Motif ID: NR1H4.p2

Z-value: 2.384


Transcription factors associated with NR1H4.p2:

Gene SymbolEntrez IDGene Name
NR1H4 9971 nuclear receptor subfamily 1, group H, member 4



Activity profile for motif NR1H4.p2.

activity profile for motif NR1H4.p2


Sorted Z-values histogram for motif NR1H4.p2

Sorted Z-values for motif NR1H4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1H4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_27113018 3.613 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr6_+_31731647 3.262 NM_019101
APOM
apolipoprotein M
chr8_+_145692916 3.155 NM_032902
PPP1R16A
protein phosphatase 1, regulatory (inhibitor) subunit 16A
chr17_+_7474177 3.084 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr6_+_31731667 3.071 APOM
apolipoprotein M
chr17_+_7474128 3.051 SHBG
sex hormone-binding globulin
chr1_-_25619863 2.782 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr11_+_61389756 2.760 FADS2
fatty acid desaturase 2
chr1_+_25471470 2.650 NM_001127691
NM_016124
RHD

Rh blood group, D antigen

chr12_+_56802 2.636 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr1_+_160618143 2.599 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr16_+_25135783 2.494 NM_001169
AQP8
aquaporin 8
chr22_+_19651446 2.469 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_-_6418705 2.448 NM_000613
HPX
hemopexin
chr20_-_43889339 2.428 NM_003279
TNNC2
troponin C type 2 (fast)
chr1_-_180622083 2.268 GLUL
glutamate-ammonia ligase
chr2_+_27225362 2.133 NM_175769
TCF23
transcription factor 23
chr1_+_152560179 2.066 NM_080429
AQP10
aquaporin 10
chr15_+_63124760 2.025 NM_178859
OSTBETA
organic solute transporter beta
chr3_+_50291521 2.023 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr11_-_46674233 2.016 ARHGAP1
Rho GTPase activating protein 1
chr20_-_3097070 1.895 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr14_-_23623657 1.825 NM_006177
NRL
neural retina leucine zipper
chr17_+_18796202 1.764 NM_001042450
NM_152351
SLC5A10

solute carrier family 5 (sodium/glucose cotransporter), member 10

chr2_-_178645718 1.762 NM_016953
PDE11A
phosphodiesterase 11A
chr17_-_43390108 1.734 NM_024320
PRR15L
proline rich 15-like
chr7_+_100037817 1.697 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr1_+_559618 1.654


chr3_+_52803823 1.631 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr3_-_127719283 1.612 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chrX_-_153903963 1.587 NM_000132
F8
coagulation factor VIII, procoagulant component
chr19_+_40299058 1.584 FXYD3
FXYD domain containing ion transport regulator 3
chr2_-_73723001 1.581 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr12_+_68028407 1.536 LYZ
lysozyme
chr12_-_7172641 1.514 NM_031491
RBP5
retinol binding protein 5, cellular
chr19_-_56585603 1.481 NM_001193623
LOC147646
hypothetical protein LOC147646
chr11_-_64459910 1.474 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr1_+_158603480 1.425 NM_005598
NHLH1
nescient helix loop helix 1
chr1_-_150070849 1.401 NM_005060
RORC
RAR-related orphan receptor C
chr20_+_57027703 1.394 NM_030773
TUBB1
tubulin, beta 1
chr19_-_54350457 1.365 NM_002152
HRC
histidine rich calcium binding protein
chr7_+_134567270 1.356 NM_182489
STRA8
stimulated by retinoic acid gene 8 homolog (mouse)
chr16_+_56259657 1.334 NM_170776
GPR97
G protein-coupled receptor 97
chr3_-_129777618 1.317 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr16_+_24765052 1.313 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr8_-_13018123 1.311 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_180621272 1.307 GLUL
glutamate-ammonia ligase
chr3_+_188043156 1.297 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr12_+_56299959 1.296 NM_133489
SLC26A10
solute carrier family 26, member 10
chr14_+_54238581 1.293 SAMD4A
sterile alpha motif domain containing 4A
chr19_+_810673 1.273 CFD
complement factor D (adipsin)
chr11_-_64133908 1.266


chr19_+_55398680 1.251 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chr2_+_218929822 1.246 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr19_-_63556632 1.240 NM_130786
A1BG
alpha-1-B glycoprotein
chr22_+_43451351 1.240 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_-_77092831 1.221 ACTG1
actin, gamma 1
chr2_-_85490997 1.213 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr3_+_188043172 1.209 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr2_+_108271526 1.182 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr2_-_105381855 1.182 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr19_-_47638890 1.110 NM_198477
CXCL17
chemokine (C-X-C motif) ligand 17
chr1_+_54880014 1.099 NM_001039464
HEATR8-TTC4
HEATR8
HEATR8-TTC4 read-through transcript
HEAT repeat containing 8
chr17_-_24426752 1.098 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr3_-_49701085 1.094 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr1_+_149221122 1.092 NM_003568
ANXA9
annexin A9
chr22_-_22304486 1.066 NM_016449
C22orf43
chromosome 22 open reading frame 43
chr22_-_29231597 1.049 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr11_-_64368616 1.045 NM_017525
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr17_+_37247568 1.040 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr3_-_50315983 1.033 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chrX_+_106336517 1.031 NM_001169154
NM_173494
CXorf41

chromosome X open reading frame 41

chr22_+_23329113 1.031 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr19_+_15644885 1.030 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr19_+_810658 1.028 NM_001928
CFD
complement factor D (adipsin)
chr22_+_43451600 1.012 PRR5
proline rich 5 (renal)
chr3_-_197726587 1.005 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr3_-_15349086 1.005 NM_004844
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr6_+_44234525 1.004 NM_007058
CAPN11
calpain 11
chr1_-_172153024 0.994 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr7_+_128099581 0.992 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr8_-_37576515 0.978 LOC157860
hypothetical protein LOC157860
chr15_-_38185578 0.976 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr22_+_18085891 0.976 SEPT5
septin 5
chr3_-_52463070 0.976 NM_003280
TNNC1
troponin C type 1 (slow)
chr1_+_33003814 0.974 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_15941503 0.967 NM_001013641
TMEM82
transmembrane protein 82
chr16_+_87765661 0.965 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr19_-_56567602 0.961 NM_005601
NKG7
natural killer cell group 7 sequence
chr1_-_47468029 0.956 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr20_-_54534387 0.953 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr1_+_29086156 0.950 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr16_+_55373241 0.940 NUP93
nucleoporin 93kDa
chr1_+_85819004 0.934 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_3651236 0.930 NM_002208
ITGAE
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
chr1_+_148496792 0.929 NM_012113
CA14
carbonic anhydrase XIV
chr22_+_18085990 0.923 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr17_-_51164443 0.908 NM_001099640
TMEM100
transmembrane protein 100
chr19_+_10424581 0.880 NM_006202
PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_+_18588050 0.878 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr16_+_8722068 0.863 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr2_+_220087135 0.860 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr11_-_116168316 0.859 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr2_+_176724358 0.854 NM_014621
HOXD4
homeobox D4
chr6_-_32268267 0.848 GPSM3
G-protein signaling modulator 3
chr1_+_33003847 0.844 KIAA1522
KIAA1522
chr11_-_113082233 0.842 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr12_+_52105131 0.839 AMHR2
anti-Mullerian hormone receptor, type II
chr1_-_205186330 0.836 NM_002644
PIGR
polymeric immunoglobulin receptor
chr4_-_69852090 0.828 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_12046020 0.826 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_+_29086206 0.821 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_-_143708467 0.819 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr16_-_73012740 0.812 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr3_-_15348811 0.812 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr1_+_6537924 0.808 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr19_-_40317829 0.808 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chr8_+_110443881 0.807 NM_177531
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr11_+_118561375 0.804 NM_001168468
NM_024791
PDZD3

PDZ domain containing 3

chr17_+_37942034 0.800


chr16_+_30102426 0.793 CORO1A
coronin, actin binding protein, 1A
chr22_-_20637188 0.792 PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr12_+_107797985 0.791 NM_001917
DAO
D-amino-acid oxidase
chr6_+_112775224 0.779 NM_001013734
RFPL4B
ret finger protein-like 4B
chr11_-_5232480 0.774 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr1_-_16411690 0.770 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_-_11029737 0.762 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr2_+_97696462 0.761 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr17_-_77421980 0.759 NM_001185077
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
chr1_+_114295289 0.758 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr1_+_203179976 0.754 NM_001160331
NFASC
neurofascin
chr16_+_29892714 0.753 NM_004783
NM_016151
TAOK2

TAO kinase 2

chr1_+_116727514 0.752 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chrX_+_128966844 0.747 NM_021946
BCORL1
BCL6 corepressor-like 1
chr6_+_44302973 0.747 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr2_-_85490984 0.746 CAPG
capping protein (actin filament), gelsolin-like
chr22_-_20637212 0.742 NM_014634
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr17_-_42250961 0.741 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr10_-_75304225 0.739 NM_001222
NM_172169
NM_172171
NM_172173
NM_172170
CAMK2G




calcium/calmodulin-dependent protein kinase II gamma




chr10_-_101831579 0.735 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr17_+_71097147 0.734 MYO15B
myosin XVB pseudogene
chr11_+_61276576 0.731 NM_001127392
C11orf9
chromosome 11 open reading frame 9
chr13_-_99422163 0.731 NM_033132
ZIC5
Zic family member 5 (odd-paired homolog, Drosophila)
chr2_+_176724583 0.731


chr19_-_18246166 0.726 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr3_-_180460372 0.723 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr18_+_75967902 0.718 NM_014913
ADNP2
ADNP homeobox 2
chr18_-_26935883 0.717 NM_004949
NM_024422
DSC2

desmocollin 2

chr6_-_2785682 0.715 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr20_-_3592045 0.704 NM_022139
NM_145762
GFRA4

GDNF family receptor alpha 4

chr17_-_43283529 0.703 SP6
Sp6 transcription factor
chr17_+_2627099 0.703 RAP1GAP2
RAP1 GTPase activating protein 2
chr20_+_36643251 0.703 NM_001018082
ADIG
adipogenin
chr11_+_67007155 0.699 AIP
aryl hydrocarbon receptor interacting protein
chr11_+_64114857 0.697 NM_144585
NM_153378
SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12

chr14_-_69333624 0.693 NM_003049
SLC10A1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr3_+_48388712 0.692 NM_001159927
NM_001159929
NM_207102
FBXW12


F-box and WD repeat domain containing 12


chr6_-_27988152 0.691 NM_033057
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr1_+_148020869 0.690 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr7_+_44045202 0.690 FLJ35390
hypothetical LOC255031
chr6_-_32184975 0.689 NM_019105
TNXB
tenascin XB
chr17_-_39500512 0.687 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chrX_-_106033202 0.684 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr6_+_43373972 0.682 NM_006672
NM_153320
SLC22A7

solute carrier family 22 (organic anion transporter), member 7

chr15_+_70734091 0.681 NM_018652
GOLGA6A
GOLGA6B
golgin A6 family, member A
golgin A6 family, member B
chr4_+_74500748 0.681 ALB
albumin
chr9_-_103237851 0.678 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chrX_-_70243362 0.671 NM_001025265
CXorf65
chromosome X open reading frame 65
chr1_+_15675182 0.669 NM_015849
CELA2B
chymotrypsin-like elastase family, member 2B
chr11_+_75106512 0.668 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr16_-_70080678 0.667 NM_006961
ZNF19
zinc finger protein 19
chr14_-_23968570 0.665 NM_001039771
CBLN3
cerebellin 3 precursor
chr10_+_71060008 0.665 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_+_24465109 0.661 NM_181337
KAAG1
kidney associated antigen 1
chr17_+_75319476 0.659 NM_178543
ENPP7
ectonucleotide pyrophosphatase/phosphodiesterase 7
chr17_+_61729193 0.658 PRKCA
protein kinase C, alpha
chr11_+_63030131 0.655 LGALS12
lectin, galactoside-binding, soluble, 12
chr20_-_34921689 0.655 NM_199181
KIAA0889
KIAA0889
chr5_+_131621276 0.647 PDLIM4
PDZ and LIM domain 4
chr1_-_109386112 0.645 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr7_+_12595672 0.643 NM_033128
SCIN
scinderin
chr17_+_42641426 0.641 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr1_+_149877955 0.639 SNX27
sorting nexin family member 27
chr7_-_44547382 0.637 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr2_+_178893216 0.637 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_-_2129031 0.635 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr1_-_59020875 0.634 JUN
jun proto-oncogene
chr1_-_148174722 0.632 NM_181873
MTMR11
myotubularin related protein 11
chr11_+_74539679 0.631 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr7_+_36395913 0.630 NM_018685
ANLN
anillin, actin binding protein
chr12_+_52103905 0.630 NM_001164690
NM_001164691
NM_020547
AMHR2


anti-Mullerian hormone receptor, type II


chr11_-_56846246 0.624 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr22_+_23309717 0.623 NM_013430
GGT1
gamma-glutamyltransferase 1
chr17_+_77910411 0.618 NM_207459
TEX19
testis expressed 19
chr9_-_103185621 0.613 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr1_+_26433200 0.613 NM_022778
CCDC21
coiled-coil domain containing 21
chr16_+_1979959 0.613 NM_004209
SYNGR3
synaptogyrin 3
chr17_-_77386156 0.612 DYSFIP1
dysferlin interacting protein 1
chr5_+_131621287 0.605 PDLIM4
PDZ and LIM domain 4
chr17_-_24062998 0.605 NM_152465
PROCA1
protein interacting with cyclin A1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.02 1.64e-02 GO:0010035 response to inorganic substance
2.24 4.49e-02 GO:0010038 response to metal ion

Nothing significant found in compartment category.

Nothing significant found in function category.