Motif ID: SRF.p3

Z-value: 1.800


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432471790.273.3e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_73973640 4.193 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_73973600 4.188 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr15_-_32875040 3.583 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr20_+_34603290 3.580 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 3.243 MYL9
myosin, light chain 9, regulatory
chr5_+_137829065 2.975 EGR1
early growth response 1
chr1_-_16217025 2.874 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr3_+_189413414 2.757 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr18_-_3209846 2.755 MYOM1
myomesin 1, 185kDa
chr1_-_11830328 2.503 NM_006172
NPPA
natriuretic peptide A
chr2_+_218992053 2.378 NM_007127
VIL1
villin 1
chr19_-_50517971 2.229 CKM
creatine kinase, muscle
chr3_-_46879883 2.070 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr15_-_63147350 1.980 NM_016563
RASL12
RAS-like, family 12
chr16_-_11282595 1.907 NM_002761
PRM1
protamine 1
chr10_-_90702490 1.860 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_+_137829077 1.749 NM_001964
EGR1
early growth response 1
chr17_+_30498948 1.633 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr3_-_71376919 1.592 FOXP1
forkhead box P1
chr3_+_150675117 1.578 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr16_-_66535457 1.516 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr10_+_88418147 1.479 NM_001171610
LDB3
LIM domain binding 3
chr10_+_88418243 1.457 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr1_-_240228987 1.451 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr6_-_109882116 1.441 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr11_-_16387001 1.402 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr2_+_88148413 1.377 NM_198274
SMYD1
SET and MYND domain containing 1
chr18_-_3209986 1.377 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr2_-_225086564 1.376 CUL3
cullin 3
chr3_-_124821868 1.285 MYLK
myosin light chain kinase
chr19_-_50518072 1.268 NM_001824
CKM
creatine kinase, muscle
chr3_-_187124290 1.229 TRA2B
transformer 2 beta homolog (Drosophila)
chrX_-_11194015 1.198 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr3_-_153470022 1.195 LOC401093
hypothetical LOC401093
chr2_+_42128521 1.175 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr19_+_50109416 1.153 APOC1
apolipoprotein C-I
chr1_-_227636462 1.103 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr6_-_123999640 1.086 NM_006073
TRDN
triadin
chr17_+_3326045 1.079 NM_000049
ASPA
aspartoacylase
chr3_-_124822113 0.991 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr15_-_63147228 0.983 RASL12
RAS-like, family 12
chr4_+_24406182 0.967 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr1_-_31618405 0.959 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr2_+_100545827 0.957 NM_024065
PDCL3
phosducin-like 3
chr10_+_112247614 0.900 NM_004419
DUSP5
dual specificity phosphatase 5
chr19_+_2427122 0.876 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr19_+_59064795 0.874 MYADM
myeloid-associated differentiation marker
chr12_-_23995220 0.852 SOX5
SRY (sex determining region Y)-box 5
chr3_+_150675169 0.833 TM4SF4
transmembrane 4 L six family member 4
chr17_+_38256710 0.824 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr14_-_93512818 0.823 ASB2
ankyrin repeat and SOCS box containing 2
chr4_+_14985272 0.784 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr6_+_151602787 0.738 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_15957832 0.728 NM_017556
FBLIM1
filamin binding LIM protein 1
chr1_-_20178680 0.717 NM_001161729
PLA2G2A
phospholipase A2, group IIA (platelets, synovial fluid)
chr17_+_29707583 0.709 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr10_+_123912930 0.698 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_-_33783409 0.698 RBM39
RNA binding motif protein 39
chr2_-_105381855 0.697 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr20_-_33706532 0.696 RBM12
RNA binding motif protein 12
chr1_-_152431175 0.691 NM_152263
TPM3
tropomyosin 3
chr1_+_165865953 0.681 NM_052862
RCSD1
RCSD domain containing 1
chr6_+_144654565 0.669 NM_007124
UTRN
utrophin
chr2_-_105421661 0.661 NM_201557
FHL2
four and a half LIM domains 2
chr6_-_29635680 0.650 NM_006398
UBD
ubiquitin D
chr6_+_158322875 0.637 NM_003898
SYNJ2
synaptojanin 2
chr14_-_93512647 0.635 ASB2
ankyrin repeat and SOCS box containing 2
chr11_+_62189354 0.622 NM_001043229
METTL12
methyltransferase like 12
chr1_+_165866127 0.600 RCSD1
RCSD domain containing 1
chr11_+_116575249 0.585 NM_001001522
NM_003186
TAGLN

transgelin

chr8_-_22606653 0.578 NM_004430
EGR3
early growth response 3
chr19_+_50663089 0.570 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr6_+_44322764 0.555 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr2_+_46560207 0.553 NM_001145051
LOC388946
transmembrane protein ENSP00000343375
chr20_-_33198721 0.548 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr11_-_57038891 0.540 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr12_-_23995109 0.537 SOX5
SRY (sex determining region Y)-box 5
chr12_+_50731457 0.536 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr17_-_69869552 0.533 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr2_-_73373956 0.531 NM_001965
EGR4
early growth response 4
chr17_-_38385511 0.525 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr11_+_59564323 0.503 NM_173801
PLAC1L
placenta-specific 1-like
chr6_-_16869579 0.501 NM_000332
NM_001128164
ATXN1

ataxin 1

chr18_-_42804291 0.496 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr17_+_29636799 0.472 NM_002986
CCL11
chemokine (C-C motif) ligand 11
chr16_+_30015899 0.468


chr11_-_75599433 0.467 WNT11
wingless-type MMTV integration site family, member 11
chr10_+_114033403 0.459 NM_058222
TECTB
tectorin beta
chr2_-_21120420 0.449 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr20_-_61728866 0.446 GMEB2
glucocorticoid modulatory element binding protein 2
chr17_+_16259636 0.442 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr11_-_2118743 0.441 IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_158704056 0.440 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr18_-_42804531 0.425 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr6_-_29635456 0.424 UBD
ubiquitin D
chr11_+_66070949 0.410 NM_001104
ACTN3
actinin, alpha 3
chr7_-_107430566 0.406 NM_002291
LAMB1
laminin, beta 1
chr5_-_178983241 0.401 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_-_40939756 0.399 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr6_-_25834733 0.398 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr16_+_31105579 0.390


chr17_+_16259573 0.388 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr5_+_60663842 0.388 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr7_+_111908143 0.385 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr19_-_52666886 0.383 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr11_-_65424385 0.377 FOSL1
FOS-like antigen 1
chr12_+_48784057 0.376 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr20_-_21442663 0.375 NM_002509
NKX2-2
NK2 homeobox 2
chr17_-_36456949 0.366 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr14_-_54438913 0.358 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr12_-_90029672 0.357 NM_002345
LUM
lumican
chr19_+_59064471 0.357 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr11_+_65945050 0.353 NM_178864
NPAS4
neuronal PAS domain protein 4
chr6_+_43247179 0.352 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr10_+_80777234 0.349 PPIF
peptidylprolyl isomerase F
chr6_+_158322904 0.344 SYNJ2
synaptojanin 2
chr5_+_88220846 0.332


chr17_-_34603577 0.326 CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr18_-_42810446 0.324 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr2_-_128149112 0.323 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr7_-_5536783 0.315 ACTB
actin, beta
chr11_+_46339691 0.314 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr6_+_44322831 0.312 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr10_+_80777199 0.309 NM_005729
PPIF
peptidylprolyl isomerase F
chr17_-_77094426 0.308 ACTG1
actin, gamma 1
chr17_-_77094375 0.299 NM_001614
ACTG1
actin, gamma 1
chr22_+_24468110 0.292 NM_032608
MYO18B
myosin XVIIIB
chr17_+_16259812 0.290 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr17_-_77386156 0.288 DYSFIP1
dysferlin interacting protein 1
chr14_+_74815233 0.288 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr15_-_53369261 0.286 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr5_+_6799100 0.284 NM_001171806
PAPD7
PAP associated domain containing 7
chr4_-_88669625 0.282 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr6_+_43246897 0.282 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr17_-_23721351 0.280 VTN
vitronectin
chr17_-_23721420 0.275 VTN
vitronectin
chr20_+_4650499 0.271 NM_012409
PRND
prion protein 2 (dublet)
chr11_-_65424434 0.263 FOSL1
FOS-like antigen 1
chr6_+_43247168 0.256 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_+_107969410 0.252 NM_021815
SLC5A7
solute carrier family 5 (choline transporter), member 7
chr10_+_6226909 0.250 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr20_+_60558104 0.250 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr14_+_104338423 0.248 ZBTB42
zinc finger and BTB domain containing 42
chr12_-_55730125 0.247 NM_005379
MYO1A
myosin IA
chr3_-_158695832 0.243 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr17_-_46296376 0.243 NM_005749
TOB1
transducer of ERBB2, 1
chr2_+_55312542 0.240 NM_001135592
RPS27A
ribosomal protein S27a
chr1_-_120737466 0.240 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr17_-_77386212 0.235 NM_001007533
DYSFIP1
dysferlin interacting protein 1
chr9_+_96561750 0.234 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr1_+_11917330 0.233 NM_000302
PLOD1
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
chr22_+_28206180 0.225 NM_021076
NEFH
neurofilament, heavy polypeptide
chr2_-_21120398 0.224 APOB
apolipoprotein B (including Ag(x) antigen)
chr7_+_143378393 0.221 NM_012365
OR2A5
olfactory receptor, family 2, subfamily A, member 5
chr7_+_113842284 0.215 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr16_+_55523526 0.211 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr20_-_604443 0.210


chr18_-_42798364 0.209 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr7_-_75280962 0.207 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr19_+_39402167 0.204 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr6_-_88468667 0.204 AKIRIN2
akirin 2
chr5_+_176955595 0.202


chr16_+_22011362 0.199 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr18_+_9698299 0.197 RAB31
RAB31, member RAS oncogene family
chr6_+_151603201 0.195 AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_50975603 0.195 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr17_-_36181927 0.192 NM_181539
KRT26
keratin 26
chr20_-_61728774 0.189 NM_012384
GMEB2
glucocorticoid modulatory element binding protein 2
chr20_-_18425811 0.187 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_+_156899575 0.185 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr4_-_88669267 0.185 SPARCL1
SPARC-like 1 (hevin)
chr2_+_138975819 0.184 NM_001001664
SPOPL
speckle-type POZ protein-like
chr10_+_6226884 0.182 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_-_121731721 0.180 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr15_+_38462213 0.178 NM_001142761
NM_001142762
NM_033286
C15orf23


chromosome 15 open reading frame 23


chr22_+_24468168 0.176 MYO18B
myosin XVIIIB
chr20_-_62151216 0.173 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr7_+_113842470 0.171 FOXP2
forkhead box P2
chr16_-_67943157 0.171 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr6_-_88468591 0.169 AKIRIN2
akirin 2
chr17_-_36938111 0.169 NM_002276
KRT19
keratin 19
chr1_-_120737416 0.168 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr19_+_3536541 0.167 NM_133261
GIPC3
GIPC PDZ domain containing family, member 3
chr11_-_19180092 0.167 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr1_-_148080888 0.166 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr15_+_38430517 0.165 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr15_-_68177280 0.163 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr2_+_138975946 0.160


chr1_-_166373434 0.159 GPR161
G protein-coupled receptor 161
chr1_-_925215 0.157 HES4
hairy and enhancer of split 4 (Drosophila)
chr2_-_151052391 0.157 NM_005168
RND3
Rho family GTPase 3
chr6_+_158322916 0.156 SYNJ2
synaptojanin 2
chr15_-_99847395 0.155 PCSK6
proprotein convertase subtilisin/kexin type 6
chr11_+_43920385 0.154 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr16_+_29984611 0.154 ALDOA
aldolase A, fructose-bisphosphate
chr10_+_6226764 0.154 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chrX_-_152592450 0.154 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr15_+_79276273 0.150 NM_001172128
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr21_+_34112456 0.147 ITSN1
intersectin 1 (SH3 domain protein)
chr11_-_47330797 0.145 NM_000256
MYBPC3
myosin binding protein C, cardiac

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.79 6.18e-07 GO:0003012 muscle system process
6.96 1.41e-06 GO:0006936 muscle contraction
16.26 3.09e-06 GO:0070252 actin-mediated cell contraction
1.61 7.26e-06 GO:0032501 multicellular organismal process
12.12 4.89e-05 GO:0030048 actin filament-based movement
14.85 5.21e-05 GO:0030049 muscle filament sliding
14.85 5.21e-05 GO:0033275 actin-myosin filament sliding
5.60 8.83e-05 GO:0007517 muscle organ development
4.51 2.80e-04 GO:0061061 muscle structure development
1.66 2.51e-03 GO:0007275 multicellular organismal development
4.06 2.57e-03 GO:0030029 actin filament-based process
1.62 3.22e-03 GO:0032502 developmental process
2.82 3.48e-03 GO:0010628 positive regulation of gene expression
1.95 5.20e-03 GO:0048513 organ development
3.18 5.98e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.81 9.26e-03 GO:0045893 positive regulation of transcription, DNA-dependent
2.17 9.68e-03 GO:0010033 response to organic substance
1.65 1.33e-02 GO:0048856 anatomical structure development
2.53 1.48e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
2.62 2.83e-02 GO:0051254 positive regulation of RNA metabolic process
2.12 3.97e-02 GO:0031325 positive regulation of cellular metabolic process
1.67 4.28e-02 GO:0048518 positive regulation of biological process
1.65 4.45e-02 GO:0048731 system development
2.36 4.84e-02 GO:0031328 positive regulation of cellular biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
10.33 1.15e-10 GO:0044449 contractile fiber part
9.49 4.77e-10 GO:0043292 contractile fiber
10.51 2.11e-09 GO:0030017 sarcomere
9.47 2.21e-09 GO:0030016 myofibril
4.56 7.71e-06 GO:0015629 actin cytoskeleton
11.45 7.65e-05 GO:0031674 I band
2.09 4.12e-04 GO:0005856 cytoskeleton
19.07 8.59e-04 GO:0005859 muscle myosin complex
17.17 1.52e-03 GO:0016460 myosin II complex
21.13 5.27e-03 GO:0031672 A band
7.51 7.27e-03 GO:0016459 myosin complex
11.45 1.24e-02 GO:0032432 actin filament bundle
10.41 1.99e-02 GO:0042641 actomyosin
2.28 2.02e-02 GO:0005615 extracellular space
10.10 2.31e-02 GO:0005884 actin filament
1.21 3.07e-02 GO:0043229 intracellular organelle
1.21 3.44e-02 GO:0043226 organelle
9.04 3.97e-02 GO:0030018 Z disc

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.78 3.60e-05 GO:0008307 structural constituent of muscle
1.40 5.57e-05 GO:0005515 protein binding
2.31 1.89e-03 GO:0030528 transcription regulator activity
2.67 2.77e-03 GO:0046983 protein dimerization activity
1.18 2.88e-03 GO:0005488 binding
3.48 3.55e-03 GO:0003779 actin binding
13.73 5.64e-03 GO:0017022 myosin binding
2.61 8.98e-03 GO:0005198 structural molecule activity
6.11 1.07e-02 GO:0003704 specific RNA polymerase II transcription factor activity
2.66 1.55e-02 GO:0008092 cytoskeletal protein binding
4.91 4.99e-02 GO:0008201 heparin binding