Motif ID: NKX2-1,4.p2

Z-value: 3.020


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4



Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_81271859 6.066 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr15_+_72253077 4.732 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_180836050 4.674


chr2_-_100125402 4.531 NM_002285
AFF3
AF4/FMR2 family, member 3
chr19_-_6621598 4.516 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr6_+_152053323 4.234 NM_001122742
ESR1
estrogen receptor 1
chrX_+_78087484 4.234 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_143706196 3.929 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_6621078 3.708 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_159817752 3.513 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_+_111053488 3.425 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr9_+_114671635 3.053 SNX30
sorting nexin family member 30
chr14_+_63752424 2.957 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr6_-_11887265 2.871 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_+_159899528 2.797 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_+_118259684 2.715 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr19_-_45132372 2.670 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr10_+_126620681 2.663 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_-_143706265 2.646 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_119733062 2.569 SPPL3
signal peptide peptidase 3
chr1_-_143706300 2.553 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr3_+_190831909 2.542 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_+_109498082 2.506 HHLA2
HERV-H LTR-associating 2
chr3_-_188492163 2.471 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr16_+_11966464 2.461 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr20_+_56455866 2.458 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr17_+_7846636 2.361 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chrX_-_154216929 2.281 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_226462363 2.266 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr10_-_75005421 2.182 NM_152586
USP54
ubiquitin specific peptidase 54
chr12_-_53064565 2.148 ZNF385A
zinc finger protein 385A
chr9_+_102380156 2.141 NM_001018116
MURC
muscle-related coiled-coil protein
chr8_-_7207899 2.136 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_+_59979857 2.091 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr5_-_88155360 2.041 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_-_82536312 2.037 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr2_+_38009405 2.028 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr7_-_7724762 1.991 NM_002947
RPA3
replication protein A3, 14kDa
chr13_-_35842289 1.840 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr12_-_51887266 1.771 NM_000889
ITGB7
integrin, beta 7
chr12_-_54392328 1.746 NM_001144997
ITGA7
integrin, alpha 7
chr3_+_38238080 1.725 OXSR1
oxidative-stress responsive 1
chr5_-_88004891 1.720 LOC645323
hypothetical LOC645323
chrX_-_100920493 1.719 GK
glycerol kinase
chr15_+_72253224 1.711 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr8_+_67201684 1.658 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_+_72423633 1.656 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_+_154120170 1.654 SYT11
synaptotagmin XI
chr3_+_46386636 1.653 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chrX_+_41468351 1.648 NM_080817
GPR82
G protein-coupled receptor 82
chr12_+_54700955 1.592 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr22_-_37211467 1.574 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr5_-_131907071 1.564 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr21_+_37714470 1.518 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr12_+_15590552 1.506 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr12_+_130004404 1.496 NM_198827
GPR133
G protein-coupled receptor 133
chr1_-_43168247 1.493 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr10_-_49152918 1.474 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr1_-_156013487 1.434 NM_030764
FCRL2
Fc receptor-like 2
chr1_-_41398126 1.417 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_-_51971915 1.378 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_156590109 1.367 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr1_+_169747788 1.365 PRRC2C
proline-rich coiled-coil 2C
chr2_+_178893216 1.355 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr16_-_31007630 1.330 NM_001039503
PRSS53
protease, serine, 53
chrX_+_71280758 1.311 NM_207422
FLJ44635
TPT1-like protein
chr12_-_110410730 1.286 ATXN2
ataxin 2
chr5_+_150008030 1.278 SYNPO
synaptopodin
chr8_-_134156437 1.250 SLA
Src-like-adaptor
chr4_-_68793928 1.229 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr2_+_28469850 1.213 FOSL2
FOS-like antigen 2
chr12_+_117067214 1.212 PEBP1
phosphatidylethanolamine binding protein 1
chr2_+_28469864 1.200 FOSL2
FOS-like antigen 2
chrX_+_48427103 1.191 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_151498802 1.182 NM_000427
LOR
loricrin
chr17_-_10393664 1.159 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr7_+_50318801 1.149 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_-_11614279 1.147 NM_001080491
USP6NL
USP6 N-terminal like
chr2_+_102401580 1.147 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_158653679 1.128 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr10_+_86121526 1.115 FAM190B
family with sequence similarity 190, member B
chr12_-_53064723 1.114 NM_015481
ZNF385A
zinc finger protein 385A
chr15_-_29734833 1.111 NM_130901
OTUD7A
OTU domain containing 7A
chr1_-_207891264 1.104 NM_001017402
LAMB3
laminin, beta 3
chr15_-_72287447 1.097 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_-_53761119 1.091 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr10_-_13584950 1.090 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr2_+_28469275 1.070 NM_005253
FOSL2
FOS-like antigen 2
chr15_-_70385709 1.059 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr15_-_48192804 1.042 ATP8B4
ATPase, class I, type 8B, member 4
chr18_+_19286784 1.031 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr13_+_110637173 1.029 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr5_-_134810696 1.014 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr2_+_28469199 1.005 FOSL2
FOS-like antigen 2
chr17_+_20048890 0.991 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_238842071 0.988 NM_022469
GREM2
gremlin 2
chr6_+_32057779 0.985 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr12_+_6819635 0.979 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr10_-_69125932 0.955 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_32489426 0.949 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_51887318 0.943 ITGB7
integrin, beta 7
chr12_+_8216416 0.933 NM_001004328
ZNF705A
zinc finger protein 705A
chr19_+_45797413 0.931 LTBP4
latent transforming growth factor beta binding protein 4
chr20_-_42561725 0.931


chr2_+_28892366 0.919 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr3_+_2908920 0.914 NM_175613
CNTN4
contactin 4
chr6_-_149847809 0.912 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr17_-_31353196 0.912 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr5_-_147996769 0.909 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr4_-_100359353 0.908 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr7_+_129634935 0.907 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr9_-_124329392 0.907 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr11_+_66152309 0.893


chr9_-_33385265 0.891 AQP7
aquaporin 7
chr20_+_35266581 0.887 RPN2
ribophorin II
chr17_+_63338500 0.876 BPTF
bromodomain PHD finger transcription factor
chr6_+_30212488 0.866 NM_138700
TRIM40
tripartite motif containing 40
chr9_+_126158935 0.863


chr2_+_28469172 0.860 FOSL2
FOS-like antigen 2
chr1_-_21250039 0.853 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_38033666 0.848 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr6_-_116488458 0.827 NM_002031
FRK
fyn-related kinase
chr1_+_172683834 0.825 NM_005684
GPR52
G protein-coupled receptor 52
chr17_-_44022595 0.823 HOXB3
homeobox B3
chr20_+_4650499 0.817 NM_012409
PRND
prion protein 2 (dublet)
chr2_-_74235860 0.815


chr13_+_45174446 0.798 NM_152719
SPERT
spermatid associated
chr19_+_50144267 0.789 APOC2
apolipoprotein C-II
chr10_-_6144119 0.785 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr4_-_176970407 0.779 GPM6A
glycoprotein M6A
chr15_+_38430517 0.763 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr5_+_131424245 0.758 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr3_+_171560104 0.747 NM_001145097
SKIL
SKI-like oncogene
chr17_-_3407780 0.747 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_+_26476384 0.745 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_-_245120900 0.745 AHCTF1
AT hook containing transcription factor 1
chr4_-_176970372 0.743 GPM6A
glycoprotein M6A
chr4_-_102487506 0.740 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr15_-_76313896 0.738 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr1_-_178100204 0.738


chrX_+_70682204 0.734 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr11_-_5212168 0.730 NM_000519
HBD
hemoglobin, delta
chr8_-_6901661 0.730 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr4_-_123761615 0.727 NM_021803
IL21
interleukin 21
chr20_-_33706532 0.723 RBM12
RNA binding motif protein 12
chr17_-_5078773 0.717 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr5_-_160211623 0.709 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_-_39306465 0.709 FYB
FYN binding protein
chr11_+_22646229 0.704 NM_177553
GAS2
growth arrest-specific 2
chr6_-_149847718 0.696 ZC3H12D
zinc finger CCCH-type containing 12D
chr3_-_69120188 0.696 C3orf64
chromosome 3 open reading frame 64
chr1_-_21310462 0.692 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_+_57554977 0.692 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr4_-_174774368 0.691 NM_006792
MORF4
mortality factor 4
chr12_-_192752 0.685 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr1_-_158948176 0.683 NM_001778
CD48
CD48 molecule
chr1_+_200698493 0.678 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr15_-_53349775 0.674 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr4_+_102954005 0.672 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr16_+_74901235 0.669 NM_138994
CNTNAP4
contactin associated protein-like 4
chr1_-_33613729 0.667 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_-_238842011 0.665 GREM2
gremlin 2
chr1_-_201586910 0.663 NM_002023
FMOD
fibromodulin
chr3_+_46894239 0.660 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr9_-_99740243 0.649 NM_197978
HEMGN
hemogen
chr1_+_144124547 0.645 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_+_150020595 0.639 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr1_-_158815850 0.639 CD84
CD84 molecule
chr11_-_10672079 0.634 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr5_-_134815886 0.628 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr2_-_160838397 0.627 RBMS1
RNA binding motif, single stranded interacting protein 1
chr15_-_23201740 0.622 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr11_+_46651090 0.621 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr17_-_60439764 0.612 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr3_-_120761092 0.605 NM_005191
CD80
CD80 molecule
chr20_+_56912146 0.605 GNAS
GNAS complex locus
chr4_+_78172966 0.603 SEPT11
septin 11
chr12_+_1608672 0.602 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chrX_-_137649180 0.599 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_13325242 0.597 NM_001099854
PRAMEF14
PRAME family member 14
chr15_-_53350383 0.597 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr16_-_70306198 0.588 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr6_+_155453114 0.574 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr4_+_114433551 0.569 ANK2
ankyrin 2, neuronal
chr11_-_123799976 0.568 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr6_+_31081707 0.568 NM_001198815
PBMUCL1
panbronchiolitis related mucin-like 1
chr3_-_180460372 0.566 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr1_-_158815895 0.566 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr5_+_155686333 0.563 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chrX_+_144716619 0.563 NM_004709
CXorf1
chromosome X open reading frame 1
chr10_+_114125003 0.562 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_21249974 0.561 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr8_+_77928372 0.558 ZFHX4
zinc finger homeobox 4
chr14_-_20694023 0.557 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr11_+_61279436 0.554 NM_013279
C11orf9
chromosome 11 open reading frame 9
chrX_+_48427137 0.546 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr9_+_135994734 0.546 NM_052821
WDR5
WD repeat domain 5
chr9_-_94206648 0.537 NM_014057
NM_033014
OGN

osteoglycin

chr6_-_32184975 0.534 NM_019105
TNXB
tenascin XB
chr7_+_143457083 0.532 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 3.81e-04 GO:0032501 multicellular organismal process
1.32 3.31e-03 GO:0050896 response to stimulus
2.56 4.26e-03 GO:0001775 cell activation
3.57 9.31e-03 GO:0046649 lymphocyte activation
3.21 1.28e-02 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.17 5.87e-04 GO:0005615 extracellular space
1.91 3.40e-03 GO:0044421 extracellular region part
4.02 1.14e-02 GO:0030016 myofibril
3.79 2.02e-02 GO:0043292 contractile fiber

Nothing significant found in function category.