Motif ID: ETS1,2.p2

Z-value: 2.838


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)



Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_65152004 5.761


chr10_+_49562866 4.862 WDFY4
WDFY family member 4
chr7_+_50318801 4.641 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr6_+_31661934 4.604 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr22_+_35586950 3.770 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr19_+_16860871 3.459 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_+_16860807 3.433 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr16_+_28413421 3.403 NM_018690
APOBR
apolipoprotein B receptor
chr9_-_129707392 3.358 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_-_53044495 3.214 NM_020370
GPR84
G protein-coupled receptor 84
chr1_+_159899528 3.174 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr16_-_29664765 3.093 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr19_-_10311262 3.020 NM_002162
ICAM3
intercellular adhesion molecule 3
chr3_-_123223658 2.774 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr1_+_18680010 2.704 NM_152375
KLHDC7A
kelch domain containing 7A
chr3_-_184756101 2.700 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr3_+_47004457 2.698 NBEAL2
neurobeachin-like 2
chr1_-_155788775 2.614 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr2_+_113648020 2.606 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr19_+_16157198 2.568 NM_014077
FAM32A
family with sequence similarity 32, member A
chr19_+_17495109 2.565 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr2_+_102401580 2.530 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr9_+_263025 2.435 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_-_56825400 2.343 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr2_+_113648036 2.264 PSD4
pleckstrin and Sec7 domain containing 4
chr12_-_6615348 2.262 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr19_+_17723285 2.198 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr19_+_54530546 2.192 CD37
CD37 molecule
chr6_-_11490487 2.146 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_94766379 2.127 FGD3
FYVE, RhoGEF and PH domain containing 3
chr16_-_49272617 2.125 SNX20
sorting nexin 20
chr6_+_37081387 2.094 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr19_+_54530458 2.026 CD37
CD37 molecule
chr15_+_36776090 2.009 NM_207444
C15orf53
chromosome 15 open reading frame 53
chr1_-_181826086 1.926 NCF2
neutrophil cytosolic factor 2
chr3_+_188197029 1.910


chr3_-_13032130 1.881


chr17_-_3766708 1.850 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr19_+_54530512 1.850 CD37
CD37 molecule
chr19_+_63386193 1.815 NM_016324
NM_016325
NM_133502
ZNF274


zinc finger protein 274


chr3_-_180460372 1.810 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr19_+_54530485 1.807 NM_001040031
NM_001774
CD37

CD37 molecule

chr7_-_100078270 1.803 TFR2
transferrin receptor 2
chr1_-_111848265 1.785 NM_000677
NM_020683
ADORA3

adenosine A3 receptor

chr3_+_120799411 1.777 NM_015900
PLA1A
phospholipase A1 member A
chr3_+_32968069 1.775 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr19_+_54530497 1.759 CD37
CD37 molecule
chr11_+_60495690 1.745 NM_006725
CD6
CD6 molecule
chr9_-_70780574 1.737


chr9_-_139043035 1.708 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_-_72032519 1.698 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr17_-_35328368 1.691 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr11_+_66927955 1.674 TBC1D10C
TBC1 domain family, member 10C
chr3_-_126136261 1.669 NM_033049
MUC13
mucin 13, cell surface associated
chr9_+_135277264 1.659 ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr14_+_104462195 1.658 PLD4
phospholipase D family, member 4
chr15_+_79376295 1.656 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr22_-_35875890 1.635 NM_000878
IL2RB
interleukin 2 receptor, beta
chr6_+_31662454 1.633 NM_205837
LST1
leukocyte specific transcript 1
chr10_-_72032447 1.620 PRF1
perforin 1 (pore forming protein)
chr7_+_150065594 1.620 GIMAP5
GTPase, IMAP family member 5
chr2_+_68815416 1.617 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr4_-_185921384 1.603 ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_-_7855764 1.578 NM_001142389
NM_001172672
PNPLA4

patatin-like phospholipase domain containing 4

chr19_+_40632456 1.568 NM_005306
FFAR2
free fatty acid receptor 2
chr6_+_152053323 1.533 NM_001122742
ESR1
estrogen receptor 1
chr16_-_30301634 1.531 NM_052838
SEPT1
septin 1
chr12_+_9033403 1.523 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr22_+_42908548 1.520 PARVG
parvin, gamma
chr9_-_35608300 1.487 NM_001782
CD72
CD72 molecule
chr7_-_44985202 1.478 NM_033054
MYO1G
myosin IG
chr17_+_4283967 1.476 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr9_+_92629525 1.474 NM_001174167
SYK
spleen tyrosine kinase
chr1_+_202000906 1.462 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr19_+_47073029 1.453 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr14_+_102636233 1.452 NM_001077594
EXOC3L4
exocyst complex component 3-like 4
chr2_+_68855436 1.448 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr16_+_19329557 1.444 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr7_-_44985175 1.441 MYO1G
myosin IG
chr1_-_200395741 1.440 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr6_-_30188845 1.438 NM_007028
TRIM31
tripartite motif containing 31
chr16_+_29581783 1.435 NM_001030288
SPN
sialophorin
chr22_+_42908589 1.417 NM_001137606
PARVG
parvin, gamma
chr12_+_6926014 1.415 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_27825633 1.404 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr22_+_25398690 1.376 LOC388889
hypothetical LOC388889
chr12_-_109372481 1.371 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr16_+_30391460 1.358 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr19_-_1125257 1.357 SBNO2
strawberry notch homolog 2 (Drosophila)
chr11_+_65164767 1.352 SIPA1
signal-induced proliferation-associated 1
chr5_+_57823017 1.335 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr19_-_60483302 1.332 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr21_+_41663853 1.331 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr12_-_56157898 1.330 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr22_+_33792125 1.319 NM_001008494
ISX
intestine-specific homeobox
chr7_-_44985084 1.312 MYO1G
myosin IG
chr19_-_1125263 1.304 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr22_+_42908612 1.301 PARVG
parvin, gamma
chr1_+_26744893 1.298 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_53153639 1.296 NM_144594
GTSF1
gametocyte specific factor 1
chr11_+_1818007 1.296 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr7_+_150065376 1.285 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr20_+_61654816 1.282 NM_024059
C20orf195
chromosome 20 open reading frame 195
chr1_-_205161821 1.281 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr11_+_59979857 1.281 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr19_-_1125201 1.272


chr6_+_31662954 1.271 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr12_+_6925997 1.268 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr14_+_20319049 1.267 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr14_-_106064887 1.258 LOC100126583
IGHV3-48
IGHA1
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 3-48
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant mu
chr12_+_53241365 1.254 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_-_181826292 1.250 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr15_-_41879426 1.248 NM_001033517
SERINC4
serine incorporator 4
chr2_-_120697382 1.242 TMEM185B
transmembrane protein 185B (pseudogene)
chr1_-_159306273 1.236 ARHGAP30
Rho GTPase activating protein 30
chr12_-_109372489 1.232 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr17_-_20311411 1.226 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr1_-_31003260 1.222 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr12_+_55018925 1.221 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr21_+_44597911 1.216 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr6_-_133120587 1.214 NM_004665
VNN2
vanin 2
chr17_-_35975227 1.208 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_+_30391550 1.207 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr15_-_38387164 1.207 PLCB2
phospholipase C, beta 2
chr2_-_120697148 1.204 TMEM185B
transmembrane protein 185B (pseudogene)
chr14_+_104462260 1.199 PLD4
phospholipase D family, member 4
chr1_+_32489426 1.194 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr1_-_159306210 1.178 ARHGAP30
Rho GTPase activating protein 30
chrX_+_151636039 1.176 NM_153488
MAGEA2B
MAGEA2
melanoma antigen family A, 2B
melanoma antigen family A, 2
chr10_-_50066386 1.173 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr19_-_48977247 1.168 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_+_30212488 1.152 NM_138700
TRIM40
tripartite motif containing 40
chr14_+_59782222 1.150 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr1_+_26744929 1.148 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_109611934 1.144 NM_001040107
HVCN1
hydrogen voltage-gated channel 1
chr22_-_16080265 1.139 CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_56841819 1.137 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr12_-_6611075 1.130 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr7_-_3049872 1.123 NM_032415
CARD11
caspase recruitment domain family, member 11
chr10_-_97190885 1.118 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr2_-_96174865 1.116 NM_004418
DUSP2
dual specificity phosphatase 2
chr14_+_104462210 1.106 NM_138790
PLD4
phospholipase D family, member 4
chr14_+_104462199 1.102 PLD4
phospholipase D family, member 4
chr16_+_28903647 1.095 NM_001014989
LAT
linker for activation of T cells
chr12_-_8271460 1.089 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr14_-_106289751 1.086 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_+_35031185 1.084 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr10_-_6144119 1.076 NM_000417
IL2RA
interleukin 2 receptor, alpha
chrX_-_7855400 1.069 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr15_-_38387410 1.068 NM_004573
PLCB2
phospholipase C, beta 2
chr12_+_91620749 1.068 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr22_+_36008465 1.067 CYTH4
cytohesin 4
chr9_-_99740243 1.067 NM_197978
HEMGN
hemogen
chr8_-_127032577 1.066 LOC100130231
similar to hCG1814455
chr1_-_155374793 1.065 NM_005240
NM_001145312
ETV3

ets variant 3

chr11_-_67528103 1.065 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr17_+_18320822 1.063 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr7_+_149779011 1.063 GIMAP8
GTPase, IMAP family member 8
chr21_-_45165302 1.058 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_-_107257205 1.054 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr1_-_159306037 1.052 ARHGAP30
Rho GTPase activating protein 30
chr16_-_49272741 1.049 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chrX_-_31000079 1.046 NM_031894
FTHL17
ferritin, heavy polypeptide-like 17
chr22_+_36008511 1.040 CYTH4
cytohesin 4
chr12_-_53153613 1.036 GTSF1
gametocyte specific factor 1
chrX_-_40479718 1.035 NM_004229
MED14
mediator complex subunit 14
chr16_+_28903870 1.034 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr2_-_120697441 1.026 TMEM185B
transmembrane protein 185B (pseudogene)
chr12_-_109372517 1.024 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr19_-_4491024 1.019 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr12_-_50004102 1.018 BIN2
bridging integrator 2
chr19_-_4491078 1.012 LRG1
leucine-rich alpha-2-glycoprotein 1
chr12_-_56159631 1.011 NM_001080157
ARHGAP9
Rho GTPase activating protein 9
chr12_-_109372535 1.008 NM_005719
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_-_210654858 1.004 TMEM206
transmembrane protein 206
chr19_-_13074973 1.001 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr8_-_21827057 0.998 NM_003974
DOK2
docking protein 2, 56kDa
chrX_-_40480005 0.990 MED14
mediator complex subunit 14
chr15_+_41879912 0.989 NM_016400
C15orf63
chromosome 15 open reading frame 63
chr1_-_210654862 0.982 NM_001198862
NM_018252
TMEM206

transmembrane protein 206

chr19_-_60483256 0.981 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr13_-_98708549 0.980 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_71280758 0.966 NM_207422
FLJ44635
TPT1-like protein
chr14_+_99601498 0.964 NM_016337
EVL
Enah/Vasp-like
chr12_-_101396459 0.963 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr11_-_117589283 0.961 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_-_158815895 0.959 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chrX_+_128741562 0.959 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_-_40479607 0.958 MED14
mediator complex subunit 14
chr15_+_41880074 0.957 C15orf63
chromosome 15 open reading frame 63
chrX_+_128741578 0.956 SASH3
SAM and SH3 domain containing 3
chr1_+_245646080 0.955 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr1_+_111217314 0.955 CD53
CD53 molecule
chr17_+_18971506 0.954 NM_001129778
GRAPL
GRB2-related adaptor protein-like
chr10_-_98021144 0.948 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_-_106184988 0.947 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_158883666 0.947 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr1_+_111217244 0.946 NM_000560
CD53
CD53 molecule
chr4_-_10295412 0.940 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr16_+_29582065 0.936 SPN
sialophorin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.52 7.65e-11 GO:0002376 immune system process
1.85 2.05e-10 GO:0001775 cell activation
2.12 5.21e-08 GO:0030168 platelet activation
1.31 1.51e-05 GO:0048583 regulation of response to stimulus
1.65 1.98e-05 GO:0007599 hemostasis
1.64 2.51e-05 GO:0007596 blood coagulation
1.64 2.51e-05 GO:0050817 coagulation
1.66 4.96e-05 GO:0050776 regulation of immune response
1.58 5.56e-05 GO:0050878 regulation of body fluid levels
1.12 5.74e-05 GO:0065007 biological regulation
1.52 5.96e-05 GO:0002682 regulation of immune system process
1.46 6.11e-04 GO:0006955 immune response
1.17 7.69e-04 GO:0044260 cellular macromolecule metabolic process
1.31 1.70e-03 GO:0009966 regulation of signal transduction
1.50 1.72e-03 GO:0042060 wound healing
1.12 1.75e-03 GO:0050794 regulation of cellular process
2.45 2.04e-03 GO:0002576 platelet degranulation
1.22 2.08e-03 GO:0048518 positive regulation of biological process
1.58 2.23e-03 GO:0002684 positive regulation of immune system process
1.26 2.37e-03 GO:0043412 macromolecule modification
1.27 2.80e-03 GO:0006464 protein modification process
1.78 2.96e-03 GO:0045321 leukocyte activation
1.11 3.18e-03 GO:0050789 regulation of biological process
1.18 3.65e-03 GO:0007165 signal transduction
2.26 3.84e-03 GO:0050851 antigen receptor-mediated signaling pathway
2.18 4.21e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.21 9.89e-03 GO:0048522 positive regulation of cellular process
2.14 1.20e-02 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.60 1.32e-02 GO:0018193 peptidyl-amino acid modification
1.38 1.73e-02 GO:0048584 positive regulation of response to stimulus
1.13 2.05e-02 GO:0043170 macromolecule metabolic process
1.15 2.44e-02 GO:0019222 regulation of metabolic process
3.80 2.75e-02 GO:0050853 B cell receptor signaling pathway
1.16 2.96e-02 GO:0031323 regulation of cellular metabolic process
1.06 3.03e-02 GO:0009987 cellular process
1.16 3.12e-02 GO:0080090 regulation of primary metabolic process
1.24 4.99e-02 GO:0016070 RNA metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.38 1.50e-02 GO:0031091 platelet alpha granule
2.25 2.97e-02 GO:0031256 leading edge membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 7.59e-06 GO:0005515 protein binding
1.37 9.93e-03 GO:0042802 identical protein binding
4.51 1.31e-02 GO:0042974 retinoic acid receptor binding
2.70 2.54e-02 GO:0003823 antigen binding
1.59 4.14e-02 GO:0032403 protein complex binding