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Motif ID: bHLH_family.p2

Z-value: 1.955

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_+_54660954	3.308	NM_133267	GSX2	GS homeobox 2
chr8_+_120289735	2.813	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_-_27162688	2.655	NM_006896	HOXA7	homeobox A7
chr12_-_47604930	2.535	NM_001143781	FKBP11	FK506 binding protein 11, 19 kDa
chr17_-_36469869	2.493	NM_001165252	LOC730755	keratin associated protein 2-4-like
chr7_-_1562272	2.461	NM_001097620	TMEM184A	transmembrane protein 184A
chr2_-_219826854	2.350	NM_006000	TUBA4A	tubulin, alpha 4a
chr16_-_66827449	2.274	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chr4_-_17392232	2.208	NM_015688	FAM184B	family with sequence similarity 184, member B
chr12_-_50871953	2.195	NM_001081492 NM_182507	KRT80	keratin 80
chr17_+_36515166	2.153	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr11_+_126378507	2.138		NCRNA00288	non-protein coding RNA 288
chr3_-_11585264	2.118	NM_001128221	VGLL4	vestigial like 4 (Drosophila)
chr9_+_696744	2.115	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr1_+_201364050	2.104		ADORA1	adenosine A1 receptor
chr2_-_217267742	2.090		IGFBP5	insulin-like growth factor binding protein 5
chr19_+_1226510	1.967	NM_017914	C19orf24	chromosome 19 open reading frame 24
chrX_-_114703273	1.953
chr16_+_639278	1.942	NM_145294	WDR90	WD repeat domain 90
chr2_-_133144094	1.892		LYPD1	LY6/PLAUR domain containing 1
chr11_-_116168316	1.823	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr6_-_18230829	1.819	NM_198586	NHLRC1	NHL repeat containing 1
chr2_-_219633481	1.817	NM_002181	IHH	Indian hedgehog
chr16_+_84204424	1.805	NM_014615	KIAA0182	KIAA0182
chr3_-_126414252	1.787	NM_024628	SLC12A8	solute carrier family 12 (potassium/chloride transporters), member 8
chr13_+_112999538	1.776		LAMP1	lysosomal-associated membrane protein 1
chr10_+_112826774	1.747	NM_000681	ADRA2A	adrenergic, alpha-2A-, receptor
chr9_-_129869211	1.739	NM_197956	NAIF1	nuclear apoptosis inducing factor 1
chr22_+_34107087	1.729		HMOX1	heme oxygenase (decycling) 1
chr3_-_49370755	1.721	NM_000581 NM_201397	GPX1	glutathione peroxidase 1
chr19_-_10625449	1.710		LOC147727	hypothetical LOC147727
chr8_-_75396016	1.698	NM_020647	JPH1	junctophilin 1
chr11_+_66915997	1.686	NM_004584	RAD9A	RAD9 homolog A (S. pombe)
chr12_+_6703686	1.644	NM_001164093	COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr2_+_176680251	1.626	NM_021192	HOXD11	homeobox D11
chr17_-_17050326	1.623		PLD6	phospholipase D family, member 6
chr3_-_49370682	1.613		GPX1	glutathione peroxidase 1
chr3_+_49034494	1.595		NDUFAF3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chrX_+_55760774	1.573	NM_006064 NM_016656	RRAGB	Ras-related GTP binding B
chr8_+_22492198	1.568	NM_021630	PDLIM2	PDZ and LIM domain 2 (mystique)
chr14_-_19999475	1.557	NM_001100814 NM_144568	TMEM55B	transmembrane protein 55B
chr11_+_7491789	1.557		PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_-_19599973	1.544	NM_004720	LPAR2	lysophosphatidic acid receptor 2
chr17_-_17050355	1.538	NM_178836	PLD6	phospholipase D family, member 6
chr17_-_36507900	1.536	NM_031960	KRTAP4-8	keratin associated protein 4-8
chr10_+_101079099	1.533		CNNM1	cyclin M1
chrX_-_107866262	1.532	NM_003604	IRS4	insulin receptor substrate 4
chr13_+_112999462	1.521	NM_005561	LAMP1	lysosomal-associated membrane protein 1
chr11_+_7491576	1.497	NM_003621	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_176761552	1.445	NM_024501	HOXD1	homeobox D1
chr20_-_43953036	1.422	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr9_+_17124974	1.392	NM_001114395 NM_017738	CNTLN	centlein, centrosomal protein
chr1_-_152459506	1.376		C1orf43	chromosome 1 open reading frame 43
chr4_-_15694407	1.361		PROM1	prominin 1
chr1_-_152459667	1.337		C1orf43	chromosome 1 open reading frame 43
chr20_+_43952997	1.337	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chr10_-_91285290	1.331	NM_213606	SLC16A12	solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr16_-_52876390	1.313		IRX3	iroquois homeobox 3
chr20_+_46971618	1.279	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr7_-_27149750	1.268	NM_019102	HOXA5	homeobox A5
chr2_-_154043403	1.260	NM_019845	RPRM	reprimo, TP53 dependent G2 arrest mediator candidate
chr17_-_29930431	1.254	NM_207454	C17orf102	chromosome 17 open reading frame 102
chr17_-_71362971	1.253	NM_012478	WBP2	WW domain binding protein 2
chr3_+_139636104	1.237	NM_031913	ESYT3	extended synaptotagmin-like protein 3
chr22_-_49317408	1.229		ODF3B	outer dense fiber of sperm tails 3B
chr6_+_96570565	1.212	NM_006581	FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr18_+_17076166	1.206	NM_001142966	GREB1L	growth regulation by estrogen in breast cancer-like
chr2_+_215885063	1.195		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr2_-_133144950	1.195	NM_144586	LYPD1	LY6/PLAUR domain containing 1
chr1_+_148137778	1.180	NM_016074	BOLA1	bolA homolog 1 (E. coli)
chr20_+_37024383	1.157	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr10_+_101078784	1.156	NM_020348	CNNM1	cyclin M1
chr16_-_65742323	1.149	NM_033309	B3GNT9	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr12_+_6703549	1.148		COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr3_+_139636111	1.148		ESYT3	extended synaptotagmin-like protein 3
chr13_+_27392136	1.144	NM_000209	PDX1	pancreatic and duodenal homeobox 1
chr3_-_172109119	1.137	NM_020390	EIF5A2	eukaryotic translation initiation factor 5A2
chr17_+_7416780	1.120	NM_001416	EIF4A1	eukaryotic translation initiation factor 4A1
chr8_-_109165012	1.111	NM_178565	RSPO2	R-spondin 2 homolog (Xenopus laevis)
chr20_-_2769245	1.109	NM_022760	FAM113A	family with sequence similarity 113, member A
chr2_-_11727705	1.105	NM_012344	NTSR2	neurotensin receptor 2
chr17_-_4405367	1.098	NM_001105538 NM_014520	MYBBP1A	MYB binding protein (P160) 1a
chr3_-_50304706	1.096	NM_006764	IFRD2	interferon-related developmental regulator 2
chr22_-_42619139	1.094	NM_001177675 NM_138814	PNPLA5	patatin-like phospholipase domain containing 5
chr1_+_152459918	1.092	NM_014847	UBAP2L	ubiquitin associated protein 2-like
chr17_-_74433048	1.091	NM_003255	TIMP2	TIMP metallopeptidase inhibitor 2
chr20_+_18066473	1.086	NM_001164811	PET117	cytochrome c oxidase assembly factor-like
chr3_-_50335113	1.075	NM_003773 NM_033158	HYAL2	hyaluronoglucosaminidase 2
chr17_-_7078399	1.068		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr6_-_80713589	1.053	NM_022726	ELOVL4	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr1_+_222870573	1.044		CNIH3	cornichon homolog 3 (Drosophila)
chr1_+_148521852	1.023	NM_144697	C1orf51	chromosome 1 open reading frame 51
chr12_+_6703525	1.023		COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr5_+_80292213	1.023		RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr8_+_32525269	1.018	NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013960 NM_013964	NRG1	neuregulin 1
chr7_-_47588652	1.008		TNS3	tensin 3
chr3_+_98016114	1.005	NM_001080448	EPHA6	EPH receptor A6
chr5_+_94981735	1.000	NM_199243	GPR150	G protein-coupled receptor 150
chr16_+_29374479	1.000	NM_001017389 NM_003166	SULT1A4 SULT1A3 SLX1B	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr17_-_7078446	1.000	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr16_+_57106883	0.996	NM_001160305 NM_024860	SETD6	SET domain containing 6
chr6_-_42218692	0.995	NM_001164446	C6orf132	chromosome 6 open reading frame 132
chr10_-_14090459	0.984		FRMD4A	FERM domain containing 4A
chr1_-_152459697	0.984	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr2_+_215885053	0.981		ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr5_+_80292313	0.968	NM_006909	RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr20_-_2769120	0.962		FAM113A	family with sequence similarity 113, member A
chr22_+_48740432	0.959		PIM3	pim-3 oncogene
chr2_+_215884923	0.958	NM_004044	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr20_+_43953372	0.956		CTSA	cathepsin A
chr17_-_68769613	0.953	NM_001129885	CPSF4L	cleavage and polyadenylation specific factor 4-like
chr21_+_36993302	0.952
chr14_-_67051773	0.947	NM_182526	TMEM229B	transmembrane protein 229B
chr16_+_2510323	0.945	NM_001145815 NM_015944	AMDHD2	amidohydrolase domain containing 2
chr8_-_121893468	0.944	NM_021021	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr16_-_69277355	0.941	NM_138383	MTSS1L	metastasis suppressor 1-like
chr7_-_23476497	0.935	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr12_+_32546243	0.935	NM_139241	FGD4	FYVE, RhoGEF and PH domain containing 4
chr1_-_92721633	0.933		GFI1	growth factor independent 1 transcription repressor
chr7_-_84654106	0.930		SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr6_-_46566969	0.929		RCAN2	regulator of calcineurin 2
chr17_-_2561676	0.926	NM_015229	KIAA0664	KIAA0664
chr13_-_19665036	0.926		GJB2	gap junction protein, beta 2, 26kDa
chr4_+_146820805	0.925	NM_001080531	C4orf51	chromosome 4 open reading frame 51
chr17_+_4434582	0.923	NM_001114974	SMTNL2	smoothelin-like 2
chr17_-_2250967	0.916	NM_020310	MNT	MAX binding protein
chr2_-_139254273	0.916	NM_007226	NXPH2	neurexophilin 2
chr11_-_106394039	0.915	NM_000855	GUCY1A2	guanylate cyclase 1, soluble, alpha 2
chr9_-_34038869	0.914		UBAP2	ubiquitin associated protein 2
chr14_+_23575460	0.912	NM_001082488	DHRS4L1	dehydrogenase/reductase (SDR family) member 4 like 1
chr10_-_120504267	0.905
chr8_-_99375739	0.904	NM_024759	NIPAL2	NIPA-like domain containing 2
chrX_+_102749489	0.903	NM_001006933 NM_032926	TCEAL3	transcription elongation factor A (SII)-like 3
chr14_-_23981493	0.896	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr1_+_95058488	0.895	NM_001114106	SLC44A3	solute carrier family 44, member 3
chr17_-_18848713	0.894	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr17_+_74542066	0.893	NM_198593	C1QTNF1	C1q and tumor necrosis factor related protein 1
chr20_+_43953331	0.888		CTSA	cathepsin A
chr3_-_69064364	0.886	NM_001005527 NM_182522	FAM19A4	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
chr19_+_60688349	0.886	NM_020378	NAT14	N-acetyltransferase 14 (GCN5-related, putative)
chr14_+_104226769	0.883	NM_001031714 NM_022489 NM_032714	INF2	inverted formin, FH2 and WH2 domain containing
chr15_-_98699628	0.879	NM_139057	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr7_+_55054416	0.878		EGFR	epidermal growth factor receptor
chr13_+_112999590	0.878		LAMP1	lysosomal-associated membrane protein 1
chr19_-_40938251	0.876		HSPB6	heat shock protein, alpha-crystallin-related, B6
chr20_+_61054443	0.876	NM_022082	SLC17A9	solute carrier family 17, member 9
chr2_+_74594093	0.874		TLX2	T-cell leukemia homeobox 2
chr3_+_51992339	0.874	NM_000666 NM_001198895 NM_001198896 NM_001198897 NM_001198898	ACY1	aminoacylase 1
chr9_+_115265827	0.865	NM_017790	RGS3	regulator of G-protein signaling 3
chr12_-_47605478	0.858	NM_001143782 NM_016594	FKBP11	FK506 binding protein 11, 19 kDa
chr7_-_11838260	0.855	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr17_+_36493927	0.854	NM_033061	KRTAP4-7	keratin associated protein 4-7
chr1_-_20931288	0.849		SH2D5	SH2 domain containing 5
chr2_-_133145539	0.849	NM_001077427	LYPD1	LY6/PLAUR domain containing 1
chr12_+_48641545	0.847	NM_001651	AQP5	aquaporin 5
chr7_-_45927263	0.843	NM_000598 NM_001013398	IGFBP3	insulin-like growth factor binding protein 3
chr2_+_217206327	0.842	NM_000597	IGFBP2	insulin-like growth factor binding protein 2, 36kDa
chr14_-_19999324	0.839		TMEM55B	transmembrane protein 55B
chr19_+_748444	0.835		PTBP1	polypyrimidine tract binding protein 1
chr17_+_77529070	0.829		ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr14_+_64240902	0.829	NM_015549	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_-_131919896	0.827		HS6ST2	heparan sulfate 6-O-sulfotransferase 2
chr20_+_43953428	0.824		CTSA	cathepsin A
chr2_-_216944911	0.818	NM_020814	MARCH4	membrane-associated ring finger (C3HC4) 4
chr17_-_74487527	0.818	NM_005567	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein
chr1_+_150937463	0.817	NM_178428	LCE2A	late cornified envelope 2A
chr8_+_22492586	0.817		PDLIM2	PDZ and LIM domain 2 (mystique)
chr2_+_223625105	0.816	NM_080671	KCNE4	potassium voltage-gated channel, Isk-related family, member 4
chr14_-_76807302	0.809	NM_021257	NGB	neuroglobin
chr17_-_40866062	0.807	NM_174919	SH3D20	SH3 domain containing 20
chr14_-_63830830	0.806	NM_001040275 NM_001437	ESR2	estrogen receptor 2 (ER beta)
chr16_+_65790514	0.806	NM_024712	ELMO3	engulfment and cell motility 3
chr6_-_33822659	0.801	NM_001142883 NM_054111	IP6K3	inositol hexakisphosphate kinase 3
chr19_+_10673105	0.796	NM_031209	QTRT1	queuine tRNA-ribosyltransferase 1
chr12_+_52806103	0.795		LOC400043	hypothetical LOC400043
chr10_-_104463947	0.795	NM_004311	ARL3	ADP-ribosylation factor-like 3
chr7_-_27136876	0.793	NM_002141	HOXA4	homeobox A4
chr6_+_37245860	0.792	NM_002648	PIM1	pim-1 oncogene
chr19_-_40938046	0.792		HSPB6	heat shock protein, alpha-crystallin-related, B6
chr1_+_45565126	0.788	NM_032756	HPDL	4-hydroxyphenylpyruvate dioxygenase-like
chr7_-_72822471	0.788	NM_001306	CLDN3	claudin 3
chr5_+_63838183	0.788	NM_001029875	RGS7BP	regulator of G-protein signaling 7 binding protein
chr3_-_172109075	0.787		EIF5A2	eukaryotic translation initiation factor 5A2
chr17_-_77478835	0.785	NM_002359	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr15_+_38082041	0.783		EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4
chr17_+_21131940	0.782	NM_002756	MAP2K3	mitogen-activated protein kinase kinase 3
chr10_+_52421120	0.778		PRKG1	protein kinase, cGMP-dependent, type I
chr3_+_49482474	0.771	NM_001165928 NM_001177634 NM_001177635 NM_001177636 NM_001177637 NM_001177638 NM_001177639 NM_001177640 NM_001177641 NM_001177642 NM_001177644 NM_004393	DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr20_+_61796731	0.768	NM_032945	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy
chr5_-_94646033	0.767	NM_024717	MCTP1	multiple C2 domains, transmembrane 1
chr17_-_76064842	0.762	NM_002522	NPTX1	neuronal pentraxin I
chr2_-_232037308	0.761	NM_005381	NCL	nucleolin
chr19_+_748390	0.761	NM_002819 NM_031990 NM_031991 NM_175847	PTBP1	polypyrimidine tract binding protein 1
chr18_-_72973750	0.760	NM_001025100 NM_001025101	MBP	myelin basic protein
chr22_+_34107051	0.759	NM_002133	HMOX1	heme oxygenase (decycling) 1
chr16_+_51646292	0.757	NM_025134	CHD9	chromodomain helicase DNA binding protein 9
chr9_+_132309914	0.757	NM_000050 NM_054012	ASS1	argininosuccinate synthase 1
chr12_-_57600564	0.755		LRIG3	leucine-rich repeats and immunoglobulin-like domains 3
chr5_+_122452739	0.754	NM_001136239	PRDM6	PR domain containing 6
chr4_+_8251818	0.751	NM_018986	SH3TC1	SH3 domain and tetratricopeptide repeats 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.10	4.34e-11	GO:0009987	cellular process
1.29	1.13e-09	GO:0048731	system development
1.27	1.26e-09	GO:0048856	anatomical structure development
1.25	7.80e-09	GO:0007275	multicellular organismal development
1.23	2.25e-08	GO:0032502	developmental process
1.36	1.15e-06	GO:0007399	nervous system development
1.29	5.26e-06	GO:0030154	cell differentiation
1.28	9.68e-06	GO:0048869	cellular developmental process
1.44	2.05e-05	GO:0048468	cell development
1.32	7.74e-05	GO:0009653	anatomical structure morphogenesis
1.38	1.44e-03	GO:0022008	neurogenesis
1.25	1.77e-03	GO:0048513	organ development
1.52	3.13e-03	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.62	3.49e-03	GO:0007411	axon guidance
1.39	3.96e-03	GO:0051173	positive regulation of nitrogen compound metabolic process
1.37	5.20e-03	GO:0048699	generation of neurons
1.37	6.08e-03	GO:0031328	positive regulation of cellular biosynthetic process
1.31	7.23e-03	GO:0031325	positive regulation of cellular metabolic process
1.29	1.07e-02	GO:0009893	positive regulation of metabolic process
1.38	1.20e-02	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36	1.30e-02	GO:0009891	positive regulation of biosynthetic process
1.40	1.74e-02	GO:0010628	positive regulation of gene expression
1.41	2.52e-02	GO:0045893	positive regulation of transcription, DNA-dependent
1.32	3.40e-02	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.38	4.03e-02	GO:0030182	neuron differentiation
1.40	4.92e-02	GO:0009887	organ morphogenesis
1.41	4.92e-02	GO:0048666	neuron development

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.06	2.21e-03	GO:0044424	intracellular part
1.22	4.49e-03	GO:0031981	nuclear lumen
1.08	5.14e-03	GO:0005737	cytoplasm
1.05	7.29e-03	GO:0005622	intracellular
1.18	2.49e-02	GO:0044428	nuclear part
1.17	3.25e-02	GO:0031974	membrane-enclosed lumen
1.61	3.53e-02	GO:0045177	apical part of cell
1.06	4.26e-02	GO:0043226	organelle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.13	3.46e-08	GO:0005515	protein binding
1.06	1.16e-04	GO:0005488	binding
1.41	1.26e-03	GO:0043565	sequence-specific DNA binding