Motif ID: HLF.p2

Z-value: 2.568


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor



Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_113601608 4.900 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr16_+_70646008 3.645 NM_001126102
NM_005143
HP

haptoglobin

chr2_+_113601616 3.395 IL1RN
interleukin 1 receptor antagonist
chr19_+_40465249 3.272 NM_021175
HAMP
hepcidin antimicrobial peptide
chr15_-_75259714 3.068 PEAK1
NKF3 kinase family member
chr14_+_20493467 2.981 NM_002934
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr14_-_69333624 2.933 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr3_-_58175437 2.912 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr6_-_30188845 2.840 NM_007028
TRIM31
tripartite motif containing 31
chr9_-_94338072 2.764 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr22_+_49272078 2.730 NM_017584
MIOX
myo-inositol oxygenase
chr18_+_75967902 2.685 NM_014913
ADNP2
ADNP homeobox 2
chr17_+_31455332 2.644 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr16_+_70654625 2.472 NM_020995
HPR
haptoglobin-related protein
chr1_+_149221122 2.447 NM_003568
ANXA9
annexin A9
chr9_+_116131889 2.413 NM_000608
ORM2
orosomucoid 2
chr3_+_187917791 2.403 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr1_-_205210567 2.365 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr2_+_219453487 2.305 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr2_+_3683660 2.300 NM_018436
ALLC
allantoicase
chr9_+_116125123 2.277 NM_000607
ORM1
orosomucoid 1
chr3_+_187866464 2.264 NM_000412
HRG
histidine-rich glycoprotein
chr14_-_22354457 2.239 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr16_+_30391550 2.182 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr3_+_46591048 2.157 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr10_+_85994788 2.139 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr17_-_17426416 2.079 PEMT
phosphatidylethanolamine N-methyltransferase
chr14_-_22354389 2.040 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr16_+_30391460 2.021 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr3_+_42107711 1.921 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr1_-_171441234 1.916 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_-_6722848 1.861 NM_005218
DEFB1
defensin, beta 1
chr9_+_110664366 1.860 NM_006687
ACTL7A
actin-like 7A
chr9_-_129752687 1.841 NM_203305
FAM102A
family with sequence similarity 102, member A
chr2_-_32344192 1.838 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr11_-_6418705 1.829 NM_000613
HPX
hemopexin
chr6_+_131936057 1.815 NM_000045
ARG1
arginase, liver
chr4_-_77147625 1.814 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr19_+_53951155 1.797 NM_019113
FGF21
fibroblast growth factor 21
chr22_+_33792125 1.778 NM_001008494
ISX
intestine-specific homeobox
chr17_-_17426469 1.772 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr16_+_30391609 1.721


chr12_-_121767272 1.694 NM_006018
GPR109B
G protein-coupled receptor 109B
chr1_+_205328834 1.688 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr12_-_120591938 1.676 NM_173855
MORN3
MORN repeat containing 3
chr16_+_55963899 1.636 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chrX_-_15530112 1.632 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr6_+_37511383 1.541


chr17_+_39280041 1.462 NM_001168322
NM_001168323
NM_001168324
NM_145273
CD300LG



CD300 molecule-like family member g



chr7_-_129379947 1.450 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr15_+_60838053 1.412 TLN2
talin 2
chr11_-_116168316 1.412 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_+_3326045 1.410 NM_000049
ASPA
aspartoacylase
chr3_+_120984246 1.400 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr14_-_94053933 1.393 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr20_+_61842880 1.388 SLC2A4RG
SLC2A4 regulator
chr21_+_44597911 1.374 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr6_-_30151526 1.331 NM_170769
NM_025236
RNF39

ring finger protein 39

chrX_+_41191630 1.325 NM_022567
NYX
nyctalopin
chr12_-_28016182 1.319 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_-_82039158 1.315 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_-_31353196 1.299 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr3_-_49701085 1.291 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_-_62557655 1.274 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr9_-_70780574 1.262


chr2_+_190710730 1.209 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr8_-_145187553 1.209 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr19_+_53801811 1.185 NM_133498
SPACA4
sperm acrosome associated 4
chr15_+_72315719 1.176 NM_025055
CCDC33
coiled-coil domain containing 33
chr22_+_23309717 1.169 NM_013430
GGT1
gamma-glutamyltransferase 1
chr5_+_156628929 1.144 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr3_-_171070314 1.122 NM_024727
LRRC31
leucine rich repeat containing 31
chr13_+_47948586 1.118 RB1
retinoblastoma 1
chr19_+_40541327 1.116 NM_005304
FFAR3
free fatty acid receptor 3
chr16_-_54424517 1.113 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr19_-_40684638 1.106 NM_001035516
DMKN
dermokine
chr2_+_64540843 1.103 HSPC159
galectin-related protein
chr3_+_187813538 1.100 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr12_-_53044495 1.094 NM_020370
GPR84
G protein-coupled receptor 84
chr11_-_66431910 1.090 NM_022172
PC
pyruvate carboxylase
chr2_-_73723001 1.069 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_31352720 1.056 CCL14-CCL15
CCL14-CCL15 read-through transcript
chr20_+_58064360 1.053 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr8_-_101384633 1.037 NM_015435
RNF19A
ring finger protein 19A
chr20_+_16676997 1.033 NM_020157
OTOR
otoraplin
chr2_-_191580567 1.019 STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_-_103846186 1.008 NM_032148
SLC41A2
solute carrier family 41, member 2
chr6_-_52217185 1.008 NM_052872
IL17F
interleukin 17F
chr14_-_23754977 1.008 NM_138476
MDP1
magnesium-dependent phosphatase 1
chr12_-_121753795 1.002 NM_177551
GPR109A
G protein-coupled receptor 109A
chr6_-_64087806 0.995 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr17_-_31352643 0.995 CCL14-CCL15
CCL15
CCL14-CCL15 read-through transcript
chemokine (C-C motif) ligand 15
chr9_-_103237851 0.991 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_246682699 0.988 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr17_-_36346240 0.986 KRT23
keratin 23 (histone deacetylase inducible)
chr3_+_123526700 0.978 NM_005213
CSTA
cystatin A (stefin A)
chr10_+_5228756 0.976 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr8_+_124263932 0.960 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_-_133895795 0.960 NCKAP5
NCK-associated protein 5
chr16_-_54424473 0.957 CES1
carboxylesterase 1
chr4_+_155703581 0.947 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr20_+_2030527 0.934 NM_080836
STK35
serine/threonine kinase 35
chr18_+_19286784 0.925 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr14_-_22354851 0.924 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr11_+_93394025 0.920 NM_001098672
HEPHL1
hephaestin-like 1
chr11_-_10487212 0.914 NM_001190702
MTRNR2L8
MT-RNR2-like 8
chr2_+_201464884 0.907 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. pombe)
chr9_+_102987137 0.907 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr6_+_32003180 0.901 NM_000063
NM_001145903
C2

complement component 2

chr12_-_115803614 0.899 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr12_+_56424930 0.887 NM_005981
TSPAN31
tetraspanin 31
chr8_+_26569709 0.885 DPYSL2
dihydropyrimidinase-like 2
chr18_+_53967544 0.878 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr17_+_31562577 0.873 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr3_+_134976965 0.858 TF
transferrin
chr6_+_32003380 0.856 C2
complement component 2
chr2_-_42844705 0.837 NM_148962
OXER1
oxoeicosanoid (OXE) receptor 1
chr1_+_152644471 0.822 IL6R
interleukin 6 receptor
chr8_+_124264054 0.819 FAM83A
family with sequence similarity 83, member A
chr12_-_121946635 0.816 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_-_246869181 0.816 NM_001001827
OR2T35
olfactory receptor, family 2, subfamily T, member 35
chr20_+_23419765 0.809 NM_005492
CST8
cystatin 8 (cystatin-related epididymal specific)
chr10_+_124141808 0.803 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_+_40716153 0.803 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr12_-_4624536 0.795 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr12_-_8656705 0.794 NM_020661
AICDA
activation-induced cytidine deaminase
chr2_+_218954995 0.785 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr18_+_75968133 0.780 ADNP2
ADNP homeobox 2
chr11_+_59027624 0.756 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr20_+_4614796 0.755 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr13_-_45577144 0.754 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr10_-_128199986 0.753 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr20_-_43316597 0.746 NM_003064
SLPI
secretory leukocyte peptidase inhibitor
chr14_+_23633101 0.743 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr17_-_68819713 0.738 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr7_-_37923040 0.737 NM_003014
SFRP4
secreted frizzled-related protein 4
chr3_-_121883647 0.734 HGD
homogentisate 1,2-dioxygenase
chr19_-_47638890 0.733 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr3_+_138132006 0.733 NM_001190796
NCK1
NCK adaptor protein 1
chr10_+_114123765 0.729 ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_4853878 0.727 NM_001080523
ARRDC5
arrestin domain containing 5
chr20_-_43177137 0.726 NM_145652
WFDC5
WAP four-disulfide core domain 5
chr4_+_71096830 0.724 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr22_+_23333610 0.718 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr17_-_75427644 0.707 NM_003655
CBX4
chromobox homolog 4
chr18_+_74957475 0.702


chr1_-_228916559 0.700 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_-_24597717 0.684 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr4_+_35962038 0.671 NM_001170700
DTHD1
death domain containing 1
chr5_+_112877251 0.669 NM_022828
YTHDC2
YTH domain containing 2
chr20_+_54533191 0.662 NM_001012971
C20orf106
C20orf107
chromosome 20 open reading frame 106
chromosome 20 open reading frame 107
chr8_+_24207524 0.661 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr2_+_101974737 0.660 NM_004633
IL1R2
interleukin 1 receptor, type II
chr5_-_138746840 0.652 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr3_+_187813553 0.643 AHSG
alpha-2-HS-glycoprotein
chr1_-_62557559 0.642 KANK4
KN motif and ankyrin repeat domains 4
chr11_+_62893836 0.616 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr9_-_106705867 0.614 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr5_+_147695314 0.610 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr16_-_3485421 0.594 NM_001080524
C16orf90
chromosome 16 open reading frame 90
chr3_-_101316038 0.592 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr9_+_96528814 0.591 C9orf3
chromosome 9 open reading frame 3
chr2_-_31491102 0.588 NM_000379
XDH
xanthine dehydrogenase
chr17_-_77824849 0.586 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr5_+_73145098 0.585 RGNEF
190 kDa guanine nucleotide exchange factor
chr20_+_41621079 0.582 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_31491057 0.574 XDH
xanthine dehydrogenase
chr9_+_135994734 0.570 NM_052821
WDR5
WD repeat domain 5
chr20_+_43531806 0.561 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr6_-_133076873 0.554 NM_004666
VNN1
vanin 1
chr3_-_152585226 0.554 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr14_-_19871267 0.551 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr1_-_228916958 0.550 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_-_138746917 0.549 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr1_+_166414706 0.545 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr14_-_23802184 0.544 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr21_-_42659671 0.542 NM_003225
TFF1
trefoil factor 1
chr15_+_56217686 0.542 NM_020980
AQP9
aquaporin 9
chr2_-_113310796 0.534 NM_000576
IL1B
interleukin 1, beta
chr15_-_81412354 0.533 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr10_+_114033403 0.533 NM_058222
TECTB
tectorin beta
chrX_+_65152004 0.532


chr4_+_170817787 0.525 CLCN3
chloride channel 3
chr6_-_24491498 0.523 NM_001195610
DCDC2
doublecortin domain containing 2
chr20_+_41621119 0.514 SGK2
serum/glucocorticoid regulated kinase 2
chr1_+_151117421 0.513 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chrX_+_18370264 0.512 NM_001037343
CDKL5
cyclin-dependent kinase-like 5
chr3_-_155524898 0.508 NM_001114397
NM_020865
DHX36

DEAH (Asp-Glu-Ala-His) box polypeptide 36

chr4_-_153493133 0.507 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_-_211087570 0.505 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr1_-_228916486 0.500 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_150731720 0.499 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr21_-_42644138 0.498 NM_005423
TFF2
trefoil factor 2
chr20_-_1548589 0.495 NM_001083910
NM_001135844
NM_006065
SIRPB1


signal-regulatory protein beta 1


chr16_-_4528739 0.486 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr2_+_161980865 0.480 NM_006593
TBR1
T-box, brain, 1
chr10_+_89257569 0.476 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr3_+_187813405 0.471 AHSG
alpha-2-HS-glycoprotein
chr17_+_37122138 0.467 NM_000805
GAST
gastrin
chr15_-_72282581 0.467 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.11 2.56e-05 GO:0006954 inflammatory response
2.15 9.08e-05 GO:0006955 immune response
2.10 9.37e-05 GO:0006952 defense response
2.39 3.60e-03 GO:0051707 response to other organism
2.82 3.83e-03 GO:0009617 response to bacterium
1.86 7.99e-03 GO:0051704 multi-organism process
3.58 1.89e-02 GO:0042742 defense response to bacterium
1.66 2.95e-02 GO:0002376 immune system process
1.78 4.03e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.17 1.48e-06 GO:0005615 extracellular space
1.63 8.97e-06 GO:0005576 extracellular region
1.92 2.13e-05 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.09 8.83e-03 GO:0042379 chemokine receptor binding
5.08 2.33e-02 GO:0008009 chemokine activity
2.89 3.72e-02 GO:0061135 endopeptidase regulator activity
2.67 4.27e-02 GO:0005126 cytokine receptor binding