Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.417


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)



Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_13997588 2.619 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr10_-_105835609 1.967 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_-_105835525 1.957 COL17A1
collagen, type XVII, alpha 1
chr15_-_64108718 1.942


chr3_+_89239494 1.875 EPHA3
EPH receptor A3
chr11_+_7574992 1.841 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr13_-_45323757 1.839 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr18_+_27152049 1.832 NM_001942
DSG1
desmoglein 1
chr3_-_152517204 1.757 NM_023915
GPR87
G protein-coupled receptor 87
chr14_+_99633570 1.730 EVL
Enah/Vasp-like
chr10_-_116241572 1.678


chr15_+_97990705 1.671 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr4_-_152368492 1.663 SH3D19
SH3 domain containing 19
chr5_+_127012611 1.644 NM_001048252
CTXN3
cortexin 3
chr18_+_19826734 1.606 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr4_+_114433551 1.543 ANK2
ankyrin 2, neuronal
chr1_+_207944807 1.530 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_-_104411065 1.530 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr1_-_181826633 1.523 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr10_-_98021144 1.519 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_37282516 1.465 LOC100505876
hypothetical LOC100505876
chr16_+_10878539 1.393 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_-_25685175 1.391 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr13_-_85271329 1.346 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr20_-_43163021 1.275 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr13_-_59485299 1.269 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr1_-_214963279 1.265 NM_001438
ESRRG
estrogen-related receptor gamma
chr13_-_35327798 1.259 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr13_+_77007809 1.239 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr17_-_36347197 1.192 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_17861266 1.187 NM_001105569
MSGN1
mesogenin 1
chr8_+_67096344 1.152 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr14_+_51025604 1.150 NM_001042481
FRMD6
FERM domain containing 6
chr5_+_59819761 1.117 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr11_-_128567302 1.114 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr21_-_35343065 1.063 RUNX1
runt-related transcription factor 1
chr5_+_140848905 1.055 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr11_-_104477367 1.047 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr1_+_213245507 1.027 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr9_+_129066576 1.021 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_+_81544432 1.020 LPHN2
latrophilin 2
chr10_-_123346148 1.008 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr9_+_117955890 0.988 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_18502342 0.981 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr5_+_166644420 0.972 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr12_-_51173238 0.949 NM_005554
KRT6A
keratin 6A
chr7_+_115650240 0.942 NM_152829
TES
testis derived transcript (3 LIM domains)
chr11_+_93678450 0.940 NM_001080486
FOLR4
folate receptor 4 (delta) homolog (mouse)
chr17_-_39191658 0.932 NM_025237
SOST
sclerostin
chr11_-_85115105 0.930 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr10_+_86174665 0.926 FAM190B
family with sequence similarity 190, member B
chr4_-_23500706 0.908 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_-_141973875 0.907 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_36346240 0.906 KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_102081654 0.890 NM_022122
MMP27
matrix metallopeptidase 27
chr12_-_121753795 0.882 NM_177551
GPR109A
G protein-coupled receptor 109A
chr15_+_38082041 0.874 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr2_-_215711313 0.868 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_121767272 0.860 NM_006018
GPR109B
G protein-coupled receptor 109B
chr8_+_55691179 0.856 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chrX_+_28515479 0.854 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr9_+_12683385 0.847 NM_000550
TYRP1
tyrosinase-related protein 1
chr6_+_50894397 0.847 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr12_-_28016182 0.842 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr5_+_152850276 0.837 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr5_+_147562531 0.832 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr4_+_90252990 0.821 NM_145715
TIGD2
tigger transposable element derived 2
chr14_-_64479198 0.821 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_-_59819642 0.821 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_-_36836620 0.820 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr4_+_72423633 0.813 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr4_-_38710376 0.808 NM_024943
TMEM156
transmembrane protein 156
chr2_+_234266250 0.807 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_-_83071084 0.806 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr22_-_36836478 0.804 BAIAP2L2
BAI1-associated protein 2-like 2
chr2_+_113546365 0.797 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chrX_-_10504852 0.793 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr3_+_89239363 0.785 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr20_+_19863716 0.776 RIN2
Ras and Rab interactor 2
chr6_-_136888771 0.774 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr15_+_56217686 0.767 NM_020980
AQP9
aquaporin 9
chr10_-_31328426 0.761 NM_001143769
ZNF438
zinc finger protein 438
chr1_+_156229686 0.753 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_+_208568218 0.740 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr6_+_134800533 0.731 LOC154092
hypothetical LOC154092
chr9_-_116305273 0.730 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr8_-_122722674 0.728 NM_005328
HAS2
hyaluronan synthase 2
chr12_-_16650687 0.721 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_161981138 0.718 TBR1
T-box, brain, 1
chr14_+_22059212 0.718


chr10_+_101532544 0.713 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr15_-_59308708 0.707 RORA
RAR-related orphan receptor A
chr10_+_101532450 0.705 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_+_182040837 0.700 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_+_3341521 0.700 NM_198227
RGS12
regulator of G-protein signaling 12
chrX_-_64112993 0.699 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr5_-_22889487 0.699 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_16650697 0.695 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_139315011 0.694 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr4_-_87593306 0.692 NM_002753
MAPK10
mitogen-activated protein kinase 10
chrX_+_21960841 0.686 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr15_-_68781662 0.684 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_+_13903936 0.683 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_-_181889070 0.674 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr17_+_72982919 0.672 NM_001113495
SEPT9
septin 9
chr13_-_46368968 0.671 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr7_+_113842284 0.671 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_+_154520693 0.657 NM_032323
TMEM79
transmembrane protein 79
chr14_+_22059174 0.655


chr18_+_30544193 0.655 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr13_+_96726415 0.653 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_161981046 0.652 TBR1
T-box, brain, 1
chr13_-_37070862 0.650 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr11_-_123353607 0.644 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr6_+_136214495 0.641 NM_018945
PDE7B
phosphodiesterase 7B
chr15_+_75074793 0.636 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chrX_+_66705407 0.634 NM_001011645
AR
androgen receptor
chr4_-_68432293 0.631 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr10_+_95507555 0.627 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr4_+_68995761 0.625 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_221168388 0.625 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr3_-_101316038 0.623 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_-_21308415 0.622 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr20_-_49747397 0.621 ATP9A
ATPase, class II, type 9A
chr2_+_113542017 0.620 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr4_-_83566045 0.619


chr12_+_79362256 0.617 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr10_+_102113410 0.614


chr7_+_18501876 0.614 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr6_+_71192862 0.612 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr12_-_14024187 0.611 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_+_9871343 0.611 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr2_+_161980865 0.609 NM_006593
TBR1
T-box, brain, 1
chr15_-_59308770 0.605 NM_134261
RORA
RAR-related orphan receptor A
chr15_+_75074743 0.601 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr10_+_80743769 0.597 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_-_11598829 0.596 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr16_+_20682812 0.595 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_+_185064654 0.594 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr6_-_52882419 0.594 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr3_-_110155237 0.592 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr15_-_53996597 0.592 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr16_+_22432344 0.585 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr11_-_117305277 0.581 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr15_+_38849450 0.579 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr1_-_57057956 0.575 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr21_-_42219849 0.561 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_90552466 0.561 NM_001128215
LIPM
lipase, family member M
chr3_+_63928459 0.551 NM_001128149
ATXN7
ataxin 7
chrX_+_105823723 0.549 NM_024539
RNF128
ring finger protein 128
chr9_-_33455191 0.545 NOL6
nucleolar protein family 6 (RNA-associated)
chr12_-_10173947 0.544 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr5_-_39255335 0.543 NM_001465
NM_199335
FYB

FYN binding protein

chr10_-_105427898 0.540 SH3PXD2A
SH3 and PX domains 2A
chr4_-_57242492 0.539 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr10_+_24795446 0.534 KIAA1217
KIAA1217
chr12_+_39372456 0.532 NM_001843
NM_175038
CNTN1

contactin 1

chr12_+_8866416 0.532 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr20_-_33489383 0.531 NM_000557
GDF5
growth differentiation factor 5
chrX_-_133620103 0.524 NM_021796
PLAC1
placenta-specific 1
chr17_+_56843893 0.524 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr17_-_19290745 0.523


chr3_+_2528272 0.521 CNTN4
contactin 4
chr19_+_42689881 0.519 ZNF793
zinc finger protein 793
chr3_+_101316463 0.519 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr7_-_112513379 0.518 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr4_-_83566246 0.517 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_27133163 0.516 NM_153631
HOXA3
homeobox A3
chr20_-_62052922 0.515 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr3_+_160269734 0.514 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr1_-_155336223 0.512 NM_001004341
ETV3L
ets variant 3-like
chr11_+_117452995 0.510 TMPRSS4
transmembrane protease, serine 4
chr4_-_116254381 0.506 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr21_-_38955487 0.500 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_-_19703371 0.500 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr18_-_26996742 0.500 NM_004948
NM_024421
DSC1

desmocollin 1

chr20_+_9236446 0.499 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_40593074 0.496 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chrX_+_111005934 0.496 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr7_+_80113903 0.494 CD36
CD36 molecule (thrombospondin receptor)
chr4_-_176970895 0.493 GPM6A
glycoprotein M6A
chr21_-_35343331 0.491 RUNX1
runt-related transcription factor 1
chr4_-_176971175 0.490 NM_201591
GPM6A
glycoprotein M6A
chr14_+_51397134 0.488 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr8_-_110689396 0.488 SYBU
syntabulin (syntaxin-interacting)
chr11_+_126378507 0.486 NCRNA00288
non-protein coding RNA 288
chrX_-_43717864 0.486 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_-_42156913 0.484


chr8_-_102872614 0.477 NM_032041
NCALD
neurocalcin delta
chr12_-_6354650 0.476 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_42165740 0.475 TRAK1
trafficking protein, kinesin binding 1
chr3_+_42165829 0.471 TRAK1
trafficking protein, kinesin binding 1
chr5_+_140772691 0.470 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr8_-_67253234 0.468 NM_000756
CRH
corticotropin releasing hormone
chr7_-_87694218 0.466 NM_198901
SRI
sorcin
chr17_+_71232370 0.463 NM_001005619
ITGB4
integrin, beta 4
chr12_+_28301399 0.462 NM_018318
CCDC91
coiled-coil domain containing 91
chr18_+_18989786 0.462 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_+_54400417 0.462 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr1_+_50342168 0.451 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.49e-09 GO:0032501 multicellular organismal process
1.39 9.98e-06 GO:0032502 developmental process
1.38 1.96e-04 GO:0007275 multicellular organismal development
1.52 2.46e-04 GO:0030154 cell differentiation
1.41 6.07e-04 GO:0048731 system development
1.38 8.60e-04 GO:0048856 anatomical structure development
1.48 1.34e-03 GO:0048869 cellular developmental process
1.79 1.74e-03 GO:0009888 tissue development
1.52 2.83e-03 GO:0003008 system process
3.11 7.57e-03 GO:0034329 cell junction assembly
1.79 9.41e-03 GO:0007155 cell adhesion
1.79 9.41e-03 GO:0022610 biological adhesion
1.21 1.18e-02 GO:0050896 response to stimulus
2.94 1.19e-02 GO:0034330 cell junction organization
3.02 1.26e-02 GO:0007156 homophilic cell adhesion
3.02 1.26e-02 GO:0048589 developmental growth
1.78 1.32e-02 GO:2000026 regulation of multicellular organismal development
2.69 1.42e-02 GO:0030855 epithelial cell differentiation
1.46 1.49e-02 GO:0048513 organ development
2.02 1.64e-02 GO:0051094 positive regulation of developmental process
1.29 2.12e-02 GO:0023052 signaling
2.42 2.30e-02 GO:0040007 growth
1.55 3.14e-02 GO:0051239 regulation of multicellular organismal process
1.78 3.55e-02 GO:0045595 regulation of cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 2.42e-06 GO:0005886 plasma membrane
1.35 2.77e-06 GO:0071944 cell periphery
1.43 1.27e-03 GO:0005576 extracellular region
1.39 4.63e-03 GO:0044459 plasma membrane part
1.75 1.78e-02 GO:0030054 cell junction
1.17 3.71e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.58 1.70e-03 GO:0004888 transmembrane receptor activity
1.47 3.64e-03 GO:0004872 receptor activity
1.41 6.03e-03 GO:0004871 signal transducer activity
1.41 6.03e-03 GO:0060089 molecular transducer activity