Motif ID: HAND1,2.p2

Z-value: 3.436


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_174687931-0.572.7e-02Click!
HAND1chr5_-_153838013-0.243.9e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_45339605 8.142 NM_182493
 MYLK3
myosin light chain kinase 3
chr19_-_10074332 7.676 NM_031917
 ANGPTL6
angiopoietin-like 6
chr11_-_63087430 6.471 NM_017878
 HRASLS2
HRAS-like suppressor 2
chr22_+_23333610 6.425 NM_001032365
 GGT1
gamma-glutamyltransferase 1
chr10_-_75080784 5.756 NM_024875
 SYNPO2L
synaptopodin 2-like
chr19_+_40465249 5.556 NM_021175
 HAMP
hepcidin antimicrobial peptide
chr16_+_56286212 5.351 NM_032269
 CCDC135
coiled-coil domain containing 135
chr12_-_55917134 5.160 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr11_+_66927976 5.153 NM_198517
 TBC1D10C
TBC1 domain family, member 10C
chr16_+_28413421 5.077 NM_018690
 APOBR
apolipoprotein B receptor
chr16_-_31054321 4.897 PRSS8
protease, serine, 8
chr16_-_28515868 4.853 NM_001054
 SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr4_+_76700281 4.754 NM_178497
 C4orf26
chromosome 4 open reading frame 26
chr19_+_61624 4.728 NM_001005240
 OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr1_-_166149867 4.677 NM_001167749
NM_018417
 ADCY10

adenylate cyclase 10 (soluble)

chrX_-_48213508 4.497 SLC38A5
solute carrier family 38, member 5
chr19_+_41085221 4.113 NM_001007469
NM_014266
 HCST

hematopoietic cell signal transducer

chr11_+_118463906 4.022 NM_001024382
 HMBS
hydroxymethylbilane synthase
chr16_-_31054563 4.016 NM_002773
 PRSS8
protease, serine, 8
chrX_-_48213545 3.995 NM_033518
 SLC38A5
solute carrier family 38, member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
7.04 1.43e-02 GO:0006693 prostaglandin metabolic process
5.79 2.52e-02 GO:0006692 prostanoid metabolic process
2.43 6.07e-03 GO:0008202 steroid metabolic process
1.61 2.25e-02 GO:0006629 lipid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.69 1.61e-03 GO:0005615 extracellular space
1.62 2.42e-09 GO:0005576 extracellular region
1.51 2.26e-02 GO:0044421 extracellular region part
1.46 2.58e-02 GO:0005887 integral to plasma membrane
1.39 1.17e-03 GO:0044459 plasma membrane part
1.34 1.08e-06 GO:0071944 cell periphery
1.34 1.22e-06 GO:0005886 plasma membrane
1.24 1.25e-04 GO:0031224 intrinsic to membrane
1.23 4.58e-04 GO:0016021 integral to membrane
1.22 8.68e-05 GO:0044425 membrane part
1.17 9.87e-04 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
13.38 3.08e-02 GO:0032052 bile acid binding
4.60 7.90e-03 GO:0003823 antigen binding
2.88 7.95e-04 GO:0004252 serine-type endopeptidase activity
2.49 1.16e-02 GO:0008236 serine-type peptidase activity
2.45 1.57e-02 GO:0017171 serine hydrolase activity
1.56 1.09e-05 GO:0004872 receptor activity
1.37 9.14e-03 GO:0004871 signal transducer activity
1.37 9.14e-03 GO:0060089 molecular transducer activity