Motif ID: POU1F1.p2

Z-value: 1.363


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1



Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_59564323 3.022 NM_173801
PLAC1L
placenta-specific 1-like
chr17_-_36232366 2.236 NM_000421
KRT10
keratin 10
chr1_+_149877955 1.956 SNX27
sorting nexin family member 27
chr6_-_52736231 1.841 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr9_+_130056513 1.779


chr4_-_110942783 1.731 NM_000204
CFI
complement factor I
chr12_+_9925354 1.685 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr5_-_75954807 1.551 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr21_-_42659671 1.520 NM_003225
TFF1
trefoil factor 1
chr11_-_16387001 1.519 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr7_+_137411717 1.459 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr3_-_139960874 1.424 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr6_+_167456230 1.413 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr4_-_100461530 1.410 NM_000668
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_+_153074118 1.383 NM_033050
SUCNR1
succinate receptor 1
chr2_-_77602843 1.348 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr2_+_102136833 1.330 NM_000877
IL1R1
interleukin 1 receptor, type I
chr5_+_141326620 1.317 NM_183399
RNF14
ring finger protein 14
chr18_+_52575442 1.204 WDR7
WD repeat domain 7
chr5_-_41249270 1.192 NM_000065
C6
complement component 6
chr12_-_43593977 1.188 NM_001145110
NELL2
NEL-like 2 (chicken)
chr20_-_36191623 1.182 TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_+_158603480 1.172 NM_005598
NHLH1
nescient helix loop helix 1
chr7_+_29486010 1.166 NM_001039936
CHN2
chimerin (chimaerin) 2
chr19_+_47073029 1.162 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr6_+_44076281 1.161 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr1_-_41399632 1.151 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr21_-_32879617 1.140 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr2_-_88208650 1.109 NM_001443
FABP1
fatty acid binding protein 1, liver
chr7_+_143043871 1.107 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr1_+_166516901 1.089 NM_005149
TBX19
T-box 19
chr7_-_99115454 1.036 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr6_-_52776558 1.018 NM_145740
GSTA1
glutathione S-transferase alpha 1
chr2_+_86998248 1.010 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr3_+_188197029 1.005


chr1_+_195213289 0.992 NM_030787
CFHR5
complement factor H-related 5
chr2_+_201464884 0.985 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr6_+_28217590 0.960 NM_006298
ZNF192
zinc finger protein 192
chr9_-_70780574 0.959


chr2_-_27215781 0.943 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr13_+_45174446 0.927 NM_152719
SPERT
spermatid associated
chr16_+_82540172 0.924 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr5_-_39238818 0.924 FYB
FYN binding protein
chr2_-_6924092 0.917 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_+_132000134 0.911 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr6_-_49942147 0.906 NM_001131
NM_170609
CRISP1

cysteine-rich secretory protein 1

chr17_+_30472710 0.902 NM_017559
FNDC8
fibronectin type III domain containing 8
chr8_-_82536312 0.901 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr12_-_78831821 0.898 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
chr19_-_53081326 0.888 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_205344200 0.880 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr1_-_33613729 0.878 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr11_-_18913121 0.878 NM_147199
MRGPRX1
MAS-related GPR, member X1
chr17_+_71975224 0.875 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr6_-_109795925 0.872 CD164
CD164 molecule, sialomucin
chr10_+_5976354 0.864 NM_032807
FBXO18
F-box protein, helicase, 18
chr12_+_130004404 0.855 NM_198827
GPR133
G protein-coupled receptor 133
chr1_-_51660328 0.853 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr6_+_53043729 0.852 NM_012347
FBXO9
F-box protein 9
chr4_-_47831002 0.843 NM_003328
TXK
TXK tyrosine kinase
chr11_-_124831391 0.842 FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr1_-_1701313 0.834 NM_001198994
NADK
NAD kinase
chr1_+_165565006 0.833 POU2F1
POU class 2 homeobox 1
chr17_-_64649608 0.829 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_+_123600553 0.827 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr1_+_184532027 0.825 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr20_+_56397568 0.823 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr18_-_3001944 0.811 NM_014646
LPIN2
lipin 2
chr1_-_159546348 0.810 NM_000530
MPZ
myelin protein zero
chr10_-_127559841 0.798 NM_018180
DHX32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr13_+_97856148 0.791


chr5_+_137701122 0.784 NM_001135647
FAM53C
family with sequence similarity 53, member C
chr15_+_43036194 0.776 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr4_-_100492854 0.773 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr15_-_75259714 0.765 PEAK1
NKF3 kinase family member
chr6_+_135558572 0.764


chr6_-_26038817 0.757 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr13_+_48582389 0.746 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr10_+_89107404 0.743 NM_001009610
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr10_+_88975184 0.732 NM_001099338
FAM22A
FAM22D
family with sequence similarity 22, member A
family with sequence similarity 22, member D
chr4_+_74566325 0.731 NM_001133
AFM
afamin
chr6_+_16251260 0.712 MYLIP
myosin regulatory light chain interacting protein
chr16_-_28528149 0.709 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_+_51870684 0.706 NM_203424
IQCF2
IQ motif containing F2
chr1_-_120737466 0.705 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr11_+_18150959 0.703 NM_054032
MRGPRX4
MAS-related GPR, member X4
chr6_+_131936057 0.701 NM_000045
ARG1
arginase, liver
chr17_-_59817456 0.698 PECAM1
platelet/endothelial cell adhesion molecule
chr5_-_134290789 0.691


chr14_+_59782222 0.690 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_+_100394787 0.687 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr16_-_88604029 0.684 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr17_+_18588050 0.680 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chrX_-_49347279 0.678 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr16_-_28528780 0.670 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr1_-_180822686 0.660 NM_021133
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr3_+_12367993 0.654 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr10_+_116687904 0.654 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr9_+_95886558 0.645 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr6_+_64344307 0.639 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_-_37220702 0.638 C5orf42
chromosome 5 open reading frame 42
chr6_-_116553918 0.629 NM_000493
COL10A1
collagen, type X, alpha 1
chr7_-_135263737 0.627 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr5_-_78318112 0.625 NM_000046
ARSB
arylsulfatase B
chr12_-_23628774 0.623 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr7_+_77307382 0.619 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr2_+_143351536 0.614 NM_001032998
NM_003937
KYNU

kynureninase

chr17_-_38529638 0.609 NM_007298
BRCA1
breast cancer 1, early onset
chr19_-_45141473 0.608 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr17_-_64568641 0.606 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_-_158815895 0.603 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr6_+_105511615 0.602 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_+_38238080 0.601 OXSR1
oxidative-stress responsive 1
chr4_+_74500748 0.599 ALB
albumin
chr20_-_118263 0.599 NM_001037732
DEFB128
defensin, beta 128
chr2_-_39310176 0.598 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr3_-_19950675 0.598 NM_144715
EFHB
EF-hand domain family, member B
chr7_+_106897737 0.595 NM_005295
GPR22
G protein-coupled receptor 22
chr9_-_99746923 0.585 NM_018437
HEMGN
hemogen
chr3_+_3056307 0.578 NM_175612
CNTN4
contactin 4
chr7_-_44985175 0.577 MYO1G
myosin IG
chr12_-_11066436 0.576 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr17_-_38385511 0.574 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr7_-_44985202 0.569 NM_033054
MYO1G
myosin IG
chr21_-_14840506 0.567 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_36991189 0.563 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_+_100714995 0.557 MTTP
microsomal triglyceride transfer protein
chrX_-_49852397 0.548 NM_003886
AKAP4
A kinase (PRKA) anchor protein 4
chr1_+_169421011 0.547 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr5_+_55276278 0.544 RPL41P5
ribosomal protein L41 pseudogene 5
chr7_-_44985084 0.544 MYO1G
myosin IG
chr18_-_50776276 0.541 NM_001143829
CCDC68
coiled-coil domain containing 68
chr15_-_29734833 0.538 NM_130901
OTUD7A
OTU domain containing 7A
chr16_-_46823682 0.536 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr1_+_160733587 0.528 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr11_-_35235325 0.525 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_+_118370441 0.525 NM_005396
PNLIPRP2
pancreatic lipase-related protein 2
chr6_-_131333173 0.524 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr4_+_73123712 0.520 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr17_-_29714293 0.520 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr18_-_27594696 0.518 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr8_+_39890484 0.517 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr9_+_124072947 0.515 NM_199177
MRRF
mitochondrial ribosome recycling factor
chr12_-_14740694 0.512 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr11_+_93940121 0.509 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr12_-_101835183 0.507 PAH
phenylalanine hydroxylase
chr10_+_91488704 0.506 KIF20B
kinesin family member 20B
chr6_-_76022565 0.506 TMEM30A
transmembrane protein 30A
chr1_-_21373816 0.506 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_178232379 0.505 CEP350
centrosomal protein 350kDa
chr11_+_10439253 0.505 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr3_-_186752952 0.498 NM_139248
LIPH
lipase, member H
chr2_-_178461710 0.491 NM_001077196
PDE11A
phosphodiesterase 11A
chr17_-_36418869 0.490 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr2_-_74235860 0.489


chr9_-_122852356 0.488 NM_001735
C5
complement component 5
chr1_+_179164195 0.485


chr14_-_105862080 0.485 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG2
IGHG3
IGHM
SCFV
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 2 (G2m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
single-chain Fv fragment
chr1_+_190811479 0.485 NM_002922
RGS1
regulator of G-protein signaling 1
chr19_+_60019704 0.483 NM_013289
KIR3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
chr18_-_62422195 0.481 NM_021153
CDH19
cadherin 19, type 2
chr10_-_29794484 0.479 SVIL
supervillin
chr1_+_84646621 0.479 NM_058248
DNASE2B
deoxyribonuclease II beta
chr17_-_59817575 0.479 PECAM1
platelet/endothelial cell adhesion molecule
chr3_-_27473248 0.479 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr12_-_10953427 0.475 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr15_-_53349775 0.475 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr12_+_21570457 0.473 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr1_+_13903936 0.469 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr3_+_46594079 0.469 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr15_+_83467295 0.466 PDE8A
phosphodiesterase 8A
chrX_-_30505804 0.464 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_-_157003095 0.463 NM_001005185
OR6N1
olfactory receptor, family 6, subfamily N, member 1
chr6_+_27400518 0.463 NM_032030
FKSG83
FKSG83
chr14_-_106249999 0.459 IGHA1
immunoglobulin heavy constant alpha 1
chr16_-_21221872 0.458 NM_001014444
NM_001888
CRYM

crystallin, mu

chr9_+_78263887 0.458 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr4_+_74520796 0.458 NM_001134
AFP
alpha-fetoprotein
chr2_-_157890400 0.456 NM_020711
ERMN
ermin, ERM-like protein
chr8_+_26569709 0.455 DPYSL2
dihydropyrimidinase-like 2
chr14_-_105845570 0.455 IGHA1
immunoglobulin heavy constant alpha 1
chr8_-_38127489 0.453 NM_000349
STAR
steroidogenic acute regulatory protein
chr11_-_85053807 0.453 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr1_-_246869181 0.448 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr6_+_31647854 0.443 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_71319559 0.443 NM_005455
NM_203350
ZRANB2

zinc finger, RAN-binding domain containing 2

chr1_+_179269183 0.436 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr17_+_3324096 0.436 NM_001128085
ASPA
aspartoacylase
chr5_-_178977441 0.434 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr16_+_11966464 0.433 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr3_-_195553297 0.431 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr10_+_5478521 0.428 NM_005863
NET1
neuroepithelial cell transforming 1
chr1_+_12728749 0.426 NM_152290
C1orf158
chromosome 1 open reading frame 158
chrX_+_117410693 0.426 WDR44
WD repeat domain 44
chr19_+_44662891 0.425 NM_001001563
TIMM50
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr13_+_108079570 0.425 NM_001198950
MYO16
myosin XVI
chr7_-_142369534 0.425 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr1_-_28113817 0.422 NM_002946
RPA2
replication protein A2, 32kDa
chr3_-_198784590 0.420 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr7_-_143213296 0.418 FAM115A
family with sequence similarity 115, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.11 9.04e-11 GO:0007608 sensory perception of smell
2.94 2.34e-10 GO:0007606 sensory perception of chemical stimulus
1.33 7.75e-08 GO:0050896 response to stimulus
2.12 1.01e-05 GO:0006955 immune response
1.77 1.20e-04 GO:0002376 immune system process
1.89 8.65e-04 GO:0007600 sensory perception
2.70 6.99e-03 GO:0002253 activation of immune response
1.79 1.55e-02 GO:0006952 defense response
2.09 1.99e-02 GO:0050776 regulation of immune response
4.11 2.26e-02 GO:0002449 lymphocyte mediated immunity
4.35 2.63e-02 GO:0072376 protein activation cascade
2.37 2.68e-02 GO:0050778 positive regulation of immune response
3.37 3.27e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.94 4.17e-02 GO:0002252 immune effector process
3.89 4.21e-02 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 5.21e-06 GO:0071944 cell periphery
1.36 9.04e-06 GO:0005886 plasma membrane
9.48 4.88e-03 GO:0042613 MHC class II protein complex
1.22 8.05e-03 GO:0031224 intrinsic to membrane
1.19 1.53e-02 GO:0044425 membrane part
1.21 2.36e-02 GO:0016021 integral to membrane
1.38 4.04e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.20 1.14e-11 GO:0004984 olfactory receptor activity
2.25 2.74e-09 GO:0004930 G-protein coupled receptor activity
1.97 3.60e-09 GO:0004888 transmembrane receptor activity
1.72 4.97e-07 GO:0004872 receptor activity
1.57 1.07e-05 GO:0004871 signal transducer activity
1.57 1.07e-05 GO:0060089 molecular transducer activity
4.98 2.51e-02 GO:0003823 antigen binding