Motif ID: GTF2I.p2

Z-value: 1.834


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_737099910.468.4e-02Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_86600658 2.290 NM_001007156
NM_001012338
NM_002530
NTRK3


neurotrophic tyrosine kinase, receptor, type 3


chr11_+_12355600 2.204 NM_018222
PARVA
parvin, alpha
chr1_-_20685314 2.102 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr13_+_113574925 2.015 NM_001143945
GAS6
growth arrest-specific 6
chr3_+_42675841 2.001 ZBTB47
zinc finger and BTB domain containing 47
chr2_-_218551786 1.761 TNS1
tensin 1
chr9_+_138341752 1.701 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr19_-_60573552 1.698 NM_000641
IL11
interleukin 11
chrX_+_152413540 1.625 NM_001711
BGN
biglycan
chr12_+_93066370 1.599 NM_005761
PLXNC1
plexin C1
chr2_+_220033777 1.595 NM_001173476
SPEG
SPEG complex locus
chr9_+_35528890 1.538 RUSC2
RUN and SH3 domain containing 2
chr16_+_56219802 1.512 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_-_56418295 1.495 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_68470585 1.493 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr2_-_19421852 1.467 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chrX_+_152413646 1.467 BGN
biglycan
chr12_+_6363482 1.466 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr2_+_100802923 1.448 NM_002518
NPAS2
neuronal PAS domain protein 2
chr12_-_6354818 1.417 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr22_+_44277354 1.413 NM_001996
NM_006485
NM_006486
NM_006487
FBLN1



fibulin 1



chr11_-_45643711 1.397 NM_003654
CHST1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr7_+_5289079 1.397 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr12_-_6354650 1.371 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr15_+_72861767 1.326 CSK
c-src tyrosine kinase
chr9_+_35528628 1.298 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr5_+_135392482 1.290 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr1_-_24307514 1.289 MYOM3
myomesin family, member 3
chr8_-_22044463 1.280 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr7_-_23476497 1.273 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr13_+_57103944 1.218 PCDH17
protocadherin 17
chr19_-_55914837 1.209


chr13_+_87122778 1.207 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr17_+_19255083 1.205 NM_007148
RNF112
ring finger protein 112
chr1_+_226404037 1.190 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr4_+_61749540 1.188 LPHN3
latrophilin 3
chr14_-_36058648 1.188 NM_003317
NKX2-1
NK2 homeobox 1
chr5_-_81082614 1.187 SSBP2
single-stranded DNA binding protein 2
chr2_-_218575922 1.176 TNS1
tensin 1
chr9_-_34579679 1.165 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr14_+_104244998 1.163 INF2
inverted formin, FH2 and WH2 domain containing
chr5_-_142057692 1.153 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr12_+_46133 1.151 NM_001170738
IQSEC3
IQ motif and Sec7 domain 3
chr11_-_27697768 1.138 NM_001143807
BDNF
brain-derived neurotrophic factor
chr19_+_59061422 1.132 NM_001020820
MYADM
myeloid-associated differentiation marker
chr13_+_57103789 1.121 NM_001040429
PCDH17
protocadherin 17
chr9_+_8848130 1.094


chr16_+_66244314 1.092 RLTPR
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr14_-_104507862 1.073 AHNAK2
AHNAK nucleoprotein 2
chr19_+_1226510 1.067 NM_017914
C19orf24
chromosome 19 open reading frame 24
chr3_+_185580554 1.061 NM_003741
CHRD
chordin
chr11_-_62445308 1.061 CHRM1
cholinergic receptor, muscarinic 1
chr6_+_1335067 1.045 NM_001452
FOXF2
forkhead box F2
chr1_+_156229686 1.037 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_-_220788048 1.026 NM_024746
HHIPL2
HHIP-like 2
chr11_+_129823667 1.023 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr17_+_70984173 1.019 KIAA0195
KIAA0195
chr19_-_56178882 1.014 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr7_+_68702516 1.009 AUTS2
autism susceptibility candidate 2
chr20_+_42807901 1.003 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr22_-_35914200 0.997 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr17_-_38421363 0.997 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr11_+_66499323 0.997 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr7_-_78920806 0.996 NM_012301
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_-_39632845 0.996 ATXN7L3
ataxin 7-like 3
chr11_-_1728385 0.993 LOC402778
CD225 family protein FLJ76511
chr11_-_65082705 0.981 LTBP3
latent transforming growth factor beta binding protein 3
chr1_+_156229934 0.980 KIRREL
kin of IRRE like (Drosophila)
chr3_-_42282665 0.975 NM_000729
CCK
cholecystokinin
chr12_-_105057940 0.971 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr19_-_60740246 0.951 NM_001101401
SBK2
SH3-binding domain kinase family, member 2
chr20_+_29870836 0.946 NM_033118
MYLK2
myosin light chain kinase 2
chr7_+_73080422 0.935 ELN
elastin
chr11_-_62445587 0.934 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr3_-_197103848 0.933 TNK2
tyrosine kinase, non-receptor, 2
chr8_-_93184629 0.932 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr19_-_59676153 0.932 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr19_+_60691671 0.919 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr5_+_135392624 0.918 TGFBI
transforming growth factor, beta-induced, 68kDa
chr19_+_60691733 0.915 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr1_+_201711505 0.905 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr19_+_54786723 0.903 NM_020719
PRR12
proline rich 12
chr3_-_193609531 0.901 NM_021032
FGF12
fibroblast growth factor 12
chr16_+_68516401 0.888 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr3_-_62334229 0.887 NM_018008
FEZF2
FEZ family zinc finger 2
chr14_-_26136799 0.886 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr7_+_73080387 0.884 ELN
elastin
chr17_-_72045218 0.882 NM_134268
CYGB
cytoglobin
chr19_+_50144267 0.876 APOC2
apolipoprotein C-II
chr7_+_73080362 0.867 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr7_-_27136876 0.866 NM_002141
HOXA4
homeobox A4
chr7_+_30917939 0.858 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr7_+_150390566 0.855 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr1_+_221955876 0.851 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_-_194844299 0.850 KCNT2
potassium channel, subfamily T, member 2
chr2_-_200028977 0.841 SATB2
SATB homeobox 2
chr19_+_40321584 0.837 FXYD1
FXYD domain containing ion transport regulator 1
chrX_+_144707022 0.832 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr2_+_176665694 0.830 NM_000523
HOXD13
homeobox D13
chr11_+_47236072 0.813 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr5_+_148766632 0.811 LOC728264
hypothetical LOC728264
chr17_-_45427565 0.810 NM_005220
DLX3
distal-less homeobox 3
chr1_+_202308814 0.802 NM_005686
SOX13
SRY (sex determining region Y)-box 13
chr3_-_64648703 0.800 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr7_+_73080404 0.794 ELN
elastin
chr1_-_200946038 0.791 NM_177402
SYT2
synaptotagmin II
chr1_-_221604023 0.790 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr8_-_26427304 0.779 NM_007257
PNMA2
paraneoplastic antigen MA2
chr17_-_34635446 0.779 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr20_-_22512893 0.778 FOXA2
forkhead box A2
chr9_+_117955890 0.778 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr19_+_40321567 0.774 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr16_-_30929217 0.773 NM_052874
STX1B
syntaxin 1B
chr15_-_59308708 0.772 RORA
RAR-related orphan receptor A
chr14_-_53491019 0.769 NM_130851
BMP4
bone morphogenetic protein 4
chr1_+_2975590 0.766 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr11_+_17714070 0.766 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr11_-_124272891 0.763 NM_019055
ROBO4
roundabout homolog 4, magic roundabout (Drosophila)
chr8_-_21702273 0.759 NM_001165038
NM_001165039
NM_001495
GFRA2


GDNF family receptor alpha 2


chr19_-_60350122 0.755 TNNT1
troponin T type 1 (skeletal, slow)
chr1_-_202432165 0.753 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr2_-_72228427 0.750 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr10_+_99322187 0.748 NM_001129981
NM_020349
ANKRD2

ankyrin repeat domain 2 (stretch responsive muscle)

chr1_+_15957832 0.739 NM_017556
FBLIM1
filamin binding LIM protein 1
chr22_-_35938298 0.738 NM_001051
SSTR3
somatostatin receptor 3
chr5_-_178704934 0.735 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr1_-_57661373 0.733 DAB1
disabled homolog 1 (Drosophila)
chr7_-_32077504 0.728 NM_001191059
NM_005020
PDE1C

phosphodiesterase 1C, calmodulin-dependent 70kDa

chr8_+_104582151 0.722 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr8_+_27547379 0.720 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr19_-_60412624 0.718 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chr19_+_40322231 0.718 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr3_+_77171938 0.715 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr19_+_43572679 0.712 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr7_+_68702252 0.712 AUTS2
autism susceptibility candidate 2
chr12_-_6355165 0.707 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr14_-_88953059 0.704 NM_005197
FOXN3
forkhead box N3
chr7_-_27120015 0.694 HOXA3
homeobox A3
chr15_-_49174107 0.694 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr19_-_48113784 0.693 NM_002782
NM_001031850
PSG6

pregnancy specific beta-1-glycoprotein 6

chr2_-_227371698 0.686 NM_005544
IRS1
insulin receptor substrate 1
chr12_-_113606322 0.684 NM_005996
NM_016569
TBX3

T-box 3

chr2_-_192767494 0.683 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr8_+_26427378 0.682 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr4_-_177950658 0.682 NM_005429
VEGFC
vascular endothelial growth factor C
chr4_-_122213018 0.682 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr15_+_45796802 0.681 SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr8_-_143692814 0.681 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr5_-_141981083 0.676 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr2_+_85515428 0.673 NM_198482
SH2D6
SH2 domain containing 6
chr7_-_100667750 0.673 NM_014343
CLDN15
claudin 15
chr5_-_142045770 0.673 NM_000800
FGF1
fibroblast growth factor 1 (acidic)
chr2_-_29997935 0.672 NM_004304
ALK
anaplastic lymphoma receptor tyrosine kinase
chr2_-_133145539 0.663 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr2_-_241408296 0.662 NM_004321
KIF1A
kinesin family member 1A
chr19_-_242335 0.660 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr4_-_187764213 0.659


chr15_+_90738108 0.659 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr9_-_106705867 0.655 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_-_60634271 0.655 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr14_+_85069217 0.653


chr2_+_45022540 0.652 NM_005413
SIX3
SIX homeobox 3
chr19_+_60487578 0.644 BRSK1
BR serine/threonine kinase 1
chr15_+_41597097 0.643 NM_002373
MAP1A
microtubule-associated protein 1A
chr4_+_7245218 0.641 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr9_+_35782405 0.639 NM_003995
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr6_+_108593907 0.635 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr17_+_34115383 0.633 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr15_+_87147667 0.630 NM_001135
NM_013227
ACAN

aggrecan

chr20_-_61600834 0.625 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr14_-_62581656 0.624 NM_139318
NM_172375
KCNH5

potassium voltage-gated channel, subfamily H (eag-related), member 5

chr19_-_13478037 0.624 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr2_+_220200530 0.624 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr11_-_18769703 0.617 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr6_-_33268177 0.609 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr7_+_73506333 0.609 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chrX_+_152684150 0.607 PLXNB3
plexin B3
chr12_+_54400417 0.604 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr11_+_124539814 0.603 PKNOX2
PBX/knotted 1 homeobox 2
chr7_+_78920846 0.603 LOC100505881
hypothetical LOC100505881
chr11_-_44288188 0.601 NM_021926
ALX4
ALX homeobox 4
chr14_-_22891865 0.601 NM_016609
SLC22A17
solute carrier family 22, member 17
chr2_+_219432789 0.599 NM_006522
WNT6
wingless-type MMTV integration site family, member 6
chr19_-_14062230 0.598 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr13_-_35603513 0.596 NM_004734
DCLK1
doublecortin-like kinase 1
chr11_-_122571198 0.595 NM_024769
CLMP
CXADR-like membrane protein
chr16_-_29817841 0.589 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chrX_+_122922058 0.589 NM_001042749
STAG2
stromal antigen 2
chr22_+_40093245 0.585 NM_001145398
TEF
thyrotrophic embryonic factor
chr15_-_59308770 0.583 NM_134261
RORA
RAR-related orphan receptor A
chr10_+_102495327 0.583 NM_000278
NM_003987
NM_003988
NM_003989
NM_003990
PAX2




paired box 2




chr9_-_112381593 0.582 NM_153366
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr1_+_18830086 0.571 NM_001135254
NM_002584
NM_013945
PAX7


paired box 7


chr6_+_44352443 0.571 TMEM151B
transmembrane protein 151B
chr8_-_97242119 0.569 NM_001001557
GDF6
growth differentiation factor 6
chr4_-_5940893 0.567 CRMP1
collapsin response mediator protein 1
chr18_-_33399997 0.567 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr8_+_27547303 0.566 SCARA3
scavenger receptor class A, member 3
chr9_-_106705780 0.564 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_+_1543644 0.563 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 2.43e-28 GO:0048731 system development
1.30 6.86e-26 GO:0048856 anatomical structure development
1.28 9.77e-26 GO:0007275 multicellular organismal development
1.46 2.91e-25 GO:0007399 nervous system development
1.45 7.77e-25 GO:0009653 anatomical structure morphogenesis
1.16 3.53e-23 GO:0050794 regulation of cellular process
1.25 8.06e-23 GO:0032502 developmental process
1.15 4.28e-22 GO:0065007 biological regulation
1.15 1.52e-21 GO:0050789 regulation of biological process
1.55 6.79e-21 GO:0022008 neurogenesis
1.56 3.16e-20 GO:0048699 generation of neurons
1.57 1.32e-16 GO:0030182 neuron differentiation
1.65 2.30e-15 GO:0000904 cell morphogenesis involved in differentiation
1.66 2.31e-15 GO:0031175 neuron projection development
1.69 2.62e-15 GO:0048812 neuron projection morphogenesis
1.21 1.16e-14 GO:0023052 signaling
1.68 1.88e-14 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 2.09e-14 GO:0048858 cell projection morphogenesis
1.69 2.59e-14 GO:0007409 axonogenesis
1.59 2.66e-14 GO:0048666 neuron development
1.62 3.38e-14 GO:0032990 cell part morphogenesis
1.57 6.41e-14 GO:0000902 cell morphogenesis
1.28 1.53e-13 GO:0048523 negative regulation of cellular process
1.54 2.01e-13 GO:0032989 cellular component morphogenesis
1.08 3.92e-13 GO:0009987 cellular process
1.53 4.32e-13 GO:0030030 cell projection organization
1.28 6.31e-13 GO:0048869 cellular developmental process
1.26 7.59e-13 GO:0048519 negative regulation of biological process
1.29 9.52e-13 GO:0048513 organ development
1.28 1.08e-12 GO:0030154 cell differentiation
1.25 1.28e-12 GO:0048522 positive regulation of cellular process
1.23 7.06e-12 GO:0048518 positive regulation of biological process
1.41 2.78e-11 GO:0048468 cell development
1.39 1.87e-10 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 6.27e-10 GO:0023051 regulation of signaling
1.46 7.35e-10 GO:0010628 positive regulation of gene expression
1.19 9.16e-10 GO:0007165 signal transduction
1.65 1.90e-09 GO:0007411 axon guidance
1.47 1.99e-09 GO:0045893 positive regulation of transcription, DNA-dependent
1.45 2.24e-09 GO:0051254 positive regulation of RNA metabolic process
1.14 3.19e-09 GO:0032501 multicellular organismal process
1.40 8.59e-09 GO:0051173 positive regulation of nitrogen compound metabolic process
1.16 1.01e-08 GO:0051716 cellular response to stimulus
1.31 1.35e-08 GO:0009893 positive regulation of metabolic process
1.46 1.53e-08 GO:0009887 organ morphogenesis
1.34 1.91e-08 GO:0010646 regulation of cell communication
1.32 2.19e-08 GO:0031325 positive regulation of cellular metabolic process
1.18 2.21e-08 GO:0016043 cellular component organization
1.32 2.37e-08 GO:0010604 positive regulation of macromolecule metabolic process
1.62 2.89e-08 GO:0001501 skeletal system development
1.40 3.30e-08 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.30 4.35e-08 GO:0051239 regulation of multicellular organismal process
1.17 8.15e-08 GO:0071840 cellular component organization or biogenesis
1.61 1.07e-07 GO:0060284 regulation of cell development
1.48 1.21e-07 GO:0007417 central nervous system development
1.39 1.28e-07 GO:2000026 regulation of multicellular organismal development
1.39 1.43e-07 GO:0010557 positive regulation of macromolecule biosynthetic process
1.37 1.51e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.28 1.98e-07 GO:0009966 regulation of signal transduction
1.36 3.46e-07 GO:0009891 positive regulation of biosynthetic process
1.36 3.53e-07 GO:0051128 regulation of cellular component organization
1.16 4.13e-07 GO:0031323 regulation of cellular metabolic process
1.39 5.35e-07 GO:0009790 embryo development
1.47 5.73e-07 GO:0019226 transmission of nerve impulse
1.47 5.73e-07 GO:0035637 multicellular organismal signaling
2.22 6.74e-07 GO:2000027 regulation of organ morphogenesis
1.37 8.63e-07 GO:0007267 cell-cell signaling
1.34 9.68e-07 GO:0006351 transcription, DNA-dependent
1.61 1.48e-06 GO:0035295 tube development
1.18 1.59e-06 GO:0071842 cellular component organization at cellular level
1.33 1.78e-06 GO:0050793 regulation of developmental process
1.31 1.94e-06 GO:0007154 cell communication
1.34 3.09e-06 GO:0009888 tissue development
1.51 6.17e-06 GO:0007420 brain development
1.47 6.30e-06 GO:0007268 synaptic transmission
1.38 6.37e-06 GO:0007167 enzyme linked receptor protein signaling pathway
1.53 6.91e-06 GO:0007389 pattern specification process
1.58 7.20e-06 GO:0051960 regulation of nervous system development
1.44 9.12e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.14 9.49e-06 GO:0019222 regulation of metabolic process
1.30 9.86e-06 GO:0009605 response to external stimulus
1.44 1.34e-05 GO:0072358 cardiovascular system development
1.44 1.34e-05 GO:0072359 circulatory system development
1.17 1.36e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.38 1.64e-05 GO:0009725 response to hormone stimulus
1.42 1.85e-05 GO:0006935 chemotaxis
1.42 1.85e-05 GO:0042330 taxis
1.36 1.96e-05 GO:0009719 response to endogenous stimulus
1.21 2.11e-05 GO:0048583 regulation of response to stimulus
1.30 2.44e-05 GO:0032774 RNA biosynthetic process
1.14 3.23e-05 GO:0080090 regulation of primary metabolic process
1.35 6.76e-05 GO:0045595 regulation of cell differentiation
1.92 7.65e-05 GO:0030323 respiratory tube development
1.16 1.00e-04 GO:0031326 regulation of cellular biosynthetic process
1.39 1.25e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.57 1.27e-04 GO:0050767 regulation of neurogenesis
1.30 1.57e-04 GO:0040011 locomotion
1.16 1.60e-04 GO:0009889 regulation of biosynthetic process
1.42 1.66e-04 GO:0032583 regulation of gene-specific transcription
1.91 1.72e-04 GO:0030324 lung development
1.38 1.72e-04 GO:0051253 negative regulation of RNA metabolic process
1.52 1.93e-04 GO:0001944 vasculature development
1.16 2.04e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.41 2.07e-04 GO:0048646 anatomical structure formation involved in morphogenesis
1.16 2.20e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 2.42e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.57 3.55e-04 GO:0051129 negative regulation of cellular component organization
1.65 4.15e-04 GO:0030900 forebrain development
1.27 4.39e-04 GO:0032879 regulation of localization
1.14 4.42e-04 GO:0060255 regulation of macromolecule metabolic process
2.84 4.50e-04 GO:0003156 regulation of organ formation
1.49 5.05e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.19 5.32e-04 GO:0007166 cell surface receptor linked signaling pathway
1.46 6.25e-04 GO:0044057 regulation of system process
1.19 6.92e-04 GO:0010467 gene expression
1.34 8.20e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.43 8.26e-04 GO:0048598 embryonic morphogenesis
1.34 8.42e-04 GO:0010629 negative regulation of gene expression
1.59 8.43e-04 GO:0045664 regulation of neuron differentiation
1.33 1.05e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.55 1.05e-03 GO:0002009 morphogenesis of an epithelium
1.77 1.06e-03 GO:0060541 respiratory system development
1.56 1.18e-03 GO:0048514 blood vessel morphogenesis
1.48 1.24e-03 GO:0048729 tissue morphogenesis
1.33 1.58e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.25 1.80e-03 GO:0009892 negative regulation of metabolic process
1.40 1.86e-03 GO:0009968 negative regulation of signal transduction
1.15 2.32e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.67 2.34e-03 GO:0001655 urogenital system development
1.49 2.61e-03 GO:0001568 blood vessel development
1.77 2.65e-03 GO:0072001 renal system development
1.11 3.23e-03 GO:0044260 cellular macromolecule metabolic process
1.10 3.24e-03 GO:0043170 macromolecule metabolic process
1.50 3.30e-03 GO:0030036 actin cytoskeleton organization
1.26 3.44e-03 GO:0031324 negative regulation of cellular metabolic process
1.15 3.63e-03 GO:0010468 regulation of gene expression
1.77 3.71e-03 GO:0001822 kidney development
1.37 4.06e-03 GO:0023057 negative regulation of signaling
1.30 4.47e-03 GO:0009890 negative regulation of biosynthetic process
1.51 4.53e-03 GO:0003002 regionalization
1.16 5.08e-03 GO:0051252 regulation of RNA metabolic process
1.51 5.35e-03 GO:0048568 embryonic organ development
1.16 5.44e-03 GO:0006355 regulation of transcription, DNA-dependent
1.30 5.49e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.25 5.84e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.36 6.10e-03 GO:0051094 positive regulation of developmental process
1.30 6.27e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.40 6.33e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.42 6.57e-03 GO:0071495 cellular response to endogenous stimulus
1.14 7.40e-03 GO:0010556 regulation of macromolecule biosynthetic process
2.46 8.14e-03 GO:0060688 regulation of morphogenesis of a branching structure
1.36 8.14e-03 GO:0010648 negative regulation of cell communication
1.44 1.01e-02 GO:0051130 positive regulation of cellular component organization
1.34 1.02e-02 GO:0048585 negative regulation of response to stimulus
2.06 1.03e-02 GO:0060348 bone development
1.39 1.03e-02 GO:0009792 embryo development ending in birth or egg hatching
1.44 1.04e-02 GO:0030029 actin filament-based process
1.62 1.08e-02 GO:0045165 cell fate commitment
1.15 1.20e-02 GO:0065008 regulation of biological quality
1.54 1.21e-02 GO:0048732 gland development
1.51 1.21e-02 GO:0043193 positive regulation of gene-specific transcription
1.72 1.24e-02 GO:0048736 appendage development
1.72 1.24e-02 GO:0060173 limb development
1.63 1.31e-02 GO:0050678 regulation of epithelial cell proliferation
1.77 1.31e-02 GO:0030278 regulation of ossification
1.42 1.41e-02 GO:0032870 cellular response to hormone stimulus
1.15 1.45e-02 GO:0042221 response to chemical stimulus
1.55 1.52e-02 GO:0035239 tube morphogenesis
1.72 1.75e-02 GO:0035107 appendage morphogenesis
1.72 1.75e-02 GO:0035108 limb morphogenesis
1.59 1.95e-02 GO:0048562 embryonic organ morphogenesis
1.44 1.96e-02 GO:0007423 sensory organ development
1.38 2.37e-02 GO:0043009 chordate embryonic development
1.24 2.38e-02 GO:0006811 ion transport
1.64 2.66e-02 GO:0001763 morphogenesis of a branching structure
1.36 2.68e-02 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.58 3.28e-02 GO:0060562 epithelial tube morphogenesis
1.69 3.72e-02 GO:0061138 morphogenesis of a branching epithelium
1.16 4.00e-02 GO:0016070 RNA metabolic process
1.73 4.14e-02 GO:0051216 cartilage development
1.39 4.29e-02 GO:0045597 positive regulation of cell differentiation
1.17 4.35e-02 GO:0034645 cellular macromolecule biosynthetic process
1.82 4.50e-02 GO:0022612 gland morphogenesis
1.19 4.58e-02 GO:0035556 intracellular signal transduction
2.40 4.94e-02 GO:0031128 developmental induction
2.40 4.94e-02 GO:0045168 cell-cell signaling involved in cell fate commitment

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.62 3.12e-12 GO:0045202 synapse
1.56 1.45e-09 GO:0043005 neuron projection
1.41 7.49e-08 GO:0030054 cell junction
1.52 1.28e-07 GO:0031012 extracellular matrix
1.56 9.02e-07 GO:0044456 synapse part
1.31 3.28e-06 GO:0042995 cell projection
1.18 5.03e-06 GO:0044459 plasma membrane part
1.63 4.84e-05 GO:0030424 axon
1.07 1.40e-04 GO:0005737 cytoplasm
1.17 1.72e-04 GO:0005829 cytosol
1.45 1.80e-04 GO:0005578 proteinaceous extracellular matrix
1.05 3.06e-04 GO:0044424 intracellular part
1.55 8.64e-04 GO:0030425 dendrite
1.62 9.02e-04 GO:0045211 postsynaptic membrane
1.44 1.10e-03 GO:0015629 actin cytoskeleton
1.04 1.48e-03 GO:0005622 intracellular
1.50 1.61e-02 GO:0043025 neuronal cell body
2.10 2.64e-02 GO:0005581 collagen
1.47 2.88e-02 GO:0044297 cell body
1.73 3.45e-02 GO:0033267 axon part
1.70 4.26e-02 GO:0014069 postsynaptic density
1.42 4.76e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 3.75e-12 GO:0005515 protein binding
1.38 1.21e-11 GO:0001071 nucleic acid binding transcription factor activity
1.38 1.21e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 1.54e-11 GO:0030528 transcription regulator activity
1.06 1.68e-09 GO:0005488 binding
1.42 2.22e-09 GO:0043565 sequence-specific DNA binding
1.56 3.53e-07 GO:0016563 transcription activator activity
1.54 1.77e-05 GO:0005261 cation channel activity
1.49 3.67e-05 GO:0022836 gated channel activity
1.42 1.02e-04 GO:0005216 ion channel activity
1.41 1.41e-04 GO:0015267 channel activity
1.40 1.73e-04 GO:0022803 passive transmembrane transporter activity
1.40 3.52e-04 GO:0022838 substrate-specific channel activity
1.56 9.37e-04 GO:0005244 voltage-gated ion channel activity
1.56 9.37e-04 GO:0022832 voltage-gated channel activity
1.64 1.27e-03 GO:0022843 voltage-gated cation channel activity
1.41 2.10e-03 GO:0003779 actin binding
1.31 4.51e-03 GO:0008092 cytoskeletal protein binding
1.33 1.13e-02 GO:0019904 protein domain specific binding
2.40 1.34e-02 GO:0005245 voltage-gated calcium channel activity
1.79 1.37e-02 GO:0005262 calcium channel activity
1.13 3.05e-02 GO:0003677 DNA binding
1.58 4.22e-02 GO:0015276 ligand-gated ion channel activity
1.58 4.22e-02 GO:0022834 ligand-gated channel activity
1.72 4.69e-02 GO:0005201 extracellular matrix structural constituent