Motif ID: RREB1.p2

Z-value: 1.420


Transcription factors associated with RREB1.p2:

Gene SymbolEntrez IDGene Name
RREB1 6239 ras responsive element binding protein 1



Activity profile for motif RREB1.p2.

activity profile for motif RREB1.p2


Sorted Z-values histogram for motif RREB1.p2

Sorted Z-values for motif RREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RREB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_96924582 8.505 NM_001172667
FAM178B
family with sequence similarity 178, member B
chr1_-_30977931 6.778 LAPTM5
lysosomal protein transmembrane 5
chr14_+_104244998 5.104 INF2
inverted formin, FH2 and WH2 domain containing
chrX_+_17665483 3.635 NM_001037535
NM_001037536
NM_001037540
NM_006746
SCML1



sex comb on midleg-like 1 (Drosophila)



chr4_-_809879 3.398 NM_006651
CPLX1
complexin 1
chr19_-_55914837 3.340


chr19_+_540849 2.851 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr11_-_1731273 2.788


chr10_-_135000464 2.600 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr17_+_1580504 2.507 WDR81
WD repeat domain 81
chr10_-_135000358 2.398 CALY
calcyon neuron-specific vesicular protein
chr2_+_85515428 2.329 NM_198482
SH2D6
SH2 domain containing 6
chr17_+_39741306 2.260 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr10_-_75085754 2.208 NM_001114133
SYNPO2L
synaptopodin 2-like
chr19_-_13910167 2.189 NM_024825
PODNL1
podocan-like 1
chr19_-_16868674 2.165 CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr3_-_48607596 2.134 NM_000094
COL7A1
collagen, type VII, alpha 1
chr20_-_61574259 2.118 NM_004518
NM_172106
NM_172107
NM_172108
NM_172109
KCNQ2




potassium voltage-gated channel, KQT-like subfamily, member 2




chr1_-_202647526 2.100 NM_032833
PPP1R15B
protein phosphatase 1, regulatory (inhibitor) subunit 15B
chr6_-_31668476 2.062 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr19_-_60557875 1.937 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr2_+_170742900 1.930 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr20_+_55359551 1.746 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr7_+_150390566 1.715 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr17_+_72982919 1.672 NM_001113495
SEPT9
septin 9
chr4_+_191226073 1.671 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr16_-_3225070 1.645 NM_001145447
NM_003454
ZNF200

zinc finger protein 200

chr1_-_154484341 1.641 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_-_226670928 1.626 TRIM17
tripartite motif containing 17
chr1_-_1525309 1.611 LOC643988
hypothetical LOC643988
chr2_+_219453487 1.603 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr11_+_61479182 1.594 BEST1
bestrophin 1
chr1_-_1283770 1.571 NM_032348
MXRA8
matrix-remodelling associated 8
chr8_+_144706699 1.551 NM_001166237
GSDMD
gasdermin D
chr8_-_73150371 1.526 NM_007332
TRPA1
transient receptor potential cation channel, subfamily A, member 1
chr11_+_66499323 1.519 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr20_+_55359706 1.519 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr1_+_3378030 1.491 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr19_+_60487578 1.489 BRSK1
BR serine/threonine kinase 1
chr16_-_65516919 1.485 NM_001128850
NM_004165
RRAD

Ras-related associated with diabetes

chr1_-_154318412 1.485 NM_001093725
MEX3A
mex-3 homolog A (C. elegans)
chr5_-_142045770 1.461 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr4_+_191239247 1.450 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr12_+_56135353 1.445 NM_031479
INHBE
inhibin, beta E
chr4_+_191235959 1.431 NM_001177376
DUX4L4
double homeobox 4 like 4
chr8_-_145119627 1.388 NM_201378
PLEC
plectin
chr2_+_72998111 1.383 NM_004097
EMX1
empty spiracles homeobox 1
chr19_-_7896974 1.362 NM_206833
CTXN1
cortexin 1
chr8_-_41624030 1.353 NM_152568
NKX6-3
NK6 homeobox 3
chr21_-_45173061 1.342 NM_001127491
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr15_-_86600658 1.335 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr1_-_226671205 1.330 NM_001024940
NM_001134855
NM_016102
TRIM17


tripartite motif containing 17


chr6_-_32184975 1.326 NM_019105
TNXB
tenascin XB
chr12_+_6807831 1.312 NM_014262
LEPREL2
leprecan-like 2
chr11_+_10433241 1.308 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr22_-_49363711 1.307 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr12_-_47679176 1.307 NM_015086
DDN
dendrin
chr15_-_81037554 1.306 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr1_+_945331 1.306 NM_198576
AGRN
agrin
chr12_-_53071285 1.301 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr2_+_149349643 1.292


chr19_-_5291700 1.278 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr11_+_15093059 1.277 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr7_+_100111689 1.246 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr22_-_37969897 1.236 PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr19_-_60352369 1.223 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr19_-_60350122 1.220 TNNT1
troponin T type 1 (skeletal, slow)
chr22_+_36286350 1.196 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr2_-_219881937 1.192 PTPRN
protein tyrosine phosphatase, receptor type, N
chr10_-_76538859 1.189 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr20_-_47238310 1.185 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr13_-_40138607 1.173 NM_002015
FOXO1
forkhead box O1
chr1_+_221633337 1.165 NM_152610
C1orf65
chromosome 1 open reading frame 65
chr11_-_66961709 1.160 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr1_-_200879203 1.131 NM_001136504
SYT2
synaptotagmin II
chr8_-_125252884 1.129 C8orf78
chromosome 8 open reading frame 78
chr2_-_85490984 1.129 CAPG
capping protein (actin filament), gelsolin-like
chr11_+_122936145 1.126 GRAMD1B
GRAM domain containing 1B
chr19_+_60487345 1.124 NM_032430
BRSK1
BR serine/threonine kinase 1
chr2_+_42649105 1.121 NM_020744
MTA3
metastasis associated 1 family, member 3
chr19_+_10642648 1.114 ILF3
interleukin enhancer binding factor 3, 90kDa
chr12_+_52665196 1.112 NM_017409
HOXC10
homeobox C10
chr19_+_38979502 1.088 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chr21_+_44560779 1.085 PFKL
phosphofructokinase, liver
chr21_+_42946719 1.083 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr16_-_31347151 1.075 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr11_+_63876924 1.074 CCDC88B
coiled-coil domain containing 88B
chr8_+_99508425 1.067 NM_020697
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr1_-_46853380 1.052 NM_145279
MOBKL2C
MOB1, Mps One Binder kinase activator-like 2C (yeast)
chr2_+_241213334 1.051 NM_005301
GPR35
G protein-coupled receptor 35
chr19_+_811615 1.049 CFD
complement factor D (adipsin)
chr22_-_16127520 1.046 CECR3
cat eye syndrome chromosome region, candidate 3
chr4_-_5941043 1.039 CRMP1
collapsin response mediator protein 1
chr2_-_119322228 1.014 NM_001426
EN1
engrailed homeobox 1
chr17_+_75507750 1.006


chr6_+_34541827 1.002 NM_020804
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr19_+_3317589 1.001 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr7_+_134567270 0.996 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr22_-_43986896 0.991 KIAA0930
KIAA0930
chr12_-_51887266 0.987 NM_000889
ITGB7
integrin, beta 7
chrX_-_137621060 0.986 FGF13
fibroblast growth factor 13
chr3_+_50629872 0.982 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr4_+_995395 0.978 FGFRL1
fibroblast growth factor receptor-like 1
chr21_+_46367216 0.975 COL6A2
collagen, type VI, alpha 2
chr9_+_132002692 0.974 NM_001128826
NCS1
neuronal calcium sensor 1
chr19_-_14748623 0.973 EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr1_-_240754620 0.959 NM_152666
PLD5
phospholipase D family, member 5
chr15_-_73792234 0.957 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr17_-_34607257 0.957 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr14_-_91372365 0.957 NM_001128595
NM_152332
TC2N

tandem C2 domains, nuclear

chr1_-_151780720 0.948 NM_002962
S100A5
S100 calcium binding protein A5
chr11_-_57173823 0.941 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr5_+_78944151 0.940 PAPD4
PAP associated domain containing 4
chr7_+_44110470 0.938 NM_001129
AEBP1
AE binding protein 1
chrX_-_137621492 0.926 NM_004114
FGF13
fibroblast growth factor 13
chr11_+_65311104 0.924 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr10_+_135343649 0.916 NM_012147
DUX2
double homeobox 2
chr19_+_13111072 0.914 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr12_+_1608672 0.910 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chr2_-_219882302 0.910 NM_002846
PTPRN
protein tyrosine phosphatase, receptor type, N
chr18_+_42168180 0.910 NM_152470
C18orf23
RNF165
chromosome 18 open reading frame 23
ring finger protein 165
chr6_-_10527772 0.908 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr3_+_69998064 0.906 NM_198177
MITF
microphthalmia-associated transcription factor
chr17_-_77474597 0.895 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr12_+_52634950 0.891 NM_173860
HOXC12
homeobox C12
chr3_-_13089547 0.884 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr19_+_3317536 0.883 NM_005597
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr8_+_41804946 0.876


chr12_+_52689062 0.872 NM_022658
HOXC8
homeobox C8
chr5_+_169863601 0.867 NM_001034837
NM_014592
KCNIP1

Kv channel interacting protein 1

chrX_-_1532648 0.866 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr6_-_139654807 0.859 NM_153235
TXLNB
taxilin beta
chr16_+_665680 0.857 RHBDL1
rhomboid, veinlet-like 1 (Drosophila)
chr5_+_78944052 0.857 PAPD4
PAP associated domain containing 4
chr7_+_128219307 0.857 NM_022742
CCDC136
coiled-coil domain containing 136
chr15_+_72209973 0.856 ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_-_153500584 0.855 NM_001327
NM_139250
CTAG1B
CTAG1A
cancer/testis antigen 1B
cancer/testis antigen 1A
chr13_+_113574925 0.855 NM_001143945
GAS6
growth arrest-specific 6
chr9_-_129729518 0.853 NM_173492
PIP5KL1
phosphatidylinositol-4-phosphate 5-kinase-like 1
chr16_+_670115 0.852 NM_005861
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
chr19_-_50977592 0.851 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr3_+_8750485 0.851 NM_033337
NM_001234
CAV3

caveolin 3

chr12_-_46438447 0.851 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr2_+_238432925 0.848 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr9_-_139068269 0.846 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr7_+_44110527 0.846 AEBP1
AE binding protein 1
chr11_-_74740298 0.843 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr12_-_131816604 0.841 ANKLE2
ankyrin repeat and LEM domain containing 2
chr5_+_172193826 0.840 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr2_-_74455161 0.834 NM_001135041
NM_023019
DCTN1

dynactin 1

chr6_-_48144344 0.834 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr19_+_4442610 0.830 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr12_-_51887318 0.829 ITGB7
integrin, beta 7
chr17_-_19231049 0.828 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr8_-_145122884 0.828 NM_000445
PLEC
plectin
chr6_-_6265896 0.824 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr22_-_42589543 0.822 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr1_-_6162669 0.818 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr16_+_750765 0.816 NM_005823
NM_001177355
MSLN

mesothelin

chr4_-_2336328 0.816 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr7_-_150305933 0.814 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr16_-_3246587 0.814 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr5_+_140871107 0.814


chr7_+_149657810 0.814 NM_138434
C7orf29
chromosome 7 open reading frame 29
chr8_-_145725289 0.813 C8orf82
chromosome 8 open reading frame 82
chr6_-_33822659 0.810 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr21_-_43369492 0.808 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr3_-_130323295 0.803 NM_198490
RAB43
RAB43, member RAS oncogene family
chr1_-_2447848 0.802 NM_018216
PANK4
pantothenate kinase 4
chr1_-_148155986 0.799 NM_014849
SV2A
synaptic vesicle glycoprotein 2A
chr1_+_110012166 0.798 NM_000848
NM_001142368
GSTM2

glutathione S-transferase mu 2 (muscle)

chr20_-_21326046 0.796 NM_033176
NKX2-4
NK2 homeobox 4
chr16_+_620932 0.795 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr11_+_122936246 0.794 GRAMD1B
GRAM domain containing 1B
chr4_-_1097313 0.794 NM_001131034
NM_001193318
NM_194439
RNF212


ring finger protein 212


chr11_-_17454995 0.792 NM_000352
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr4_-_46086528 0.791 NM_000807
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr5_-_180163495 0.788 NM_001114619
NM_001114620
MGAT1

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

chr2_-_227737009 0.788 COL4A4
collagen, type IV, alpha 4
chr5_+_180583315 0.788 TRIM41
tripartite motif containing 41
chr5_-_138746917 0.786 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr16_-_1215254 0.786 NM_012467
TPSG1
tryptase gamma 1
chr20_-_56523251 0.775 NM_153360
APCDD1L
adenomatosis polyposis coli down-regulated 1-like
chr21_+_43985728 0.773 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr15_-_73792150 0.769 CSPG4
chondroitin sulfate proteoglycan 4
chr12_-_56157898 0.767 NM_001080156
ARHGAP9
Rho GTPase activating protein 9
chr11_-_1725662 0.767 LOC402778
CD225 family protein FLJ76511
chr10_-_103525646 0.766 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr11_-_128280801 0.766 NM_145013
C11orf45
chromosome 11 open reading frame 45
chr11_-_69228286 0.762 NM_005117
FGF19
fibroblast growth factor 19
chr18_+_55038369 0.762 NM_001012512
NM_001012513
NM_002091
GRP


gastrin-releasing peptide


chr22_+_49333327 0.759 NM_138433
KLHDC7B
kelch domain containing 7B
chr4_-_5941167 0.758 NM_001313
CRMP1
collapsin response mediator protein 1
chr7_+_73341640 0.757 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr11_+_66939720 0.755 NM_001166222
NM_020811
CARNS1

carnosine synthase 1

chr17_-_7434113 0.755 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr10_-_64248932 0.754 NM_001136178
EGR2
early growth response 2
chr15_+_72209795 0.754 NM_020851
ISLR2
immunoglobulin superfamily containing leucine-rich repeat 2
chr1_-_2115950 0.752 NM_182533
C1orf86
chromosome 1 open reading frame 86
chr19_-_13909877 0.747 PODNL1
podocan-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.56 3.09e-20 GO:0007399 nervous system development
1.35 9.46e-17 GO:0048731 system development
1.32 1.80e-16 GO:0048856 anatomical structure development
1.16 2.27e-16 GO:0065007 biological regulation
1.28 3.81e-16 GO:0032502 developmental process
1.30 1.15e-15 GO:0007275 multicellular organismal development
1.40 2.07e-13 GO:0048513 organ development
1.45 8.80e-13 GO:0009653 anatomical structure morphogenesis
1.15 1.65e-12 GO:0050789 regulation of biological process
1.60 2.80e-12 GO:0048699 generation of neurons
1.36 4.30e-12 GO:0030154 cell differentiation
1.16 6.07e-12 GO:0050794 regulation of cellular process
1.35 7.00e-12 GO:0048869 cellular developmental process
1.65 1.42e-11 GO:0030182 neuron differentiation
1.56 1.89e-11 GO:0022008 neurogenesis
1.68 8.45e-11 GO:0009887 organ morphogenesis
1.74 1.42e-10 GO:0007417 central nervous system development
1.62 3.09e-10 GO:0045595 regulation of cell differentiation
1.44 4.61e-10 GO:0051239 regulation of multicellular organismal process
1.52 9.03e-10 GO:0050793 regulation of developmental process
1.49 4.06e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.49 9.31e-09 GO:0048468 cell development
1.36 1.41e-08 GO:0023051 regulation of signaling
1.29 2.13e-08 GO:0051252 regulation of RNA metabolic process
1.22 6.64e-08 GO:0080090 regulation of primary metabolic process
1.21 7.94e-08 GO:0023052 signaling
1.29 9.25e-08 GO:0048523 negative regulation of cellular process
1.77 1.16e-07 GO:0007420 brain development
1.82 1.17e-07 GO:0060284 regulation of cell development
1.25 1.24e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.69 1.35e-07 GO:0007268 synaptic transmission
1.27 2.21e-07 GO:0048519 negative regulation of biological process
1.43 3.09e-07 GO:0007154 cell communication
1.51 3.82e-07 GO:2000026 regulation of multicellular organismal development
1.21 3.82e-07 GO:0031323 regulation of cellular metabolic process
1.28 4.18e-07 GO:0006355 regulation of transcription, DNA-dependent
1.24 4.74e-07 GO:0048518 positive regulation of biological process
1.50 5.03e-07 GO:0007267 cell-cell signaling
1.24 5.24e-07 GO:0051171 regulation of nitrogen compound metabolic process
2.28 5.46e-07 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.19 5.74e-07 GO:0019222 regulation of metabolic process
2.26 8.07e-07 GO:0022604 regulation of cell morphogenesis
1.69 1.25e-06 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.24 1.36e-06 GO:0031326 regulation of cellular biosynthetic process
1.30 1.48e-06 GO:0007166 cell surface receptor linked signaling pathway
1.40 1.60e-06 GO:0010646 regulation of cell communication
1.25 1.69e-06 GO:0048522 positive regulation of cellular process
1.61 2.04e-06 GO:0019226 transmission of nerve impulse
1.61 2.04e-06 GO:0035637 multicellular organismal signaling
2.04 2.16e-06 GO:0030900 forebrain development
1.24 2.36e-06 GO:0010468 regulation of gene expression
1.21 2.57e-06 GO:0060255 regulation of macromolecule metabolic process
1.23 3.61e-06 GO:0009889 regulation of biosynthetic process
1.50 4.20e-06 GO:0010628 positive regulation of gene expression
1.82 5.17e-06 GO:0045596 negative regulation of cell differentiation
1.15 6.10e-06 GO:0032501 multicellular organismal process
1.60 8.53e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.51 9.05e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.78 1.07e-05 GO:0051960 regulation of nervous system development
1.55 1.19e-05 GO:0051253 negative regulation of RNA metabolic process
1.55 1.60e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.49 1.76e-05 GO:0051254 positive regulation of RNA metabolic process
1.24 1.76e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.92 2.05e-05 GO:0032582 negative regulation of gene-specific transcription
1.57 2.06e-05 GO:0000904 cell morphogenesis involved in differentiation
1.45 2.72e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 2.85e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.42 3.00e-05 GO:0009888 tissue development
2.02 3.05e-05 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.69 5.26e-05 GO:0051093 negative regulation of developmental process
1.55 6.08e-05 GO:0031175 neuron projection development
1.24 6.19e-05 GO:0065008 regulation of biological quality
1.22 8.03e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.58 8.67e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 8.81e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.50 9.55e-05 GO:0048666 neuron development
1.69 1.12e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.56 1.43e-04 GO:0048812 neuron projection morphogenesis
1.96 1.49e-04 GO:0006813 potassium ion transport
1.30 2.07e-04 GO:0009966 regulation of signal transduction
1.44 2.09e-04 GO:0009790 embryo development
1.46 2.19e-04 GO:0030030 cell projection organization
1.75 2.96e-04 GO:0050767 regulation of neurogenesis
1.18 3.15e-04 GO:0007165 signal transduction
1.39 3.68e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.38 3.83e-04 GO:0009891 positive regulation of biosynthetic process
1.56 4.08e-04 GO:0007409 axonogenesis
1.51 4.27e-04 GO:0048858 cell projection morphogenesis
1.66 5.40e-04 GO:0048729 tissue morphogenesis
1.46 5.43e-04 GO:0010629 negative regulation of gene expression
1.46 5.49e-04 GO:0000902 cell morphogenesis
1.41 5.88e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.45 6.74e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.62 6.86e-04 GO:0044057 regulation of system process
1.80 7.13e-04 GO:0045664 regulation of neuron differentiation
1.50 7.54e-04 GO:0032990 cell part morphogenesis
1.45 7.87e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 7.89e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.06 8.49e-04 GO:0009987 cellular process
1.24 9.69e-04 GO:0048583 regulation of response to stimulus
1.60 9.92e-04 GO:0007389 pattern specification process
1.44 1.08e-03 GO:0032989 cellular component morphogenesis
1.67 1.11e-03 GO:0061061 muscle structure development
1.92 1.14e-03 GO:0045165 cell fate commitment
1.57 1.29e-03 GO:0048598 embryonic morphogenesis
3.37 1.29e-03 GO:0071300 cellular response to retinoic acid
1.41 1.37e-03 GO:0009890 negative regulation of biosynthetic process
1.43 1.85e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.70 2.10e-03 GO:0048663 neuron fate commitment
1.42 2.11e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.64 2.34e-03 GO:0007423 sensory organ development
3.24 3.02e-03 GO:0071299 cellular response to vitamin A
1.50 3.36e-03 GO:0032583 regulation of gene-specific transcription
2.30 3.67e-03 GO:0050770 regulation of axonogenesis
1.82 4.45e-03 GO:0006936 muscle contraction
1.69 5.18e-03 GO:0002009 morphogenesis of an epithelium
1.92 6.54e-03 GO:0051969 regulation of transmission of nerve impulse
1.35 6.55e-03 GO:0051128 regulation of cellular component organization
1.56 6.71e-03 GO:0045597 positive regulation of cell differentiation
1.34 7.11e-03 GO:0006351 transcription, DNA-dependent
2.23 8.02e-03 GO:0010721 negative regulation of cell development
1.95 1.11e-02 GO:0050804 regulation of synaptic transmission
1.65 1.17e-02 GO:0003002 regionalization
1.90 1.46e-02 GO:0010975 regulation of neuron projection development
1.27 1.49e-02 GO:0009893 positive regulation of metabolic process
1.59 1.75e-02 GO:0035295 tube development
1.73 2.00e-02 GO:0003012 muscle system process
1.32 2.05e-02 GO:0031324 negative regulation of cellular metabolic process
1.30 2.11e-02 GO:0009605 response to external stimulus
1.43 2.26e-02 GO:0030001 metal ion transport
1.45 2.27e-02 GO:0051094 positive regulation of developmental process
1.27 2.73e-02 GO:0031325 positive regulation of cellular metabolic process
1.85 2.75e-02 GO:0042692 muscle cell differentiation
1.81 2.90e-02 GO:0031644 regulation of neurological system process
1.37 3.11e-02 GO:0007167 enzyme linked receptor protein signaling pathway
2.79 3.19e-02 GO:0071295 cellular response to vitamin
1.41 3.83e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.77 4.98e-02 GO:0060562 epithelial tube morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 2.54e-07 GO:0044459 plasma membrane part
1.51 1.62e-06 GO:0030054 cell junction
1.61 2.95e-06 GO:0045202 synapse
1.66 4.61e-05 GO:0044456 synapse part
1.76 9.07e-05 GO:0034702 ion channel complex
1.95 1.51e-04 GO:0034703 cation channel complex
1.14 2.15e-04 GO:0005886 plasma membrane
1.14 5.10e-04 GO:0071944 cell periphery
1.51 1.10e-03 GO:0031012 extracellular matrix
1.54 1.95e-03 GO:0005578 proteinaceous extracellular matrix
2.05 2.95e-03 GO:0008076 voltage-gated potassium channel complex
2.05 2.95e-03 GO:0034705 potassium channel complex
1.48 3.91e-03 GO:0009986 cell surface
1.78 3.98e-03 GO:0045211 postsynaptic membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.83 9.38e-21 GO:0043565 sequence-specific DNA binding
1.55 1.60e-13 GO:0001071 nucleic acid binding transcription factor activity
1.55 1.60e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.49 8.70e-11 GO:0030528 transcription regulator activity
1.12 4.05e-08 GO:0005515 protein binding
1.86 5.09e-08 GO:0005261 cation channel activity
1.65 6.84e-07 GO:0022838 substrate-specific channel activity
1.65 9.28e-07 GO:0005216 ion channel activity
2.10 1.77e-06 GO:0022843 voltage-gated cation channel activity
1.62 3.00e-06 GO:0015267 channel activity
1.61 3.57e-06 GO:0022803 passive transmembrane transporter activity
2.09 1.86e-05 GO:0005267 potassium channel activity
1.66 3.33e-05 GO:0022836 gated channel activity
1.86 3.66e-05 GO:0005244 voltage-gated ion channel activity
1.86 3.66e-05 GO:0022832 voltage-gated channel activity
1.82 4.29e-05 GO:0000975 regulatory region DNA binding
1.82 4.29e-05 GO:0001067 regulatory region nucleic acid binding
1.82 4.29e-05 GO:0044212 transcription regulatory region DNA binding
1.81 8.39e-05 GO:0010843 promoter binding
1.21 2.35e-04 GO:0003677 DNA binding
2.07 8.86e-04 GO:0005249 voltage-gated potassium channel activity
1.55 2.31e-03 GO:0016563 transcription activator activity
1.37 1.48e-02 GO:0008324 cation transmembrane transporter activity
1.05 1.92e-02 GO:0005488 binding
1.32 1.98e-02 GO:0015075 ion transmembrane transporter activity
1.49 3.30e-02 GO:0016564 transcription repressor activity