Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.098


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39362122-0.713.3e-03Click!
ZHX1chr8_-_124355670-0.468.4e-02Click!
IRX5chr16_+_53522611-0.322.4e-01Click!
ZHX2chr8_+_1238631690.204.7e-01Click!
SIX2chr2_-_45090025-0.204.7e-01Click!
IRX4chr5_-_19357640.185.2e-01Click!
SIX5chr19_-_50964336-0.165.8e-01Click!
ADNPchr20_-_48980858-0.107.2e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_57209319 1.642 NM_003865
HESX1
HESX homeobox 1
chr8_-_72431274 1.555 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chrX_-_15593074 1.315 NM_020665
TMEM27
transmembrane protein 27
chr11_-_83071084 1.173 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr5_+_147562531 1.086 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_-_123353607 1.064 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_-_108032645 0.973 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_-_110155237 0.945 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr18_-_59480082 0.917 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr5_+_73145098 0.911 RGNEF
190 kDa guanine nucleotide exchange factor
chr14_-_80934523 0.901 NM_033104
STON2
stonin 2
chr5_+_60969392 0.899 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr18_-_26996742 0.891 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_-_104515670 0.874 NM_021571
CARD18
caspase recruitment domain family, member 18
chrX_-_137649180 0.849 NM_033642
FGF13
fibroblast growth factor 13
chr6_-_52060327 0.848 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr3_-_55489973 0.840 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_556968 0.836


chr9_-_14076901 0.835 NFIB
nuclear factor I/B
chr10_+_124310170 0.823 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr15_+_91244563 0.817 CHD2
chromodomain helicase DNA binding protein 2
chr12_-_51200347 0.812 NM_000424
KRT5
keratin 5
chr8_-_17797127 0.785 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr11_-_5946299 0.771 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr9_-_99740243 0.769 NM_197978
HEMGN
hemogen
chr11_-_118405288 0.759 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr20_+_58064360 0.709 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr12_-_10983072 0.703 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr18_+_19826734 0.693 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr4_-_70760381 0.684 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr3_-_58175437 0.681 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr8_-_86477585 0.677 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr2_+_96269703 0.651 NM_001037228
LOC285033
hypothetical protein LOC285033
chrX_-_18600108 0.648 NM_000330
RS1
retinoschisin 1
chr6_+_167445284 0.641 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr21_-_30460841 0.634 NM_012131
CLDN17
claudin 17
chr20_+_58004811 0.624 NM_021810
CDH26
cadherin 26
chr11_+_34599227 0.597 EHF
ets homologous factor
chr11_+_34599163 0.594 NM_012153
EHF
ets homologous factor
chr11_-_16454493 0.590 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr15_-_40173949 0.572 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr4_-_77147625 0.553 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr5_-_22889487 0.553 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr14_-_64479198 0.553 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr11_-_26550243 0.552 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr12_-_10497195 0.550 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr7_-_141293185 0.549 NM_013252
CLEC5A
C-type lectin domain family 5, member A
chr2_+_102401580 0.547 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr18_+_27152049 0.546 NM_001942
DSG1
desmoglein 1
chr1_+_165565006 0.545 POU2F1
POU class 2 homeobox 1
chr2_-_99238001 0.544 NM_175735
LYG2
lysozyme G-like 2
chr7_-_141604323 0.542 NM_001001317
TRYX3
trypsin X3
chr22_-_34566367 0.537 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_-_32892705 0.537 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr19_-_51236113 0.536 NM_001002923
IGFL4
IGF-like family member 4
chr1_+_200246312 0.535 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr1_+_78243181 0.533 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr7_-_93027057 0.529 NM_001164738
CALCR
calcitonin receptor
chrX_+_85404626 0.529 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr1_+_200246370 0.523 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr3_+_88270951 0.521 NM_018293
ZNF654
zinc finger protein 654
chr8_+_12847521 0.520 NM_020844
KIAA1456
KIAA1456
chr3_+_187840842 0.520 NM_014375
FETUB
fetuin B
chr9_-_205892 0.516 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr11_+_10433241 0.513 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_+_99465814 0.508 ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr11_+_65027721 0.507


chr9_+_27514311 0.503 NM_020124
IFNK
interferon, kappa
chr15_-_64108718 0.501


chr3_+_115099007 0.501 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr12_-_51173238 0.498 NM_005554
KRT6A
keratin 6A
chr4_-_91979113 0.495 NM_183049
TMSL3
thymosin-like 3
chr1_+_165564904 0.492 NM_001198783
POU2F1
POU class 2 homeobox 1
chr5_-_168204430 0.479


chr13_+_107753764 0.476


chr16_+_2593351 0.475 LOC652276
hypothetical LOC652276
chr17_-_37022465 0.475 NM_005557
KRT16
keratin 16
chr2_-_207291364 0.474 NM_001093730
DYTN
dystrotelin
chr3_+_123256902 0.471 NM_175862
CD86
CD86 molecule
chr15_+_91244422 0.469 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr7_+_128802719 0.465 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr11_+_117452995 0.461 TMPRSS4
transmembrane protease, serine 4
chr7_-_25234582 0.457 NM_022150
NPVF
neuropeptide VF precursor
chr6_+_21701942 0.455 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr11_+_120478584 0.446 NM_005422
TECTA
tectorin alpha
chr7_-_16811131 0.445 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr5_+_141326620 0.439 NM_183399
RNF14
ring finger protein 14
chr5_+_156628929 0.438 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_+_28301399 0.437 NM_018318
CCDC91
coiled-coil domain containing 91
chr11_-_128399218 0.436 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr20_-_33658823 0.434 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr2_-_29150630 0.429 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr13_-_85271329 0.429 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr18_+_30812205 0.426 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_-_64752550 0.425 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr21_+_38550739 0.425 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_+_70831387 0.421 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr14_-_68424653 0.421 ACTN1
actinin, alpha 1
chr2_-_98646367 0.420 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_158975662 0.414 NM_021181
SLAMF7
SLAM family member 7
chr1_+_86662356 0.411 NM_006536
CLCA2
chloride channel accessory 2
chr2_+_161981138 0.410 TBR1
T-box, brain, 1
chr17_-_25685175 0.410 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr20_-_43601542 0.405 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr10_+_63331401 0.405 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_-_96927557 0.403 NM_016490
FAM178B
family with sequence similarity 178, member B
chr5_+_67622242 0.402 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_-_22889192 0.399 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_-_205272619 0.398 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr3_+_137224266 0.397 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr10_-_98021144 0.396 NM_001114094
NM_013314
BLNK

B-cell linker

chr12_+_52696908 0.392 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr4_-_77547481 0.392 NM_001042784
CCDC158
coiled-coil domain containing 158
chr5_-_148738980 0.392 NM_014443
IL17B
interleukin 17B
chr4_+_106693225 0.389 NM_017700
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr11_-_64484184 0.388 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr8_+_77756061 0.385 NM_024721
ZFHX4
zinc finger homeobox 4
chr17_-_36347197 0.384 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr6_-_138862273 0.382


chr2_+_234266250 0.382 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_11591692 0.382 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr5_-_1935764 0.382 NM_016358
IRX4
iroquois homeobox 4
chrX_-_15198093 0.380 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr6_+_29534109 0.379 NM_030883
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr7_-_92693716 0.378 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_114215768 0.377 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr15_+_56217686 0.374 NM_020980
AQP9
aquaporin 9
chr1_-_151352587 0.373 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr11_+_123600553 0.373 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr18_+_59726183 0.372 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr5_+_59819761 0.371 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr3_+_112743615 0.370 NM_005816
NM_198196
CD96

CD96 molecule

chrX_+_110074124 0.368 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr2_-_227952249 0.367 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr12_+_52697160 0.364 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_-_72868598 0.364 NM_000583
GC
group-specific component (vitamin D binding protein)
chr4_-_153493133 0.364 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_+_20577521 0.363 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr4_+_120029426 0.359 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chrX_+_99726445 0.355 NM_022144
TNMD
tenomodulin
chr3_+_46370228 0.354 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr8_+_77756077 0.349 ZFHX4
zinc finger homeobox 4
chr1_+_86785346 0.347 NM_012128
CLCA4
chloride channel accessory 4
chr13_-_83354425 0.345 SLITRK1
SLIT and NTRK-like family, member 1
chr12_-_51153788 0.345 NM_173086
KRT6C
keratin 6C
chr12_-_51476047 0.345 NM_057088
KRT3
keratin 3
chr12_-_55614311 0.344 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr1_+_35623688 0.343 ZMYM4
zinc finger, MYM-type 4
chr7_-_16471817 0.342 NM_015464
SOSTDC1
sclerostin domain containing 1
chr5_-_134290789 0.342


chr12_-_16321885 0.340 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr13_-_83354474 0.339 NM_052910
SLITRK1
SLIT and NTRK-like family, member 1
chr2_-_20390601 0.338 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr9_+_106496480 0.337 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr10_+_68355797 0.337 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chrX_+_107174855 0.336 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr4_+_88973144 0.336 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chrX_-_15198509 0.333 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr15_+_38319326 0.331 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_205068844 0.331 NM_013371
IL19
interleukin 19
chr4_-_74704964 0.329 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr12_-_14024187 0.328 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr8_-_72436519 0.328 EYA1
eyes absent homolog 1 (Drosophila)
chr2_+_161981046 0.327 TBR1
T-box, brain, 1
chr3_-_156904690 0.327 NM_014996
PLCH1
phospholipase C, eta 1
chr13_+_77007809 0.325 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr22_-_34566276 0.325 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr10_+_49279647 0.323 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr7_-_135263737 0.323 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr2_-_1905508 0.323 MYT1L
myelin transcription factor 1-like
chr17_-_36192311 0.322 NM_181537
KRT27
keratin 27
chr10_-_85975263 0.320 NM_001017924
LRIT2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr10_+_4995453 0.318 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_234624266 0.317 NM_145861
EDARADD
EDAR-associated death domain
chr1_-_163680941 0.317 NM_006917
RXRG
retinoid X receptor, gamma
chr20_+_57966865 0.316 NM_177980
CDH26
cadherin 26
chr12_-_101036407 0.316 NM_024057
NUP37
nucleoporin 37kDa
chrX_+_70682204 0.315 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr4_-_54152385 0.312 LNX1
ligand of numb-protein X 1
chr4_-_87989291 0.312 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr6_+_7524691 0.312 DSP
desmoplakin
chr14_-_93493519 0.310 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr3_+_176059763 0.308 NM_207015
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr12_+_103677388 0.306 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr4_+_109033868 0.305 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr4_+_47181987 0.304 NM_020453
ATP10D
ATPase, class V, type 10D
chr11_+_117452936 0.303 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chrX_+_37750778 0.302 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chr19_+_12995782 0.301 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_130745580 0.301 NM_001048209
NTM
neurotrimin
chr4_-_122304925 0.297 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr3_+_112743729 0.297 CD96
CD96 molecule
chr19_+_40632456 0.296 NM_005306
FFAR2
free fatty acid receptor 2
chr10_+_70172257 0.295 CCAR1
cell division cycle and apoptosis regulator 1
chr2_-_69033515 0.294 NM_182536
GKN2
gastrokine 2
chr2_+_161980865 0.293 NM_006593
TBR1
T-box, brain, 1
chr15_-_74091817 0.293 NM_138573
NRG4
neuregulin 4
chr3_-_56673113 0.293 NM_015224
C3orf63
chromosome 3 open reading frame 63
chr4_+_68995761 0.292 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr4_+_76700281 0.291 NM_178497
C4orf26
chromosome 4 open reading frame 26

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.76 9.75e-20 GO:0007606 sensory perception of chemical stimulus
2.77 1.33e-17 GO:0007608 sensory perception of smell
2.15 4.11e-16 GO:0007600 sensory perception
1.71 8.15e-11 GO:0050877 neurological system process
1.61 2.94e-10 GO:0003008 system process
1.27 4.21e-08 GO:0032501 multicellular organismal process
1.21 5.63e-06 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.31 7.24e-09 GO:0005886 plasma membrane
1.30 1.99e-08 GO:0071944 cell periphery
1.17 1.39e-03 GO:0031224 intrinsic to membrane
1.15 1.66e-03 GO:0044425 membrane part
1.17 2.26e-03 GO:0016021 integral to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.85 1.07e-18 GO:0004984 olfactory receptor activity
2.09 1.14e-15 GO:0004930 G-protein coupled receptor activity
1.80 8.01e-14 GO:0004888 transmembrane receptor activity
1.67 1.32e-13 GO:0004872 receptor activity
1.51 6.05e-10 GO:0004871 signal transducer activity
1.51 6.05e-10 GO:0060089 molecular transducer activity
1.52 6.19e-04 GO:0001071 nucleic acid binding transcription factor activity
1.52 6.19e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
4.39 9.29e-03 GO:0015020 glucuronosyltransferase activity