ISMARA results for ENCODE cell lines, H3K4me1 (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
PITX1..3.p2 9.434 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
HNF1A.p2 6.024 HNF1A (HNF1, LFB1)
NRF1.p2 5.574 NRF1 (EWG, ALPHA-PAL)
GATA6.p2 5.385 GATA6
HNF4A_NR2F1,2.p2 5.022 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
HIC1.p2 4.999 HIC1 (ZBTB29)
FOS_FOS{B,L1}_JUN{B,D}.p2 4.889 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
RUNX1..3.p2 4.749 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
HOX{A6,A7,B6,B7}.p2 4.529 HOXB6
HOXA7
HOXB7
HOXA6
SNAI1..3.p2 4.477 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
SPIB.p2 4.421 SPIB (SPI-B)
MEF2{A,B,C,D}.p2 4.397 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
MTF1.p2 4.252 MTF1
PRRX1,2.p2 4.047 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
TFCP2.p2 4.021 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
ELK1,4_GABP{A,B1}.p3 3.978 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
ELF1,2,4.p2 3.898 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
RREB1.p2 3.743 RREB1 (HNT)
EN1,2.p2 3.647 EN1
EN2
TCF4_dimer.p2 3.637 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
EHF.p2 3.615 EHF
KLF12.p2 3.560 KLF12 (AP-2rep, HSPC122, AP2REP)
ZNF143.p2 3.551 ZNF143 (SBF, pHZ-1, STAF)
SMAD1..7,9.p2 3.496 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
HAND1,2.p2 3.436 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
TEAD1.p2 3.411 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
KLF4.p3 3.391 KLF4 (EZF, GKLF)
YY1.p2 3.330 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
SPI1.p2 3.251 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
FEV.p2 3.247 FEV (PET-1, HSRNAFEV)
MAZ.p2 3.178 MAZ (ZF87, Pur-1, Zif87, ZNF801)
IRF1,2,7.p3 3.088 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
AHR_ARNT_ARNT2.p2 3.077 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
TFAP2{A,C}.p2 3.041 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
ZIC1..3.p2 3.006 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
TLX1..3_NFIC{dimer}.p2 2.953 TLX1
TLX3 (RNX)
NFY{A,B,C}.p2 2.849 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
EBF1.p2 2.839 EBF1 (OLF1)
MYFfamily.p2 2.829 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
NFE2L2.p2 2.756 NFE2L2 (NRF2)
RFX1..5_RFXANK_RFXAP.p2 2.734 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
CTCF.p2 2.659 CTCF
ATF5_CREB3.p2 2.616 ATF5
CREB3 (LZIP, Luman)
SP1.p2 2.564 SP1
DBP.p2 2.536 DBP (DABP)
ESR1.p2 2.504 ESR1 (NR3A1, Era)
MYOD1.p2 2.482 MYOD1 (PUM, MYOD, bHLHc1)
CRX.p2 2.450 CRX (CRD, LCA7, OTX3)
TBP.p2 2.416 TBP (TFIID)
NR5A1,2.p2 2.394 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
TFAP2B.p2 2.392 TFAP2B (AP2-B)
FOXA2.p3 2.385 FOXA2
EVI1.p2 2.358 EVI1 (MDS1-EVI1, PRDM3)
ETS1,2.p2 2.345 ETS2
ETS1 (FLJ10768, ETS-1)
CREB1.p2 2.340 CREB1
TGIF1.p2 2.335 TGIF1
GATA1..3.p2 2.332 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
NFKB1_REL_RELA.p2 2.323 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
NKX2-1,4.p2 2.317 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
GFI1.p2 2.315 GFI1
REST.p3 2.307 REST (NRSF, XBR)
NHLH1,2.p2 2.298 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
HMGA1,2.p2 2.295 HMGA1
HMGA2 (BABL, LIPO)
HOX{A5,B5}.p2 2.284 HOXB5
HOXA5
FOXL1.p2 2.256 FOXL1 (FREAC7, FKH6)
GTF2A1,2.p2 2.218 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
LMO2.p2 2.187 LMO2 (TTG2, RHOM2, RBTN2)
GLI1..3.p2 2.182 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
POU2F1..3.p2 2.169 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
ZFP161.p2 2.154 ZFP161 (ZNF478, ZBTB14)
ZNF238.p2 2.130 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
POU5F1.p2 2.112 POU5F1 (OCT3, Oct4, MGC22487)
DMAP1_NCOR{1,2}_SMARC.p2 2.087 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
E2F1..5.p2 2.087 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
HBP1_HMGB_SSRP1_UBTF.p2 2.066 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
TFDP1.p2 2.020 TFDP1 (Dp-1, DRTF1, DP1)
BPTF.p2 2.000 BPTF (FAC1, NURF301)
TFAP4.p2 1.969 TFAP4 (AP-4)
ZBTB16.p2 1.964 ZBTB16 (PLZF)
HLF.p2 1.958 HLF (MGC33822)
bHLH_family.p2 1.955 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
NKX2-2,8.p2 1.935 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
RXR{A,B,G}.p2 1.926 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
ZNF423.p2 1.921 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
LEF1_TCF7_TCF7L1,2.p2 1.908 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
IKZF2.p2 1.889 IKZF2 (Helios)
GFI1B.p2 1.883 GFI1B
MZF1.p2 1.869 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
NFATC1..3.p2 1.858 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
POU3F1..4.p2 1.858 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
ZNF384.p2 1.850 ZNF384 (CAGH1A, CIZ, NMP4, NP)
NR1H4.p2 1.845 NR1H4 (FXR, RIP14, HRR1, HRR-1)
GTF2I.p2 1.834 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
NR3C1.p2 1.826 NR3C1 (GR)
FOXO1,3,4.p2 1.822 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
HOX{A4,D4}.p2 1.814 HOXA4
HOXD4
ZEB1.p2 1.803 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
SRF.p3 1.800 SRF (MCM1)
JUN.p2 1.796 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
NFE2.p2 1.794 NFE2 (NF-E2)
EP300.p2 1.787 EP300 (p300, KAT3B)
FOXP3.p2 1.783 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
ONECUT1,2.p2 1.766 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 1.757 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
PAX5.p2 1.755 PAX5 (BSAP)
HSF1,2.p2 1.744 HSF1 (HSTF1)
HSF2
MAFB.p2 1.733 MAFB
POU6F1.p2 1.730 POU6F1 (BRN5, MPOU, TCFB1)
SRY.p2 1.721 SRY (TDF)
HMX1.p2 1.719 HMX1 (H6, NKX5-3)
NFIX.p2 1.717 NFIX (NF1A)
PATZ1.p2 1.699 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
POU1F1.p2 1.697 POU1F1 (GHF-1)
MSX1,2.p2 1.693 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
ARID5B.p2 1.691 ARID5B (FLJ21150, MRF2)
NFE2L1.p2 1.669 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
PRDM1.p3 1.668 PRDM1 (PRDI-BF1)
STAT5{A,B}.p2 1.663 STAT5B
STAT5A (MGF)
CEBPA,B_DDIT3.p2 1.657 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
ZNF148.p2 1.654 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
NKX6-1,2.p2 1.623 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
EOMES.p2 1.612 EOMES (TBR2)
MYB.p2 1.606 MYB (c-myb)
POU5F1_SOX2{dimer}.p2 1.577 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
EGR1..3.p2 1.568 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
TBX4,5.p2 1.564 TBX5
TBX4
ATF2.p2 1.530 ATF2 (TREB7, CRE-BP1, HB16)
T.p2 1.502 T
FOX{I1,J2}.p2 1.491 FOXI1 (FREAC6)
FOXJ2 (FHX)
CDX1,2,4.p2 1.476 CDX1
CDX2
CDX4
RXRA_VDR{dimer}.p2 1.474 VDR (NR1I1)
FOSL2.p2 1.447 FOSL2 (FRA2, FLJ23306)
PAX2.p2 1.420 PAX2
ESRRA.p2 1.416 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
RXRG_dimer.p3 1.415 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
RBPJ.p2 1.411 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
STAT2,4,6.p2 1.377 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
TLX2.p2 1.376 TLX2 (Enx, Tlx2, NCX)
MYBL2.p2 1.350 MYBL2 (BMYB, B-MYB)
HES1.p2 1.328 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
PAX4.p2 1.328 PAX4
FOXQ1.p2 1.323 FOXQ1 (HFH1)
HOXA9_MEIS1.p2 1.309 MEIS1
HOXA9
ATF4.p2 1.309 ATF4 (TAXREB67, CREB-2)
NANOG{mouse}.p2 1.303 NANOG (FLJ12581, FLJ40451)
NKX3-1.p2 1.287 NKX3-1 (NKX3.1, BAPX2)
NANOG.p2 1.270 NANOG (FLJ12581, FLJ40451)
SPZ1.p2 1.269 SPZ1 (NYD-TSP1, FLJ25709)
FOX{D1,D2}.p2 1.268 FOXD2 (FREAC9)
FOXD1 (FREAC4)
NKX2-3_NKX2-5.p2 1.255 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
BACH2.p2 1.255 BACH2
FOX{C1,C2}.p2 1.246 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
NFIL3.p2 1.222 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
NKX3-2.p2 1.220 NKX3-2 (NKX3B, NKX3.2)
NR6A1.p2 1.219 NR6A1 (GCNF1, RTR)
PBX1.p2 1.212 PBX1
FOX{F1,F2,J1}.p2 1.209 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
EWSR1-FLI1.p2 1.203 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
FOXN1.p2 1.199 FOXN1 (FKHL20)
FOXD3.p2 1.198 FOXD3 (Genesis, HFH2)
VSX1,2.p2 1.176 VSX2 (RET1)
VSX1 (PPD)
SOX5.p2 1.156 SOX5 (L-SOX5, MGC35153)
SREBF1,2.p2 1.153 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
XBP1.p3 1.118 XBP1
ADNP_IRX_SIX_ZHX.p2 1.098 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
SOX2.p2 1.069 SOX2
SOX{8,9,10}.p2 1.069 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
ZBTB6.p2 1.019 ZBTB6 (ZID)
STAT1,3.p3 1.003 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
TAL1_TCF{3,4,12}.p2 0.996 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
CDC5L.p2 0.980 CDC5L (PCDC5RP, hCDC5, CEF1)
TFEB.p2 0.971 TFEB
CUX2.p2 0.968 CUX2 (KIAA0293, CDP2)
AR.p2 0.962 AR (AIS, NR3C4, SMAX1, HUMARA)
TP53.p2 0.956 TP53 (p53, LFS1)
ATF6.p2 0.920 ATF6 (ATF6A)
IKZF1.p2 0.916 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
PPARG.p2 0.913 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
AIRE.p2 0.894 AIRE (PGA1, APS1)
SOX17.p2 0.837 SOX17
HIF1A.p2 0.799 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
LHX3,4.p2 0.778 LHX3
LHX4 (Gsh4)
RORA.p2 0.754 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
ALX1.p2 0.726 ALX1
PDX1.p2 0.702 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
PAX6.p2 0.648 PAX6 (D11S812E, AN, WAGR)
GZF1.p2 0.575 GZF1 (dJ322G13.2, ZBTB23)
PAX8.p2 0.290 PAX8
PAX3,7.p2 0.197 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Project name:

Sample name Condition Replicate/Batch
Rep1_GM12878
Rep1_HepG2
Rep1_HMEC
Rep1_HSMM
Rep1_Huvec
Rep1_K562
Rep1_NHEK
Rep1_NHLF
Rep2_GM12878
Rep2_HMEC
Rep2_HSMM
Rep2_Huvec
Rep2_K562
Rep2_NHEK
Rep2_NHLF