Motif ID: IRF1,2,7.p3

Z-value: 3.628


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7



Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_88358946 8.483 FANCA
Fanconi anemia, complementation group A
chr1_+_78858675 5.973 NM_006820
IFI44L
interferon-induced protein 44-like
chr9_-_21375258 5.656 NM_000605
IFNA2
interferon, alpha 2
chr22_-_16080265 5.409 CECR1
cat eye syndrome chromosome region, candidate 1
chr9_+_5500544 5.018 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr8_+_39890484 4.567 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr11_-_63087430 4.390 NM_017878
HRASLS2
HRAS-like suppressor 2
chr20_-_55628852 4.382 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr22_-_34886727 4.124 NM_145640
APOL3
apolipoprotein L, 3
chr7_+_150013716 4.076 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr4_-_169476391 4.036 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_-_104274606 3.999 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr19_-_7672978 3.948 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr19_+_59866217 3.714 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr1_+_245646080 3.619 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr12_+_8499788 3.528 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr9_+_139758336 3.482 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr1_-_25164061 3.462 NM_001031680
RUNX3
runt-related transcription factor 3
chr19_-_47724365 3.459 NM_001024912
NM_001184813
NM_001184815
NM_001184816
NM_001712
CEACAM1




carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)




chr7_+_73826244 3.410 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr1_+_156416360 3.406 NM_001766
CD1D
CD1d molecule
chr19_+_59866237 3.380 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr2_+_6935246 3.333 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr18_+_59726183 3.237 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr11_+_1830763 3.148 NM_002339
LSP1
lymphocyte-specific protein 1
chr3_+_188568861 3.133 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr6_+_37081387 3.031 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chrX_+_110252960 3.013 NM_001128168
NM_001128172
NM_001128173
PAK3


p21 protein (Cdc42/Rac)-activated kinase 3


chr19_+_17495109 2.920 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr16_-_28425632 2.882 NM_145659
IL27
interleukin 27
chr5_+_156628929 2.881 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr6_+_116889248 2.845 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr11_-_18226743 2.788 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr6_+_31648071 2.778 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr4_-_77163609 2.776 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr9_-_21229975 2.713 NM_002172
IFNA14
interferon, alpha 14
chr21_+_41655786 2.706 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr7_-_5428043 2.639 TNRC18
trinucleotide repeat containing 18
chr19_-_46504831 2.617


chr6_+_88026338 2.613 ZNF292
zinc finger protein 292
chr21_-_33107813 2.560 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr19_-_44427446 2.544 NM_172139
IL28B
interleukin 28B (interferon, lambda 3)
chr11_-_104421240 2.488 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_+_38905053 2.474 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr9_-_21132143 2.470 NM_002177
IFNW1
interferon, omega 1
chr3_+_120904555 2.455 NM_033364
C3orf15
chromosome 3 open reading frame 15
chr13_+_30207668 2.449 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_+_6533932 2.421 NM_004271
LY86
lymphocyte antigen 86
chr16_-_49272617 2.407 SNX20
sorting nexin 20
chr12_+_8167494 2.397 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr3_+_2528272 2.368 CNTN4
contactin 4
chr9_-_21218132 2.360 NM_021268
IFNA17
interferon, alpha 17
chr11_+_71387572 2.339 NM_001039659
NM_001039660
NM_173042
IL18BP


interleukin 18 binding protein


chr9_-_21358005 2.327 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr17_+_18320822 2.282 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr16_-_49272741 2.281 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr7_+_128367961 2.270 NM_001098627
IRF5
interferon regulatory factor 5
chr19_+_6838576 2.256 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr4_-_40212670 2.199 NM_019027
RBM47
RNA binding motif protein 47
chr15_-_48192804 2.166 ATP8B4
ATPase, class I, type 8B, member 4
chr11_-_104399104 2.162 NM_001136109
NM_001136110
NM_001136112
NM_004347
CASP5



caspase 5, apoptosis-related cysteine peptidase



chr19_-_52427698 2.120 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr10_+_91077581 2.099 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr11_-_60880799 2.082 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr15_-_40537002 2.072 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr6_-_27948065 2.045 NM_003533
HIST1H3I
histone cluster 1, H3i
chr12_+_12115668 2.030 NM_030766
NM_138722
BCL2L14

BCL2-like 14 (apoptosis facilitator)

chr2_-_47771917 2.029 RPL18A
ribosomal protein L18a
chr1_+_157167965 2.004 NM_152501
NM_198928
NM_198929
NM_198930
PYHIN1



pyrin and HIN domain family, member 1



chr9_-_21067804 1.996 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr12_-_53064723 1.972 NM_015481
ZNF385A
zinc finger protein 385A
chr15_+_73278285 1.944 C15orf39
chromosome 15 open reading frame 39
chr11_+_18244383 1.917 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr11_-_58736897 1.911 NM_001039396
MPEG1
macrophage expressed 1
chrX_+_71280758 1.880 NM_207422
FLJ44635
TPT1-like protein
chr21_+_41714311 1.863 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_+_117345894 1.862 NM_004258
CD101
CD101 molecule
chr9_-_21340885 1.860 NM_021002
IFNA6
interferon, alpha 6
chr2_+_218641982 1.847 NM_198483
RUFY4
RUN and FYVE domain containing 4
chr13_+_30207690 1.846 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr8_+_18123456 1.846 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr19_-_59573869 1.844 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr17_-_31219943 1.830 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr7_-_149960218 1.828 GIMAP6
GTPase, IMAP family member 6
chr11_-_104477367 1.823 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr12_-_8584658 1.811 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr10_+_97461525 1.792 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr4_+_35962038 1.783 NM_001170700
DTHD1
death domain containing 1
chr10_+_82290554 1.781 NM_001145719
SH2D4B
SH2 domain containing 4B
chr17_-_37518213 1.756 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_+_157067729 1.753 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr12_+_111900650 1.725 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr10_+_91142301 1.723 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr8_-_27997306 1.719 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr2_-_175337386 1.717 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr12_+_111860684 1.717 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr5_-_77880731 1.715 LHFPL2
lipoma HMGIC fusion partner-like 2
chr2_+_68855436 1.708 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr15_-_40089736 1.680 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr1_+_219119358 1.678 NM_021958
HLX
H2.0-like homeobox
chr7_-_86433139 1.668 NM_152748
KIAA1324L
KIAA1324-like
chr12_+_111860609 1.650 NM_006187
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr12_+_111860384 1.646 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr9_+_5440455 1.616 NM_014143
CD274
CD274 molecule
chr11_+_72660894 1.610 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_-_40325194 1.604 LGI4
leucine-rich repeat LGI family, member 4
chr11_+_10439253 1.598 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr3_+_109504021 1.596 NM_007072
HHLA2
HERV-H LTR-associating 2
chr12_+_111829121 1.593 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr3_+_123526700 1.583 NM_005213
CSTA
cystatin A (stefin A)
chr1_+_78888064 1.580 NM_006417
IFI44
interferon-induced protein 44
chr1_-_9052253 1.573 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr1_+_89602023 1.571 NM_198460
GBP6
guanylate binding protein family, member 6
chr9_+_21430439 1.562 NM_024013
IFNA1
interferon, alpha 1
chr6_-_29635680 1.557 NM_006398
UBD
ubiquitin D
chr1_+_154390939 1.542 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_-_231697999 1.527 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr1_-_9052170 1.521 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_-_20318578 1.520 NM_012400
PLA2G2D
phospholipase A2, group IID
chr17_+_69939130 1.509 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chrX_-_1291526 1.508 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr19_-_18058632 1.500 NM_005535
NM_153701
IL12RB1

interleukin 12 receptor, beta 1

chr11_-_35235325 1.496 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr19_-_55091942 1.490 NM_152899
IL4I1
interleukin 4 induced 1
chr1_-_9052207 1.485 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr9_-_21156609 1.483 NM_002175
IFNA21
interferon, alpha 21
chr7_-_76667045 1.474 NM_006682
FGL2
fibrinogen-like 2
chr4_+_142777172 1.455 NM_000585
NM_172174
IL15

interleukin 15

chr16_+_10878539 1.434 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr19_+_44478804 1.432 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr10_+_91082218 1.424 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr11_-_104344473 1.406 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr22_+_34374358 1.393 NM_030641
APOL6
apolipoprotein L, 6
chr2_-_144991556 1.383 ZEB2
zinc finger E-box binding homeobox 2
chr14_-_94677807 1.383 NM_030621
DICER1
dicer 1, ribonuclease type III
chr17_-_35328368 1.379 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr8_+_79740813 1.378 NM_016010
FAM164A
family with sequence similarity 164, member A
chr1_-_155336223 1.377 NM_001004341
ETV3L
ets variant 3-like
chr9_-_21197141 1.374 NM_002171
IFNA10
interferon, alpha 10
chr1_+_158063278 1.367 SLAMF8
SLAM family member 8
chr1_+_219119430 1.367 HLX
H2.0-like homeobox
chr12_-_53064565 1.359 ZNF385A
zinc finger protein 385A
chrX_+_154263553 1.351 NM_001017991
NM_001017990
NM_080720
H2AFB2
H2AFB1
H2AFB3
H2A histone family, member B2
H2A histone family, member B1
H2A histone family, member B3
chr1_+_20353284 1.345


chr10_+_97505398 1.344 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr19_-_2233174 1.340 NM_198532
C19orf35
chromosome 19 open reading frame 35
chr2_+_204279624 1.331 CD28
CD28 molecule
chr16_+_56134077 1.331 NM_153837
GPR114
G protein-coupled receptor 114
chr4_+_160408447 1.312 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr11_+_63060848 1.300 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr2_-_230792844 1.292 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr1_+_24518501 1.258 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr8_-_82536312 1.234 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr12_+_12115139 1.227 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr19_-_56726704 1.211 NM_001177547
NM_001177548
NM_001177549
NM_001245
NM_198845
NM_198846
SIGLEC6





sialic acid binding Ig-like lectin 6





chr9_+_21399132 1.206 NM_002170
IFNA8
interferon, alpha 8
chr10_+_22765996 1.197 LOC100289455
hypothetical LOC100289455
chr17_-_40695216 1.189 NM_152343
C17orf46
chromosome 17 open reading frame 46
chr2_+_204279442 1.178 NM_006139
CD28
CD28 molecule
chr17_-_30783631 1.178 NM_018042
SLFN12
schlafen family member 12
chr1_+_24518398 1.167 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr21_-_42219849 1.165 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr4_+_86918870 1.164 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr1_+_100776280 1.157 NM_022049
GPR88
G protein-coupled receptor 88
chr22_+_36008465 1.156 CYTH4
cytohesin 4
chr16_+_56134037 1.140 GPR114
G protein-coupled receptor 114
chr2_-_88946767 1.135


chr11_+_5667392 1.129 TRIM22
tripartite motif containing 22
chr11_+_71388310 1.128 NM_001145057
IL18BP
interleukin 18 binding protein
chr3_+_46258875 1.126 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr7_+_10979978 1.119 NM_014660
PHF14
PHD finger protein 14
chrX_+_41433169 1.119 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr7_-_99604171 1.107 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr2_-_101134146 1.090 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_+_158063130 1.086 SLAMF8
SLAM family member 8
chr14_-_93512647 1.085 ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_242205556 1.076 NM_001164356
THAP4
THAP domain containing 4
chr12_+_9713472 1.074 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr4_-_77354011 1.064 NM_005506
SCARB2
scavenger receptor class B, member 2
chr9_-_35802142 1.062 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr17_-_15526917 1.054 NM_006470
TRIM16
tripartite motif containing 16
chr8_-_95343696 1.050 GEM
GTP binding protein overexpressed in skeletal muscle
chr9_-_21295311 1.049 NM_002169
IFNA5
interferon, alpha 5
chr10_-_35143900 1.039 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr4_-_169638146 1.026 DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr11_-_4585947 0.999 NM_018073
TRIM68
tripartite motif containing 68
chr3_+_51870684 0.997 NM_203424
IQCF2
IQ motif containing F2
chr2_-_225519974 0.990 DOCK10
dedicator of cytokinesis 10
chr3_-_162305319 0.987 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr1_-_89303478 0.985 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr17_+_69974116 0.976 NM_007261
CD300A
CD300a molecule
chr13_+_42034871 0.971 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_+_219119623 0.971 HLX
H2.0-like homeobox
chr3_+_120799411 0.967 NM_015900
PLA1A
phospholipase A1 member A
chr2_+_113389240 0.961 NM_173205
IL1F7
interleukin 1 family, member 7 (zeta)
chr7_-_99604127 0.958 GAL3ST4
galactose-3-O-sulfotransferase 4
chr17_-_4589387 0.955 CXCL16
chemokine (C-X-C motif) ligand 16
chr16_-_46823682 0.954 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr4_+_86918882 0.949 ARHGAP24
Rho GTPase activating protein 24
chr18_-_6404900 0.949 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.43 2.08e-19 GO:0034340 response to type I interferon
8.30 1.81e-18 GO:0060337 type I interferon-mediated signaling pathway
8.30 1.81e-18 GO:0071357 cellular response to type I interferon
2.14 1.36e-15 GO:0002376 immune system process
2.51 3.77e-15 GO:0006955 immune response
4.63 1.62e-14 GO:0009615 response to virus
3.07 1.26e-12 GO:0045087 innate immune response
2.30 2.23e-12 GO:0006952 defense response
9.96 9.92e-12 GO:0060338 regulation of type I interferon-mediated signaling pathway
3.70 4.42e-10 GO:0019221 cytokine-mediated signaling pathway
3.50 8.73e-10 GO:0071345 cellular response to cytokine stimulus
2.99 3.54e-09 GO:0034097 response to cytokine stimulus
2.58 4.17e-08 GO:0051707 response to other organism
2.33 3.70e-07 GO:0009607 response to biotic stimulus
2.41 4.45e-07 GO:0050776 regulation of immune response
1.95 5.63e-07 GO:0051704 multi-organism process
5.35 6.52e-07 GO:0001959 regulation of cytokine-mediated signaling pathway
5.27 9.02e-07 GO:0060759 regulation of response to cytokine stimulus
3.34 9.64e-07 GO:0045088 regulation of innate immune response
2.58 4.53e-06 GO:0031347 regulation of defense response
2.02 6.22e-06 GO:0002682 regulation of immune system process
3.45 2.98e-05 GO:0001819 positive regulation of cytokine production
2.20 9.85e-05 GO:0002684 positive regulation of immune system process
1.43 3.05e-04 GO:0006950 response to stress
2.00 9.76e-04 GO:0080134 regulation of response to stress
3.49 1.01e-03 GO:0050670 regulation of lymphocyte proliferation
3.45 1.20e-03 GO:0032944 regulation of mononuclear cell proliferation
1.21 1.73e-03 GO:0050896 response to stimulus
3.35 2.00e-03 GO:0070663 regulation of leukocyte proliferation
3.76 4.11e-03 GO:0002699 positive regulation of immune effector process
2.70 5.29e-03 GO:0050863 regulation of T cell activation
2.13 5.36e-03 GO:0044419 interspecies interaction between organisms
2.49 5.92e-03 GO:0051249 regulation of lymphocyte activation
1.44 8.24e-03 GO:0048583 regulation of response to stimulus
1.30 9.31e-03 GO:0007165 signal transduction
13.83 1.08e-02 GO:0060907 positive regulation of macrophage cytokine production
2.85 1.17e-02 GO:0050870 positive regulation of T cell activation
2.26 1.25e-02 GO:0001817 regulation of cytokine production
1.47 1.28e-02 GO:0023051 regulation of signaling
2.63 1.32e-02 GO:0051251 positive regulation of lymphocyte activation
1.18 1.35e-02 GO:0050794 regulation of cellular process
1.50 1.44e-02 GO:0009966 regulation of signal transduction
3.25 1.91e-02 GO:0051222 positive regulation of protein transport
2.50 2.27e-02 GO:0050867 positive regulation of cell activation
2.07 3.18e-02 GO:0044257 cellular protein catabolic process
1.25 3.44e-02 GO:0051716 cellular response to stimulus
11.85 3.59e-02 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
1.26 3.73e-02 GO:0023052 signaling
2.24 3.74e-02 GO:0050865 regulation of cell activation
1.16 3.81e-02 GO:0050789 regulation of biological process
1.74 4.05e-02 GO:0071310 cellular response to organic substance
1.76 4.30e-02 GO:0009057 macromolecule catabolic process
2.26 4.40e-02 GO:0002694 regulation of leukocyte activation
3.32 4.52e-02 GO:0034341 response to interferon-gamma
2.45 4.80e-02 GO:0002696 positive regulation of leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.53 2.65e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.59 5.56e-10 GO:0005126 cytokine receptor binding
3.25 2.60e-08 GO:0005125 cytokine activity
16.59 9.21e-08 GO:0005132 interferon-alpha/beta receptor binding