Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.098


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39362122-0.713.3e-03Click!
ZHX1chr8_-_124355670-0.468.4e-02Click!
IRX5chr16_+_53522611-0.322.4e-01Click!
ZHX2chr8_+_1238631690.204.7e-01Click!
SIX2chr2_-_45090025-0.204.7e-01Click!
IRX4chr5_-_19357640.185.2e-01Click!
SIX5chr19_-_50964336-0.165.8e-01Click!
ADNPchr20_-_48980858-0.107.2e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_57209319 1.642 NM_003865
HESX1
HESX homeobox 1
chr8_-_72431274 1.555 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chrX_-_15593074 1.315 NM_020665
TMEM27
transmembrane protein 27
chr11_-_83071084 1.173 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr5_+_147562531 1.086 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_-_123353607 1.064 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_-_108032645 0.973 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_-_110155237 0.945 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr18_-_59480082 0.917 NM_006919
SERPINB3
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 3
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr5_+_73145098 0.911 RGNEF
190 kDa guanine nucleotide exchange factor
chr14_-_80934523 0.901 NM_033104
STON2
stonin 2
chr5_+_60969392 0.899 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr18_-_26996742 0.891 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_-_104515670 0.874 NM_021571
CARD18
caspase recruitment domain family, member 18
chrX_-_137649180 0.849 NM_033642
FGF13
fibroblast growth factor 13
chr6_-_52060327 0.848 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr3_-_55489973 0.840 WNT5A
wingless-type MMTV integration site family, member 5A
chr1_+_556968 0.836


chr9_-_14076901 0.835 NFIB
nuclear factor I/B
chr10_+_124310170 0.823 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.77 1.33e-17 GO:0007608 sensory perception of smell
2.76 9.75e-20 GO:0007606 sensory perception of chemical stimulus
2.15 4.11e-16 GO:0007600 sensory perception
1.71 8.15e-11 GO:0050877 neurological system process
1.61 2.94e-10 GO:0003008 system process
1.27 4.21e-08 GO:0032501 multicellular organismal process
1.21 5.63e-06 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.31 7.24e-09 GO:0005886 plasma membrane
1.30 1.99e-08 GO:0071944 cell periphery
1.17 1.39e-03 GO:0031224 intrinsic to membrane
1.17 2.26e-03 GO:0016021 integral to membrane
1.15 1.66e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
4.39 9.29e-03 GO:0015020 glucuronosyltransferase activity
2.85 1.07e-18 GO:0004984 olfactory receptor activity
2.09 1.14e-15 GO:0004930 G-protein coupled receptor activity
1.80 8.01e-14 GO:0004888 transmembrane receptor activity
1.67 1.32e-13 GO:0004872 receptor activity
1.52 6.19e-04 GO:0001071 nucleic acid binding transcription factor activity
1.52 6.19e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.51 6.05e-10 GO:0004871 signal transducer activity
1.51 6.05e-10 GO:0060089 molecular transducer activity