Motif ID: NFE2L1.p2

Z-value: 1.669


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFE2L1chr17_+_43480724-0.283.2e-01Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_40711034 2.505 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr4_-_23500706 2.439 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr17_-_36475652 2.078 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr12_-_88573949 1.676 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr5_+_140848905 1.558 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr1_+_26973804 1.558 ARID1A
AT rich interactive domain 1A (SWI-like)
chr2_+_220017617 1.540 SPEG
SPEG complex locus
chrX_-_10495476 1.463 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr2_+_201182187 1.448 AOX1
aldehyde oxidase 1
chr5_+_36644187 1.410 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_150442652 1.335 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr9_+_35032222 1.328 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr17_-_36469869 1.303 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr11_-_62213577 1.267 LRRN4CL
LRRN4 C-terminal like
chr7_+_129634935 1.258 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr8_-_37847095 1.232 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr9_-_131555111 1.164 NM_004878
PTGES
prostaglandin E synthase
chr17_-_51155073 1.157 NM_018286
TMEM100
transmembrane protein 100
chr11_+_125781157 1.156 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr3_-_158695832 1.139 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr4_-_187764213 1.139


chr17_-_36877002 1.114 NM_002278
KRT32
keratin 32
chr1_-_215329569 1.097 NM_206594
NM_206595
ESRRG

estrogen-related receptor gamma

chr7_+_129720209 1.096 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr10_+_75343352 1.092 PLAU
plasminogen activator, urokinase
chr2_-_74455161 1.083 NM_001135041
NM_023019
DCTN1

dynactin 1

chr15_+_60726801 1.082 NM_015059
TLN2
talin 2
chr5_-_34020445 1.078 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr11_-_85108030 1.076 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr5_-_16561936 1.040 NM_019000
FAM134B
family with sequence similarity 134, member B
chr7_-_13992351 1.037 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_-_54317102 1.034 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr7_-_135083906 1.033 NM_205855
FAM180A
family with sequence similarity 180, member A
chr8_-_93099040 1.011 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_173794692 1.009 ZAK
sterile alpha motif and leucine zipper containing kinase AZK
chr19_+_52113772 0.979 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr19_+_10642648 0.969 ILF3
interleukin enhancer binding factor 3, 90kDa
chr11_-_62213946 0.942 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr12_-_50871953 0.924 NM_001081492
NM_182507
KRT80

keratin 80

chr8_-_72431274 0.921 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr6_-_46401363 0.920 NM_005822
RCAN2
regulator of calcineurin 2
chrX_+_86659370 0.907 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr12_+_7038240 0.887 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr5_+_166644420 0.886 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr8_-_108579270 0.886 NM_001146
ANGPT1
angiopoietin 1
chr20_+_2743613 0.883 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr12_-_51173238 0.875 NM_005554
KRT6A
keratin 6A
chr5_-_56814310 0.851 NM_001017992
ACTBL2
actin, beta-like 2
chr6_-_130224108 0.850 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr16_+_66476281 0.843 NM_198443
NRN1L
neuritin 1-like
chr11_-_85107569 0.843 NM_206929
SYTL2
synaptotagmin-like 2
chr15_+_40427592 0.842 NM_212465
CAPN3
calpain 3, (p94)
chr3_-_145049853 0.841 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr11_+_7574992 0.838 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_154520693 0.814 NM_032323
TMEM79
transmembrane protein 79
chr15_+_65205107 0.811 NM_001145102
SMAD3
SMAD family member 3
chrX_+_105856531 0.811 NM_194463
RNF128
ring finger protein 128
chr3_+_69895310 0.810 NM_001184967
MITF
microphthalmia-associated transcription factor
chr14_+_99555471 0.809 EVL
Enah/Vasp-like
chr6_+_158990982 0.808 NM_001009991
SYTL3
synaptotagmin-like 3
chr11_+_58146721 0.805 NM_000614
CNTF
ciliary neurotrophic factor
chr1_+_205137410 0.804 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr16_+_56219802 0.798 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_+_79625538 0.796 NM_002469
MYF6
myogenic factor 6 (herculin)
chr17_+_76549658 0.791 RPTOR
regulatory associated protein of MTOR, complex 1
chr17_-_7434113 0.780 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr4_-_177427252 0.780 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr8_+_145718702 0.778


chr17_-_26672757 0.775 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr1_-_166965034 0.770 NM_001937
DPT
dermatopontin
chr2_+_220033777 0.767 NM_001173476
SPEG
SPEG complex locus
chrX_-_33267646 0.767 NM_000109
DMD
dystrophin
chr8_+_32698892 0.758 NM_001159996
NRG1
neuregulin 1
chr13_+_23042722 0.755 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr19_+_51804260 0.753 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr12_-_10215942 0.750 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_+_63928459 0.739 NM_001128149
ATXN7
ataxin 7
chr8_-_124734346 0.737 NM_001081675
KLHL38
kelch-like 38 (Drosophila)
chr17_-_36996611 0.729 NM_000526
KRT14
keratin 14
chr11_-_123353607 0.728 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr22_-_49062461 0.726 PLXNB2
plexin B2
chr17_-_45619038 0.713 COL1A1
collagen, type I, alpha 1
chr1_-_20682541 0.712


chr5_-_138238877 0.705 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr11_-_123772456 0.701 NM_001005467
OR8B3
olfactory receptor, family 8, subfamily B, member 3
chr11_+_5714253 0.700 NM_001005180
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr2_-_227952249 0.696 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr21_-_30510113 0.688 NM_199328
CLDN8
claudin 8
chr5_-_32424444 0.687 ZFR
zinc finger RNA binding protein
chr11_-_46674233 0.685 ARHGAP1
Rho GTPase activating protein 1
chr1_-_23393808 0.680 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr4_-_139382672 0.677 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr9_+_88953378 0.674 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr8_-_145090892 0.674 NM_201381
PLEC
plectin
chr11_-_7941617 0.669 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr6_-_46401174 0.668 RCAN2
regulator of calcineurin 2
chr11_-_5523328 0.662 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr2_+_88148413 0.660 NM_198274
SMYD1
SET and MYND domain containing 1
chr5_+_132237253 0.659 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr5_+_53787187 0.657 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_+_159943385 0.655 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr15_+_60838053 0.651 TLN2
talin 2
chr1_+_15128882 0.651 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr3_+_63613383 0.641 NM_001080537
SNTN
sentan, cilia apical structure protein
chr5_-_138238891 0.641 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr13_-_59223074 0.641


chr4_+_114190233 0.641 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr5_+_174084137 0.636 NM_002449
MSX2
msh homeobox 2
chr5_-_138238953 0.625 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr17_-_37034288 0.624 NM_000422
KRT17
keratin 17
chr12_-_46405477 0.620 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr5_-_32424352 0.618 ZFR
zinc finger RNA binding protein
chr6_+_42896771 0.610 NM_015349
KIAA0240
KIAA0240
chr1_-_203657803 0.608 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr2_-_160838397 0.606 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_+_72380323 0.600 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr7_+_116447527 0.600 ST7
suppression of tumorigenicity 7
chr12_-_54392328 0.592 NM_001144997
ITGA7
integrin, alpha 7
chr3_+_191588354 0.590 NM_006580
CLDN16
claudin 16
chr14_-_64359565 0.589 NM_000347
NM_001024858
SPTB

spectrin, beta, erythrocytic

chr17_-_37022465 0.588 NM_005557
KRT16
keratin 16
chr17_+_36515166 0.585 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr8_+_67568044 0.584 NM_152765
C8orf46
chromosome 8 open reading frame 46
chr7_+_30927439 0.583 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr18_-_51219880 0.582 TCF4
transcription factor 4
chr11_+_6847499 0.582 NM_001004460
OR10A2
olfactory receptor, family 10, subfamily A, member 2
chr17_+_36493927 0.581 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr15_+_87540238 0.581 ABHD2
abhydrolase domain containing 2
chrX_-_32340291 0.568 NM_004011
NM_004012
DMD

dystrophin

chr2_+_157822355 0.562 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr21_-_14677310 0.561 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr11_-_27700180 0.561 NM_170731
BDNF
brain-derived neurotrophic factor
chr1_+_199519202 0.559 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr9_+_35528628 0.558 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr13_-_98757634 0.557 NM_004951
GPR183
G protein-coupled receptor 183
chr8_+_75899326 0.557 NM_015886
PI15
peptidase inhibitor 15
chr7_+_116447499 0.556 ST7
suppression of tumorigenicity 7
chr2_+_170742900 0.554 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr5_+_59819761 0.550 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr6_-_56615544 0.547 NM_001723
NM_015548
DST

dystonin

chr3_-_12561962 0.546 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr10_-_105228986 0.543 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr17_+_36665161 0.542 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr13_-_98428244 0.542 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr6_-_56824371 0.538 DST
dystonin
chr15_-_31147376 0.534 NM_001103184
FMN1
formin 1
chr12_-_131725848 0.534 POLE
polymerase (DNA directed), epsilon
chr8_+_70541412 0.532 NM_001128204
NM_015170
SULF1

sulfatase 1

chr12_-_118725672 0.532 CIT
citron (rho-interacting, serine/threonine kinase 21)
chr1_-_201420927 0.531 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr20_-_22978141 0.527 NM_000361
THBD
thrombomodulin
chr11_-_7917642 0.523 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr9_-_16717887 0.522 BNC2
basonuclin 2
chr11_-_57947358 0.522 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr7_+_110518297 0.519 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr1_-_152445432 0.514 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr10_-_90601655 0.512 NM_144590
ANKRD22
ankyrin repeat domain 22
chr1_-_157772420 0.511 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr8_+_12847521 0.509 NM_020844
KIAA1456
KIAA1456
chr12_+_99712504 0.509 NM_178826
ANO4
anoctamin 4
chr11_-_8788765 0.507 NM_213618
ST5
suppression of tumorigenicity 5
chr11_+_123625632 0.506 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr12_+_7039453 0.502


chr17_+_35484204 0.501 THRA
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
chr19_+_15699833 0.501 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr9_-_35962454 0.499 YBX1
Y box binding protein 1
chr7_+_143263191 0.497 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chrX_-_135166306 0.495 NM_001173516
MAP7D3
MAP7 domain containing 3
chr11_-_57173823 0.494 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr8_-_37576515 0.494 LOC157860
hypothetical protein LOC157860
chr10_-_23673777 0.488 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr2_-_40510923 0.485 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr20_+_2744947 0.483 NM_001167670
LOC100288797
hypothetical protein LOC100288797
chr2_+_105224631 0.482 NM_007227
GPR45
G protein-coupled receptor 45
chr11_-_57171554 0.482 YPEL4
yippee-like 4 (Drosophila)
chr3_-_48576204 0.482 NM_033199
UCN2
urocortin 2
chr4_-_5881271 0.480 CRMP1
collapsin response mediator protein 1
chr15_-_81037554 0.480 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr1_+_201711505 0.478 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr10_+_18280773 0.476 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr7_-_6441109 0.474 DAGLB
diacylglycerol lipase, beta
chr13_+_97403929 0.472 NM_002271
IPO5
importin 5
chr9_-_132759045 0.471 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr14_+_20537253 0.469 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr4_+_72423633 0.469 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr10_-_92670764 0.469 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_165330710 0.468 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr1_+_213245507 0.467 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr14_+_104244998 0.467 INF2
inverted formin, FH2 and WH2 domain containing
chr16_+_15503623 0.465 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr22_-_35026950 0.462 MYH9
myosin, heavy chain 9, non-muscle
chr4_+_86968069 0.461 ARHGAP24
Rho GTPase activating protein 24
chr11_-_8636958 0.460 NM_014818
TRIM66
tripartite motif containing 66
chr11_-_123758448 0.460 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr3_-_46224791 0.459 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr9_+_119506274 0.459 NM_138554
TLR4
toll-like receptor 4
chr3_+_25445071 0.458 RARB
retinoic acid receptor, beta
chr5_-_141981083 0.453 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr8_-_107851593 0.453 NM_139166
ABRA
actin-binding Rho activating protein
chr12_-_52187638 0.452 NM_003717
NPFF
neuropeptide FF-amide peptide precursor

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.36 5.87e-29 GO:0007608 sensory perception of smell
2.23 7.46e-27 GO:0007606 sensory perception of chemical stimulus
1.78 8.24e-20 GO:0007600 sensory perception
1.49 1.29e-17 GO:0003008 system process
1.52 3.03e-15 GO:0050877 neurological system process
1.18 3.71e-08 GO:0032501 multicellular organismal process
1.11 2.80e-03 GO:0050896 response to stimulus
1.89 2.93e-03 GO:0071103 DNA conformation change
1.92 9.78e-03 GO:0006323 DNA packaging
1.18 2.18e-02 GO:0071842 cellular component organization at cellular level
1.94 2.29e-02 GO:0071824 protein-DNA complex subunit organization
1.17 3.46e-02 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 8.45e-07 GO:0005886 plasma membrane
1.23 2.17e-06 GO:0043228 non-membrane-bounded organelle
1.23 2.17e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.17 2.77e-06 GO:0071944 cell periphery
1.24 2.96e-03 GO:0005856 cytoskeleton
1.08 5.34e-03 GO:0016020 membrane
1.89 7.63e-03 GO:0030016 myofibril
1.82 1.63e-02 GO:0043292 contractile fiber
1.85 2.21e-02 GO:0044449 contractile fiber part
1.43 2.88e-02 GO:0045202 synapse
1.07 3.88e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.41 7.81e-30 GO:0004984 olfactory receptor activity
1.67 1.38e-15 GO:0004930 G-protein coupled receptor activity
1.37 7.10e-07 GO:0004888 transmembrane receptor activity
1.09 2.40e-03 GO:0005515 protein binding
1.19 2.36e-02 GO:0004871 signal transducer activity
1.19 2.36e-02 GO:0060089 molecular transducer activity
1.20 3.61e-02 GO:0004872 receptor activity