Motif ID: TLX2.p2

Z-value: 1.486


Transcription factors associated with TLX2.p2:

Gene SymbolEntrez IDGene Name
TLX2 3196 T-cell leukemia homeobox 2



Activity profile for motif TLX2.p2.

activity profile for motif TLX2.p2


Sorted Z-values histogram for motif TLX2.p2

Sorted Z-values for motif TLX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_73810383 1.408 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr12_+_55018925 1.386 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr11_-_83071084 1.205 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr7_+_31693155 1.203 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr9_+_94766379 1.165 FGD3
FYVE, RhoGEF and PH domain containing 3
chr1_-_155834357 1.082 NM_031282
FCRL4
Fc receptor-like 4
chr6_-_41114905 1.068 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr19_-_6671585 1.048 NM_000064
C3
complement component 3
chr1_-_26553168 1.041 NM_001039775
AIM1L
absent in melanoma 1-like
chr2_+_97696462 0.980 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr16_-_70763524 0.979 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_-_25164061 0.953 NM_001031680
RUNX3
runt-related transcription factor 3
chr6_+_167445284 0.938 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr11_-_60880799 0.925 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr10_-_97190885 0.895 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr20_-_34707971 0.891 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr19_-_56612653 0.886 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr1_+_159032551 0.877 NM_001033667
NM_002348
LY9

lymphocyte antigen 9

chr7_-_99411573 0.864 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr8_-_27997306 0.833 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr15_-_38185865 0.807 NM_033503
BMF
Bcl2 modifying factor
chr1_-_155788775 0.780 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chrX_-_106033202 0.776 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr1_-_159546348 0.745 NM_000530
MPZ
myelin protein zero
chr19_-_56726704 0.744 NM_001177547
NM_001177548
NM_001177549
NM_001245
NM_198845
NM_198846
SIGLEC6





sialic acid binding Ig-like lectin 6





chr1_+_158063130 0.727 SLAMF8
SLAM family member 8
chr1_+_151596953 0.726 NM_002965
S100A9
S100 calcium binding protein A9
chr22_+_33792125 0.722 NM_001008494
ISX
intestine-specific homeobox
chr14_-_24148658 0.719 NM_033423
GZMH
granzyme H (cathepsin G-like 2, protein h-CCPX)
chr18_-_26935883 0.716 NM_004949
NM_024422
DSC2

desmocollin 2

chr11_-_26550243 0.714 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr1_+_158063102 0.709 NM_020125
SLAMF8
SLAM family member 8
chr3_+_46370578 0.705 CCR2
chemokine (C-C motif) receptor 2
chr8_+_22266256 0.699 PIWIL2
piwi-like 2 (Drosophila)
chr3_+_123256902 0.697 NM_175862
CD86
CD86 molecule
chr7_+_142692165 0.688 NM_153345
TMEM139
transmembrane protein 139
chr1_+_158063278 0.687 SLAMF8
SLAM family member 8
chr8_-_101384633 0.680 NM_015435
RNF19A
ring finger protein 19A
chr2_+_102345528 0.678 NM_003855
IL18R1
interleukin 18 receptor 1
chr7_+_37689903 0.672


chr19_-_56841819 0.671 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr11_-_66245288 0.666 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr4_+_76700281 0.661 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr11_-_117589283 0.658 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr11_+_59979857 0.656 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr10_-_71753684 0.655 LRRC20
leucine rich repeat containing 20
chr16_-_70763849 0.654 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr1_-_156013487 0.651 NM_030764
FCRL2
Fc receptor-like 2
chr11_-_128217550 0.648 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chrX_-_55037235 0.648 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_-_117305277 0.646 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr21_-_42659671 0.643 NM_003225
TFF1
trefoil factor 1
chr3_+_46370228 0.636 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr15_-_38185578 0.630 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr22_+_23153529 0.618 NM_000675
ADORA2A
adenosine A2a receptor
chr5_+_75414994 0.616 NM_014979
SV2C
synaptic vesicle glycoprotein 2C
chr6_+_131190237 0.616 NM_001195597
LOC285733
hypothetical LOC285733
chr6_-_149847718 0.614 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_26038817 0.613 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr2_-_88208650 0.608 NM_001443
FABP1
fatty acid binding protein 1, liver
chr2_+_24660849 0.607 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr1_+_32512298 0.607 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr7_+_99809068 0.604 PILRA
paired immunoglobin-like type 2 receptor alpha
chr1_-_153098811 0.602 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr6_-_32742265 0.600 NM_002123
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr7_+_99793561 0.599 NM_178238
PILRB
paired immunoglobin-like type 2 receptor beta
chr10_+_82163568 0.597 C10orf58
chromosome 10 open reading frame 58
chr1_+_57093030 0.591 NM_000562
C8A
complement component 8, alpha polypeptide
chr12_+_115833093 0.587 NM_012174
NM_153348
FBXW8

F-box and WD repeat domain containing 8

chr10_-_51678318 0.575 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr3_-_109292444 0.573 NM_001777
NM_198793
CD47

CD47 molecule

chr10_-_33663305 0.568 NRP1
neuropilin 1
chr3_+_123279439 0.567 NM_006889
CD86
CD86 molecule
chr7_+_50318801 0.561 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr16_-_29664765 0.557 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr8_+_21971317 0.555 NM_001114135
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr21_-_26294332 0.553 APP
amyloid beta (A4) precursor protein
chr20_+_61838389 0.548 NM_017806
LIME1
Lck interacting transmembrane adaptor 1
chr17_+_71975224 0.548 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr2_+_231968578 0.540 NM_145236
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr2_+_228386800 0.540 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr17_-_6958282 0.534 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr12_-_192752 0.530 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr3_+_187917791 0.529 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr1_-_205161821 0.526 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr6_-_159386007 0.522 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr1_-_27825633 0.519 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr12_+_108038774 0.519 ACACB
acetyl-CoA carboxylase beta
chr18_-_3209846 0.516 MYOM1
myomesin 1, 185kDa
chrX_-_70755023 0.515 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_+_50348052 0.514 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_+_7180571 0.513 NM_014716
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr7_+_99809003 0.511 NM_013439
NM_178272
NM_178273
PILRA


paired immunoglobin-like type 2 receptor alpha


chr14_-_52487022 0.511 FERMT2
fermitin family member 2
chr16_-_28515868 0.508 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_+_159899528 0.506 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr3_-_114176401 0.506 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr16_-_30301357 0.504 SEPT1
septin 1
chr12_-_49708279 0.503 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr10_-_74863303 0.503 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr16_+_30293598 0.497 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr20_-_2769120 0.496 FAM113A
family with sequence similarity 113, member A
chr1_+_116727514 0.495 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_-_82039158 0.494 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_20122638 0.491 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr20_+_5679032 0.489 NM_152504
C20orf196
chromosome 20 open reading frame 196
chr19_+_46640902 0.484 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr14_-_20807346 0.482 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr5_-_134815886 0.481 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr3_+_42107711 0.478 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr3_-_156904690 0.478 NM_014996
PLCH1
phospholipase C, eta 1
chr20_+_42417502 0.477 HNF4A
hepatocyte nuclear factor 4, alpha
chr20_-_43316597 0.472 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr1_+_228949752 0.472 NM_006615
NM_016452
CAPN9

calpain 9

chr1_+_149877955 0.471 SNX27
sorting nexin family member 27
chr3_-_49701085 0.470 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_159817752 0.469 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr6_-_149847809 0.468 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr6_-_53034547 0.465 NM_014920
NM_016513
ICK

intestinal cell (MAK-like) kinase

chr1_+_154390939 0.461 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_-_109730858 0.458 NM_014981
MYH15
myosin, heavy chain 15
chr19_-_6621078 0.456 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr5_-_176869943 0.453 NM_001144875
NM_001144876
DOK3

docking protein 3

chr8_-_134653194 0.452 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr1_-_151296611 0.444 NM_005988
SPRR2A
small proline-rich protein 2A
chr14_-_22354457 0.441 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr17_-_73640082 0.440 NM_007267
TMC6
transmembrane channel-like 6
chr1_+_179164195 0.437


chr1_+_148020869 0.437 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr1_+_26744893 0.434 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr22_+_49272078 0.430 NM_017584
MIOX
myo-inositol oxygenase
chr17_+_18221803 0.429 NM_001145127
EVPLL
envoplakin-like
chr17_-_35975227 0.428 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr2_-_207291364 0.423 NM_001093730
DYTN
dystrotelin
chr9_+_129951552 0.422 NM_005564
LCN2
lipocalin 2
chr1_-_150029529 0.421 NM_001083963
NM_001083964
NM_001083965
NM_006862
TDRKH



tudor and KH domain containing



chr5_-_39306465 0.418 FYB
FYN binding protein
chr20_+_42463279 0.416 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr21_+_41610530 0.415 NM_058186
NM_206964
FAM3B

family with sequence similarity 3, member B

chr11_+_62893836 0.413 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr1_+_207995999 0.413 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr11_+_1816808 0.413 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr1_+_151147646 0.412 NM_005547
IVL
involucrin
chr14_-_22825148 0.412 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr12_-_120591938 0.411 NM_173855
MORN3
MORN repeat containing 3
chr9_-_115877104 0.410 AMBP
alpha-1-microglobulin/bikunin precursor
chr19_-_45132372 0.410 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr15_+_73278285 0.407 C15orf39
chromosome 15 open reading frame 39
chr19_+_17723285 0.407 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr11_-_72057755 0.406 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr10_-_71713455 0.406 NM_022146
NPFFR1
neuropeptide FF receptor 1
chr18_+_27152049 0.403 NM_001942
DSG1
desmoglein 1
chr18_-_3209986 0.402 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr6_-_88095714 0.398 NM_198568
GJB7
gap junction protein, beta 7, 25kDa
chr1_+_26744929 0.398 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_15637521 0.397 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr18_+_31488530 0.396 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr21_-_37561463 0.396 DSCR3
Down syndrome critical region gene 3
chr5_-_66528330 0.395 NM_005582
CD180
CD180 molecule
chr20_-_43177137 0.392 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr3_+_46894239 0.391 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr1_-_151333624 0.391 NM_001024209
SPRR2E
small proline-rich protein 2E
chr14_+_54104383 0.391 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr17_+_55269974 0.391


chr20_+_42463419 0.390 HNF4A
hepatocyte nuclear factor 4, alpha
chr7_-_112545847 0.389 LOC401397
hypothetical LOC401397
chr20_-_3944035 0.389 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr3_-_46761248 0.385 NM_199183
PRSS45
protease, serine, 45
chr16_+_55963899 0.385 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_-_24597717 0.384 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr9_-_33437527 0.379 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr2_+_170370290 0.378 SSB
Sjogren syndrome antigen B (autoantigen La)
chr1_-_150044365 0.377 NM_001004432
LINGO4
leucine rich repeat and Ig domain containing 4
chr1_-_151630168 0.377 NM_002964
S100A8
S100 calcium binding protein A8
chr6_+_3022030 0.376 NM_003804
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr10_+_123744131 0.374 TACC2
transforming, acidic coiled-coil containing protein 2
chr6_-_52736231 0.374 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr9_-_4289574 0.371 GLIS3
GLIS family zinc finger 3
chr11_-_116199145 0.370 NM_000482
APOA4
apolipoprotein A-IV
chr20_+_42463350 0.370 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_+_52786642 0.369 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr10_-_50066386 0.369 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr3_+_144377822 0.368


chr20_+_61838479 0.368 LIME1
Lck interacting transmembrane adaptor 1
chr17_-_74231240 0.367 CYTH1
cytohesin 1
chr3_+_14419066 0.367 SLC6A6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr9_+_116125123 0.367 NM_000607
ORM1
orosomucoid 1
chr12_-_107551783 0.366 NM_003006
SELPLG
selectin P ligand
chr11_+_123986661 0.365 NM_052959
PANX3
pannexin 3
chr17_-_9863929 0.364 GAS7
growth arrest-specific 7
chr6_-_32665409 0.364 NM_002124
HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr2_-_238777070 0.363 ILKAP
integrin-linked kinase-associated serine/threonine phosphatase
chrX_+_1361570 0.361 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr14_-_34168911 0.360 SNX6
sorting nexin 6
chr11_+_2279932 0.360 TSPAN32
tetraspanin 32
chrX_-_10761729 0.358 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr10_-_75071498 0.358 NM_021245
MYOZ1
myozenin 1
chr5_+_125723686 0.357 NM_001146319
GRAMD3
GRAM domain containing 3
chr9_-_116732403 0.356 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr16_+_5061862 0.356 ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 4.29e-05 GO:0002376 immune system process
1.62 1.90e-04 GO:0006955 immune response
1.59 2.48e-03 GO:0002682 regulation of immune system process
1.27 2.48e-03 GO:0048518 positive regulation of biological process
2.05 4.01e-03 GO:0002253 activation of immune response
1.69 1.25e-02 GO:0050776 regulation of immune response
2.12 1.35e-02 GO:0002757 immune response-activating signal transduction
2.49 1.83e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.39 1.93e-02 GO:0009893 positive regulation of metabolic process
2.07 2.43e-02 GO:0002764 immune response-regulating signaling pathway
2.73 2.62e-02 GO:0050852 T cell receptor signaling pathway
1.51 3.77e-02 GO:0006915 apoptosis
2.39 4.00e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.50 4.43e-02 GO:0012501 programmed cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 3.91e-03 GO:0044459 plasma membrane part
5.32 1.33e-02 GO:0042613 MHC class II protein complex
1.25 2.13e-02 GO:0005829 cytosol
2.62 4.44e-02 GO:0016459 myosin complex
1.69 4.98e-02 GO:0015629 actin cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 8.64e-03 GO:0005515 protein binding