM1
ubiquitin related modifier 1
chr16_+_67931033 1.033 NM_016101
nuclear import 7 homolog (S. cerevisiae)
chr19_+_44589297 1.032 NM_003407
zinc finger protein 36, C3H type, homolog (mouse)
chr2_-_32118323 1.030 NM_032574
dpy-30 homolog (C. elegans)
chr9_-_122595413 1.029 FBXW2
F-box and WD repeat domain containing 2
chr1_+_45926433 1.029 NM_016486
transmembrane protein 69
chr17_-_59923547 1.028 NM_007215
polymerase (DNA directed), gamma 2, accessory subunit
chr2_-_241690365 1.028 NM_182501
MTERF domain containing 2
chr13_-_45524846 1.026 NM_015070
zinc finger CCCH-type containing 13
chr3_+_57517013 1.025 NM_177966
phosphodiesterase 12
chr9_+_138677197 1.025 NM_201446

EGF-like-domain, multiple 7

chr5_-_107744423 1.024 FBXL17
F-box and leucine-rich repeat protein 17
chr10_-_51293220 1.023 NM_006327
translocase of inner mitochondrial membrane 23 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr3_+_15444056 1.020 NM_033083
ELL associated factor 1
chr20_+_42537927 1.020 NM_001039199

tocopherol (alpha) transfer protein-like

chr3_-_95264349 1.019 NM_176815
dihydrofolate reductase-like 1
chr2_-_174968595 1.015 NM_004882
corepressor interacting with RBPJ, 1
chr6_+_18263514 1.014 NM_153042
lysine (K)-specific demethylase 1B
chr11_+_10729357 1.013 NM_014633
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr17_-_77244009 1.012 NM_001039842
chromosome 17 open reading frame 90
chr1_+_19796119 1.012

chr5_+_140051325 1.011 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr4_-_4300821 1.011 NM_032927
transmembrane protein 128
chr8_+_11179724 1.007 MTMR9
myotubularin related protein 9
chr2_+_98591492 1.007 UNC50
unc-50 homolog (C. elegans)
chr16_-_67930974 1.005 NM_032382
component of oligomeric golgi complex 8
chr8_-_146199064 1.004 ZNF252
zinc finger protein 252
chr9_+_114289178 1.002 KIAA1958
chr20_+_33750645 1.000 NM_080748
reactive oxygen species modulator 1
chr6_-_153365480 0.993 MTRF1L
mitochondrial translational release factor 1-like
chr5_+_140051404 0.992 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr22_-_28279643 0.991 NM_001002878

THO complex 5

chr15_-_50648636 0.991 ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr2_+_187162969 0.987 NM_001145000

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr2_+_74535700 0.984 NM_031288
INO80 complex subunit B
chr1_-_39111422 0.980 NM_012333
c-myc binding protein
chr6_+_30402599 0.980 NM_021253
tripartite motif containing 39
chr11_-_57054756 0.977 NM_012456
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr4_-_101086891 0.976 NM_001031723
DnaJ (Hsp40) homolog, subfamily B, member 14
chr10_-_51041156 0.973 NM_003631
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
poly(ADP-ribose) glycohydrolase pseudogene
poly (ADP-ribose) glycohydrolase
chr9_-_126217510 0.969 NM_002799
proteasome (prosome, macropain) subunit, beta type, 7
chr11_-_117628211 0.967 NM_198275
myelin protein zero-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.30e-49 GO:0044260 cellular macromolecule metabolic process
1.33 1.93e-41 GO:0043170 macromolecule metabolic process
1.48 6.22e-32 GO:0090304 nucleic acid metabolic process
1.41 1.23e-29 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 3.02e-29 GO:0044237 cellular metabolic process
1.42 7.97e-28 GO:0044267 cellular protein metabolic process
1.51 1.31e-26 GO:0016070 RNA metabolic process
1.47 3.77e-24 GO:0010467 gene expression
1.21 5.08e-24 GO:0044238 primary metabolic process
1.19 2.59e-23 GO:0008152 metabolic process
1.97 1.75e-20 GO:0016032 viral reproduction
1.84 3.23e-20 GO:0016071 mRNA metabolic process
1.32 2.68e-19 GO:0019538 protein metabolic process
1.30 3.18e-19 GO:0034641 cellular nitrogen compound metabolic process
1.75 3.27e-19 GO:0006396 RNA processing
1.29 3.08e-18 GO:0006807 nitrogen compound metabolic process
1.32 7.42e-18 GO:0071841 cellular component organization or biogenesis at cellular level
1.27 2.68e-17 GO:0071840 cellular component organization or biogenesis
1.42 6.82e-17 GO:0034645 cellular macromolecule biosynthetic process
1.41 7.72e-17 GO:0009059 macromolecule biosynthetic process
1.41 1.10e-15 GO:0006996 organelle organization
1.52 2.77e-15 GO:0007049 cell cycle
1.70 3.54e-15 GO:0000278 mitotic cell cycle
1.75 4.61e-15 GO:0006974 response to DNA damage stimulus
1.67 1.87e-14 GO:0009057 macromolecule catabolic process
1.72 4.28e-14 GO:0044265 cellular macromolecule catabolic process
1.29 1.15e-13 GO:0071842 cellular component organization at cellular level
1.25 3.51e-13 GO:0016043 cellular component organization
1.09 1.59e-12 GO:0009987 cellular process
1.79 1.66e-12 GO:0006397 mRNA processing
1.53 3.58e-12 GO:0033554 cellular response to stress
1.57 7.94e-12 GO:0022403 cell cycle phase
1.51 1.27e-11 GO:0015031 protein transport
1.87 1.66e-11 GO:0008380 RNA splicing
2.03 1.71e-11 GO:0000075 cell cycle checkpoint
1.52 2.64e-11 GO:0022402 cell cycle process
2.07 4.17e-11 GO:0022613 ribonucleoprotein complex biogenesis
1.99 4.68e-11 GO:0071156 regulation of cell cycle arrest
1.49 5.02e-11 GO:0045184 establishment of protein localization
1.77 7.79e-11 GO:0030163 protein catabolic process
2.02 8.89e-11 GO:0071843 cellular component biogenesis at cellular level
1.80 1.33e-10 GO:0051603 proteolysis involved in cellular protein catabolic process
1.51 1.37e-10 GO:0046907 intracellular transport
1.82 1.69e-10 GO:0006511 ubiquitin-dependent protein catabolic process
1.43 2.49e-10 GO:0008104 protein localization
1.81 3.06e-10 GO:0006412 translation
1.80 3.23e-10 GO:0043632 modification-dependent macromolecule catabolic process
1.78 3.34e-10 GO:0044257 cellular protein catabolic process
2.01 3.38e-10 GO:0000375 RNA splicing, via transesterification reactions
2.02 4.16e-10 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.02 4.16e-10 GO:0000398 nuclear mRNA splicing, via spliceosome
1.79 4.35e-10 GO:0019941 modification-dependent protein catabolic process
1.81 7.49e-10 GO:0051329 interphase of mitotic cell cycle
1.31 1.13e-09 GO:0006464 protein modification process
1.40 1.14e-09 GO:0044248 cellular catabolic process
1.79 1.41e-09 GO:0051325 interphase
1.30 2.33e-09 GO:0043412 macromolecule modification
1.54 4.36e-09 GO:0051726 regulation of cell cycle
2.06 1.21e-08 GO:0010498 proteasomal protein catabolic process
2.06 1.21e-08 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.71 1.36e-08 GO:0010564 regulation of cell cycle process
1.35 1.55e-08 GO:0033036 macromolecule localization
2.13 1.12e-07 GO:0007093 mitotic cell cycle checkpoint
1.24 1.55e-07 GO:0044249 cellular biosynthetic process
1.23 2.31e-07 GO:0009058 biosynthetic process
1.77 2.74e-07 GO:0016567 protein ubiquitination
1.36 3.08e-07 GO:0051649 establishment of localization in cell
2.18 3.64e-07 GO:0000084 S phase of mitotic cell cycle
2.40 4.78e-07 GO:0000216 M/G1 transition of mitotic cell cycle
2.19 4.93e-07 GO:0000077 DNA damage checkpoint
2.10 5.13e-07 GO:0042254 ribosome biogenesis
1.73 6.39e-07 GO:0032446 protein modification by small protein conjugation
1.66 8.02e-07 GO:0070647 protein modification by small protein conjugation or removal
1.33 8.88e-07 GO:0051641 cellular localization
1.31 8.97e-07 GO:0009056 catabolic process
2.14 9.51e-07 GO:0051320 S phase
1.69 9.88e-07 GO:0048285 organelle fission
2.12 1.11e-06 GO:0031570 DNA integrity checkpoint
2.34 1.56e-06 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.68 1.69e-06 GO:0000087 M phase of mitotic cell cycle
1.48 3.04e-06 GO:0006259 DNA metabolic process
2.43 4.64e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.28 4.76e-06 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.32 4.91e-06 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.67 5.14e-06 GO:0000280 nuclear division
1.67 5.14e-06 GO:0007067 mitosis
1.70 5.95e-06 GO:0007346 regulation of mitotic cell cycle
1.62 7.14e-06 GO:0006281 DNA repair
2.39 8.58e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.29 8.58e-06 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.29 8.58e-06 GO:0071779 G1/S transition checkpoint
1.36 9.18e-06 GO:0032774 RNA biosynthetic process
2.47 1.04e-05 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.47 1.04e-05 GO:0072395 signal transduction involved in cell cycle checkpoint
2.47 1.04e-05 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.47 1.04e-05 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.47 1.04e-05 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.47 1.04e-05 GO:0072422 signal transduction involved in DNA damage checkpoint
2.47 1.04e-05 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.47 1.04e-05 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.35 1.17e-05 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.37 1.20e-05 GO:0008219 cell death
1.56 1.20e-05 GO:0006886 intracellular protein transport
2.41 1.50e-05 GO:0071158 positive regulation of cell cycle arrest
2.31 1.54e-05 GO:0006353 transcription termination, DNA-dependent
1.93 1.76e-05 GO:0000082 G1/S transition of mitotic cell cycle
2.17 2.02e-05 GO:0051438 regulation of ubiquitin-protein ligase activity
1.37 2.07e-05 GO:0016265 death
2.32 2.76e-05 GO:0051352 negative regulation of ligase activity
2.32 2.76e-05 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.66 2.91e-05 GO:0034660 ncRNA metabolic process
2.53 2.96e-05 GO:0006521 regulation of cellular amino acid metabolic process
2.24 3.37e-05 GO:0051443 positive regulation of ubiquitin-protein ligase activity
2.17 3.72e-05 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.47 3.88e-05 GO:0070727 cellular macromolecule localization
1.46 7.31e-05 GO:0034613 cellular protein localization
1.56 7.99e-05 GO:0051301 cell division
1.55 8.96e-05 GO:0044419 interspecies interaction between organisms
1.76 9.20e-05 GO:0034470 ncRNA processing
1.16 9.39e-05 GO:0060255 regulation of macromolecule metabolic process
2.05 1.05e-04 GO:0006414 translational elongation
2.08 1.27e-04 GO:0051340 regulation of ligase activity
1.79 1.62e-04 GO:0043687 post-translational protein modification
1.37 1.69e-04 GO:0016192 vesicle-mediated transport
2.19 1.71e-04 GO:0006354 transcription elongation, DNA-dependent
2.13 2.41e-04 GO:0051351 positive regulation of ligase activity
1.53 2.45e-04 GO:0016568 chromatin modification
1.98 2.88e-04 GO:0042770 signal transduction in response to DNA damage
1.28 3.38e-04 GO:0044085 cellular component biogenesis
1.96 4.23e-04 GO:0031398 positive regulation of protein ubiquitination
2.08 4.37e-04 GO:0006415 translational termination
1.37 4.73e-04 GO:0006915 apoptosis
1.47 6.15e-04 GO:0000279 M phase
1.82 6.66e-04 GO:0031396 regulation of protein ubiquitination
2.06 6.74e-04 GO:0031397 negative regulation of protein ubiquitination
1.33 8.45e-04 GO:0043933 macromolecular complex subunit organization
1.66 9.96e-04 GO:0033365 protein localization to organelle
2.22 1.06e-03 GO:0033238 regulation of cellular amine metabolic process
2.41 1.16e-03 GO:0050434 positive regulation of viral transcription
2.06 1.25e-03 GO:0019080 viral genome expression
2.06 1.25e-03 GO:0019083 viral transcription
2.11 1.32e-03 GO:0031123 RNA 3'-end processing
1.43 1.39e-03 GO:0034621 cellular macromolecular complex subunit organization
1.35 1.75e-03 GO:0012501 programmed cell death
1.97 1.84e-03 GO:0043241 protein complex disassembly
1.97 1.84e-03 GO:0043624 cellular protein complex disassembly
2.24 1.94e-03 GO:0006368 transcription elongation from RNA polymerase II promoter
2.29 2.07e-03 GO:0046782 regulation of viral transcription
2.15 2.09e-03 GO:0072594 establishment of protein localization to organelle
1.90 2.35e-03 GO:0032984 macromolecular complex disassembly
1.90 2.35e-03 GO:0034623 cellular macromolecular complex disassembly
2.09 2.81e-03 GO:0000209 protein polyubiquitination
2.01 2.88e-03 GO:0071826 ribonucleoprotein complex subunit organization
1.99 3.15e-03 GO:0006364 rRNA processing
1.90 3.18e-03 GO:0090068 positive regulation of cell cycle process
2.03 3.56e-03 GO:0022618 ribonucleoprotein complex assembly
1.64 3.80e-03 GO:0006605 protein targeting
1.72 5.22e-03 GO:0022415 viral reproductive process
1.37 5.24e-03 GO:0071822 protein complex subunit organization
1.77 5.40e-03 GO:0010565 regulation of cellular ketone metabolic process
1.92 7.20e-03 GO:0016072 rRNA metabolic process
1.65 7.59e-03 GO:0006260 DNA replication
2.13 8.44e-03 GO:0031124 mRNA 3'-end processing
1.76 9.69e-03 GO:0019058 viral infectious cycle
1.41 1.08e-02 GO:0016044 cellular membrane organization
1.94 1.26e-02 GO:0018196 peptidyl-asparagine modification
1.94 1.26e-02 GO:0018279 protein N-linked glycosylation via asparagine
1.74 1.29e-02 GO:0007005 mitochondrion organization
1.90 1.40e-02 GO:0006487 protein N-linked glycosylation
1.40 1.46e-02 GO:0061024 membrane organization
1.52 1.48e-02 GO:0010608 posttranscriptional regulation of gene expression
1.63 1.56e-02 GO:0022411 cellular component disassembly
1.63 1.56e-02 GO:0071845 cellular component disassembly at cellular level
2.10 1.82e-02 GO:0048524 positive regulation of viral reproduction
1.34 2.31e-02 GO:0051276 chromosome organization
1.93 2.33e-02 GO:0051168 nuclear export
1.12 2.64e-02 GO:0019222 regulation of metabolic process
1.26 2.78e-02 GO:0032268 regulation of cellular protein metabolic process
2.32 2.90e-02 GO:0006369 termination of RNA polymerase II transcription
1.44 2.96e-02 GO:0018193 peptidyl-amino acid modification
1.24 3.79e-02 GO:0051246 regulation of protein metabolic process
1.57 4.27e-02 GO:0006457 protein folding
1.27 4.51e-02 GO:0006351 transcription, DNA-dependent
1.61 4.56e-02 GO:0051169 nuclear transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 2.74e-74 GO:0044424 intracellular part
1.18 7.72e-73 GO:0005622 intracellular
1.24 2.52e-62 GO:0043231 intracellular membrane-bounded organelle
1.24 2.85e-62 GO:0043227 membrane-bounded organelle
1.21 2.51e-59 GO:0043229 intracellular organelle
1.20 7.60e-59 GO:0043226 organelle
1.30 5.18e-43 GO:0005634 nucleus
1.55 5.43e-43 GO:0044428 nuclear part
1.29 3.10e-42 GO:0044446 intracellular organelle part
1.51 1.60e-41 GO:0031974 membrane-enclosed lumen
1.52 6.87e-41 GO:0070013 intracellular organelle lumen
1.51 7.78e-40 GO:0043233 organelle lumen
1.28 1.49e-39 GO:0044422 organelle part
1.56 8.11e-37 GO:0031981 nuclear lumen
1.19 4.75e-36 GO:0005737 cytoplasm
1.97 8.16e-28 GO:0030529 ribonucleoprotein complex
1.22 1.61e-25 GO:0044444 cytoplasmic part
1.29 1.66e-22 GO:0032991 macromolecular complex
1.49 1.21e-19 GO:0005654 nucleoplasm
1.80 1.52e-18 GO:0005730 nucleolus
1.30 4.74e-17 GO:0043228 non-membrane-bounded organelle
1.30 4.74e-17 GO:0043232 intracellular non-membrane-bounded organelle
1.33 5.60e-15 GO:0005829 cytosol
2.29 3.59e-12 GO:0005681 spliceosomal complex
2.57 2.82e-10 GO:0071013 catalytic step 2 spliceosome
1.22 2.19e-09 GO:0043234 protein complex
1.04 1.82e-08 GO:0044464 cell part
1.04 1.97e-08 GO:0005623 cell
1.89 7.86e-08 GO:0005840 ribosome
1.43 1.27e-07 GO:0044451 nucleoplasm part
1.79 1.48e-07 GO:0016604 nuclear body
1.46 1.98e-06 GO:0005694 chromosome
2.39 6.28e-06 GO:0000502 proteasome complex
1.90 8.44e-06 GO:0000151 ubiquitin ligase complex
1.48 1.49e-05 GO:0044427 chromosomal part
1.27 1.84e-05 GO:0005739 mitochondrion
1.79 8.90e-05 GO:0044445 cytosolic part
1.87 1.84e-04 GO:0016607 nuclear speck
1.19 4.09e-04 GO:0031090 organelle membrane
1.63 4.39e-04 GO:0000228 nuclear chromosome
1.70 4.81e-04 GO:0044454 nuclear chromosome part
1.98 1.38e-03 GO:0000790 nuclear chromatin
2.03 1.56e-03 GO:0022626 cytosolic ribosome
1.31 1.94e-03 GO:0031967 organelle envelope
1.32 3.27e-03 GO:0044429 mitochondrial part
2.76 4.21e-03 GO:0044452 nucleolar part
1.30 4.99e-03 GO:0031975 envelope
1.25 5.63e-03 GO:0005794 Golgi apparatus
2.49 1.14e-02 GO:0030532 small nuclear ribonucleoprotein complex
1.50 1.41e-02 GO:0000785 chromatin
2.00 2.10e-02 GO:0015934 large ribosomal subunit
1.97 2.27e-02 GO:0044450 microtubule organizing center part
1.31 2.37e-02 GO:0044431 Golgi apparatus part
1.46 2.75e-02 GO:0044440 endosomal part
1.49 3.21e-02 GO:0005813 centrosome
1.46 3.46e-02 GO:0010008 endosome membrane
1.34 3.59e-02 GO:0005768 endosome
1.39 4.73e-02 GO:0005815 microtubule organizing center

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 4.93e-30 GO:0005515 protein binding
1.10 6.72e-21 GO:0005488 binding
1.62 6.80e-19 GO:0003723 RNA binding
1.28 6.05e-18 GO:0003676 nucleic acid binding
1.13 9.20e-07 GO:0003824 catalytic activity
1.74 3.46e-06 GO:0004842 ubiquitin-protein ligase activity
1.87 1.61e-05 GO:0003735 structural constituent of ribosome
1.68 2.22e-05 GO:0019787 small conjugating protein ligase activity
1.86 7.29e-05 GO:0004386 helicase activity
1.97 1.13e-04 GO:0008026 ATP-dependent helicase activity
1.97 1.13e-04 GO:0070035 purine NTP-dependent helicase activity
1.19 2.10e-04 GO:0000166 nucleotide binding
1.20 2.84e-04 GO:0008270 zinc ion binding
1.21 8.44e-04 GO:0016740 transferase activity
1.41 1.46e-03 GO:0016874 ligase activity
1.54 1.77e-03 GO:0016881 acid-amino acid ligase activity
1.96 1.83e-03 GO:0008565 protein transporter activity
1.68 1.84e-03 GO:0008168 methyltransferase activity
1.31 2.22e-03 GO:0019899 enzyme binding
1.19 2.28e-03 GO:0017076 purine nucleotide binding
1.52 2.37e-03 GO:0042623 ATPase activity, coupled
1.19 2.69e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.21 2.89e-03 GO:0030554 adenyl nucleotide binding
1.21 3.69e-03 GO:0032559 adenyl ribonucleotide binding
1.21 3.78e-03 GO:0005524 ATP binding
1.45 4.13e-03 GO:0016887 ATPase activity
1.18 4.26e-03 GO:0032553 ribonucleotide binding
1.18 4.26e-03 GO:0032555 purine ribonucleotide binding
1.48 5.50e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.63 6.33e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.28 1.48e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.27 2.00e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.27 2.26e-02 GO:0016462 pyrophosphatase activity
1.37 2.41e-02 GO:0004674 protein serine/threonine kinase activity
1.51 3.09e-02 GO:0003713 transcription coactivator activity
1.86 3.60e-02 GO:0008135 translation factor activity, nucleic acid binding
1.27 3.88e-02 GO:0017111 nucleoside-triphosphatase activity
1.14 4.93e-02 GO:0003677 DNA binding
1.70 4.95e-02 GO:0051082 unfolded protein binding
1.38 4.99e-02 GO:0003712 transcription cofactor activity