ISMARA results for ENCODE cell lines, H3K4me1, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
PITX1..3.p2 9.150 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HNF1A.p2 8.175 HNF1A (HNF1, LFB1)
GATA6.p2 7.353 GATA6
RUNX1..3.p2 6.445 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
HNF4A_NR2F1,2.p2 6.049 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
MEF2{A,B,C,D}.p2 5.505 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
HOX{A6,A7,B6,B7}.p2 5.281 HOXB6
HOXA7
HOXB7
HOXA6
EN1,2.p2 4.910 EN1
EN2
SPIB.p2 4.680 SPIB (SPI-B)
HAND1,2.p2 4.638 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
TCF4_dimer.p2 4.478 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
TEAD1.p2 4.420 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
FOS_FOS{B,L1}_JUN{B,D}.p2 4.306 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
SPI1.p2 3.873 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
KLF4.p3 3.872 KLF4 (EZF, GKLF)
NRF1.p2 3.696 NRF1 (EWG, ALPHA-PAL)
SNAI1..3.p2 3.671 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
IRF1,2,7.p3 3.628 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
YY1.p2 3.611 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
NFE2L2.p2 3.582 NFE2L2 (NRF2)
MTF1.p2 3.545 MTF1
ZIC1..3.p2 3.469 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
RFX1..5_RFXANK_RFXAP.p2 3.371 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
ZNF143.p2 3.353 ZNF143 (SBF, pHZ-1, STAF)
CTCF.p2 3.279 CTCF
ELF1,2,4.p2 3.160 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
TLX1..3_NFIC{dimer}.p2 3.145 TLX1
TLX3 (RNX)
FEV.p2 3.133 FEV (PET-1, HSRNAFEV)
EVI1.p2 3.065 EVI1 (MDS1-EVI1, PRDM3)
ELK1,4_GABP{A,B1}.p3 3.040 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
NKX2-1,4.p2 3.020 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
NFY{A,B,C}.p2 2.979 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
POU2F1..3.p2 2.890 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
FOXA2.p3 2.886 FOXA2
HOX{A5,B5}.p2 2.882 HOXB5
HOXA5
ETS1,2.p2 2.838 ETS2
ETS1 (FLJ10768, ETS-1)
POU5F1.p2 2.837 POU5F1 (OCT3, Oct4, MGC22487)
DBP.p2 2.814 DBP (DABP)
GTF2A1,2.p2 2.812 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
MYOD1.p2 2.763 MYOD1 (PUM, MYOD, bHLHc1)
TGIF1.p2 2.680 TGIF1
HBP1_HMGB_SSRP1_UBTF.p2 2.580 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
HLF.p2 2.568 HLF (MGC33822)
NFKB1_REL_RELA.p2 2.556 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
FOXL1.p2 2.541 FOXL1 (FREAC7, FKH6)
MYFfamily.p2 2.536 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
GATA1..3.p2 2.521 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
NR5A1,2.p2 2.499 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
MAZ.p2 2.487 MAZ (ZF87, Pur-1, Zif87, ZNF801)
E2F1..5.p2 2.484 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
ZNF238.p2 2.469 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
SP1.p2 2.467 SP1
GFI1B.p2 2.443 GFI1B
DMAP1_NCOR{1,2}_SMARC.p2 2.424 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
AHR_ARNT_ARNT2.p2 2.400 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
SMAD1..7,9.p2 2.399 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
bHLH_family.p2 2.388 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
NR1H4.p2 2.384 NR1H4 (FXR, RIP14, HRR1, HRR-1)
FOXP3.p2 2.364 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
GFI1.p2 2.363 GFI1
ONECUT1,2.p2 2.343 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
NFE2.p2 2.330 NFE2 (NF-E2)
POU6F1.p2 2.316 POU6F1 (BRN5, MPOU, TCFB1)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 2.300 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
MSX1,2.p2 2.277 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
JUN.p2 2.235 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
NHLH1,2.p2 2.230 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
HIC1.p2 2.218 HIC1 (ZBTB29)
ARID5B.p2 2.192 ARID5B (FLJ21150, MRF2)
GTF2I.p2 2.143 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
HSF1,2.p2 2.141 HSF1 (HSTF1)
HSF2
EOMES.p2 2.127 EOMES (TBR2)
CEBPA,B_DDIT3.p2 2.109 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
MZF1.p2 2.055 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
PRRX1,2.p2 2.042 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
PATZ1.p2 2.036 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
T.p2 2.025 T
NR3C1.p2 2.025 NR3C1 (GR)
HOX{A4,D4}.p2 2.022 HOXA4
HOXD4
TBX4,5.p2 1.979 TBX5
TBX4
NFE2L1.p2 1.956 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
SRF.p3 1.930 SRF (MCM1)
EHF.p2 1.928 EHF
PRDM1.p3 1.926 PRDM1 (PRDI-BF1)
ZEB1.p2 1.922 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
ATF5_CREB3.p2 1.921 ATF5
CREB3 (LZIP, Luman)
FOSL2.p2 1.909 FOSL2 (FRA2, FLJ23306)
RBPJ.p2 1.904 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
FOX{I1,J2}.p2 1.869 FOXI1 (FREAC6)
FOXJ2 (FHX)
ATF2.p2 1.833 ATF2 (TREB7, CRE-BP1, HB16)
EGR1..3.p2 1.830 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
PAX5.p2 1.824 PAX5 (BSAP)
MAFB.p2 1.822 MAFB
ZFP161.p2 1.813 ZFP161 (ZNF478, ZBTB14)
ESRRA.p2 1.798 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
GLI1..3.p2 1.765 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
LEF1_TCF7_TCF7L1,2.p2 1.738 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
NFATC1..3.p2 1.733 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
LMO2.p2 1.723 LMO2 (TTG2, RHOM2, RBTN2)
KLF12.p2 1.719 KLF12 (AP-2rep, HSPC122, AP2REP)
RXRA_VDR{dimer}.p2 1.700 VDR (NR1I1)
EBF1.p2 1.699 EBF1 (OLF1)
POU5F1_SOX2{dimer}.p2 1.698 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
TFDP1.p2 1.673 TFDP1 (Dp-1, DRTF1, DP1)
CRX.p2 1.665 CRX (CRD, LCA7, OTX3)
FOXO1,3,4.p2 1.663 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
HES1.p2 1.656 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
NR6A1.p2 1.634 NR6A1 (GCNF1, RTR)
POU3F1..4.p2 1.623 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
TBP.p2 1.617 TBP (TFIID)
NANOG{mouse}.p2 1.601 NANOG (FLJ12581, FLJ40451)
ZBTB16.p2 1.594 ZBTB16 (PLZF)
HOXA9_MEIS1.p2 1.594 MEIS1
HOXA9
NKX6-1,2.p2 1.591 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
ATF4.p2 1.589 ATF4 (TAXREB67, CREB-2)
HMX1.p2 1.573 HMX1 (H6, NKX5-3)
BPTF.p2 1.563 BPTF (FAC1, NURF301)
BACH2.p2 1.553 BACH2
RXR{A,B,G}.p2 1.541 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
CDX1,2,4.p2 1.541 CDX1
CDX2
CDX4
VSX1,2.p2 1.539 VSX2 (RET1)
VSX1 (PPD)
NKX3-1.p2 1.534 NKX3-1 (NKX3.1, BAPX2)
NKX2-2,8.p2 1.531 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
TFCP2.p2 1.512 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
FOX{C1,C2}.p2 1.504 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
FOX{F1,F2,J1}.p2 1.490 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
PBX1.p2 1.487 PBX1
TLX2.p2 1.486 TLX2 (Enx, Tlx2, NCX)
NANOG.p2 1.478 NANOG (FLJ12581, FLJ40451)
PAX4.p2 1.459 PAX4
FOXD3.p2 1.451 FOXD3 (Genesis, HFH2)
FOX{D1,D2}.p2 1.450 FOXD2 (FREAC9)
FOXD1 (FREAC4)
TFAP4.p2 1.438 TFAP4 (AP-4)
FOXN1.p2 1.425 FOXN1 (FKHL20)
RREB1.p2 1.420 RREB1 (HNT)
NKX2-3_NKX2-5.p2 1.417 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
ZNF384.p2 1.391 ZNF384 (CAGH1A, CIZ, NMP4, NP)
POU1F1.p2 1.363 POU1F1 (GHF-1)
SOX{8,9,10}.p2 1.356 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
STAT2,4,6.p2 1.355 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
EWSR1-FLI1.p2 1.339 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
STAT1,3.p3 1.338 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
NFIL3.p2 1.333 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
TAL1_TCF{3,4,12}.p2 1.310 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
EP300.p2 1.300 EP300 (p300, KAT3B)
NFIX.p2 1.293 NFIX (NF1A)
PAX2.p2 1.285 PAX2
CUX2.p2 1.282 CUX2 (KIAA0293, CDP2)
CREB1.p2 1.280 CREB1
RXRG_dimer.p3 1.275 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
TFAP2B.p2 1.270 TFAP2B (AP2-B)
ZNF148.p2 1.265 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
SRY.p2 1.230 SRY (TDF)
XBP1.p3 1.224 XBP1
HMGA1,2.p2 1.211 HMGA1
HMGA2 (BABL, LIPO)
PPARG.p2 1.202 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
AR.p2 1.198 AR (AIS, NR3C4, SMAX1, HUMARA)
NKX3-2.p2 1.187 NKX3-2 (NKX3B, NKX3.2)
SOX2.p2 1.168 SOX2
SPZ1.p2 1.152 SPZ1 (NYD-TSP1, FLJ25709)
TFAP2{A,C}.p2 1.144 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
MYBL2.p2 1.143 MYBL2 (BMYB, B-MYB)
SOX5.p2 1.106 SOX5 (L-SOX5, MGC35153)
FOXQ1.p2 1.103 FOXQ1 (HFH1)
AIRE.p2 1.048 AIRE (PGA1, APS1)
TP53.p2 1.045 TP53 (p53, LFS1)
REST.p3 1.037 REST (NRSF, XBR)
ADNP_IRX_SIX_ZHX.p2 1.007 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
RORA.p2 0.997 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
SREBF1,2.p2 0.992 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
ALX1.p2 0.968 ALX1
STAT5{A,B}.p2 0.958 STAT5B
STAT5A (MGF)
MYB.p2 0.951 MYB (c-myb)
ZBTB6.p2 0.921 ZBTB6 (ZID)
TFEB.p2 0.917 TFEB
LHX3,4.p2 0.878 LHX3
LHX4 (Gsh4)
IKZF2.p2 0.876 IKZF2 (Helios)
ESR1.p2 0.861 ESR1 (NR3A1, Era)
IKZF1.p2 0.854 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
PDX1.p2 0.820 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
CDC5L.p2 0.815 CDC5L (PCDC5RP, hCDC5, CEF1)
PAX6.p2 0.807 PAX6 (D11S812E, AN, WAGR)
GZF1.p2 0.763 GZF1 (dJ322G13.2, ZBTB23)
HIF1A.p2 0.642 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
ZNF423.p2 0.576 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
SOX17.p2 0.543 SOX17
ATF6.p2 0.534 ATF6 (ATF6A)
PAX8.p2 0.371 PAX8
PAX3,7.p2 0.141 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF