Motif ID: JUN.p2

Z-value: 2.235


Transcription factors associated with JUN.p2:

Gene SymbolEntrez IDGene Name
JUN 3725 jun oncogene
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene



Activity profile for motif JUN.p2.

activity profile for motif JUN.p2


Sorted Z-values histogram for motif JUN.p2

Sorted Z-values for motif JUN.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of JUN.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_129379947 4.022 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr11_-_5487728 3.226 NM_017481
UBQLN3
ubiquilin 3
chr1_+_26368969 3.134 NM_015871
ZNF593
zinc finger protein 593
chr1_-_152394215 3.054 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr11_-_118740069 2.878 NM_171997
USP2
ubiquitin specific peptidase 2
chr1_+_110328850 2.576 AHCYL1
adenosylhomocysteinase-like 1
chr1_+_110328941 2.246 AHCYL1
adenosylhomocysteinase-like 1
chr3_+_188222337 2.213 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_-_56919032 2.211 NM_001523
HAS1
hyaluronan synthase 1
chr11_-_118739838 2.125 USP2
ubiquitin specific peptidase 2
chr2_+_219991342 1.997 NM_001927
DES
desmin
chr7_+_134483305 1.970 NM_018295
TMEM140
transmembrane protein 140
chr9_-_19023183 1.821 NM_153707
FAM154A
family with sequence similarity 154, member A
chr11_-_8636958 1.762 NM_014818
TRIM66
tripartite motif containing 66
chr8_-_142446546 1.757 NM_005293
GPR20
G protein-coupled receptor 20
chr9_+_129900590 1.719 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr2_-_26554413 1.712 NM_004802
NM_194322
NM_194323
OTOF


otoferlin


chr7_+_116447499 1.693 ST7
suppression of tumorigenicity 7
chr1_+_110328830 1.682 NM_006621
AHCYL1
adenosylhomocysteinase-like 1
chr2_-_74455161 1.668 NM_001135041
NM_023019
DCTN1

dynactin 1

chr7_+_30927439 1.638 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr1_-_149955870 1.627 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr19_-_53941835 1.620 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr4_-_187884721 1.574


chr1_+_110328955 1.527 AHCYL1
adenosylhomocysteinase-like 1
chr15_-_81037554 1.492 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr6_-_32184975 1.474 NM_019105
TNXB
tenascin XB
chr1_+_22251706 1.454 NM_001039802
NM_001791
NM_044472
CDC42


cell division cycle 42 (GTP binding protein, 25kDa)


chr20_+_55569542 1.453 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr21_+_34112456 1.449 ITSN1
intersectin 1 (SH3 domain protein)
chr1_+_110328922 1.445 AHCYL1
adenosylhomocysteinase-like 1
chr11_-_111287657 1.443 NM_001885
CRYAB
crystallin, alpha B
chr1_+_111217314 1.441 CD53
CD53 molecule
chr19_+_11510578 1.427 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr22_+_40286957 1.423 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr9_-_33392505 1.420 NM_001170
AQP7
aquaporin 7
chr1_-_160613203 1.417 NM_182581
C1orf111
chromosome 1 open reading frame 111
chr3_+_38181972 1.416 NM_005109
OXSR1
oxidative-stress responsive 1
chr22_+_20101661 1.411 NM_015094
HIC2
hypermethylated in cancer 2
chr14_+_59782222 1.401 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr10_+_50177192 1.379 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr16_-_3008162 1.367 NM_021195
CLDN6
claudin 6
chr9_+_133154896 1.359 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr3_+_142569988 1.351 ZBTB38
zinc finger and BTB domain containing 38
chr16_-_45339605 1.338 NM_182493
MYLK3
myosin light chain kinase 3
chr1_+_201541241 1.314 BTG2
BTG family, member 2
chr7_-_112515068 1.311 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr12_+_130004404 1.296 NM_198827
GPR133
G protein-coupled receptor 133
chr11_-_2149591 1.292 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr5_+_34723420 1.286 NM_001145523
RAI14
retinoic acid induced 14
chr7_-_44992729 1.253 C7orf40
chromosome 7 open reading frame 40
chr11_-_5178505 1.250 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr7_+_116447527 1.245 ST7
suppression of tumorigenicity 7
chr7_-_112515035 1.226 GPR85
G protein-coupled receptor 85
chr1_-_152431175 1.206 NM_152263
TPM3
tropomyosin 3
chr20_-_34635091 1.169


chr8_-_18710575 1.166 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_51660328 1.161 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr11_+_72203111 1.158 ATG16L2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr9_+_129900637 1.149 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr1_+_9522107 1.148 NM_032315
SLC25A33
solute carrier family 25, member 33
chr6_+_118976134 1.145 NM_002667
PLN
phospholamban
chr7_-_112514990 1.133 GPR85
G protein-coupled receptor 85
chr1_+_29086206 1.128 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr12_+_105692466 1.125 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr10_-_106083652 1.118 NM_033397
ITPRIP
inositol 1,4,5-triphosphate receptor interacting protein
chr9_-_33392463 1.112 AQP7
aquaporin 7
chr19_+_54067450 1.109 NM_014330
PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr1_+_201541269 1.095 NM_006763
BTG2
BTG family, member 2
chr19_-_54231884 1.059 NM_033377
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr7_+_128099581 1.055 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr3_+_197851052 1.049 NM_198565
LRRC33
leucine rich repeat containing 33
chr9_-_33392583 1.047 AQP7
aquaporin 7
chr1_+_29086156 1.040 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr18_+_22060383 1.040 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr4_+_75529716 1.039 NM_001657
AREG
amphiregulin
chr1_-_180822686 1.038 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr7_-_137271191 1.028 CREB3L2
cAMP responsive element binding protein 3-like 2
chr9_+_36159384 1.025 NM_005893
CCIN
calicin
chr1_-_1283770 1.023 NM_032348
MXRA8
matrix-remodelling associated 8
chr7_-_104696678 1.017 NM_182691
SRPK2
SRSF protein kinase 2
chr16_-_87300233 1.013 NM_001171815
RNF166
ring finger protein 166
chr10_+_35524060 1.005 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr19_+_54226941 0.996 NM_033378
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr6_+_39868116 0.991


chr11_-_62213577 0.984 LRRN4CL
LRRN4 C-terminal like
chr20_+_34635362 0.978 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr12_+_12829807 0.967 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr19_-_15421761 0.960 NM_021241
WIZ
widely interspaced zinc finger motifs
chr19_+_54067489 0.960 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr8_+_23442331 0.958 SLC25A37
solute carrier family 25, member 37
chr22_+_17539198 0.947


chr19_-_5291700 0.937 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr19_+_54067491 0.906 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr7_-_152004096 0.904 NM_005431
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr12_+_118515646 0.902 NM_001136534
TMEM233
transmembrane protein 233
chr21_+_43903803 0.898 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr6_-_127822227 0.898 NM_014702
KIAA0408
KIAA0408
chr22_-_18484428 0.897 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr1_+_1994943 0.897 NM_001033581
PRKCZ
protein kinase C, zeta
chr9_+_130684601 0.896 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr19_-_55671273 0.895 FAM71E1
family with sequence similarity 71, member E1
chr11_-_47356672 0.893 NM_001080547
NM_003120
SPI1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

chr7_+_140042932 0.892 NM_004546
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr11_-_62213946 0.888 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr1_+_110329224 0.874 AHCYL1
adenosylhomocysteinase-like 1
chr11_+_72203000 0.873 NM_033388
ATG16L2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr20_-_43889339 0.869 NM_003279
TNNC2
troponin C type 2 (fast)
chr11_-_85053807 0.863 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr1_+_109090789 0.856 NM_007269
STXBP3
syntaxin binding protein 3
chr11_-_47356562 0.854 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr2_+_54638957 0.854 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr11_+_60366004 0.845 NM_024098
CCDC86
coiled-coil domain containing 86
chr22_+_20326572 0.840 SDF2L1
stromal cell-derived factor 2-like 1
chr19_+_54996613 0.838


chr11_-_47356650 0.837 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr6_+_39868126 0.826 DAAM2
dishevelled associated activator of morphogenesis 2
chr22_+_30670435 0.824 NM_003405
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr6_-_87861492 0.823 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr17_+_1580504 0.821 WDR81
WD repeat domain 81
chr7_+_100037817 0.819 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr11_-_47356642 0.816 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr17_+_35075124 0.814 NM_003673
TCAP
titin-cap (telethonin)
chr16_+_66614645 0.810 NM_017803
DUS2L
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
chr1_-_31883051 0.808 PEF1
penta-EF-hand domain containing 1
chr22_+_18499354 0.806 NM_001185024
NM_013373
ZDHHC8

zinc finger, DHHC-type containing 8

chr1_+_1104939 0.805 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr11_-_47356479 0.802 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
chr10_-_50012058 0.800 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr9_+_138341752 0.785 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chrX_+_154880439 0.784 NM_002186
IL9R
interleukin 9 receptor
chr22_+_20326541 0.783 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr15_+_76343956 0.779 NM_001130182
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr3_-_155524898 0.778 NM_001114397
NM_020865
DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

chr1_+_9522133 0.769 SLC25A33
solute carrier family 25, member 33
chr9_+_130684189 0.767 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr21_-_43903755 0.762 NM_007031
HSF2BP
heat shock transcription factor 2 binding protein
chr1_-_7835681 0.758 NM_006786
UTS2
urotensin 2
chr17_+_19930926 0.758 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr1_+_110329279 0.756 AHCYL1
adenosylhomocysteinase-like 1
chr1_+_166414839 0.754 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr22_-_42589543 0.751 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr18_+_258147 0.750


chr8_+_23442413 0.749 SLC25A37
solute carrier family 25, member 37
chrX_+_9391314 0.745 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr9_+_132990760 0.744 NM_005085
NUP214
nucleoporin 214kDa
chr1_+_46151845 0.742 MAST2
microtubule associated serine/threonine kinase 2
chr1_-_149955415 0.738 NM_001172648
NM_001172649
CELF3

CUGBP, Elav-like family member 3

chr1_-_46957377 0.738 KIAA0494
KIAA0494
chr19_+_60487578 0.735 BRSK1
BR serine/threonine kinase 1
chr22_+_20326615 0.728 SDF2L1
stromal cell-derived factor 2-like 1
chr1_+_51855343 0.726 OSBPL9
oxysterol binding protein-like 9
chrX_+_148671394 0.726 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr1_+_51855133 0.724 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr2_+_151922350 0.723 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_27591738 0.723 NM_005281
GPR3
G protein-coupled receptor 3
chr5_-_135259403 0.722 NM_000590
IL9
interleukin 9
chr7_+_120378052 0.719 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr19_+_47593137 0.717


chr9_+_114376709 0.717 KIAA1958
KIAA1958
chr8_-_18585721 0.716 PSD3
pleckstrin and Sec7 domain containing 3
chr2_-_74634569 0.713 NM_032603
LOXL3
lysyl oxidase-like 3
chr22_-_18807805 0.713 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr1_-_35097922 0.711 NM_001164825
NM_138428
C1orf212

chromosome 1 open reading frame 212

chr20_+_31717964 0.705 NM_001024675
C20orf134
chromosome 20 open reading frame 134
chrX_-_119593646 0.705 NM_003588
CUL4B
cullin 4B
chr1_-_46957317 0.704 NM_014774
KIAA0494
KIAA0494
chr17_+_24095135 0.703 NM_004295
TRAF4
TNF receptor-associated factor 4
chr6_-_46401174 0.700 RCAN2
regulator of calcineurin 2
chr11_+_61473931 0.700 NM_001139443
NM_004183
BEST1

bestrophin 1

chr19_-_45611110 0.699 NM_020956
NM_181882
PRX

periaxin

chr9_+_130684248 0.697 LRRC8A
leucine rich repeat containing 8 family, member A
chr22_+_20326591 0.695 SDF2L1
stromal cell-derived factor 2-like 1
chr3_+_159771646 0.688 NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434
NM_022443
MLF1





myeloid leukemia factor 1





chr19_+_44591589 0.687


chrX_+_153325643 0.687 NM_004699
FAM50A
family with sequence similarity 50, member A
chr21_+_43963597 0.685 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr6_-_31778825 0.684 NM_001177515
ABHD16A
abhydrolase domain containing 16A
chr19_+_48808092 0.678 NM_001145641
SRRM5
serine/arginine repetitive matrix 5
chr6_-_91063301 0.678 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr3_+_38182120 0.674 OXSR1
oxidative-stress responsive 1
chr11_-_33139449 0.673 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr6_-_46401363 0.672 NM_005822
RCAN2
regulator of calcineurin 2
chr6_-_31779068 0.671 ABHD16A
abhydrolase domain containing 16A
chr1_+_111217244 0.669 NM_000560
CD53
CD53 molecule
chr12_+_131194962 0.669


chr1_+_166414706 0.668 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr12_+_131194967 0.667 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr7_-_100595552 0.662 NM_003378
VGF
VGF nerve growth factor inducible
chr9_-_14076901 0.659 NFIB
nuclear factor I/B
chr1_-_202647526 0.655 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr17_+_58915909 0.655 NM_001178057
NM_152830
ACE

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

chr7_-_105304159 0.654 NM_020725
NM_152749
ATXN7L1

ataxin 7-like 1

chr19_-_60611136 0.653 NM_014501
UBE2S
ubiquitin-conjugating enzyme E2S
chr20_+_186376 0.652 NM_207469
DEFB132
defensin, beta 132
chr8_+_23442307 0.651 NM_016612
SLC25A37
solute carrier family 25, member 37
chr6_-_166321516 0.651 C6orf176
chromosome 6 open reading frame 176
chr17_-_39499527 0.649 LSM12
LSM12 homolog (S. cerevisiae)
chr9_+_139152595 0.644 GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr7_+_5598964 0.639 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 2.12e-03 GO:0043170 macromolecule metabolic process
1.23 3.94e-03 GO:0044260 cellular macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 6.91e-06 GO:0005634 nucleus
1.10 3.06e-05 GO:0044424 intracellular part
1.10 3.30e-05 GO:0005622 intracellular
1.13 4.48e-05 GO:0043229 intracellular organelle
1.13 4.85e-05 GO:0043226 organelle
1.13 1.62e-03 GO:0005737 cytoplasm
1.12 2.93e-03 GO:0043231 intracellular membrane-bounded organelle
1.12 3.53e-03 GO:0043227 membrane-bounded organelle
2.69 9.96e-03 GO:0030017 sarcomere
2.56 1.01e-02 GO:0044449 contractile fiber part
2.45 1.40e-02 GO:0043292 contractile fiber
2.49 1.56e-02 GO:0030016 myofibril

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 5.39e-07 GO:0005515 protein binding
2.03 5.97e-04 GO:0003779 actin binding
1.73 2.59e-03 GO:0008092 cytoskeletal protein binding
1.07 2.51e-02 GO:0005488 binding