Motif ID: NKX2-1,4.p2

Z-value: 2.317


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-1chr14_-_36059084-0.421.2e-01Click!
NKX2-4chr20_-_213260460.136.5e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_81271859 6.066 NM_001007122
 FSD2
fibronectin type III and SPRY domain containing 2
chr15_+_72253077 4.732 NM_005545
 ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_180836050 4.674


chr2_-_100125402 4.531 NM_002285
 AFF3
AF4/FMR2 family, member 3
chr19_-_6621598 4.516 NM_003807
NM_172014
 TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr6_+_152053323 4.234 NM_001122742
 ESR1
estrogen receptor 1
chrX_+_78087484 4.234 NM_014499
NM_198333
 P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_143706196 3.929 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_6621078 3.708 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_159817752 3.513 NM_201563
 FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr4_+_111053488 3.425 NM_001178130
NM_001178131
NM_001963
 EGF


epidermal growth factor


chr9_+_114671635 3.053 SNX30
sorting nexin family member 30
chr14_+_63752424 2.957 NM_182910
 SYNE2
spectrin repeat containing, nuclear envelope 2
chr6_-_11887265 2.871 NM_001143948
NM_032744
 C6orf105

chromosome 6 open reading frame 105

chr1_+_159899528 2.797 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
 FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr11_+_118259684 2.715 NM_001716
 CXCR5
chemokine (C-X-C motif) receptor 5
chr19_-_45132372 2.670 NM_003890
 FCGBP
Fc fragment of IgG binding protein
chr10_+_126620681 2.663 NM_017580
 ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_-_143706265 2.646 PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_119733062 2.569 SPPL3
signal peptide peptidase 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
3.57 9.31e-03 GO:0046649 lymphocyte activation
3.21 1.28e-02 GO:0045321 leukocyte activation
2.56 4.26e-03 GO:0001775 cell activation
1.40 3.81e-04 GO:0032501 multicellular organismal process
1.32 3.31e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
4.02 1.14e-02 GO:0030016 myofibril
3.79 2.02e-02 GO:0043292 contractile fiber
2.17 5.87e-04 GO:0005615 extracellular space
1.91 3.40e-03 GO:0044421 extracellular region part

Nothing significant found in function category.