Motif ID: HAND1,2.p2

Z-value: 3.436


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_174687931-0.572.7e-02Click!
HAND1chr5_-_153838013-0.243.9e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_45339605 8.142 NM_182493
MYLK3
myosin light chain kinase 3
chr19_-_10074332 7.676 NM_031917
ANGPTL6
angiopoietin-like 6
chr11_-_63087430 6.471 NM_017878
HRASLS2
HRAS-like suppressor 2
chr22_+_23333610 6.425 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr10_-_75080784 5.756 NM_024875
SYNPO2L
synaptopodin 2-like
chr19_+_40465249 5.556 NM_021175
HAMP
hepcidin antimicrobial peptide
chr16_+_56286212 5.351 NM_032269
CCDC135
coiled-coil domain containing 135
chr12_-_55917134 5.160 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr11_+_66927976 5.153 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr16_+_28413421 5.077 NM_018690
APOBR
apolipoprotein B receptor
chr16_-_31054321 4.897 PRSS8
protease, serine, 8
chr16_-_28515868 4.853 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr4_+_76700281 4.754 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr19_+_61624 4.728 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_-_166149867 4.677 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chrX_-_48213508 4.497 SLC38A5
solute carrier family 38, member 5
chr19_+_41085221 4.113 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr11_+_118463906 4.022 NM_001024382
HMBS
hydroxymethylbilane synthase
chr16_-_31054563 4.016 NM_002773
PRSS8
protease, serine, 8
chrX_-_48213545 3.995 NM_033518
SLC38A5
solute carrier family 38, member 5
chr2_-_31293882 3.904 NM_001145122
CAPN14
calpain 14
chr1_+_159943385 3.655 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr17_-_37590910 3.535 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr11_+_71580816 3.288 NM_016729
FOLR1
folate receptor 1 (adult)
chr20_+_34937928 3.287 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr2_-_85490984 3.268 CAPG
capping protein (actin filament), gelsolin-like
chr9_-_99740243 3.238 NM_197978
HEMGN
hemogen
chr6_+_31016755 3.227 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr6_-_34632061 3.160 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr6_+_167445284 3.119 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr6_+_6533932 3.074 NM_004271
LY86
lymphocyte antigen 86
chr11_-_5130174 3.054 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr1_+_159899528 3.002 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr15_+_42815851 2.982 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr11_+_2279932 2.948 TSPAN32
tetraspanin 32
chr22_+_23329113 2.932 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr6_+_37081387 2.881 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr12_-_52016270 2.869 NM_001173467
SP7
Sp7 transcription factor
chr7_+_99654806 2.868 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr12_+_1596482 2.856 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chr20_-_1113116 2.802 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr19_-_12807221 2.791 NM_031429
RTBDN
retbindin
chr19_+_55614006 2.774 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr16_-_4794749 2.768 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_28134090 2.744 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr11_+_2279812 2.718 NM_139022
TSPAN32
tetraspanin 32
chr1_-_158815895 2.706 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr7_+_142270634 2.697 EPHB6
EPH receptor B6
chr11_-_2279642 2.665 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr2_-_85490997 2.662 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr1_+_159817752 2.641 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr19_+_60279032 2.639 NM_133180
EPS8L1
EPS8-like 1
chr19_-_60360768 2.492 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_-_56585603 2.485 NM_001193623
LOC147646
hypothetical protein LOC147646
chr6_-_41823056 2.482 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr12_+_56114724 2.456 NM_005538
INHBC
inhibin, beta C
chr2_+_113591940 2.429 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr22_+_38090120 2.419 NM_145738
SYNGR1
synaptogyrin 1
chr13_+_112860968 2.366 NM_003891
PROZ
protein Z, vitamin K-dependent plasma glycoprotein
chr1_-_158815850 2.364 CD84
CD84 molecule
chr9_-_70780574 2.354


chr2_+_74913289 2.322 NM_000189
HK2
hexokinase 2
chr11_-_60880799 2.293 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr22_+_43451600 2.288 PRR5
proline rich 5 (renal)
chr2_+_218954995 2.278 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr10_-_121286034 2.265 NM_002925
RGS10
regulator of G-protein signaling 10
chr1_+_26517045 2.225 CD52
CD52 molecule
chr10_-_70846573 2.224 NM_001057
TACR2
tachykinin receptor 2
chr10_+_82287637 2.162 NM_207372
SH2D4B
SH2 domain containing 4B
chr14_-_106241445 2.159 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_+_205328834 2.156 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr11_+_34599227 2.135 EHF
ets homologous factor
chr8_-_19584373 2.134 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr22_+_21393107 2.124 IGLJ3
immunoglobulin lambda joining 3
chr1_+_556968 2.120


chr17_-_35328368 2.119 NM_001042471
NM_001165958
NM_001165959
GSDMB


gasdermin B


chr20_-_48686832 2.113 NM_080829
FAM65C
family with sequence similarity 65, member C
chr19_+_44886785 2.101 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr7_+_100037817 2.094 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr14_-_64479198 2.059 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr3_+_99733432 2.045 NM_005290
GPR15
G protein-coupled receptor 15
chr13_-_45640679 2.039 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr11_-_117305277 2.028 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr19_+_11510578 2.006 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr8_-_86477585 1.982 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_+_116744992 1.907 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr14_-_106240998 1.905 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_-_100630912 1.904 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr14_-_106249999 1.901 IGHA1
immunoglobulin heavy constant alpha 1
chr12_-_55134692 1.865 NM_012064
MIP
major intrinsic protein of lens fiber
chr3_+_51870684 1.862 NM_203424
IQCF2
IQ motif containing F2
chr10_-_5035967 1.833 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_+_26516967 1.822 NM_001803
CD52
CD52 molecule
chr22_+_43451351 1.801 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr5_-_149772563 1.798 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr5_-_121842680 1.788


chr12_-_52015696 1.788 NM_152860
SP7
Sp7 transcription factor
chr1_-_26517342 1.783 NM_145345
UBXN11
UBX domain protein 11
chr1_+_557269 1.779


chr21_+_41616590 1.749 FAM3B
family with sequence similarity 3, member B
chr13_-_59485299 1.722 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr17_+_35038276 1.697 NM_181505
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr1_-_120413542 1.660 NOTCH2
notch 2
chr14_-_20694023 1.659 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr12_-_51887318 1.617 ITGB7
integrin, beta 7
chr19_+_52113772 1.613 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr11_+_34599163 1.612 NM_012153
EHF
ets homologous factor
chr2_+_218929822 1.612 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr11_-_64283945 1.600 PYGM
phosphorylase, glycogen, muscle
chr19_-_56196611 1.586 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr19_-_56564068 1.585 NM_152353
CLDND2
claudin domain containing 2
chr17_+_45617676 1.582


chr16_-_66590856 1.570 NM_022355
DPEP2
dipeptidase 2
chr22_-_21814208 1.569 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr22_+_40416492 1.565 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr7_-_142293382 1.553 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr18_+_19826734 1.553 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr6_+_88026338 1.546 ZNF292
zinc finger protein 292
chr5_-_149304475 1.507 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr11_-_62753574 1.505 NM_199352
SLC22A25
solute carrier family 22, member 25
chr20_+_43764068 1.504 NM_172005
WFDC13
WAP four-disulfide core domain 13
chr2_-_127817143 1.496 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_+_56802 1.492 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr12_-_56496107 1.491 NM_006576
AVIL
advillin
chr2_+_68815416 1.488 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr11_+_118332217 1.482 NM_006760
UPK2
uroplakin 2
chr5_+_148766632 1.477 LOC728264
hypothetical LOC728264
chr11_+_71605466 1.460 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr9_+_107464558 1.447 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr11_-_7941617 1.445 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr17_-_9863929 1.442 GAS7
growth arrest-specific 7
chr11_-_119504726 1.441 TRIM29
tripartite motif containing 29
chr12_+_102859354 1.440 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr11_+_117720268 1.439 NM_000073
CD3G
CD3g molecule, gamma (CD3-TCR complex)
chr1_+_36121403 1.435 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr11_+_5558682 1.418 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr6_-_167491305 1.415 NM_005299
GPR31
G protein-coupled receptor 31
chr22_+_37823174 1.412 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr19_-_12802206 1.411 NM_001080997
RTBDN
retbindin
chr6_-_25940247 1.410 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr16_-_3089253 1.409 ZSCAN10
zinc finger and SCAN domain containing 10
chr14_+_19365447 1.406 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr17_-_24426752 1.403 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr9_+_124177421 1.399 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_18244383 1.389 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr16_+_21152516 1.386 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr9_+_71009746 1.384 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr6_+_37511383 1.374


chr19_+_3659358 1.368 TJP3
tight junction protein 3 (zona occludens 3)
chr6_+_158654464 1.353 TULP4
tubby like protein 4
chr1_-_41398126 1.353 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_-_30977931 1.352 LAPTM5
lysosomal protein transmembrane 5
chr5_-_147996769 1.352 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr16_-_88669833 1.342 NM_001098173
PRDM7
PR domain containing 7
chr19_+_10404110 1.342 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_-_158948176 1.340 NM_001778
CD48
CD48 molecule
chr8_-_82769761 1.336 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr19_-_56567602 1.333 NM_005601
NKG7
natural killer cell group 7 sequence
chr20_-_30703219 1.331 NM_182584
C20orf203
chromosome 20 open reading frame 203
chr12_+_117067214 1.329 PEBP1
phosphatidylethanolamine binding protein 1
chr2_+_113533155 1.300 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr2_+_169645862 1.295 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_+_154389945 1.294 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr6_-_109795925 1.292 CD164
CD164 molecule, sialomucin
chr16_+_29582065 1.289 SPN
sialophorin
chr20_+_36643251 1.289 NM_001018082
ADIG
adipogenin
chr10_-_76529253 1.286 NM_016364
DUSP13
dual specificity phosphatase 13
chr1_+_23994914 1.280


chr6_-_52736231 1.273 NM_000846
GSTA2
glutathione S-transferase alpha 2
chr10_-_35403173 1.264 NM_001198778
NM_001198779
CUL2

cullin 2

chr17_+_26446082 1.263 NF1
neurofibromin 1
chr1_+_111215343 1.262 NM_001040033
CD53
CD53 molecule
chr6_-_21631992 1.254


chr1_+_152560179 1.251 NM_080429
AQP10
aquaporin 10
chr1_+_160615319 1.249 NM_001135240
C1orf226
chromosome 1 open reading frame 226
chr4_+_40032146 1.248 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr1_-_180622083 1.246 GLUL
glutamate-ammonia ligase
chr12_-_51887266 1.244 NM_000889
ITGB7
integrin, beta 7
chr19_-_51236113 1.244 NM_001002923
IGFL4
IGF-like family member 4
chr19_-_56537189 1.241 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr12_+_46802695 1.239 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr3_+_120347686 1.231 NM_152539
C3orf30
chromosome 3 open reading frame 30
chr11_+_45899747 1.229 NM_152312
GYLTL1B
glycosyltransferase-like 1B
chr1_+_33003814 1.226 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_154297588 1.225 NM_020387
RAB25
RAB25, member RAS oncogene family
chr5_-_149772528 1.222


chr1_-_232681471 1.220 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr19_+_40298571 1.217 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr22_+_21053972 1.215


chr5_-_41906459 1.212 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr19_-_63715135 1.212 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr1_+_15858950 1.197 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr1_-_159099090 1.192 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr1_+_205038837 1.190 NM_153758
IL19
interleukin 19
chr15_-_41300526 1.187 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr11_+_359723 1.186 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr14_-_30927931 1.184 NM_015473
HEATR5A
HEAT repeat containing 5A
chr11_+_66927955 1.182 TBC1D10C
TBC1 domain family, member 10C
chr1_-_26553168 1.174 NM_001039775
AIM1L
absent in melanoma 1-like
chr5_-_150928697 1.170 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.43 6.07e-03 GO:0008202 steroid metabolic process
7.04 1.43e-02 GO:0006693 prostaglandin metabolic process
1.61 2.25e-02 GO:0006629 lipid metabolic process
5.79 2.52e-02 GO:0006692 prostanoid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 2.42e-09 GO:0005576 extracellular region
1.34 1.08e-06 GO:0071944 cell periphery
1.34 1.22e-06 GO:0005886 plasma membrane
1.22 8.68e-05 GO:0044425 membrane part
1.24 1.25e-04 GO:0031224 intrinsic to membrane
1.23 4.58e-04 GO:0016021 integral to membrane
1.17 9.87e-04 GO:0016020 membrane
1.39 1.17e-03 GO:0044459 plasma membrane part
1.69 1.61e-03 GO:0005615 extracellular space
1.51 2.26e-02 GO:0044421 extracellular region part
1.46 2.58e-02 GO:0005887 integral to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.56 1.09e-05 GO:0004872 receptor activity
2.88 7.95e-04 GO:0004252 serine-type endopeptidase activity
4.60 7.90e-03 GO:0003823 antigen binding
1.37 9.14e-03 GO:0004871 signal transducer activity
1.37 9.14e-03 GO:0060089 molecular transducer activity
2.49 1.16e-02 GO:0008236 serine-type peptidase activity
2.45 1.57e-02 GO:0017171 serine hydrolase activity
13.38 3.08e-02 GO:0032052 bile acid binding