Motif ID: NR5A1,2.p2

Z-value: 2.499


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2



Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_37576515 3.743 LOC157860
hypothetical protein LOC157860
chr15_+_60838053 3.227 TLN2
talin 2
chr5_+_176449156 2.931 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr7_+_29486010 2.889 NM_001039936
CHN2
chimerin (chimaerin) 2
chr22_+_19239221 2.573 MED15
mediator complex subunit 15
chr3_+_50281582 2.481 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr12_-_120781002 2.388 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr1_+_46413335 2.331 NM_005727
TSPAN1
tetraspanin 1
chr16_-_65510230 2.314 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr17_-_45626967 2.252


chr3_-_124821868 2.242 MYLK
myosin light chain kinase
chr17_+_37247568 2.196 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr11_-_118740069 2.117 NM_171997
USP2
ubiquitin specific peptidase 2
chr3_-_49435114 2.077 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr20_-_43889339 2.027 NM_003279
TNNC2
troponin C type 2 (fast)
chr7_+_30758269 2.002 NM_006774
INMT-FAM188B
INMT
INMT-FAM188B read-through transcript
indolethylamine N-methyltransferase
chr10_+_44726635 1.960 NM_001123376
TMEM72
transmembrane protein 72
chr17_+_1586034 1.949 WDR81
WD repeat domain 81
chr17_-_35774467 1.937 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr1_-_169888373 1.875 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr5_+_80564894 1.844 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr3_-_51971915 1.836 NM_033010
PCBP4
poly(rC) binding protein 4
chr2_-_32344192 1.828 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr3_-_124822113 1.824 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr2_-_105421661 1.818 NM_201557
FHL2
four and a half LIM domains 2
chr22_+_19458378 1.796 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr16_+_82540172 1.783 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr2_+_27358800 1.771 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr15_+_87540238 1.728 ABHD2
abhydrolase domain containing 2
chr12_+_7038240 1.715 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr1_-_224143389 1.712 NM_020997
LEFTY1
left-right determination factor 1
chr17_-_38421363 1.684 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr16_+_70646008 1.677 NM_001126102
NM_005143
HP

haptoglobin

chr9_+_33230165 1.641 NM_014471
SPINK4
serine peptidase inhibitor, Kazal type 4
chr20_-_44713466 1.639 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr1_-_27604656 1.636 WASF2
WAS protein family, member 2
chr17_-_45621571 1.603 COL1A1
collagen, type I, alpha 1
chr7_-_44071640 1.583 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr11_-_47427263 1.580 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr3_-_188492163 1.568 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr20_-_34921689 1.558 NM_199181
KIAA0889
KIAA0889
chr17_-_45621312 1.546 COL1A1
collagen, type I, alpha 1
chr6_-_2785682 1.517 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr11_-_118739838 1.482 USP2
ubiquitin specific peptidase 2
chr3_+_50281309 1.480 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr19_+_11211282 1.478 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr10_+_102722275 1.474 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr11_-_16380967 1.471 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr17_-_24972471 1.460 NM_032854
CORO6
coronin 6
chr3_+_50279993 1.439 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr16_+_30903963 1.435 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr7_+_100037817 1.433 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr3_+_52787478 1.425 NM_001166434
ITIH1
inter-alpha (globulin) inhibitor H1
chr18_+_606671 1.396 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr11_-_118722575 1.386 NM_015645
NM_031433
C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chrX_+_106030049 1.353 NM_001171092
CLDN2
claudin 2
chr22_+_29848923 1.328 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr22_+_19651446 1.326 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr1_+_2026014 1.302 NM_001033582
PRKCZ
protein kinase C, zeta
chr12_-_54392328 1.295 NM_001144997
ITGA7
integrin, alpha 7
chr1_+_46151845 1.271 MAST2
microtubule associated serine/threonine kinase 2
chr6_-_135312899 1.249 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr19_-_4468715 1.241 NM_001080400
PLIN4
perilipin 4
chr5_+_154072654 1.222 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr16_-_65781499 1.219 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr17_-_19231049 1.210 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr15_+_61676604 1.205 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr7_+_101704145 1.190 CUX1
cut-like homeobox 1
chr11_-_64284762 1.189 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr10_+_685887 1.188 C10orf108
chromosome 10 open reading frame 108
chr17_-_45619038 1.181 COL1A1
collagen, type I, alpha 1
chr5_-_148738980 1.180 NM_014443
IL17B
interleukin 17B
chr1_+_221168388 1.179 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr16_-_28515868 1.177 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_-_27473248 1.176 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr17_-_45626364 1.172


chr22_-_35938298 1.162 NM_001051
SSTR3
somatostatin receptor 3
chr11_+_7463175 1.150 NM_198474
OLFML1
olfactomedin-like 1
chr16_+_8722068 1.139 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr1_+_17817397 1.134 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_77110011 1.132 NM_001077182
NM_012418
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr17_-_77386156 1.131 DYSFIP1
dysferlin interacting protein 1
chr19_+_52113772 1.117 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr3_-_50580066 1.112 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr17_-_77386212 1.104 NM_001007533
DYSFIP1
dysferlin interacting protein 1
chr16_+_31391998 1.097 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_+_46651090 1.096 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr19_+_11510578 1.096 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr1_-_143708467 1.094 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_6768966 1.090 CD4
CD4 molecule
chr7_-_98643024 1.078 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr12_-_119249938 1.069 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr6_+_131190237 1.066 NM_001195597
LOC285733
hypothetical LOC285733
chr20_-_42249631 1.060 NM_020433
NM_175913
JPH2

junctophilin 2

chr8_-_13018123 1.058 NM_001164271
DLC1
deleted in liver cancer 1
chr6_-_46401363 1.057 NM_005822
RCAN2
regulator of calcineurin 2
chr1_+_16242833 1.051 NM_000085
CLCNKB
chloride channel Kb
chr2_+_85515428 1.050 NM_198482
SH2D6
SH2 domain containing 6
chr11_-_6418705 1.044 NM_000613
HPX
hemopexin
chr3_-_127719283 1.043 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr9_-_14900992 1.034 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr2_-_40510923 1.033 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr17_-_17426416 1.021 PEMT
phosphatidylethanolamine N-methyltransferase
chr12_-_88573949 1.012 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr1_+_15935395 1.008 NM_207348
SLC25A34
solute carrier family 25, member 34
chr17_-_74361620 1.004 TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_21701942 1.000 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr17_-_45621140 0.996


chr2_-_88208650 0.996 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_-_180621272 0.994 GLUL
glutamate-ammonia ligase
chr6_+_37360144 0.993 TBC1D22B
TBC1 domain family, member 22B
chr1_+_54132447 0.988 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr17_+_1595012 0.983 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr22_-_29290875 0.982 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr9_-_14769530 0.982 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr11_-_7941617 0.979 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr17_-_43390108 0.978 NM_024320
PRR15L
proline rich 15-like
chr22_-_35011703 0.974 MYH9
myosin, heavy chain 9, non-muscle
chr1_+_18680010 0.974 NM_152375
KLHDC7A
kelch domain containing 7A
chr17_+_35471971 0.969 NM_001190919
THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr17_+_3324096 0.969 NM_001128085
ASPA
aspartoacylase
chr1_-_42978320 0.966 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr16_+_22011362 0.966 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr2_-_165259334 0.961 COBLL1
COBL-like 1
chr1_+_54880014 0.959 NM_001039464
HEATR8-TTC4
HEATR8
HEATR8-TTC4 read-through transcript
HEAT repeat containing 8
chr3_-_52839727 0.956 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr4_+_37262249 0.945 NM_018302
C4orf19
chromosome 4 open reading frame 19
chr6_-_108252200 0.938 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr1_-_54392030 0.933 NM_201546
CDCP2
CUB domain containing protein 2
chr17_+_38250122 0.933 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chrX_-_24600661 0.930 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr19_-_47638890 0.925 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr6_+_42896771 0.924 NM_015349
KIAA0240
KIAA0240
chr16_-_23068010 0.906 NM_020718
USP31
ubiquitin specific peptidase 31
chr12_-_52975777 0.901 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr1_+_144124547 0.899 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr11_+_116205830 0.899 NM_000040
APOC3
apolipoprotein C-III
chr2_-_179380301 0.887 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr10_-_75085754 0.887 NM_001114133
SYNPO2L
synaptopodin 2-like
chr19_-_4486202 0.879 NM_001013706
PLIN5
perilipin 5
chr18_-_28606839 0.878 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr6_+_32114060 0.874 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr1_+_54786394 0.861 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr7_+_138859213 0.859 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr5_+_140848905 0.858 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr20_+_54420574 0.858 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr17_+_38306339 0.855 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr9_-_139262009 0.851 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr12_-_52975823 0.849 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_+_6768866 0.848 NM_000616
CD4
CD4 molecule
chr17_+_7474128 0.843 SHBG
sex hormone-binding globulin
chr2_-_201930311 0.842 NM_001127391
NM_139163
ALS2CR12

amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12

chr17_-_45620313 0.840


chr6_+_32090516 0.836 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr12_+_52708460 0.835 NM_004503
HOXC6
homeobox C6
chr16_+_620932 0.834 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr9_+_133154896 0.832 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr17_+_7474177 0.831 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr3_+_52803823 0.829 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr17_-_17426469 0.827 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr16_-_65984836 0.827 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr22_-_29231597 0.826 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr4_+_72321113 0.821 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chrX_-_39921525 0.818 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr19_-_54350457 0.817 NM_002152
HRC
histidine rich calcium binding protein
chr12_+_56299959 0.814 NM_133489
SLC26A10
solute carrier family 26, member 10
chr13_+_112825113 0.807 NM_000504
F10
coagulation factor X
chr17_+_71109734 0.801 MYO15B
myosin XVB pseudogene
chr6_+_43565192 0.799 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr16_-_11277806 0.797 NM_002762
PRM2
protamine 2
chr2_-_240728745 0.797 NM_148961
OTOS
otospiralin
chr2_+_108751033 0.797 RANBP2
RAN binding protein 2
chr20_-_3097070 0.796 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr5_-_42847716 0.796 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr5_-_41249270 0.790 NM_000065
C6
complement component 6
chr19_+_540849 0.789 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr3_+_120983556 0.787 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr1_-_206263170 0.787 PLXNA2
plexin A2
chr15_+_57691272 0.785 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_+_145297490 0.782 SH3RF2
SH3 domain containing ring finger 2
chr2_+_220007943 0.780 NM_005876
SPEG
SPEG complex locus
chr12_-_49878216 0.771 NM_002702
POU6F1
POU class 6 homeobox 1
chr3_-_49434874 0.770 AMT
aminomethyltransferase
chr22_+_16423147 0.769 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr3_-_12175339 0.764 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_1701313 0.763 NM_001198994
NADK
NAD kinase
chr1_+_149877955 0.763 SNX27
sorting nexin family member 27
chr17_+_45404677 0.758 DLX4
distal-less homeobox 4
chr8_+_145692916 0.758 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr8_-_59575249 0.757 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr12_+_107797985 0.755 NM_001917
DAO
D-amino-acid oxidase
chr5_+_139856688 0.754 ANKHD1
ankyrin repeat and KH domain containing 1
chr20_+_30019465 0.754 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr10_+_88418147 0.754 NM_001171610
LDB3
LIM domain binding 3
chr22_-_37569962 0.754 NM_014293
NPTXR
neuronal pentraxin receptor
chr2_+_54638957 0.753 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr16_+_3642940 0.748 NM_005223
DNASE1
deoxyribonuclease I
chr4_-_184480572 0.745 NM_001185149
CLDN24
claudin 24
chr12_+_52105131 0.744 AMHR2
anti-Mullerian hormone receptor, type II
chr2_-_42844705 0.743 NM_148962
OXER1
oxoeicosanoid (OXE) receptor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 4.56e-04 GO:0032501 multicellular organismal process
2.05 1.56e-03 GO:0007517 muscle organ development
1.27 2.49e-03 GO:0065008 regulation of biological quality
1.07 2.77e-03 GO:0009987 cellular process
1.96 7.53e-03 GO:0010817 regulation of hormone levels
1.97 1.86e-02 GO:0003012 muscle system process
1.99 2.63e-02 GO:0006936 muscle contraction
1.58 2.68e-02 GO:0006066 alcohol metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.38 7.46e-05 GO:0043292 contractile fiber
2.38 2.13e-04 GO:0044449 contractile fiber part
2.32 4.27e-04 GO:0030016 myofibril
5.77 7.63e-04 GO:0005833 hemoglobin complex
1.42 2.23e-03 GO:0005626 insoluble fraction
2.27 5.48e-03 GO:0030017 sarcomere
1.40 5.94e-03 GO:0005624 membrane fraction
1.32 1.41e-02 GO:0000267 cell fraction
1.22 2.44e-02 GO:0005576 extracellular region
1.61 4.60e-02 GO:0015629 actin cytoskeleton
1.42 4.66e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.32 3.96e-03 GO:0005344 oxygen transporter activity
6.59 2.62e-02 GO:0051393 alpha-actinin binding