Motif ID: NFIX.p2

Z-value: 1.717


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_13066956-0.302.8e-01Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_85638410 2.343 NM_006168
NKX6-1
NK6 homeobox 1
chr3_+_129117007 1.911 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_+_48641545 1.906 NM_001651
AQP5
aquaporin 5
chr11_-_117200618 1.888 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr10_+_88718167 1.843 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr4_+_89597257 1.837 NM_016323
HERC5
hect domain and RLD 5
chr15_+_38849450 1.829 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr3_-_197103848 1.804 TNK2
tyrosine kinase, non-receptor, 2
chr7_-_123460722 1.727 NM_001136002
TMEM229A
transmembrane protein 229A
chr14_-_104507862 1.710 AHNAK2
AHNAK nucleoprotein 2
chr1_+_78858675 1.623 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_+_26239755 1.620 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_+_49211936 1.553 NM_001135197
CCDC36
coiled-coil domain containing 36
chr21_-_44795769 1.472 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr14_+_51025604 1.429 NM_001042481
FRMD6
FERM domain containing 6
chr17_-_5428491 1.428 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr10_-_128884411 1.408 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr1_+_219026661 1.369 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr12_+_26239535 1.327 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr4_+_158216631 1.308 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr22_+_44828338 1.300


chr11_-_117203937 1.285 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr5_-_59819642 1.234 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_150233337 1.233 NM_002966
S100A10
S100 calcium binding protein A10
chr9_+_115382760 1.232 NM_021106
RGS3
regulator of G-protein signaling 3
chr1_+_226261374 1.227 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr5_+_178919298 1.193 NM_001040451
NM_001040452
RUFY1

RUN and FYVE domain containing 1

chr2_+_37425240 1.156 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr1_+_157408000 1.150 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr10_+_124210980 1.143 NM_002775
HTRA1
HtrA serine peptidase 1
chr6_-_150285838 1.138 NM_001001788
RAET1G
retinoic acid early transcript 1G
chr13_+_27392136 1.129 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr4_-_75938710 1.129 NM_001729
BTC
betacellulin
chr5_+_122452739 1.110 NM_001136239
PRDM6
PR domain containing 6
chr4_+_148621518 1.085 NM_001166055
NM_001957
EDNRA

endothelin receptor type A

chr17_-_53335748 1.083 NM_017949
CUEDC1
CUE domain containing 1
chr2_-_56266408 1.071 LOC100129434
hypothetical LOC100129434
chr15_-_30798417 1.069


chr16_+_65790514 1.059 NM_024712
ELMO3
engulfment and cell motility 3
chr16_-_73830480 1.048 NM_001170721
BCAR1
breast cancer anti-estrogen resistance 1
chr19_-_18246166 1.030 NM_001145304
NM_001145305
NM_025249
KIAA1683


KIAA1683


chr20_+_42777419 1.021 WISP2
WNT1 inducible signaling pathway protein 2
chr8_-_101227203 1.020 NM_001029860
FBXO43
F-box protein 43
chr5_-_35266305 1.014 PRLR
prolactin receptor
chr10_+_122206455 0.990 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr6_-_26125939 0.973 NM_005325
HIST1H1A
histone cluster 1, H1a
chr17_+_72795567 0.965 NM_001113492
SEPT9
septin 9
chr11_-_72031083 0.954 NM_001143839
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr16_+_65765256 0.947 NM_003946
NM_001185057
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr8_-_68037378 0.946 NM_001193502
TCF24
transcription factor 24
chr17_-_25587079 0.934 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr4_-_76774594 0.931 NM_003948
CDKL2
cyclin-dependent kinase-like 2 (CDC2-related kinase)
chr21_-_43671355 0.931 NM_173354
SIK1
salt-inducible kinase 1
chr11_-_30564338 0.913 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr14_+_23575460 0.884 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr1_+_208568811 0.876 NM_001170587
NM_001170588
NM_018194
HHAT


hedgehog acyltransferase


chr11_+_72653197 0.873 NM_176796
NM_176797
P2RY6

pyrimidinergic receptor P2Y, G-protein coupled, 6

chr3_+_35656012 0.871 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr10_-_105352098 0.856 SH3PXD2A
SH3 and PX domains 2A
chr1_+_891739 0.855 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr9_-_25668230 0.846 TUSC1
tumor suppressor candidate 1
chr19_-_3752809 0.845 NM_002378
MATK
megakaryocyte-associated tyrosine kinase
chr16_-_674357 0.826 NM_001005920
JMJD8
jumonji domain containing 8
chr17_+_21220260 0.823 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr9_+_115382990 0.819 RGS3
regulator of G-protein signaling 3
chrX_+_150482662 0.806 NM_173493
PASD1
PAS domain containing 1
chr1_+_238321794 0.796 NM_020066
FMN2
formin 2
chr2_+_201691664 0.792 CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_42283946 0.789 NM_003396
WNT9B
wingless-type MMTV integration site family, member 9B
chr11_+_63815348 0.783 NM_033310
KCNK4
potassium channel, subfamily K, member 4
chr12_+_106236281 0.781 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr8_-_41286088 0.775 NM_003012
SFRP1
secreted frizzled-related protein 1
chr14_-_103248193 0.770 XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr4_-_143987053 0.765 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr5_+_132111034 0.763 NM_001039780
CCNI2
cyclin I family, member 2
chr5_+_94981735 0.761 NM_199243
GPR150
G protein-coupled receptor 150
chr14_+_104785936 0.756 BTBD6
BTB (POZ) domain containing 6
chr1_+_208569262 0.755 NM_001170580
HHAT
hedgehog acyltransferase
chr1_+_43386180 0.744 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr14_+_104785898 0.744 NM_033271
BTBD6
BTB (POZ) domain containing 6
chr1_+_63832067 0.718 NM_001172819
PGM1
phosphoglucomutase 1
chr17_+_6495694 0.718 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr2_-_240613357 0.718 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr17_-_3546047 0.717 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr1_+_6188727 0.712 NM_207396
RNF207
ring finger protein 207
chr1_+_77105746 0.711 NM_030965
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr15_+_72253940 0.710 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr8_+_24827173 0.705 NM_005382
NEFM
neurofilament, medium polypeptide
chr1_+_156417302 0.705 CD1D
CD1d molecule
chr7_-_32897934 0.704 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr9_-_25668855 0.704 NM_001004125
TUSC1
tumor suppressor candidate 1
chr15_-_70455355 0.702 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr6_-_55551812 0.699 NM_001042406
NM_019036
HMGCLL1

3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1

chr1_-_154484341 0.695 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_-_1346465 0.694 NM_001145210
LOC441869
hypothetical protein LOC441869
chr5_-_179162480 0.691 NM_054013
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr1_-_19487790 0.690 NM_012067
AKR7A3
aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
chr1_-_6243621 0.684 NM_207370
GPR153
G protein-coupled receptor 153
chr3_-_46481346 0.683 NM_002343
LTF
lactotransferrin
chr13_-_100866839 0.682 NALCN
sodium leak channel, non-selective
chr1_+_77105709 0.675 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr14_-_99695684 0.667 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr2_+_201691513 0.663 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chrX_-_43626537 0.645 NM_000898
MAOB
monoamine oxidase B
chr9_+_70926009 0.644 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr5_+_154072654 0.642 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr11_+_22171150 0.641 NM_001142649
NM_213599
ANO5

anoctamin 5

chr3_-_49916304 0.629 NM_002447
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr11_-_75057299 0.628 MAP6
microtubule-associated protein 6
chr7_+_33911636 0.626 NM_133468
BMPER
BMP binding endothelial regulator
chr2_-_222871577 0.625 NM_000438
NM_001127366
NM_013942
NM_181457
NM_181458
NM_181459
NM_181460
NM_181461
PAX3







paired box 3







chr2_-_240613480 0.624 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr4_-_154900466 0.624


chr4_+_148621567 0.623 EDNRA
endothelin receptor type A
chr8_+_143778529 0.616 NM_001160354
NM_001160355
NM_017527
LY6K


lymphocyte antigen 6 complex, locus K


chr17_-_3546108 0.613 P2RX5-TAX1BP3
P2RX5
P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5
chr9_-_122731263 0.609 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr13_-_97972252 0.609 NM_003576
STK24
serine/threonine kinase 24
chr19_-_19599973 0.603 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr21_+_33364316 0.602 NM_138983
OLIG1
oligodendrocyte transcription factor 1
chr9_+_70926205 0.599 TJP2
tight junction protein 2 (zona occludens 2)
chr22_-_48604455 0.599 NM_014577
BRD1
bromodomain containing 1
chr20_-_4177519 0.599 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr1_-_23393808 0.591 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr9_-_111300350 0.590 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chrX_-_107866262 0.589 NM_003604
IRS4
insulin receptor substrate 4
chr18_+_13208777 0.588 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr1_+_6008956 0.587 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr14_-_19973640 0.586 NM_001109997
KLHL33
kelch-like 33 (Drosophila)
chr22_+_23309717 0.584 NM_013430
GGT1
gamma-glutamyltransferase 1
chr8_+_24827181 0.582 NEFM
neurofilament, medium polypeptide
chr4_-_187713512 0.575 NM_005958
MTNR1A
melatonin receptor 1A
chr17_-_74432800 0.575 TIMP2
TIMP metallopeptidase inhibitor 2
chr4_+_156899575 0.573 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_+_61491793 0.570 LOC399900
hypothetical LOC399900
chr4_+_148621694 0.569 EDNRA
endothelin receptor type A
chr7_+_1063666 0.568 NM_138445
GPR146
G protein-coupled receptor 146
chrX_-_20044670 0.567 NM_001168467
MAP7D2
MAP7 domain containing 2
chr9_+_111582317 0.565 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr5_-_1687040 0.565 LOC728613
programmed cell death 6 pseudogene
chr9_+_111850770 0.561 AKAP2
A kinase (PRKA) anchor protein 2
chr15_-_40173949 0.560 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr5_-_172594691 0.559 NM_001166175
NM_001166176
NM_004387
NKX2-5


NK2 transcription factor related, locus 5 (Drosophila)


chrX_+_71047344 0.554 NM_001013627
NHSL2
NHS-like 2
chr22_+_16973556 0.554 TUBA8
tubulin, alpha 8
chr1_+_26744929 0.552 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_40532651 0.552 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr15_-_70455153 0.544 HEXA
hexosaminidase A (alpha polypeptide)
chr1_+_1250152 0.541


chr4_-_24641404 0.535 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr15_-_31147376 0.534 NM_001103184
FMN1
formin 1
chr11_+_27019084 0.532 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_+_127170717 0.531 NM_001012337
ROPN1B
rhophilin associated tail protein 1B
chr20_-_3696344 0.531 NM_001039140
C20orf27
chromosome 20 open reading frame 27
chr9_+_17568952 0.527 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chrX_+_106048245 0.525 NM_001171095
CLDN2
claudin 2
chr21_+_44941514 0.525 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr2_+_130816940 0.521 NM_033416
IMP4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr16_-_30032330 0.516 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr10_-_45488162 0.515 NM_001128324
NM_174890
ANUBL1

AN1, ubiquitin-like, homolog (Xenopus laevis)

chr20_-_23679558 0.514 NM_001898
CST1
cystatin SN
chr22_+_16973399 0.513 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr17_-_25112393 0.509 SSH2
slingshot homolog 2 (Drosophila)
chr4_+_107036042 0.504 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
NPNT




nephronectin




chr5_+_148941228 0.502 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr20_-_54013418 0.499 NM_080617
CBLN4
cerebellin 4 precursor
chr9_-_32991518 0.499 NM_001195249
NM_001195254
NM_001195248
NM_001195250
NM_001195251
NM_001195252
NM_175069
NM_175073
APTX







aprataxin







chr3_+_44571600 0.498 NM_018651
NM_025169
ZNF167

zinc finger protein 167

chr11_+_45782449 0.490 SLC35C1
solute carrier family 35, member C1
chr9_-_129656413 0.485 ENG
endoglin
chr3_-_46710137 0.485 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr14_+_64086366 0.481 NM_172365
C14orf50
chromosome 14 open reading frame 50
chr9_+_111850698 0.480 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr5_-_945613 0.476 NM_001009877
BRD9
bromodomain containing 9
chr2_-_241484245 0.474 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chrX_-_43626444 0.472 MAOB
monoamine oxidase B
chr22_+_28446288 0.472 NM_182527
CABP7
calcium binding protein 7
chr5_-_1687099 0.470 LOC728613
programmed cell death 6 pseudogene
chr19_-_15869870 0.470 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr11_-_110888273 0.469 NM_017589
BTG4
B-cell translocation gene 4
chr18_-_24010944 0.468 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr3_+_63928459 0.466 NM_001128149
ATXN7
ataxin 7
chr7_-_80386602 0.462 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_+_154264931 0.461 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr11_-_61491684 0.457 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr19_-_1993022 0.454 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr17_+_1574782 0.454 NM_001163809
WDR81
WD repeat domain 81
chr8_-_6722848 0.449 NM_005218
DEFB1
defensin, beta 1
chr16_-_49742008 0.449 NM_001127892
SALL1
sal-like 1 (Drosophila)
chr1_-_158334885 0.449 IGSF8
immunoglobulin superfamily, member 8
chr19_-_13910167 0.448 NM_024825
PODNL1
podocan-like 1
chr11_+_65023038 0.447 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr11_-_46674233 0.447 ARHGAP1
Rho GTPase activating protein 1
chr17_-_3546236 0.446 NM_002561
NM_175080
NM_175081
P2RX5-TAX1BP3
P2RX5


P2RX5-TAX1BP3 read-through transcript
purinergic receptor P2X, ligand-gated ion channel, 5


chr14_+_23937766 0.446 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chrX_-_19815586 0.446 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr4_+_166097548 0.444 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr19_-_13909877 0.444 PODNL1
podocan-like 1
chr17_-_45621140 0.443


chr17_-_4811808 0.442 NM_004890
SPAG7
sperm associated antigen 7

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.31 2.23e-02 GO:0005539 glycosaminoglycan binding