Motif ID: STAT2,4,6.p2

Z-value: 1.355


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced



Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_2743613 1.510 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr3_+_189353502 1.459 LPP
LIM domain containing preferred translocation partner in lipoma
chr10_+_75343352 1.302 PLAU
plasminogen activator, urokinase
chr19_-_49552638 1.281 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr20_+_30409649 1.088 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr10_+_95838801 1.071 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr20_-_48741481 0.994


chr19_+_49248003 0.977 NM_013361
ZNF223
zinc finger protein 223
chr5_+_71538456 0.951 MAP1B
microtubule-associated protein 1B
chr15_+_60838053 0.941 TLN2
talin 2
chr14_+_95792299 0.926 NM_000710
BDKRB1
bradykinin receptor B1
chr12_+_7038240 0.901 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr3_-_71376919 0.887 FOXP1
forkhead box P1
chr11_-_116168316 0.838 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr14_+_94148466 0.771 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_+_54700955 0.749 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr11_+_57121602 0.717 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_52839727 0.716 NM_001166449
NM_002218
ITIH4

inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)

chr11_-_85115105 0.714 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr11_+_57122153 0.713 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_156876798 0.698 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr12_-_7136147 0.698 NM_001733
C1R
complement component 1, r subcomponent
chrX_+_106030049 0.697 NM_001171092
CLDN2
claudin 2
chr1_-_27565923 0.686 NM_004672
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr9_+_135994734 0.686 NM_052821
WDR5
WD repeat domain 5
chr5_+_149867866 0.682 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr6_-_27548438 0.671 NM_007149
ZNF184
zinc finger protein 184
chr8_-_27525084 0.666 NM_001171138
CLU
clusterin
chr12_-_47532171 0.660 NM_004818
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr2_-_218516950 0.654 NM_022648
TNS1
tensin 1
chr12_-_7136189 0.652 C1R
complement component 1, r subcomponent
chr6_-_56615544 0.630 NM_001723
NM_015548
DST

dystonin

chr22_+_29848923 0.628 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr9_+_676640 0.617


chr5_+_176449156 0.616 NM_022963
FGFR4
fibroblast growth factor receptor 4
chrX_-_48661226 0.614 NM_006875
PIM2
pim-2 oncogene
chr16_+_14187965 0.572 MKL2
MKL/myocardin-like 2
chr19_+_702108 0.564 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr5_+_145296313 0.560 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr17_+_36515166 0.536 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr3_+_137224266 0.530 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr3_-_139315011 0.529 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr6_-_56824672 0.528 DST
dystonin
chrX_+_109548940 0.523 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr2_-_178645718 0.514 NM_016953
PDE11A
phosphodiesterase 11A
chr7_-_100667750 0.513 NM_014343
CLDN15
claudin 15
chr17_+_7199178 0.513 NM_198154
TMEM95
transmembrane protein 95
chr16_+_4485859 0.509 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr1_-_20682541 0.506


chr8_-_27524744 0.505 NM_203339
CLU
clusterin
chr9_-_116920232 0.505 NM_002160
TNC
tenascin C
chr9_+_22103542 0.502 CDKN2B-AS1
CDKN2B antisense RNA 1 (non-protein coding)
chr20_-_49747397 0.502 ATP9A
ATPase, class II, type 9A
chr21_-_34749908 0.500 NM_001127670
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr19_+_15079141 0.492 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_33554824 0.488 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_+_52243645 0.487 NM_002806
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr8_-_130868315 0.487 NM_031415
GSDMC
gasdermin C
chr20_-_47963682 0.479 NM_001135773
SPATA2
spermatogenesis associated 2
chr1_-_228916958 0.478 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_38979178 0.471 NM_001079675
ETV4
ets variant 4
chr1_+_154520693 0.469 NM_032323
TMEM79
transmembrane protein 79
chr10_-_121346517 0.469 NM_001033925
NM_003252
TIAL1

TIA1 cytotoxic granule-associated RNA binding protein-like 1

chr8_+_70567581 0.466 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr19_+_54996613 0.464


chr8_-_37847095 0.461 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr1_-_11029882 0.460 MASP2
mannan-binding lectin serine peptidase 2
chr3_+_11153778 0.456 NM_001098213
HRH1
histamine receptor H1
chr11_+_7463175 0.452 NM_198474
OLFML1
olfactomedin-like 1
chr1_-_228916559 0.450 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr8_-_124734346 0.448 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr16_-_55259405 0.447 NM_005950
MT1G
metallothionein 1G
chr1_-_228916486 0.445 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr10_-_126706442 0.443 NM_022802
CTBP2
C-terminal binding protein 2
chr19_+_49361054 0.443 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr16_+_24696069 0.442 TNRC6A
trinucleotide repeat containing 6A
chr11_+_45072139 0.442 NM_020229
PRDM11
PR domain containing 11
chr16_+_30903963 0.440 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr1_-_228916470 0.439 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_+_10642648 0.435 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_-_75650355 0.433 NM_032181
FAM176A
family with sequence similarity 176, member A
chr6_+_45404031 0.432 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr10_-_121346464 0.422 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr1_-_111908085 0.422 NM_001081976
ADORA3
adenosine A3 receptor
chr2_-_105421661 0.418 NM_201557
FHL2
four and a half LIM domains 2
chr16_-_28457728 0.417 NUPR1
nuclear protein, transcriptional regulator, 1
chr12_-_6356783 0.416 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr19_-_47438518 0.411 GSK3A
glycogen synthase kinase 3 alpha
chr3_-_188935363 0.407 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr5_-_16561936 0.407 NM_019000
FAM134B
family with sequence similarity 134, member B
chr8_-_127639892 0.406 NM_174911
FAM84B
family with sequence similarity 84, member B
chr1_-_33613729 0.404 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_+_34405070 0.403 NM_032884
C1orf94
chromosome 1 open reading frame 94
chr1_-_171441234 0.403 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr16_+_68516401 0.400 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr3_+_173043832 0.399 NM_001164436
TMEM212
transmembrane protein 212
chr5_+_57914658 0.399 NM_138453
RAB3C
RAB3C, member RAS oncogene family
chr16_+_2025922 0.398 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr12_-_118725672 0.397 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr1_-_11029737 0.394 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr3_-_158700036 0.393 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr4_-_186934059 0.392 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr9_-_131555111 0.391 NM_004878
PTGES
prostaglandin E synthase
chr14_+_23849196 0.389 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr13_+_75092570 0.389 NM_005358
LMO7
LIM domain 7
chr11_-_11986704 0.388 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr9_-_90456824 0.388 NM_001100111
LOC286238
hypothetical protein LOC286238
chr22_+_38090120 0.387 NM_145738
SYNGR1
synaptogyrin 1
chr16_+_29378694 0.385 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr6_+_31190505 0.383 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr3_-_102888090 0.381 NM_000986
RPL24
ribosomal protein L24
chr12_+_79362256 0.380 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr7_+_129634935 0.379 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr5_+_131437383 0.378 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_+_134114912 0.376 CALD1
caldesmon 1
chr7_-_133652042 0.374 SLC35B4
solute carrier family 35, member B4
chr16_-_15644465 0.369 NM_001184998
NM_001184999
NM_014647
KIAA0430


KIAA0430


chr1_+_154120170 0.369 SYT11
synaptotagmin XI
chr8_-_120720200 0.366 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr7_+_134114957 0.365 CALD1
caldesmon 1
chr8_+_70567634 0.363 SULF1
sulfatase 1
chr5_-_111340421 0.362 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr19_-_47438548 0.360 GSK3A
glycogen synthase kinase 3 alpha
chr3_+_52803823 0.358 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr16_+_15644624 0.357 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr9_+_124836666 0.356 NM_005294
GPR21
G protein-coupled receptor 21
chr3_-_48607596 0.356 NM_000094
COL7A1
collagen, type VII, alpha 1
chr14_+_54238581 0.356 SAMD4A
sterile alpha motif domain containing 4A
chr19_-_47438563 0.356 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr14_-_22516271 0.356 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr17_-_51155073 0.354 NM_018286
TMEM100
transmembrane protein 100
chr7_-_83116414 0.351 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr1_-_151788341 0.349 NM_002960
S100A3
S100 calcium binding protein A3
chr15_-_53996597 0.344 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr12_-_51200347 0.344 NM_000424
KRT5
keratin 5
chr15_+_79304694 0.342 NM_172217
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr5_+_140454382 0.342 NM_018936
PCDHB2
protocadherin beta 2
chr2_-_180319013 0.341 NM_001113397
ZNF385B
zinc finger protein 385B
chr1_-_36589744 0.339


chr9_+_130722994 0.338 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr5_+_150008030 0.338 SYNPO
synaptopodin
chr5_-_140875591 0.332 DIAPH1
diaphanous homolog 1 (Drosophila)
chr7_-_149669622 0.330 NM_002889
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr16_-_66535923 0.330 SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr22_-_29866339 0.329 NM_015715
PLA2G3
phospholipase A2, group III
chr6_-_18372617 0.328 NM_001134709
NM_003472
DEK

DEK oncogene

chr3_+_186483408 0.328 LOC100505749
MAP3K13
hypothetical LOC100505749
mitogen-activated protein kinase kinase kinase 13
chr6_-_116973465 0.328 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr14_+_37746937 0.327 NM_001049
SSTR1
somatostatin receptor 1
chr16_-_28457825 0.326 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr7_-_14847479 0.322 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr4_-_87593306 0.316 NM_002753
MAPK10
mitogen-activated protein kinase 10
chr11_-_8788765 0.316 NM_213618
ST5
suppression of tumorigenicity 5
chr11_-_62218759 0.314 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr9_+_116943917 0.313 NM_017418
DEC1
deleted in esophageal cancer 1
chr10_+_92621677 0.312 NM_001104546
NM_006413
RPP30

ribonuclease P/MRP 30kDa subunit

chr5_+_145807059 0.310 NM_001040006
NM_006706
TCERG1

transcription elongation regulator 1

chr3_-_64186151 0.308 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr17_+_29606408 0.307 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr6_-_56824371 0.307 DST
dystonin
chr6_-_26393705 0.307 NM_003543
HIST1H4H
histone cluster 1, H4h
chr17_-_36528113 0.306 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr12_-_68369322 0.305 NM_152439
BEST3
bestrophin 3
chr5_+_178300799 0.304 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr6_-_42218692 0.299 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr19_-_54258935 0.297 NM_006179
NTF4
neurotrophin 4
chr10_-_116434364 0.297 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr11_-_66431910 0.296 NM_022172
PC
pyruvate carboxylase
chr18_+_30427279 0.296 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr14_-_50204771 0.295 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr3_+_189354167 0.295 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_+_19458378 0.294 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr14_-_22468393 0.293 PRMT5
protein arginine methyltransferase 5
chr4_-_40326603 0.292 NM_001098634
RBM47
RNA binding motif protein 47
chr4_+_122941921 0.285 NM_001034194
NM_005033
EXOSC9

exosome component 9

chr19_+_61742111 0.285 NM_020828
ZFP28
zinc finger protein 28 homolog (mouse)
chr12_+_52180971 0.285 NM_004178
NM_134323
TARBP2

TAR (HIV-1) RNA binding protein 2

chr12_+_50913220 0.284 NM_005556
KRT7
keratin 7
chr14_-_50204791 0.283 SAV1
salvador homolog 1 (Drosophila)
chr5_+_172415891 0.283 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr14_-_24588916 0.282 NM_014178
STXBP6
syntaxin binding protein 6 (amisyn)
chr2_+_234624084 0.281 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr15_+_46411646 0.280 NM_001948
DUT
deoxyuridine triphosphatase
chr12_+_50913274 0.278 KRT7
keratin 7
chr19_-_47438583 0.277 GSK3A
glycogen synthase kinase 3 alpha
chr7_-_87774130 0.277 NM_024636
STEAP4
STEAP family member 4
chr3_+_116824840 0.274 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr14_+_37748031 0.272 SSTR1
somatostatin receptor 1
chr9_-_130526192 0.272 NM_032799
ZDHHC12
zinc finger, DHHC-type containing 12
chr6_+_36752244 0.270 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr7_+_21434097 0.269 NM_003112
SP4
Sp4 transcription factor
chr5_+_67558217 0.268 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr22_+_40286957 0.268 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr5_-_138238877 0.267 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr5_+_149717489 0.266 TCOF1
Treacher Collins-Franceschetti syndrome 1
chr3_+_45042754 0.264 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr16_+_70646008 0.263 NM_001126102
NM_005143
HP

haptoglobin

chr22_-_35011703 0.262 MYH9
myosin, heavy chain 9, non-muscle
chr6_+_36754433 0.261 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr5_+_149717394 0.259 NM_000356
NM_001008657
NM_001135243
NM_001135244
NM_001135245
NM_001195141
TCOF1





Treacher Collins-Franceschetti syndrome 1






Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.56 2.93e-02 GO:0016032 viral reproduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.25e-05 GO:0005737 cytoplasm
1.07 6.64e-05 GO:0044424 intracellular part
1.07 3.31e-04 GO:0005622 intracellular
1.11 1.47e-02 GO:0044446 intracellular organelle part
1.11 2.00e-02 GO:0044422 organelle part
1.07 2.75e-02 GO:0043227 membrane-bounded organelle
1.07 3.06e-02 GO:0043226 organelle
1.07 3.68e-02 GO:0043231 intracellular membrane-bounded organelle
1.07 4.07e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.96e-05 GO:0005515 protein binding
1.05 1.85e-02 GO:0005488 binding