Motif ID: FOXN1.p2

Z-value: 1.425


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1



Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_64086366 1.083 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr8_-_38245694 0.800 NM_001102559
NM_001102560
NM_032483
PPAPDC1B


phosphatidic acid phosphatase type 2 domain containing 1B


chr12_-_6585785 0.777 CHD4
chromodomain helicase DNA binding protein 4
chr5_-_100266769 0.751 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr1_+_82038669 0.736 NM_012302
LPHN2
latrophilin 2
chr13_+_35903966 0.697 NM_001111046
NM_001111047
CCNA1

cyclin A1

chr13_+_23632788 0.673 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chrX_-_83329562 0.652 NM_014496
RPS6KA6
ribosomal protein S6 kinase, 90kDa, polypeptide 6
chr2_-_39040981 0.631 LOC375196
hypothetical LOC375196
chr9_-_109290107 0.613 KLF4
Kruppel-like factor 4 (gut)
chr6_-_25019173 0.605 NM_014722
FAM65B
family with sequence similarity 65, member B
chr22_+_40195058 0.605 NM_001098
ACO2
aconitase 2, mitochondrial
chr17_-_46553083 0.586 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr21_-_26867138 0.584 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr3_-_191321367 0.557 LEPREL1
leprecan-like 1
chr4_+_57066131 0.554 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr11_+_82290384 0.552 NM_145018
C11orf82
chromosome 11 open reading frame 82
chr17_-_60208083 0.542 LOC146880
hypothetical LOC146880
chr4_-_111763655 0.534 NM_000325
PITX2
paired-like homeodomain 2
chr12_-_6830667 0.532 NM_031299
CDCA3
cell division cycle associated 3
chr11_+_65357972 0.527 NM_152760
SNX32
sorting nexin 32
chr15_+_91248706 0.521 CHD2
chromodomain helicase DNA binding protein 2
chr10_-_120091795 0.519 NM_001134672
NM_022063
C10orf84

chromosome 10 open reading frame 84

chr19_-_58449752 0.510 ZNF677
zinc finger protein 677
chr13_-_45524846 0.508 NM_015070
ZC3H13
zinc finger CCCH-type containing 13
chrX_-_21586337 0.499 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr7_+_29200850 0.494 CHN2
chimerin (chimaerin) 2
chr5_-_73973004 0.494 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr11_-_133332089 0.492 NM_014987
IGSF9B
immunoglobulin superfamily, member 9B
chr3_+_52254782 0.491 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr14_+_30564433 0.486 NM_001128126
NM_007077
AP4S1

adaptor-related protein complex 4, sigma 1 subunit

chr12_+_87060176 0.486 NM_181783
TMTC3
transmembrane and tetratricopeptide repeat containing 3
chr14_+_99273751 0.483 EML1
echinoderm microtubule associated protein like 1
chr7_+_100302885 0.459 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr11_-_88864061 0.457 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr6_+_148705646 0.456 SASH1
SAM and SH3 domain containing 1
chr10_+_103103797 0.455 NM_003939
NM_033637
BTRC

beta-transducin repeat containing

chr14_+_51526071 0.455 C14orf166
chromosome 14 open reading frame 166
chr5_-_115938305 0.455 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr5_+_99899133 0.454 FAM174A
family with sequence similarity 174, member A
chr12_+_121825021 0.454 NM_032573
NM_201435
CCDC62

coiled-coil domain containing 62

chr2_+_71534260 0.440 NM_001130976
NM_001130977
NM_001130978
NM_001130979
NM_001130980
NM_001130981
NM_003494
DYSF






dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)






chrX_+_128942435 0.429


chr12_-_87059877 0.428 NM_025114
CEP290
centrosomal protein 290kDa
chr13_+_45524950 0.427


chr3_+_199171467 0.422 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chr22_-_40414765 0.421 NM_001003796
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr13_-_77390907 0.420 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr13_+_44461657 0.413 NM_018559
KIAA1704
KIAA1704
chr3_-_49370755 0.413 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr10_-_27569269 0.411 NM_145698
ACBD5
acyl-CoA binding domain containing 5
chr17_+_4743645 0.405 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr11_+_101423378 0.405 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr3_-_49370682 0.404 GPX1
glutathione peroxidase 1
chr17_-_30929669 0.403 NM_000286
PEX12
peroxisomal biogenesis factor 12
chr10_+_94342789 0.400 NM_004523
KIF11
kinesin family member 11
chr2_-_142605010 0.396 LRP1B
low density lipoprotein receptor-related protein 1B
chr1_+_45565126 0.381 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr17_+_59429442 0.381 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr5_+_72830029 0.377 BTF3
basic transcription factor 3
chr3_-_16281287 0.375 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr4_+_48038095 0.375 SLAIN2
SLAIN motif family, member 2
chr14_+_73621408 0.375 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr2_-_54051290 0.374 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr14_+_103675194 0.373 KIF26A
kinesin family member 26A
chr14_+_69148062 0.371 NM_014734
KIAA0247
KIAA0247
chr1_+_204305506 0.369 NM_001123168
FAM72B
FAM72A
family with sequence similarity 72, member B
family with sequence similarity 72, member A
chr3_-_53139457 0.369 NM_052859
RFT1
RFT1 homolog (S. cerevisiae)
chr7_-_84654106 0.367 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr14_+_74030195 0.366 NM_194279
ISCA2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr13_-_44461554 0.364 NM_012345
NUFIP1
nuclear fragile X mental retardation protein interacting protein 1
chr15_-_53487748 0.357 NM_004748
NM_020739
CCPG1

cell cycle progression 1

chr14_+_64077171 0.353 HSPA2
heat shock 70kDa protein 2
chr1_+_219026661 0.349 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr10_+_90740364 0.349 FAS
Fas (TNF receptor superfamily, member 6)
chr5_-_16518893 0.346 NM_033414
ZNF622
zinc finger protein 622
chr1_-_32479785 0.345 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr4_-_170770111 0.344 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr3_+_139388770 0.343 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr13_+_51484517 0.342 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr17_+_4922445 0.341 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr11_+_125279481 0.341 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr14_+_36196523 0.340 NM_006194
PAX9
paired box 9
chr3_-_181237210 0.339 NM_016559
PEX5L
peroxisomal biogenesis factor 5-like
chr17_-_28644118 0.339 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr12_+_56406296 0.336 LOC100130776
hypothetical LOC100130776
chr17_+_4922478 0.336 ZFP3
zinc finger protein 3 homolog (mouse)
chr15_+_70553743 0.335 ARIH1
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
chr15_-_47235057 0.335 NM_001143887
NM_004236
COPS2

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)

chr5_+_76418545 0.333 LOC728723
hypothetical LOC728723
chr10_-_93658605 0.332 FGFBP3
fibroblast growth factor binding protein 3
chr15_+_45796802 0.331 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr15_+_70553719 0.330 NM_005744
ARIH1
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
chr7_-_27120015 0.328 HOXA3
homeobox A3
chr10_+_94342940 0.327 KIF11
kinesin family member 11
chr8_-_11096257 0.326 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr9_-_33015091 0.326 APTX
aprataxin
chr7_+_91996022 0.325 NM_032120
C7orf64
chromosome 7 open reading frame 64
chr4_+_41687249 0.325 NM_006345
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr10_+_94342853 0.324 KIF11
kinesin family member 11
chr19_+_10900502 0.323 C19orf52
chromosome 19 open reading frame 52
chr4_+_41687304 0.322 SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr4_+_41687302 0.320 SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr19_-_10305186 0.320 NM_133452
RAVER1
ribonucleoprotein, PTB-binding 1
chr2_-_202215593 0.320 NM_152388
ALS2CR4
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
chr11_-_116607968 0.316 PCSK7
proprotein convertase subtilisin/kexin type 7
chr13_-_94162249 0.316 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr14_-_87859284 0.316 NM_138317
KCNK10
potassium channel, subfamily K, member 10
chr17_-_74433048 0.315 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr14_-_76856776 0.315 NM_013382
POMT2
protein-O-mannosyltransferase 2
chr6_+_108593907 0.314 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr15_+_76517623 0.313 IREB2
iron-responsive element binding protein 2
chr9_-_32991518 0.313 NM_001195249
NM_001195254
NM_001195248
NM_001195250
NM_001195251
NM_001195252
NM_175069
NM_175073
APTX







aprataxin







chr18_+_17076166 0.313 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr5_+_72830003 0.311 NM_001037637
NM_001207
BTF3

basic transcription factor 3

chr5_-_16518847 0.311 ZNF622
zinc finger protein 622
chr5_+_94981735 0.311 NM_199243
GPR150
G protein-coupled receptor 150
chr22_-_29015452 0.309 NM_001037666
GATSL3
GATS protein-like 3
chr16_-_56038771 0.309 NM_020313
CIAPIN1
cytokine induced apoptosis inhibitor 1
chr13_-_95094920 0.309 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr3_-_52418933 0.308 NM_004656
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr14_+_60517682 0.305 SLC38A6
solute carrier family 38, member 6
chr7_-_22363036 0.303 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr10_+_111959978 0.303 NM_001008541
MXI1
MAX interactor 1
chr12_-_12606511 0.302 NM_030640
DUSP16
dual specificity phosphatase 16
chr2_+_99320181 0.302 NM_015904
EIF5B
eukaryotic translation initiation factor 5B
chr14_+_69148066 0.299 KIAA0247
KIAA0247
chr1_+_78243181 0.298 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_-_158091296 0.297 C1orf204
chromosome 1 open reading frame 204
chr4_-_156517394 0.296 MAP9
microtubule-associated protein 9
chr10_+_102810904 0.295 NM_030929
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr3_-_52419086 0.295 BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr4_+_4594619 0.295 LOC100507266
hypothetical LOC100507266
chr12_+_4889309 0.294 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr17_-_74432671 0.292 TIMP2
TIMP metallopeptidase inhibitor 2
chr22_+_27798887 0.291 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr17_-_74432800 0.289 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_119418299 0.286 DYNLL1
dynein, light chain, LC8-type 1
chr2_-_43676603 0.286 NM_001083953
NM_022065
THADA

thyroid adenoma associated

chr14_-_60517464 0.285 NM_020810
TRMT5
TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)
chr9_+_33015287 0.285 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr9_-_114135754 0.285 NM_001163788
NM_001163790
NM_005156
ROD1


ROD1 regulator of differentiation 1 (S. pombe)


chr17_+_40581704 0.284 HEXIM1
hexamethylene bis-acetamide inducible 1
chr16_+_56038837 0.282 NM_020312
COQ9
coenzyme Q9 homolog (S. cerevisiae)
chr14_+_101297887 0.279 NM_001161725
NM_001161726
PPP2R5C

protein phosphatase 2, regulatory subunit B', gamma

chr14_+_60517702 0.278 SLC38A6
solute carrier family 38, member 6
chrX_+_67830204 0.277 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr17_+_6856521 0.276 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr17_+_45940743 0.276 NM_032133
MYCBPAP
MYCBP associated protein
chr7_+_23111928 0.275 KLHL7
kelch-like 7 (Drosophila)
chr10_-_97443560 0.275 TCTN3
tectonic family member 3
chr3_-_121944052 0.275 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr13_-_47510033 0.274 SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit
chr11_-_65139277 0.272 MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr4_-_4594648 0.271 NM_016930
STX18
syntaxin 18
chr11_-_93774223 0.271 NM_016540
GPR83
G protein-coupled receptor 83
chr9_+_33015270 0.269 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr7_-_74909928 0.268 POM121C
POM121 membrane glycoprotein C
chr14_+_60517584 0.266 NM_001172702
NM_153811
SLC38A6

solute carrier family 38, member 6

chr17_+_7125702 0.265 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr17_+_7279485 0.265 NM_178518
TMEM102
transmembrane protein 102
chrX_-_46503415 0.260 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr4_+_172971149 0.259 NM_001034845
GALNTL6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr2_-_130655616 0.258 NM_001171083
NM_017751
NM_017951
SMPD4


sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)


chr6_+_30142910 0.258 NM_021959
PPP1R11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr16_+_84490267 0.256 NM_002163
IRF8
interferon regulatory factor 8
chr14_+_51525942 0.256 NM_016039
C14orf166
chromosome 14 open reading frame 166
chr13_+_48448950 0.255 FNDC3A
fibronectin type III domain containing 3A
chr1_-_77921681 0.255 ZZZ3
zinc finger, ZZ-type containing 3
chr14_+_75521806 0.254 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr18_-_44729700 0.254 NM_001190822
SMAD7
SMAD family member 7
chr3_-_100103142 0.254 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr4_+_110574274 0.254 SEC24B
SEC24 family, member B (S. cerevisiae)
chr5_+_88220846 0.253


chr6_-_75972286 0.253 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr18_-_50004770 0.253 MBD2
methyl-CpG binding domain protein 2
chr6_-_90405156 0.250 NM_020466
LYRM2
LYR motif containing 2
chr12_-_67012303 0.249 NM_017440
NM_020128
MDM1

Mdm1 nuclear protein homolog (mouse)

chr12_-_6586736 0.249 CHD4
chromodomain helicase DNA binding protein 4
chr2_-_165406098 0.249 COBLL1
COBL-like 1
chr12_+_54798236 0.248 NM_032786
ZC3H10
zinc finger CCCH-type containing 10
chr9_-_113285636 0.247 KIAA0368
KIAA0368
chr17_+_17339059 0.245


chr3_-_192063158 0.245 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr8_+_121892719 0.244


chrX_+_67830215 0.244 STARD8
StAR-related lipid transfer (START) domain containing 8
chr12_+_103133631 0.244 NM_001093771
TXNRD1
thioredoxin reductase 1
chr2_+_68548173 0.244 NM_173545
APLF
aprataxin and PNKP like factor
chrX_-_13307425 0.243


chr5_+_156819782 0.243 NIPAL4
NIPA-like domain containing 4
chr16_-_730889 0.242 NM_022493
NARFL
nuclear prelamin A recognition factor-like
chr10_+_127575097 0.241 NM_145235
FANK1
fibronectin type III and ankyrin repeat domains 1
chr11_+_7997366 0.241 TUB
tubby homolog (mouse)
chr12_+_119418294 0.240 DYNLL1
dynein, light chain, LC8-type 1
chr4_-_156517423 0.240 MAP9
microtubule-associated protein 9
chr10_+_21863099 0.240 NM_001195627
NM_001195628
NM_001195630
NM_004641
MLLT10



myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10



chr12_-_29425349 0.239 ERGIC2
ERGIC and golgi 2
chr15_+_97609059 0.239 NM_144598
LRRC28
leucine rich repeat containing 28
chr10_+_70385889 0.238 NM_004728
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr12_-_29425336 0.238 ERGIC2
ERGIC and golgi 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.32 4.51e-08 GO:0044260 cellular macromolecule metabolic process
1.21 1.39e-05 GO:0044237 cellular metabolic process
1.25 2.29e-05 GO:0043170 macromolecule metabolic process
1.37 2.16e-04 GO:0044267 cellular protein metabolic process
1.10 3.92e-04 GO:0009987 cellular process
1.16 1.30e-03 GO:0008152 metabolic process
1.18 2.32e-03 GO:0044238 primary metabolic process
1.39 2.73e-03 GO:0043412 macromolecule modification
1.39 3.73e-03 GO:0006464 protein modification process
1.93 1.96e-02 GO:0070647 protein modification by small protein conjugation or removal

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 1.21e-15 GO:0044424 intracellular part
1.15 8.02e-15 GO:0005622 intracellular
1.32 3.23e-13 GO:0005634 nucleus
1.20 2.10e-11 GO:0043231 intracellular membrane-bounded organelle
1.20 2.85e-11 GO:0043227 membrane-bounded organelle
1.17 1.68e-10 GO:0043229 intracellular organelle
1.17 2.83e-10 GO:0043226 organelle
1.16 6.86e-06 GO:0005737 cytoplasm
1.45 8.54e-06 GO:0031981 nuclear lumen
1.37 1.79e-04 GO:0044428 nuclear part
1.47 4.56e-04 GO:0005654 nucleoplasm
1.19 5.35e-04 GO:0044446 intracellular organelle part
1.34 5.81e-04 GO:0070013 intracellular organelle lumen
1.32 1.69e-03 GO:0043233 organelle lumen
1.18 1.81e-03 GO:0044422 organelle part
1.31 2.58e-03 GO:0031974 membrane-enclosed lumen
1.04 1.53e-02 GO:0044464 cell part
1.04 1.57e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 5.64e-05 GO:0005488 binding
1.15 8.44e-04 GO:0005515 protein binding
1.70 2.16e-02 GO:0016874 ligase activity
1.91 3.55e-02 GO:0016881 acid-amino acid ligase activity
2.74 4.27e-02 GO:0016790 thiolester hydrolase activity
1.96 4.87e-02 GO:0019787 small conjugating protein ligase activity