Motif ID: NFE2.p2

Z-value: 2.330


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa



Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_221955876 14.113 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_-_68369322 8.414 NM_152439
BEST3
bestrophin 3
chr21_+_29439768 4.895 C21orf7
chromosome 21 open reading frame 7
chr5_+_150000394 4.147 NM_001109974
NM_007286
SYNPO

synaptopodin

chr5_-_141041982 4.094 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_148747208 3.678 ECM1
extracellular matrix protein 1
chr1_+_148747110 3.389 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr9_+_676640 3.388


chr1_+_153232685 3.367 NM_018655
LENEP
lens epithelial protein
chr5_-_141041933 3.365 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_-_93030538 3.352 NM_005665
EVI5
ecotropic viral integration site 5
chr11_-_102174102 3.279 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102174032 3.198 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr17_+_18566060 3.183 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr21_-_35343065 2.848 RUNX1
runt-related transcription factor 1
chr13_+_51334117 2.804 NM_031290
CCDC70
coiled-coil domain containing 70
chr2_+_169634330 2.772 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_-_28429950 2.759 NM_145909
ZNF323
zinc finger protein 323
chr19_+_43572679 2.703 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr2_-_73170290 2.646 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr3_+_11153778 2.633 NM_001098213
HRH1
histamine receptor H1
chr13_-_35327798 2.632 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr9_+_102231616 2.625 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr7_+_1543644 2.622 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_+_29606408 2.592 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chrX_+_153423652 2.549 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr9_-_35744271 2.436 NM_001044264
MSMP
microseminoprotein, prostate associated
chr19_-_53935648 2.432 NM_017805
RASIP1
Ras interacting protein 1
chr12_-_51629874 2.412 KRT8
keratin 8
chr12_+_76749199 2.286 NM_014903
NAV3
neuron navigator 3
chr19_+_43486640 2.281 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr18_+_54039779 2.281 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_74825138 2.278 NM_000584
IL8
interleukin 8
chr6_+_41712907 2.275 MDFI
MyoD family inhibitor
chr18_+_54039730 2.246 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_-_15005761 2.199 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr19_-_4510713 2.198 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr11_+_12265022 2.183 NM_032867
MICALCL
MICAL C-terminal like
chr20_-_17487480 2.182 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr16_+_56219802 2.177 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr16_+_15503623 2.174 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr1_-_242073094 2.154 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chrX_+_99786044 2.134 SRPX2
sushi-repeat containing protein, X-linked 2
chr14_-_104507862 2.102 AHNAK2
AHNAK nucleoprotein 2
chr3_+_69998064 2.086 NM_198177
MITF
microphthalmia-associated transcription factor
chr21_-_35343331 2.085 RUNX1
runt-related transcription factor 1
chrX_+_100361588 2.026 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr17_-_26665213 2.013 EVI2B
ecotropic viral integration site 2B
chr18_+_54039818 2.009 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_+_111850367 2.009 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr6_+_44302973 1.979 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr11_-_128399218 1.977 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_+_66094324 1.923 NM_173471
SLC25A26
solute carrier family 25, member 26
chr15_-_38417564 1.899 C15orf52
chromosome 15 open reading frame 52
chr10_+_70745615 1.898 NM_033496
HK1
hexokinase 1
chr17_-_26665194 1.888 EVI2B
ecotropic viral integration site 2B
chr17_-_26665144 1.845 EVI2B
ecotropic viral integration site 2B
chr16_+_51690564 1.843 CHD9
chromodomain helicase DNA binding protein 9
chr4_-_68678181 1.839 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr1_+_81544432 1.821 LPHN2
latrophilin 2
chr11_-_10546654 1.816 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr11_-_102331643 1.815 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_+_17507276 1.793 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr22_+_19699441 1.773 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr17_-_37022465 1.753 NM_005557
KRT16
keratin 16
chr18_+_30544193 1.743 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr8_+_22900863 1.735 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr21_-_35343428 1.730 RUNX1
runt-related transcription factor 1
chr6_+_31190505 1.715 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr4_-_38710376 1.715 NM_024943
TMEM156
transmembrane protein 156
chr1_-_6474346 1.708 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_-_122722674 1.707 NM_005328
HAS2
hyaluronan synthase 2
chr3_+_50259329 1.703 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chrX_+_99785818 1.701 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr1_+_181421984 1.701 LAMC2
laminin, gamma 2
chr4_-_977163 1.670 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr3_+_161877640 1.667 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr10_+_115302767 1.660 NM_004132
HABP2
hyaluronan binding protein 2
chr13_-_98757634 1.659 NM_004951
GPR183
G protein-coupled receptor 183
chrX_-_33139349 1.641 NM_004006
DMD
dystrophin
chr3_+_185521139 1.622 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr9_+_35528628 1.610 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr5_-_90645974 1.609 LOC100505994
hypothetical LOC100505994
chrX_-_53327473 1.601 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr4_+_120276386 1.592 NM_016599
MYOZ2
myozenin 2
chr11_+_20341806 1.559 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr18_+_59405513 1.550 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chrX_-_15421279 1.542 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr11_+_20341900 1.484 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr20_+_33223434 1.472 NM_006404
PROCR
protein C receptor, endothelial
chr7_-_128330615 1.464 KCP
kielin/chordin-like protein
chr21_-_35343448 1.462 RUNX1
runt-related transcription factor 1
chr6_+_47732181 1.452 NM_153839
GPR111
G protein-coupled receptor 111
chr11_+_20341835 1.448 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20342262 1.434 NM_001098523
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr17_-_36928604 1.429 NM_002275
KRT15
keratin 15
chrX_-_15593074 1.419 NM_020665
TMEM27
transmembrane protein 27
chr16_+_2023279 1.414 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr9_+_35528890 1.403 RUSC2
RUN and SH3 domain containing 2
chr14_-_73323629 1.399 NM_001043318
C14orf43
chromosome 14 open reading frame 43
chr15_+_38849450 1.370 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr1_+_12698704 1.359 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr18_+_59593591 1.341 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_+_47867667 1.325 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr5_-_95184121 1.320 GLRX
glutaredoxin (thioltransferase)
chr19_-_50977485 1.314 DMPK
dystrophia myotonica-protein kinase
chr6_+_32229278 1.312 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chrX_-_24575375 1.311 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr21_-_35343456 1.310 NM_001754
RUNX1
runt-related transcription factor 1
chr3_+_101720753 1.308 TMEM45A
transmembrane protein 45A
chr7_+_22733290 1.305 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr3_+_57069508 1.304 NM_181727
SPATA12
spermatogenesis associated 12
chr1_-_110108048 1.297 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr10_-_31328426 1.296 NM_001143769
ZNF438
zinc finger protein 438
chr17_-_26665220 1.286 NM_006495
EVI2B
ecotropic viral integration site 2B
chr1_+_181422016 1.261 LAMC2
laminin, gamma 2
chr3_+_185520744 1.255 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr8_-_145097031 1.249 NM_201380
PLEC
plectin
chrX_-_24575146 1.245 PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_74462226 1.241 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr1_-_223683141 1.238 NM_194442
LBR
lamin B receptor
chr2_+_113591940 1.232 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr9_+_130231027 1.198 CERCAM
cerebral endothelial cell adhesion molecule
chr16_+_88515917 1.188 NM_001197181
TUBB3
tubulin, beta 3
chr5_+_35892747 1.160 NM_002185
IL7R
interleukin 7 receptor
chr3_+_142569988 1.154 ZBTB38
zinc finger and BTB domain containing 38
chr8_-_13018123 1.123 NM_001164271
DLC1
deleted in liver cancer 1
chr16_+_65868913 1.121 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr4_+_88076418 1.116


chr1_-_159325709 1.114 PVRL4
poliovirus receptor-related 4
chr8_+_24827173 1.102 NM_005382
NEFM
neurofilament, medium polypeptide
chr4_-_101658094 1.100 NM_001159694
NM_016242
EMCN

endomucin

chr17_+_29621352 1.083 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr1_-_151788341 1.078 NM_002960
S100A3
S100 calcium binding protein A3
chr12_-_15706340 1.077 EPS8
epidermal growth factor receptor pathway substrate 8
chr11_-_123685871 1.076 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr1_-_151614681 1.057 NM_005621
S100A12
S100 calcium binding protein A12
chr19_-_50977592 1.055 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr12_-_101115677 1.053 NM_002674
PMCH
pro-melanin-concentrating hormone
chr2_-_219881937 1.042 PTPRN
protein tyrosine phosphatase, receptor type, N
chr10_+_30763056 1.029 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr7_-_150352484 1.025 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr8_+_24827181 1.021 NEFM
neurofilament, medium polypeptide
chr18_+_50646616 1.016 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr8_-_11748330 1.014


chr19_-_50977586 1.013 DMPK
dystrophia myotonica-protein kinase
chr11_-_123261549 1.009 NM_001013743
TMEM225
transmembrane protein 225
chr8_-_82557956 1.006 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr5_-_95184221 1.006 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr16_+_14187965 1.005 MKL2
MKL/myocardin-like 2
chr12_-_55316350 1.004 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr19_+_45564549 1.004 PLD3
phospholipase D family, member 3
chr14_-_23802184 0.996 NM_000359
TGM1
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
chr7_-_92300573 0.994 CDK6
cyclin-dependent kinase 6
chr1_-_156923111 0.993 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_-_25692754 0.986 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr11_-_71458739 0.983 NUMA1
nuclear mitotic apparatus protein 1
chr15_+_65245546 0.975 NM_001145104
SMAD3
SMAD family member 3
chr17_-_43254117 0.974 OSBPL7
oxysterol binding protein-like 7
chr19_-_60573552 0.974 NM_000641
IL11
interleukin 11
chr7_-_150561233 0.963


chr12_-_54522881 0.959 NM_002429
MMP19
matrix metallopeptidase 19
chr22_-_43986896 0.957 KIAA0930
KIAA0930
chr1_+_181421796 0.940 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr7_+_130445394 0.938 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr22_+_18388656 0.935 C22orf25
chromosome 22 open reading frame 25
chrX_+_9391314 0.926 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr16_+_80626331 0.926 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr4_-_159312973 0.924 FAM198B
family with sequence similarity 198, member B
chr11_+_62136788 0.923 NM_000327
ROM1
retinal outer segment membrane protein 1
chr1_+_207668787 0.918 NM_001104548
LOC642587
NPC-A-5
chr9_+_4975082 0.905 JAK2
Janus kinase 2
chr4_+_109033868 0.903 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_+_49002285 0.895 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr18_-_45630154 0.892 MYO5B
myosin VB
chr11_-_62136778 0.888 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr11_-_101906640 0.872 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr9_+_71009746 0.869 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr17_-_43254132 0.859 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr1_-_117554999 0.851 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr15_+_96304911 0.832 NM_183376
ARRDC4
arrestin domain containing 4
chr11_-_123353607 0.829 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr17_+_25292748 0.829 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr9_-_116920232 0.828 NM_002160
TNC
tenascin C
chr1_-_45760115 0.824 NM_002574
NM_181696
NM_181697
PRDX1


peroxiredoxin 1


chr3_-_167037946 0.821 NM_000055
BCHE
butyrylcholinesterase
chr12_-_51153788 0.821 NM_173086
KRT6C
keratin 6C
chr5_-_75954807 0.816 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_-_172258129 0.813


chr18_+_53863865 0.811 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_-_85512937 0.811 NM_013438
NM_053067
UBQLN1

ubiquilin 1

chr22_-_43987010 0.810 NM_015264
KIAA0930
KIAA0930
chr12_+_67489063 0.809 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr21_-_35343500 0.809 RUNX1
runt-related transcription factor 1
chr6_-_29563657 0.802 NM_052967
MAS1L
MAS1 oncogene-like
chr1_-_152201814 0.799 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr17_+_77261477 0.789 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_-_46601687 0.788 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr19_-_55914837 0.786


chr4_-_174687104 0.785 HAND2
heart and neural crest derivatives expressed 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.20 2.75e-02 GO:0050896 response to stimulus
1.59 2.77e-02 GO:0051246 regulation of protein metabolic process
1.30 2.94e-02 GO:0007165 signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 1.65e-04 GO:0005856 cytoskeleton
1.42 1.99e-03 GO:0005829 cytosol
6.79 3.61e-03 GO:0001533 cornified envelope
1.67 4.14e-03 GO:0005626 insoluble fraction
1.65 8.48e-03 GO:0005624 membrane fraction
3.68 1.39e-02 GO:0000502 proteasome complex
1.53 1.62e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
17.83 5.32e-03 GO:0015037 peptide disulfide oxidoreductase activity
5.18 1.92e-02 GO:0015036 disulfide oxidoreductase activity