Motif ID: ONECUT1,2.p2

Z-value: 1.766


Transcription factors associated with ONECUT1,2.p2:

Gene SymbolEntrez IDGene Name
ONECUT1 3175 one cut homeobox 1
ONECUT2 9480 one cut homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ONECUT1chr15_-_50869379-0.165.6e-01Click!
ONECUT2chr18_+_53253775-0.019.6e-01Click!


Activity profile for motif ONECUT1,2.p2.

activity profile for motif ONECUT1,2.p2


Sorted Z-values histogram for motif ONECUT1,2.p2

Sorted Z-values for motif ONECUT1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_30238961 9.817 NM_033229
TRIM15
tripartite motif containing 15
chr1_+_357502 8.408 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr5_+_180726874 8.296 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr1_-_611896 7.935 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr8_-_107023 6.124 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr6_-_41823056 5.631 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr15_-_100280784 3.880 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chrX_-_24600661 3.500 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr19_+_61624 3.414 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr7_-_13992351 3.349 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr19_-_9087438 3.317 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr14_+_87560646 3.223 LOC283587
hypothetical protein LOC283587
chr1_-_51660328 3.049 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chrX_+_46825179 2.900 RGN
regucalcin (senescence marker protein-30)
chr16_-_20610078 2.899 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr7_+_116238309 2.852 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr7_-_100077072 2.826 NM_003227
TFR2
transferrin receptor 2
chr7_+_99263571 2.758 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr8_-_86477585 2.600 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr4_-_145159889 2.583 NM_002100
GYPB
glycophorin B (MNS blood group)
chr5_-_43448174 2.432 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr7_-_135263737 2.280 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr3_+_142525744 2.275 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr2_+_132196533 2.204 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr3_-_198784590 2.112 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr2_-_32344192 2.067 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr6_+_26609427 2.009 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr16_-_70591377 1.961 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr6_+_32003180 1.900 NM_000063
NM_001145903
C2

complement component 2

chr17_+_69950782 1.891 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr20_+_186376 1.852 NM_207469
DEFB132
defensin, beta 132
chrX_+_123307812 1.825 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr9_-_14076901 1.786 NFIB
nuclear factor I/B
chr1_+_40635058 1.772 NM_001198980
SMAP2
small ArfGAP2
chr16_+_21152516 1.764 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_+_62893836 1.734 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chrX_+_49718954 1.697 NM_000084
CLCN5
chloride channel 5
chr15_+_70477707 1.691 NM_001080462
TMEM202
transmembrane protein 202
chr1_-_198643885 1.677 ZNF281
zinc finger protein 281
chr1_-_144779601 1.674 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr16_-_11274952 1.659 NM_021247
PRM3
protamine 3
chr15_-_41300316 1.652 EPB42
erythrocyte membrane protein band 4.2
chr13_+_97856148 1.645


chr4_-_155731288 1.621 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr11_+_89624017 1.620


chr7_+_143043871 1.615 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr6_+_28032997 1.605 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_-_74478405 1.592 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr1_+_111215343 1.576 NM_001040033
CD53
CD53 molecule
chr22_+_21384862 1.563 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr3_+_173043832 1.559 NM_001164436
TMEM212
transmembrane protein 212
chr3_+_171022403 1.552 NM_001080460
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr2_+_172530120 1.549 HAT1
histone acetyltransferase 1
chr15_-_41300526 1.489 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr11_+_62813947 1.487 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr15_-_41300488 1.455 EPB42
erythrocyte membrane protein band 4.2
chr5_+_147754467 1.397 FBXO38
F-box protein 38
chr1_-_146076704 1.343 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr5_+_140719773 1.341 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr7_+_94135384 1.300 PEG10
paternally expressed 10
chr10_+_102722275 1.289 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr9_-_122852356 1.289 NM_001735
C5
complement component 5
chr18_-_28606839 1.281 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr7_-_86433139 1.266 NM_152748
KIAA1324L
KIAA1324-like
chr18_+_27425727 1.262 NM_000371
TTR
transthyretin
chr16_-_29797172 1.261 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_+_147006065 1.255 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr6_-_41811916 1.242 NM_001167827
TFEB
transcription factor EB
chr16_-_73708118 1.237 LDHD
lactate dehydrogenase D
chr9_+_95886625 1.237 PTPDC1
protein tyrosine phosphatase domain containing 1
chr16_-_65510230 1.237 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr4_-_69852090 1.229 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr15_+_91244563 1.207 CHD2
chromodomain helicase DNA binding protein 2
chr11_+_123639909 1.203 NM_001005198
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr20_+_56919233 1.175 GNAS
GNAS complex locus
chr9_+_95886558 1.166 NM_152422
PTPDC1
protein tyrosine phosphatase domain containing 1
chr8_+_26569709 1.162 DPYSL2
dihydropyrimidinase-like 2
chr19_-_5797465 1.143 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr7_+_128099581 1.137 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr16_+_68238460 1.134 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_95514205 1.127 NM_001164464
TRIM43
TRIM43B
tripartite motif containing 43
tripartite motif containing 43B
chr20_-_33705244 1.126 NM_003915
CPNE1
copine I
chr2_+_130703384 1.119


chr2_+_170074457 1.114 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr16_-_73708165 1.111 NM_153486
NM_194436
LDHD

lactate dehydrogenase D

chr3_-_57209319 1.096 NM_003865
HESX1
HESX homeobox 1
chr16_-_68346299 1.096 NM_014062
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
chr1_+_58899 1.094 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr6_-_49820030 1.090 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr2_-_88208650 1.087 NM_001443
FABP1
fatty acid binding protein 1, liver
chr7_-_104696678 1.085 NM_182691
SRPK2
SRSF protein kinase 2
chr5_-_149772563 1.079 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_64344307 1.078 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_+_51219558 1.074 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr11_-_59369501 1.069 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr10_-_921694 1.066 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr17_-_53849929 1.061 NM_017763
RNF43
ring finger protein 43
chr1_-_32054164 1.056 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_196874839 1.047 PTPRC
protein tyrosine phosphatase, receptor type, C
chr2_+_161980865 1.047 NM_006593
TBR1
T-box, brain, 1
chr6_+_132000134 1.043 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr5_+_139856688 1.036 ANKHD1
ankyrin repeat and KH domain containing 1
chr1_-_171838802 1.035 NM_178527
SLC9A11
solute carrier family 9, member 11
chr8_-_30121741 1.034 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr17_+_28342994 1.032 NM_173847
SPACA3
sperm acrosome associated 3
chr9_-_139262009 1.027 NM_001001710
FAM166A
family with sequence similarity 166, member A
chr19_+_58239802 1.022 NM_001191055
HERV-V2
envelope glycoprotein ENVV2
chr1_+_196874759 1.016 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr14_+_66901237 1.008 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr1_-_198644111 0.998 ZNF281
zinc finger protein 281
chr3_-_180452096 0.988 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_-_207738858 0.983 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_-_150422474 0.983 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_-_21106291 0.979 APOB
apolipoprotein B (including Ag(x) antigen)
chr2_-_21081694 0.978 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_-_23117833 0.972 NM_001146028
NM_032452
JPH4

junctophilin 4

chr1_-_21373816 0.970 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_+_120490054 0.960 C7orf58
chromosome 7 open reading frame 58
chr1_-_20014180 0.960 NM_019062
RNF186
ring finger protein 186
chr10_-_73953699 0.960 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr12_-_52975777 0.943 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_+_123625632 0.941 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr5_-_149772528 0.933


chr3_-_184756101 0.924 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr4_+_636965 0.920 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr11_-_123799976 0.920 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr14_-_23090606 0.912 NM_033400
ZFHX2
zinc finger homeobox 2
chr2_+_113601616 0.912 IL1RN
interleukin 1 receptor antagonist
chr2_-_88946767 0.903


chr1_+_62835759 0.902 NM_014495
ANGPTL3
angiopoietin-like 3
chr19_-_44518516 0.901 NM_004877
GMFG
glia maturation factor, gamma
chr1_+_117098579 0.889 NM_001767
CD2
CD2 molecule
chr3_+_85858321 0.889 NM_153184
CADM2
cell adhesion molecule 2
chr12_-_7709734 0.889 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr11_-_118055564 0.887 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chr14_-_73095396 0.887 NM_203309
HEATR4
HEAT repeat containing 4
chr15_-_38908197 0.884 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr5_-_149772469 0.871 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr11_+_57285809 0.863 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr15_+_72687765 0.862 NM_003992
CLK3
CDC-like kinase 3
chr1_+_51855343 0.860 OSBPL9
oxysterol binding protein-like 9
chr1_-_67366807 0.857 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr6_+_4781330 0.855 NM_001143970
CDYL
chromodomain protein, Y-like
chr2_+_113601608 0.853 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr6_+_53043729 0.842 NM_012347
FBXO9
F-box protein 9
chr21_-_42608774 0.842 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr5_+_148711419 0.820 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr11_-_46364681 0.809 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr15_-_56093477 0.808 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr4_+_187385618 0.805 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr14_+_19513442 0.803 NM_001005486
OR4K15
olfactory receptor, family 4, subfamily K, member 15
chr3_-_9895633 0.800 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr4_+_186587537 0.796 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr15_+_91244422 0.795 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr6_-_138581319 0.789 NM_021635
PBOV1
prostate and breast cancer overexpressed 1
chr19_+_40632456 0.789 NM_005306
FFAR2
free fatty acid receptor 2
chr11_+_59612712 0.784 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr9_-_115877104 0.782 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_-_21310462 0.782 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_-_55539769 0.778 NAPSB
napsin B aspartic peptidase pseudogene
chr5_+_68703036 0.774 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr3_-_171070314 0.773 NM_024727
LRRC31
leucine rich repeat containing 31
chr20_+_36408237 0.772 NM_004139
LBP
lipopolysaccharide binding protein
chr10_+_7785235 0.768 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chrX_+_15435351 0.768 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr11_-_47467094 0.767 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr9_+_263025 0.764 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr12_-_52975823 0.761 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr19_+_7468444 0.757 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr5_+_176449156 0.754 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr1_-_149698272 0.751 POGZ
pogo transposable element with ZNF domain
chr4_+_74496575 0.750 ALB
albumin
chr14_-_20179689 0.749 NM_001001968
OR6S1
olfactory receptor, family 6, subfamily S, member 1
chr4_+_74496660 0.748 ALB
albumin
chr4_+_37638450 0.745 NM_006607
PTTG2
pituitary tumor-transforming 2
chr20_-_34841107 0.742 KIAA0889
KIAA0889
chr5_+_140532385 0.739 NM_018940
PCDHB7
protocadherin beta 7
chr14_+_19735334 0.738 NM_001005503
OR11G2
olfactory receptor, family 11, subfamily G, member 2
chr4_+_69716298 0.736 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr13_+_108046500 0.729 NM_015011
MYO16
myosin XVI
chr14_-_22496196 0.717 HAUS4
HAUS augmin-like complex, subunit 4
chr16_+_68156497 0.705 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NFAT5




nuclear factor of activated T-cells 5, tonicity-responsive




chr1_+_166516901 0.703 NM_005149
TBX19
T-box 19
chr19_+_45563603 0.699 PLD3
phospholipase D family, member 3
chr12_+_130004404 0.696 NM_198827
GPR133
G protein-coupled receptor 133
chr7_+_128136347 0.690 FAM71F1
family with sequence similarity 71, member F1
chr12_+_40117751 0.690 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr19_+_45563594 0.686 PLD3
phospholipase D family, member 3
chr19_+_45563607 0.685 PLD3
phospholipase D family, member 3
chr19_-_53081326 0.685 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr20_+_42417502 0.684 HNF4A
hepatocyte nuclear factor 4, alpha
chr9_+_129066576 0.683 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr14_-_23117614 0.683 JPH4
junctophilin 4
chr20_+_31613800 0.682 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr19_-_61876057 0.681 NM_001005850
ZNF835
zinc finger protein 835
chr1_+_111544469 0.676


chr16_+_29971971 0.665 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr12_+_94200306 0.660 VEZT
vezatin, adherens junctions transmembrane protein
chr6_-_24827265 0.657 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr16_+_65938753 0.645 NM_001161575
LRRC36
leucine rich repeat containing 36

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.92 3.24e-10 GO:0007608 sensory perception of smell
2.79 3.57e-10 GO:0007606 sensory perception of chemical stimulus
2.00 9.06e-06 GO:0007600 sensory perception
1.29 1.91e-04 GO:0032501 multicellular organismal process
1.56 6.03e-04 GO:0003008 system process
1.62 1.47e-03 GO:0050877 neurological system process
1.22 7.57e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 7.38e-05 GO:0071944 cell periphery
1.31 1.05e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.01 3.73e-11 GO:0004984 olfactory receptor activity
2.22 3.73e-10 GO:0004930 G-protein coupled receptor activity
1.78 1.06e-06 GO:0004888 transmembrane receptor activity
1.59 3.52e-05 GO:0004872 receptor activity
1.45 1.13e-03 GO:0004871 signal transducer activity
1.45 1.13e-03 GO:0060089 molecular transducer activity
4.47 2.79e-02 GO:0043498 cell surface binding