Motif ID: NKX2-1,4.p2

Z-value: 2.317


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36059084-0.421.2e-01Click!
NKX2-4chr20_-_213260460.136.5e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_81271859 6.066 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr15_+_72253077 4.732 NM_005545
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_180836050 4.674


chr2_-_100125402 4.531 NM_002285
AFF3
AF4/FMR2 family, member 3
chr19_-_6621598 4.516 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr6_+_152053323 4.234 NM_001122742
ESR1
estrogen receptor 1
chrX_+_78087484 4.234 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_143706196 3.929 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_6621078 3.708 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_159817752 3.513 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_+_111053488 3.425 NM_001178130
NM_001178131
NM_001963
EGF


epidermal growth factor


chr9_+_114671635 3.053 SNX30
sorting nexin family member 30
chr14_+_63752424 2.957 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr6_-_11887265 2.871 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr1_+_159899528 2.797 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_+_118259684 2.715 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr19_-_45132372 2.670 NM_003890
FCGBP
Fc fragment of IgG binding protein
chr10_+_126620681 2.663 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_-_143706265 2.646 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_119733062 2.569 SPPL3
signal peptide peptidase 3
chr1_-_143706300 2.553 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr3_+_190831909 2.542 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr3_+_109498082 2.506 HHLA2
HERV-H LTR-associating 2
chr3_-_188492163 2.471 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr16_+_11966464 2.461 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr20_+_56455866 2.458 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr17_+_7846636 2.361 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chrX_-_154216929 2.281 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_226462363 2.266 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr10_-_75005421 2.182 NM_152586
USP54
ubiquitin specific peptidase 54
chr12_-_53064565 2.148 ZNF385A
zinc finger protein 385A
chr9_+_102380156 2.141 NM_001018116
MURC
muscle-related coiled-coil protein
chr8_-_7207899 2.136 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_+_59979857 2.091 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr5_-_88155360 2.041 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr8_-_82536312 2.037 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr2_+_38009405 2.028 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr7_-_7724762 1.991 NM_002947
RPA3
replication protein A3, 14kDa
chr13_-_35842289 1.840 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr12_-_51887266 1.771 NM_000889
ITGB7
integrin, beta 7
chr12_-_54392328 1.746 NM_001144997
ITGA7
integrin, alpha 7
chr3_+_38238080 1.725 OXSR1
oxidative-stress responsive 1
chr5_-_88004891 1.720 LOC645323
hypothetical LOC645323
chrX_-_100920493 1.719 GK
glycerol kinase
chr15_+_72253224 1.711 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr8_+_67201684 1.658 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_+_72423633 1.656 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr1_+_154120170 1.654 SYT11
synaptotagmin XI
chr3_+_46386636 1.653 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chrX_+_41468351 1.648 NM_080817
GPR82
G protein-coupled receptor 82
chr12_+_54700955 1.592 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr22_-_37211467 1.574 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr5_-_131907071 1.564 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr21_+_37714470 1.518 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr12_+_15590552 1.506 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr12_+_130004404 1.496 NM_198827
GPR133
G protein-coupled receptor 133
chr1_-_43168247 1.493 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr10_-_49152918 1.474 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr1_-_156013487 1.434 NM_030764
FCRL2
Fc receptor-like 2
chr1_-_41398126 1.417 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr3_-_51971915 1.378 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_156590109 1.367 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr1_+_169747788 1.365 PRRC2C
proline-rich coiled-coil 2C
chr2_+_178893216 1.355 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr16_-_31007630 1.330 NM_001039503
PRSS53
protease, serine, 53
chrX_+_71280758 1.311 NM_207422
FLJ44635
TPT1-like protein
chr12_-_110410730 1.286 ATXN2
ataxin 2
chr5_+_150008030 1.278 SYNPO
synaptopodin
chr8_-_134156437 1.250 SLA
Src-like-adaptor
chr4_-_68793928 1.229 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr2_+_28469850 1.213 FOSL2
FOS-like antigen 2
chr12_+_117067214 1.212 PEBP1
phosphatidylethanolamine binding protein 1
chr2_+_28469864 1.200 FOSL2
FOS-like antigen 2
chrX_+_48427103 1.191 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr1_+_151498802 1.182 NM_000427
LOR
loricrin
chr17_-_10393664 1.159 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr7_+_50318801 1.149 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr10_-_11614279 1.147 NM_001080491
USP6NL
USP6 N-terminal like
chr2_+_102401580 1.147 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_158653679 1.128 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr10_+_86121526 1.115 FAM190B
family with sequence similarity 190, member B
chr12_-_53064723 1.114 NM_015481
ZNF385A
zinc finger protein 385A
chr15_-_29734833 1.111 NM_130901
OTUD7A
OTU domain containing 7A
chr1_-_207891264 1.104 NM_001017402
LAMB3
laminin, beta 3
chr15_-_72287447 1.097 NM_001199041
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr17_-_53761119 1.091 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr10_-_13584950 1.090 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr2_+_28469275 1.070 NM_005253
FOSL2
FOS-like antigen 2
chr15_-_70385709 1.059 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr15_-_48192804 1.042 ATP8B4
ATPase, class I, type 8B, member 4
chr18_+_19286784 1.031 NM_003831
RIOK3
RIO kinase 3 (yeast)
chr13_+_110637173 1.029 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr5_-_134810696 1.014 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr2_+_28469199 1.005 FOSL2
FOS-like antigen 2
chr17_+_20048890 0.991 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_238842071 0.988 NM_022469
GREM2
gremlin 2
chr6_+_32057779 0.985 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr12_+_6819635 0.979 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr10_-_69125932 0.955 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_32489426 0.949 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_51887318 0.943 ITGB7
integrin, beta 7
chr12_+_8216416 0.933 NM_001004328
ZNF705A
zinc finger protein 705A
chr19_+_45797413 0.931 LTBP4
latent transforming growth factor beta binding protein 4
chr20_-_42561725 0.931


chr2_+_28892366 0.919 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr3_+_2908920 0.914 NM_175613
CNTN4
contactin 4
chr6_-_149847809 0.912 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr17_-_31353196 0.912 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr5_-_147996769 0.909 NM_001040169
NM_001040172
NM_001040173
NM_199453
HTR4



5-hydroxytryptamine (serotonin) receptor 4



chr4_-_100359353 0.908 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr7_+_129634935 0.907 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr9_-_124329392 0.907 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr11_+_66152309 0.893


chr9_-_33385265 0.891 AQP7
aquaporin 7
chr20_+_35266581 0.887 RPN2
ribophorin II
chr17_+_63338500 0.876 BPTF
bromodomain PHD finger transcription factor
chr6_+_30212488 0.866 NM_138700
TRIM40
tripartite motif containing 40
chr9_+_126158935 0.863


chr2_+_28469172 0.860 FOSL2
FOS-like antigen 2
chr1_-_21250039 0.853 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_38033666 0.848 NM_152496
MANEAL
mannosidase, endo-alpha-like
chr6_-_116488458 0.827 NM_002031
FRK
fyn-related kinase
chr1_+_172683834 0.825 NM_005684
GPR52
G protein-coupled receptor 52
chr17_-_44022595 0.823 HOXB3
homeobox B3
chr20_+_4650499 0.817 NM_012409
PRND
prion protein 2 (dublet)
chr2_-_74235860 0.815


chr13_+_45174446 0.798 NM_152719
SPERT
spermatid associated
chr19_+_50144267 0.789 APOC2
apolipoprotein C-II
chr10_-_6144119 0.785 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr4_-_176970407 0.779 GPM6A
glycoprotein M6A
chr15_+_38430517 0.763 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr5_+_131424245 0.758 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr3_+_171560104 0.747 NM_001145097
SKIL
SKI-like oncogene
chr17_-_3407780 0.747 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr6_+_26476384 0.745 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_-_245120900 0.745 AHCTF1
AT hook containing transcription factor 1
chr4_-_176970372 0.743 GPM6A
glycoprotein M6A
chr4_-_102487506 0.740 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr15_-_76313896 0.738 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr1_-_178100204 0.738


chrX_+_70682204 0.734 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr11_-_5212168 0.730 NM_000519
HBD
hemoglobin, delta
chr8_-_6901661 0.730 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr4_-_123761615 0.727 NM_021803
IL21
interleukin 21
chr20_-_33706532 0.723 RBM12
RNA binding motif protein 12
chr17_-_5078773 0.717 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr5_-_160211623 0.709 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_-_39306465 0.709 FYB
FYN binding protein
chr11_+_22646229 0.704 NM_177553
GAS2
growth arrest-specific 2
chr6_-_149847718 0.696 ZC3H12D
zinc finger CCCH-type containing 12D
chr3_-_69120188 0.696 C3orf64
chromosome 3 open reading frame 64
chr1_-_21310462 0.692 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr11_+_57554977 0.692 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr4_-_174774368 0.691 NM_006792
MORF4
mortality factor 4
chr12_-_192752 0.685 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr1_-_158948176 0.683 NM_001778
CD48
CD48 molecule
chr1_+_200698493 0.678 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr15_-_53349775 0.674 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr4_+_102954005 0.672 NM_001083907
BANK1
B-cell scaffold protein with ankyrin repeats 1
chr16_+_74901235 0.669 NM_138994
CNTNAP4
contactin associated protein-like 4
chr1_-_33613729 0.667 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_-_238842011 0.665 GREM2
gremlin 2
chr1_-_201586910 0.663 NM_002023
FMOD
fibromodulin
chr3_+_46894239 0.660 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr9_-_99740243 0.649 NM_197978
HEMGN
hemogen
chr1_+_144124547 0.645 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr5_+_150020595 0.639 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr1_-_158815850 0.639 CD84
CD84 molecule
chr11_-_10672079 0.634 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr5_-_134815886 0.628 NM_001099221
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr2_-_160838397 0.627 RBMS1
RNA binding motif, single stranded interacting protein 1
chr15_-_23201740 0.622 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr11_+_46651090 0.621 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr17_-_60439764 0.612 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr3_-_120761092 0.605 NM_005191
CD80
CD80 molecule
chr20_+_56912146 0.605 GNAS
GNAS complex locus
chr4_+_78172966 0.603 SEPT11
septin 11
chr12_+_1608672 0.602 NM_032642
WNT5B
wingless-type MMTV integration site family, member 5B
chrX_-_137649180 0.599 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_13325242 0.597 NM_001099854
PRAMEF14
PRAME family member 14
chr15_-_53350383 0.597 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr16_-_70306198 0.588 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr6_+_155453114 0.574 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr4_+_114433551 0.569 ANK2
ankyrin 2, neuronal
chr11_-_123799976 0.568 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr6_+_31081707 0.568 NM_001198815
PBMUCL1
panbronchiolitis related mucin-like 1
chr3_-_180460372 0.566 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr1_-_158815895 0.566 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr5_+_155686333 0.563 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chrX_+_144716619 0.563 NM_004709
CXorf1
chromosome X open reading frame 1
chr10_+_114125003 0.562 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_21249974 0.561 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr8_+_77928372 0.558 ZFHX4
zinc finger homeobox 4
chr14_-_20694023 0.557 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr11_+_61279436 0.554 NM_013279
C11orf9
chromosome 11 open reading frame 9
chrX_+_48427137 0.546 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr9_+_135994734 0.546 NM_052821
WDR5
WD repeat domain 5
chr9_-_94206648 0.537 NM_014057
NM_033014
OGN

osteoglycin

chr6_-_32184975 0.534 NM_019105
TNXB
tenascin XB
chr7_+_143457083 0.532 NM_001001659
OR2A14
olfactory receptor, family 2, subfamily A, member 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.40 3.81e-04 GO:0032501 multicellular organismal process
1.32 3.31e-03 GO:0050896 response to stimulus
2.56 4.26e-03 GO:0001775 cell activation
3.57 9.31e-03 GO:0046649 lymphocyte activation
3.21 1.28e-02 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.17 5.87e-04 GO:0005615 extracellular space
1.91 3.40e-03 GO:0044421 extracellular region part
4.02 1.14e-02 GO:0030016 myofibril
3.79 2.02e-02 GO:0043292 contractile fiber

Nothing significant found in function category.