Motif ID: bHLH_family.p2

Z-value: 1.955


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NPAS2chr2_+_1008029230.722.5e-03Click!
TFE3chrX_-_48787696-0.712.9e-03Click!
ARNTLchr11_+_132559520.703.8e-03Click!
CLOCKchr4_-_56107725-0.582.3e-02Click!
HES6chr2_-_2388133650.562.8e-02Click!
MXD4chr4_-_22335040.534.2e-02Click!
ARNTL2chr12_+_273770340.524.7e-02Click!
HEYLchr1_-_39877883-0.459.0e-02Click!
MXI1chr10_+_1119599780.391.6e-01Click!
MNTchr17_-_22509670.381.6e-01Click!
MITFchr3_+_69895651-0.361.9e-01Click!
OLIG1chr21_+_333658740.302.7e-01Click!
MXD3chr5_-_1766718970.283.1e-01Click!
OLIG2chr21_+_333200800.283.1e-01Click!
HEY2chr6_+_126112417-0.263.5e-01Click!
MLXIPLchr7_-_72676750-0.214.5e-01Click!
ID1chr20_+_296567440.156.0e-01Click!
HEY1chr8_-_808424520.039.1e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_54660954 3.308 NM_133267
 GSX2
GS homeobox 2
chr8_+_120289735 2.813 NM_052886
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_-_27162688 2.655 NM_006896
 HOXA7
homeobox A7
chr12_-_47604930 2.535 NM_001143781
 FKBP11
FK506 binding protein 11, 19 kDa
chr17_-_36469869 2.493 NM_001165252
 LOC730755
keratin associated protein 2-4-like
chr7_-_1562272 2.461 NM_001097620
 TMEM184A
transmembrane protein 184A
chr2_-_219826854 2.350 NM_006000
 TUBA4A
tubulin, alpha 4a
chr16_-_66827449 2.274 NM_024939
 ESRP2
epithelial splicing regulatory protein 2
chr4_-_17392232 2.208 NM_015688
 FAM184B
family with sequence similarity 184, member B
chr12_-_50871953 2.195 NM_001081492
NM_182507
 KRT80

keratin 80

chr17_+_36515166 2.153 NM_001146041
 KRTAP4-9
keratin associated protein 4-9
chr11_+_126378507 2.138 NCRNA00288
non-protein coding RNA 288
chr3_-_11585264 2.118 NM_001128221
 VGLL4
vestigial like 4 (Drosophila)
chr9_+_696744 2.115 NM_153186
 KANK1
KN motif and ankyrin repeat domains 1
chr1_+_201364050 2.104 ADORA1
adenosine A1 receptor
chr2_-_217267742 2.090 IGFBP5
insulin-like growth factor binding protein 5
chr19_+_1226510 1.967 NM_017914
 C19orf24
chromosome 19 open reading frame 24
chrX_-_114703273 1.953


chr16_+_639278 1.942 NM_145294
 WDR90
WD repeat domain 90
chr2_-_133144094 1.892 LYPD1
LY6/PLAUR domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.62 3.49e-03 GO:0007411 axon guidance
1.52 3.13e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.44 2.05e-05 GO:0048468 cell development
1.41 2.52e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.41 4.92e-02 GO:0048666 neuron development
1.40 1.74e-02 GO:0010628 positive regulation of gene expression
1.40 4.92e-02 GO:0009887 organ morphogenesis
1.39 3.96e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.38 1.44e-03 GO:0022008 neurogenesis
1.38 1.20e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 4.03e-02 GO:0030182 neuron differentiation
1.37 5.20e-03 GO:0048699 generation of neurons
1.37 6.08e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.36 1.15e-06 GO:0007399 nervous system development
1.36 1.30e-02 GO:0009891 positive regulation of biosynthetic process
1.32 7.74e-05 GO:0009653 anatomical structure morphogenesis
1.32 3.40e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.31 7.23e-03 GO:0031325 positive regulation of cellular metabolic process
1.29 1.13e-09 GO:0048731 system development
1.29 5.26e-06 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.61 3.53e-02 GO:0045177 apical part of cell
1.22 4.49e-03 GO:0031981 nuclear lumen
1.18 2.49e-02 GO:0044428 nuclear part
1.17 3.25e-02 GO:0031974 membrane-enclosed lumen
1.08 5.14e-03 GO:0005737 cytoplasm
1.06 2.21e-03 GO:0044424 intracellular part
1.06 4.26e-02 GO:0043226 organelle
1.05 7.29e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.41 1.26e-03 GO:0043565 sequence-specific DNA binding
1.13 3.46e-08 GO:0005515 protein binding
1.06 1.16e-04 GO:0005488 binding