Motif ID: SRF.p3

Z-value: 1.800


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432471790.273.3e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_73973640 4.193 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_+_73973600 4.188 NM_001615
 ACTG2
actin, gamma 2, smooth muscle, enteric
chr15_-_32875040 3.583 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr20_+_34603290 3.580 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr20_+_34603311 3.243 MYL9
myosin, light chain 9, regulatory
chr5_+_137829065 2.975 EGR1
early growth response 1
chr1_-_16217025 2.874 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr3_+_189413414 2.757 NM_005578
 LPP
LIM domain containing preferred translocation partner in lipoma
chr18_-_3209846 2.755 MYOM1
myomesin 1, 185kDa
chr1_-_11830328 2.503 NM_006172
 NPPA
natriuretic peptide A
chr2_+_218992053 2.378 NM_007127
 VIL1
villin 1
chr19_-_50517971 2.229 CKM
creatine kinase, muscle
chr3_-_46879883 2.070 NM_000258
 MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr15_-_63147350 1.980 NM_016563
 RASL12
RAS-like, family 12
chr16_-_11282595 1.907 NM_002761
 PRM1
protamine 1
chr10_-_90702490 1.860 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_+_137829077 1.749 NM_001964
 EGR1
early growth response 1
chr17_+_30498948 1.633 NM_001033576
NM_173167
 UNC45B

unc-45 homolog B (C. elegans)

chr3_-_71376919 1.592 FOXP1
forkhead box P1
chr3_+_150675117 1.578 NM_004617
 TM4SF4
transmembrane 4 L six family member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
16.26 3.09e-06 GO:0070252 actin-mediated cell contraction
14.85 5.21e-05 GO:0030049 muscle filament sliding
14.85 5.21e-05 GO:0033275 actin-myosin filament sliding
12.12 4.89e-05 GO:0030048 actin filament-based movement
6.96 1.41e-06 GO:0006936 muscle contraction
6.79 6.18e-07 GO:0003012 muscle system process
5.60 8.83e-05 GO:0007517 muscle organ development
4.51 2.80e-04 GO:0061061 muscle structure development
4.06 2.57e-03 GO:0030029 actin filament-based process
3.18 5.98e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.82 3.48e-03 GO:0010628 positive regulation of gene expression
2.81 9.26e-03 GO:0045893 positive regulation of transcription, DNA-dependent
2.62 2.83e-02 GO:0051254 positive regulation of RNA metabolic process
2.53 1.48e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
2.36 4.84e-02 GO:0031328 positive regulation of cellular biosynthetic process
2.17 9.68e-03 GO:0010033 response to organic substance
2.12 3.97e-02 GO:0031325 positive regulation of cellular metabolic process
1.95 5.20e-03 GO:0048513 organ development
1.67 4.28e-02 GO:0048518 positive regulation of biological process
1.66 2.51e-03 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
21.13 5.27e-03 GO:0031672 A band
19.07 8.59e-04 GO:0005859 muscle myosin complex
17.17 1.52e-03 GO:0016460 myosin II complex
11.45 7.65e-05 GO:0031674 I band
11.45 1.24e-02 GO:0032432 actin filament bundle
10.51 2.11e-09 GO:0030017 sarcomere
10.41 1.99e-02 GO:0042641 actomyosin
10.33 1.15e-10 GO:0044449 contractile fiber part
10.10 2.31e-02 GO:0005884 actin filament
9.49 4.77e-10 GO:0043292 contractile fiber
9.47 2.21e-09 GO:0030016 myofibril
9.04 3.97e-02 GO:0030018 Z disc
7.51 7.27e-03 GO:0016459 myosin complex
4.56 7.71e-06 GO:0015629 actin cytoskeleton
2.28 2.02e-02 GO:0005615 extracellular space
2.09 4.12e-04 GO:0005856 cytoskeleton
1.21 3.07e-02 GO:0043229 intracellular organelle
1.21 3.44e-02 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
13.73 5.64e-03 GO:0017022 myosin binding
12.78 3.60e-05 GO:0008307 structural constituent of muscle
6.11 1.07e-02 GO:0003704 specific RNA polymerase II transcription factor activity
4.91 4.99e-02 GO:0008201 heparin binding
3.48 3.55e-03 GO:0003779 actin binding
2.67 2.77e-03 GO:0046983 protein dimerization activity
2.66 1.55e-02 GO:0008092 cytoskeletal protein binding
2.61 8.98e-03 GO:0005198 structural molecule activity
2.31 1.89e-03 GO:0030528 transcription regulator activity
1.40 5.57e-05 GO:0005515 protein binding
1.18 2.88e-03 GO:0005488 binding