Motif ID: RORA.p2

Z-value: 0.997


Transcription factors associated with RORA.p2:

Gene SymbolEntrez IDGene Name
RORA 6095 RAR-related orphan receptor A



Activity profile for motif RORA.p2.

activity profile for motif RORA.p2


Sorted Z-values histogram for motif RORA.p2

Sorted Z-values for motif RORA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RORA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_90780604 1.638 NM_001177676
GPR68
G protein-coupled receptor 68
chr3_-_126215069 1.621 HEG1
HEG homolog 1 (zebrafish)
chr3_+_185520744 1.553 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr18_-_54447168 1.235 NM_052947
ALPK2
alpha-kinase 2
chr11_-_64283945 1.128 PYGM
phosphorylase, glycogen, muscle
chr4_+_157044296 0.960 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr2_+_219180862 0.891 PLCD4
phospholipase C, delta 4
chr1_-_171442937 0.862 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr7_+_18501876 0.809 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr2_+_219180875 0.796 NM_032726
PLCD4
phospholipase C, delta 4
chr17_+_38250122 0.789 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr1_-_233879617 0.766 NM_001098722
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr2_+_219180821 0.754 PLCD4
phospholipase C, delta 4
chr6_+_37360144 0.664 TBC1D22B
TBC1 domain family, member 22B
chr14_-_69725342 0.646 NM_033262
NM_058240
NM_182932
NM_183002
SLC8A3



solute carrier family 8 (sodium/calcium exchanger), member 3



chr10_+_102285690 0.546 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr17_+_68672705 0.539 NM_001050
SSTR2
somatostatin receptor 2
chr11_-_102156531 0.532 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_35692668 0.497 KIAA0319L
KIAA0319-like
chr3_-_24511180 0.492 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr14_-_23874083 0.490 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr15_-_50051239 0.478 NM_138792
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr2_+_121271336 0.473 NM_005270
GLI2
GLI family zinc finger 2
chr5_+_66160359 0.473 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr18_+_30327243 0.470 NM_001198945
NM_001392
NM_032975
NM_032979
DTNA



dystrobrevin, alpha



chr3_-_50335113 0.463 NM_003773
NM_033158
HYAL2

hyaluronoglucosaminidase 2

chr15_-_50270856 0.455 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr9_+_74110149 0.454


chr2_-_154043403 0.454 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr6_-_112033775 0.448 TRAF3IP2
TRAF3 interacting protein 2
chr12_+_58369392 0.445 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr18_+_30327341 0.432 DTNA
dystrobrevin, alpha
chr1_+_46151845 0.425 MAST2
microtubule associated serine/threonine kinase 2
chr2_+_27358800 0.421 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr22_+_40286957 0.416 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr2_+_170742900 0.406 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr11_+_33306652 0.403 HIPK3
homeodomain interacting protein kinase 3
chr17_-_46140015 0.383 NM_052855
ANKRD40
ankyrin repeat domain 40
chr1_-_84928473 0.364 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr1_-_41259973 0.358 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr1_+_176577228 0.315 NM_004841
RASAL2
RAS protein activator like 2
chr6_-_112033752 0.304 TRAF3IP2
TRAF3 interacting protein 2
chr8_-_6407882 0.294 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr17_-_32730804 0.289 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chrX_-_102661072 0.281 NM_080879
RAB40A
RAB40A, member RAS oncogene family
chr1_+_20269239 0.278 NM_000929
PLA2G5
phospholipase A2, group V
chr3_-_24511456 0.274 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chrX_-_114703273 0.273


chr12_-_46405477 0.273 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr5_+_134209628 0.268 C5orf24
chromosome 5 open reading frame 24
chr14_-_22825148 0.249 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr4_+_52612197 0.243 NM_145263
SPATA18
spermatogenesis associated 18 homolog (rat)
chr10_-_103568197 0.243 NM_001142434
NM_012215
MGEA5

meningioma expressed antigen 5 (hyaluronidase)

chr5_-_150501393 0.234 NM_001193544
ANXA6
annexin A6
chr2_-_15999154 0.228 MYCNOS
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand
chr10_+_102285562 0.214 NM_017902
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr6_-_152664906 0.212 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_+_44571600 0.210 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr14_-_19252330 0.202 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr10_-_103568162 0.201 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chrX_-_2892288 0.200 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr8_-_134141586 0.199 NM_006748
SLA
Src-like-adaptor
chr3_-_117647053 0.194 NM_002338
LSAMP
limbic system-associated membrane protein
chr6_+_121798443 0.177 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr16_+_57091546 0.176 NDRG4
NDRG family member 4
chr10_-_103568171 0.173 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_103568169 0.169 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr5_-_137099602 0.168 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr9_-_113585593 0.159 NM_173521
C9orf84
chromosome 9 open reading frame 84
chr10_-_100164877 0.151 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr11_+_55776251 0.146 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr15_-_63457378 0.146 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr16_-_21739231 0.145 RRN3P1
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
chr4_+_144325502 0.141 NM_032557
USP38
ubiquitin specific peptidase 38
chr5_+_134209444 0.138 NM_001135586
C5orf24
chromosome 5 open reading frame 24
chr4_+_140442070 0.138 NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr19_+_43847049 0.133


chr1_-_103269356 0.130 COL11A1
collagen, type XI, alpha 1
chr11_+_131285747 0.130 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr12_+_54700955 0.129 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr7_+_101715137 0.127 SH2B2
SH2B adaptor protein 2
chr5_+_134209268 0.127 NM_152409
C5orf24
chromosome 5 open reading frame 24
chr13_-_26232777 0.125 NM_005288
GPR12
G protein-coupled receptor 12
chr17_-_2977594 0.118 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr16_-_15095590 0.117 NM_018427
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr3_+_51837608 0.115 NM_001085479
IQCF3
IQ motif containing F3
chr19_-_3930828 0.113 EEF2
eukaryotic translation elongation factor 2
chr7_-_106991941 0.111 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr7_-_83662152 0.110 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr9_+_119506274 0.108 NM_138554
TLR4
toll-like receptor 4
chr12_+_63958689 0.108 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr1_-_176205970 0.107 SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_-_3445873 0.107 NM_080705
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr11_-_47572478 0.105 NM_031909
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr11_-_2116048 0.102 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_51887266 0.101 NM_000889
ITGB7
integrin, beta 7
chr1_-_40930295 0.099 LOC100130557
hypothetical LOC100130557
chr8_-_120720200 0.098 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr11_-_119104463 0.098 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr1_-_148936123 0.098 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr11_+_13255967 0.096 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr3_+_48463184 0.095 NM_032166
NM_130384
TREX1
ATRIP

three prime repair exonuclease 1
ATR interacting protein

chr7_-_105106844 0.093 NM_138495
ATXN7L1
ataxin 7-like 1
chr6_+_43845875 0.093 VEGFA
vascular endothelial growth factor A
chr17_-_30414789 0.093 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr9_-_115877104 0.092 AMBP
alpha-1-microglobulin/bikunin precursor
chr12_-_54497770 0.092 SARNP
SAP domain containing ribonucleoprotein
chr2_+_119416214 0.086 NM_006770
MARCO
macrophage receptor with collagenous structure
chr7_+_120756325 0.084 NM_057168
WNT16
wingless-type MMTV integration site family, member 16
chr14_-_74669864 0.084 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr5_+_38294417 0.083 EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr17_-_23721430 0.082 VTN
vitronectin
chr2_+_27154938 0.081 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr1_-_176205672 0.081 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr8_+_124849923 0.081 NM_144963
FAM91A1
family with sequence similarity 91, member A1
chr3_+_48463117 0.080 ATRIP
ATR interacting protein
chr4_+_85723080 0.079 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr14_-_74458897 0.078 NM_031464
RPS6KL1
ribosomal protein S6 kinase-like 1
chr5_+_81636921 0.076 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr7_-_156161130 0.075


chr14_-_22825072 0.074 HOMEZ
homeobox and leucine zipper encoding
chr5_+_38294289 0.073 NM_152403
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr12_-_54497751 0.071 SARNP
SAP domain containing ribonucleoprotein
chr12_+_63958949 0.070 NM_001193461
MSRB3
methionine sulfoxide reductase B3
chr11_-_4585947 0.069 NM_018073
TRIM68
tripartite motif containing 68
chr2_+_102294393 0.068 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr2_-_165186232 0.067 GRB14
growth factor receptor-bound protein 14
chr12_+_119617060 0.065


chr19_+_1220244 0.064 NM_001280
CIRBP
cold inducible RNA binding protein
chr11_-_65412409 0.064 NM_004214
NM_198897
FIBP

fibroblast growth factor (acidic) intracellular binding protein

chr3_+_1109619 0.063 NM_014461
CNTN6
contactin 6
chr5_+_137716169 0.063 NM_016604
KDM3B
lysine (K)-specific demethylase 3B
chr6_+_43845915 0.061 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
VEGFA















vascular endothelial growth factor A















chr12_-_51887318 0.052 ITGB7
integrin, beta 7
chr1_+_196148241 0.050 NM_001014434
LHX9
LIM homeobox 9
chr9_-_41944687 0.048 MGC21881
hypothetical locus MGC21881
chr8_+_36760999 0.044 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr8_+_120289735 0.043 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr17_-_35774467 0.043 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr6_-_155677303 0.043 NM_016020
TFB1M
transcription factor B1, mitochondrial
chr11_+_55617328 0.042 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr1_-_157551072 0.041 NM_001004467
OR10J3
olfactory receptor, family 10, subfamily J, member 3
chrX_-_57164575 0.041 NM_001006681
NM_001006682
NM_001006683
SPIN2B


spindlin family, member 2B


chr1_+_103999663 0.039 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chrX_-_148580602 0.039 NM_005366
MAGEA11
melanoma antigen family A, 11
chr12_+_2792047 0.037 NM_018463
ITFG2
integrin alpha FG-GAP repeat containing 2
chr8_+_17440664 0.037 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr4_+_144325533 0.036 USP38
ubiquitin specific peptidase 38
chr5_-_154210341 0.036 C5orf4
chromosome 5 open reading frame 4
chr11_-_62136778 0.035 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr6_-_37333872 0.035 NM_001162900
TMEM217
transmembrane protein 217
chr1_-_148473649 0.034 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chrX_+_56772391 0.034 LOC550643
hypothetical LOC550643
chr9_-_21375258 0.033 NM_000605
IFNA2
interferon, alpha 2
chr19_+_8384181 0.032 NM_001005415
NM_001005416
NM_016496
MARCH2


membrane-associated ring finger (C3HC4) 2


chrX_+_150635162 0.032 NM_033085
FATE1
fetal and adult testis expressed 1
chr15_-_72922577 0.031 NM_001099436
ULK3
unc-51-like kinase 3 (C. elegans)
chr14_-_100420936 0.029 NM_001134888
RTL1
retrotransposon-like 1
chr11_+_106967017 0.027 NM_001130037
NM_018712
ELMOD1

ELMO/CED-12 domain containing 1

chr2_-_191580567 0.027 STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_-_246880807 0.026 NM_001001824
OR2T27
olfactory receptor, family 2, subfamily T, member 27
chr19_-_10352172 0.026 TYK2
tyrosine kinase 2
chr19_+_55013315 0.026 NM_030973
MED25
mediator complex subunit 25
chrX_-_71443725 0.026 NM_001144886
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr16_+_16233979 0.024 NOMO2
NODAL modulator 2
chr1_-_201422490 0.024 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr15_-_63871492 0.023 DENND4A
DENN/MADD domain containing 4A
chr1_-_201162938 0.023 KLHL12
kelch-like 12 (Drosophila)
chr14_-_91268136 0.022 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr3_-_127382051 0.021 ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr15_-_72922533 0.021 ULK3
unc-51-like kinase 3 (C. elegans)
chr7_+_101715110 0.020 NM_020979
SH2B2
SH2B adaptor protein 2
chr19_-_21943 0.020 WASH1
WASH3P
WASH5P
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
WAS protein family homolog 5 pseudogene
chr17_+_70554914 0.019 KCTD2
potassium channel tetramerisation domain containing 2
chr6_-_155677254 0.019 TFB1M
transcription factor B1, mitochondrial
chr11_-_56067308 0.018 NM_001005245
OR5M11
olfactory receptor, family 5, subfamily M, member 11
chr12_+_50568010 0.018 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chrX_+_10084984 0.018 NM_001830
CLCN4
chloride channel 4
chr11_+_106967165 0.016 ELMOD1
ELMO/CED-12 domain containing 1
chr11_+_2116486 0.016


chr15_-_54322767 0.016 NM_022841
RFX7
regulatory factor X, 7
chr16_+_16233989 0.015 NOMO2
NODAL modulator 2
chr14_+_28311740 0.015 C14orf23
chromosome 14 open reading frame 23
chr7_-_42938255 0.015 PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr11_+_55869996 0.015 NM_001002907
OR8K1
olfactory receptor, family 8, subfamily K, member 1
chr3_-_127382093 0.014 NM_012190
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr19_-_16111695 0.014


chr1_-_19192 0.013 WASH1
WASH3P
WASH2P
WASH7P
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
WAS protein family homolog 2 pseudogene
WAS protein family homolog 7 pseudogene
chr16_+_16233996 0.013 NOMO1
NODAL modulator 1
chr9_-_35093189 0.012 STOML2
stomatin (EPB72)-like 2
chr11_+_55554470 0.012 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr11_-_2116360 0.011 IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_-_45735333 0.011 NETO2
neuropilin (NRP) and tolloid (TLL)-like 2
chr2_+_38005875 0.010 NM_001170791
FAM82A1
family with sequence similarity 82, member A1
chr10_-_71811353 0.010 NM_207119
LRRC20
leucine rich repeat containing 20
chr1_-_159413833 0.010 NM_003779
B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chrX_-_33139349 0.007 NM_004006
DMD
dystrophin
chr1_-_201422533 0.007 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr17_+_29670171 0.006 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr2_-_138762909 0.006



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
81.34 2.35e-03 GO:0034314 Arp2/3 complex-mediated actin nucleation
54.23 1.16e-02 GO:0045010 actin nucleation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
29.58 1.70e-02 GO:0071203 WASH complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.96 1.21e-02 GO:0004871 signal transducer activity
1.96 1.21e-02 GO:0060089 molecular transducer activity