Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 3.077


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNTchr1_-_149115771-0.592.1e-02Click!
ARNT2chr15_+_784836240.553.4e-02Click!
AHRchr7_+_173047070.322.5e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_94969064 5.143 NM_005172
 ATOH1
atonal homolog 1 (Drosophila)
chr21_-_38954433 4.024 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr3_+_135996990 2.808 EPHB1
EPH receptor B1
chr3_-_62334229 2.782 NM_018008
 FEZF2
FEZ family zinc finger 2
chr9_-_34579679 2.628 NM_001842
NM_147164
 CNTFR

ciliary neurotrophic factor receptor

chr9_+_4480193 2.491 NM_004170
 SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr8_+_31616809 2.489 NM_013962
 NRG1
neuregulin 1
chr6_-_40663089 2.485 NM_020737
 LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr4_+_81337663 2.458 NM_001099403
 PRDM8
PR domain containing 8
chr2_-_213111525 2.438 NM_001042599
NM_005235
 ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr14_+_73073570 2.323 NM_001037161
 ACOT1
acyl-CoA thioesterase 1
chr2_-_45090025 2.176 NM_016932
 SIX2
SIX homeobox 2
chr15_-_77169894 2.091 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr9_-_85342868 2.086 NM_174938
 FRMD3
FERM domain containing 3
chr3_+_135996734 2.063 NM_004441
 EPHB1
EPH receptor B1
chr16_-_85099941 1.960 LOC400550
hypothetical LOC400550
chr6_+_84619703 1.957 NM_001009994
 RIPPLY2
ripply2 homolog (zebrafish)
chr2_+_219141546 1.940 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_-_18175731 1.914 NM_002866
 RAB3A
RAB3A, member RAS oncogene family
chr8_+_120497732 1.905 NM_002514
 NOV
nephroblastoma overexpressed gene

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 108 entries
enrichment   p-value GO term description
3.67 1.26e-03 GO:0045666 positive regulation of neuron differentiation
2.59 1.16e-03 GO:0060485 mesenchyme development
2.55 2.37e-02 GO:0014031 mesenchymal cell development
2.53 5.62e-04 GO:0021537 telencephalon development
2.46 3.04e-02 GO:0048762 mesenchymal cell differentiation
2.26 8.84e-06 GO:0030900 forebrain development
2.24 1.88e-04 GO:0045165 cell fate commitment
2.10 2.74e-04 GO:0035270 endocrine system development
1.87 2.67e-02 GO:0048732 gland development
1.86 6.16e-06 GO:0007420 brain development
1.84 1.51e-08 GO:0007417 central nervous system development
1.78 7.26e-04 GO:0060284 regulation of cell development
1.77 1.01e-05 GO:0007268 synaptic transmission
1.74 3.75e-06 GO:0000904 cell morphogenesis involved in differentiation
1.73 2.23e-03 GO:0007411 axon guidance
1.73 1.61e-02 GO:0035295 tube development
1.71 7.41e-03 GO:0001501 skeletal system development
1.68 5.59e-05 GO:0019226 transmission of nerve impulse
1.68 5.59e-05 GO:0035637 multicellular organismal signaling
1.68 1.23e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
2.73 9.84e-03 GO:0043197 dendritic spine
2.62 1.94e-02 GO:0044309 neuron spine
1.33 5.16e-04 GO:0005654 nucleoplasm
1.30 5.76e-05 GO:0031981 nuclear lumen
1.26 1.26e-04 GO:0070013 intracellular organelle lumen
1.25 1.93e-04 GO:0031974 membrane-enclosed lumen
1.25 8.21e-04 GO:0044428 nuclear part
1.24 4.15e-04 GO:0043233 organelle lumen
1.20 5.21e-10 GO:0005634 nucleus
1.15 2.86e-02 GO:0032991 macromolecular complex
1.12 2.57e-16 GO:0005622 intracellular
1.12 6.76e-15 GO:0044424 intracellular part
1.12 2.63e-08 GO:0043231 intracellular membrane-bounded organelle
1.12 2.87e-08 GO:0043227 membrane-bounded organelle
1.12 1.69e-06 GO:0005737 cytoplasm
1.11 3.54e-09 GO:0043226 organelle
1.11 5.99e-09 GO:0043229 intracellular organelle
1.11 4.44e-02 GO:0044446 intracellular organelle part
1.10 3.65e-02 GO:0044444 cytoplasmic part
1.03 1.29e-03 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.65 5.57e-08 GO:0043565 sequence-specific DNA binding
1.65 6.29e-03 GO:0016563 transcription activator activity
1.56 2.32e-09 GO:0030528 transcription regulator activity
1.49 1.02e-06 GO:0001071 nucleic acid binding transcription factor activity
1.49 1.02e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.25 3.24e-07 GO:0003676 nucleic acid binding
1.25 1.95e-04 GO:0003677 DNA binding
1.20 3.08e-02 GO:0000166 nucleotide binding
1.11 1.46e-03 GO:0005515 protein binding
1.08 1.26e-07 GO:0005488 binding