Motif ID: SMAD1..7,9.p2

Z-value: 2.399


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9



Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_143864933 4.060 NM_003695
 LY6D
lymphocyte antigen 6 complex, locus D
chr9_+_139239464 3.902 NM_199001
 C9orf169
chromosome 9 open reading frame 169
chr1_-_26553168 3.746 NM_001039775
 AIM1L
absent in melanoma 1-like
chr16_+_65579988 3.522 NM_173815
 CES4A
carboxylesterase 4A
chr15_+_39918302 3.435 NM_001114633
 PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr6_-_30151526 3.420 NM_170769
NM_025236
 RNF39

ring finger protein 39

chr17_-_19560470 3.391 NM_001099646
NM_152908
 SLC47A2

solute carrier family 47, member 2

chr16_-_73830025 3.293 BCAR1
breast cancer anti-estrogen resistance 1
chr2_+_233112680 3.244 NM_005199
 CHRNG
cholinergic receptor, nicotinic, gamma
chr1_+_199426575 3.234 NM_001164586
 IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr7_+_54577512 3.176 NM_182546
 VSTM2A
V-set and transmembrane domain containing 2A
chr1_+_15145001 3.166 NM_001017999
 KAZN
kazrin, periplakin interacting protein
chr1_+_15935395 3.156 NM_207348
 SLC25A34
solute carrier family 25, member 34
chr15_-_64644758 3.082 NM_207338
 LCTL
lactase-like
chr1_+_26220852 3.027 NM_004455
 EXTL1
exostoses (multiple)-like 1
chr1_+_144439069 3.024 NM_002614
 PDZK1
PDZ domain containing 1
chr17_-_36719030 3.012 NM_001146182
 KRTAP16-1
keratin associated protein 16-1
chr19_-_56204615 2.913 NM_012315
 KLK9
kallikrein-related peptidase 9
chr21_-_44911250 2.911 NM_181684
 KRTAP12-2
keratin associated protein 12-2
chr19_-_53808505 2.851 NM_017708
 FAM83E
family with sequence similarity 83, member E

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
1.89 2.28e-02 GO:0072507 divalent inorganic cation homeostasis
1.88 4.00e-02 GO:0055074 calcium ion homeostasis
1.83 3.49e-04 GO:0044057 regulation of system process
1.77 4.35e-03 GO:0007610 behavior
1.70 2.95e-02 GO:0060284 regulation of cell development
1.60 2.04e-02 GO:0048812 neuron projection morphogenesis
1.58 1.23e-02 GO:0031175 neuron projection development
1.55 3.57e-03 GO:0009887 organ morphogenesis
1.53 3.60e-03 GO:0030030 cell projection organization
1.52 2.47e-03 GO:0030182 neuron differentiation
1.52 2.04e-02 GO:0048666 neuron development
1.50 1.58e-04 GO:0022008 neurogenesis
1.50 3.10e-04 GO:0048699 generation of neurons
1.45 5.50e-07 GO:0007399 nervous system development
1.45 1.50e-03 GO:0048468 cell development
1.43 1.25e-02 GO:0009888 tissue development
1.43 4.40e-02 GO:0007267 cell-cell signaling
1.40 2.82e-05 GO:0009653 anatomical structure morphogenesis
1.40 7.32e-03 GO:0007154 cell communication
1.40 9.83e-03 GO:0009605 response to external stimulus

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
1.78 2.28e-04 GO:0005578 proteinaceous extracellular matrix
1.73 1.17e-04 GO:0031012 extracellular matrix
1.69 5.91e-03 GO:0015629 actin cytoskeleton
1.53 3.21e-02 GO:0043005 neuron projection
1.45 1.40e-02 GO:0030054 cell junction
1.36 4.74e-03 GO:0044421 extracellular region part
1.30 1.86e-05 GO:0044459 plasma membrane part
1.30 2.35e-02 GO:0005887 integral to plasma membrane
1.29 3.70e-02 GO:0031226 intrinsic to plasma membrane
1.22 4.13e-02 GO:0005576 extracellular region
1.19 6.95e-05 GO:0005886 plasma membrane
1.19 6.97e-05 GO:0071944 cell periphery
1.13 3.19e-05 GO:0016020 membrane
1.11 9.75e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
7.45 3.82e-02 GO:0050542 icosanoid binding
7.45 3.82e-02 GO:0050543 icosatetraenoic acid binding
2.19 6.37e-03 GO:0008201 heparin binding
2.11 1.16e-03 GO:0005539 glycosaminoglycan binding
2.05 1.67e-03 GO:0001871 pattern binding
2.05 1.67e-03 GO:0030247 polysaccharide binding
1.51 6.88e-03 GO:0008092 cytoskeletal protein binding