Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.255


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.553.3e-02Click!
NKX2-3chr10_+_101282679-0.048.8e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_13997588 2.619 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr10_-_105835609 1.967 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_-_105835525 1.957 COL17A1
collagen, type XVII, alpha 1
chr15_-_64108718 1.942


chr3_+_89239494 1.875 EPHA3
EPH receptor A3
chr11_+_7574992 1.841 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr13_-_45323757 1.839 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr18_+_27152049 1.832 NM_001942
DSG1
desmoglein 1
chr3_-_152517204 1.757 NM_023915
GPR87
G protein-coupled receptor 87
chr14_+_99633570 1.730 EVL
Enah/Vasp-like
chr10_-_116241572 1.678


chr15_+_97990705 1.671 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr4_-_152368492 1.663 SH3D19
SH3 domain containing 19
chr5_+_127012611 1.644 NM_001048252
CTXN3
cortexin 3
chr18_+_19826734 1.606 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr4_+_114433551 1.543 ANK2
ankyrin 2, neuronal
chr1_+_207944807 1.530 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_-_104411065 1.530 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr1_-_181826633 1.523 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr10_-_98021144 1.519 NM_001114094
NM_013314
BLNK

B-cell linker

chr2_+_37282516 1.465 LOC100505876
hypothetical LOC100505876
chr16_+_10878539 1.393 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_-_25685175 1.391 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr13_-_85271329 1.346 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr20_-_43163021 1.275 NM_002251
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr13_-_59485299 1.269 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr1_-_214963279 1.265 NM_001438
ESRRG
estrogen-related receptor gamma
chr13_-_35327798 1.259 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr13_+_77007809 1.239 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr17_-_36347197 1.192 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_17861266 1.187 NM_001105569
MSGN1
mesogenin 1
chr8_+_67096344 1.152 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr14_+_51025604 1.150 NM_001042481
FRMD6
FERM domain containing 6
chr5_+_59819761 1.117 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr11_-_128567302 1.114 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr21_-_35343065 1.063 RUNX1
runt-related transcription factor 1
chr5_+_140848905 1.055 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr11_-_104477367 1.047 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr1_+_213245507 1.027 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr9_+_129066576 1.021 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_+_81544432 1.020 LPHN2
latrophilin 2
chr10_-_123346148 1.008 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr9_+_117955890 0.988 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_18502342 0.981 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr5_+_166644420 0.972 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr12_-_51173238 0.949 NM_005554
KRT6A
keratin 6A
chr7_+_115650240 0.942 NM_152829
TES
testis derived transcript (3 LIM domains)
chr11_+_93678450 0.940 NM_001080486
FOLR4
folate receptor 4 (delta) homolog (mouse)
chr17_-_39191658 0.932 NM_025237
SOST
sclerostin
chr11_-_85115105 0.930 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr10_+_86174665 0.926 FAM190B
family with sequence similarity 190, member B
chr4_-_23500706 0.908 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr5_-_141973875 0.907 NM_033137
FGF1
fibroblast growth factor 1 (acidic)
chr17_-_36346240 0.906 KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_102081654 0.890 NM_022122
MMP27
matrix metallopeptidase 27
chr12_-_121753795 0.882 NM_177551
GPR109A
G protein-coupled receptor 109A
chr15_+_38082041 0.874 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr2_-_215711313 0.868 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_121767272 0.860 NM_006018
GPR109B
G protein-coupled receptor 109B
chr8_+_55691179 0.856 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chrX_+_28515479 0.854 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr9_+_12683385 0.847 NM_000550
TYRP1
tyrosinase-related protein 1
chr6_+_50894397 0.847 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr12_-_28016182 0.842 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr5_+_152850276 0.837 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr5_+_147562531 0.832 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr4_+_90252990 0.821 NM_145715
TIGD2
tigger transposable element derived 2
chr14_-_64479198 0.821 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr5_-_59819642 0.821 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_-_36836620 0.820 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr4_+_72423633 0.813 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr4_-_38710376 0.808 NM_024943
TMEM156
transmembrane protein 156
chr2_+_234266250 0.807 NM_001072
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_-_83071084 0.806 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr22_-_36836478 0.804 BAIAP2L2
BAI1-associated protein 2-like 2
chr2_+_113546365 0.797 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chrX_-_10504852 0.793 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr3_+_89239363 0.785 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr20_+_19863716 0.776 RIN2
Ras and Rab interactor 2
chr6_-_136888771 0.774 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr15_+_56217686 0.767 NM_020980
AQP9
aquaporin 9
chr10_-_31328426 0.761 NM_001143769
ZNF438
zinc finger protein 438
chr1_+_156229686 0.753 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr1_+_208568218 0.740 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr6_+_134800533 0.731 LOC154092
hypothetical LOC154092
chr9_-_116305273 0.730 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr8_-_122722674 0.728 NM_005328
HAS2
hyaluronan synthase 2
chr12_-_16650687 0.721 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_161981138 0.718 TBR1
T-box, brain, 1
chr14_+_22059212 0.718


chr10_+_101532544 0.713 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr15_-_59308708 0.707 RORA
RAR-related orphan receptor A
chr10_+_101532450 0.705 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_+_182040837 0.700 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_+_3341521 0.700 NM_198227
RGS12
regulator of G-protein signaling 12
chrX_-_64112993 0.699 NM_001178033
NM_018684
ZC4H2

zinc finger, C4H2 domain containing

chr5_-_22889487 0.699 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr12_-_16650697 0.695 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_139315011 0.694 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr4_-_87593306 0.692 NM_002753
MAPK10
mitogen-activated protein kinase 10
chrX_+_21960841 0.686 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr15_-_68781662 0.684 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_+_13903936 0.683 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr1_-_181889070 0.674 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr17_+_72982919 0.672 NM_001113495
SEPT9
septin 9
chr13_-_46368968 0.671 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr7_+_113842284 0.671 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_+_154520693 0.657 NM_032323
TMEM79
transmembrane protein 79
chr14_+_22059174 0.655


chr18_+_30544193 0.655 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr13_+_96726415 0.653 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_161981046 0.652 TBR1
T-box, brain, 1
chr13_-_37070862 0.650 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr11_-_123353607 0.644 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr6_+_136214495 0.641 NM_018945
PDE7B
phosphodiesterase 7B
chr15_+_75074793 0.636 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chrX_+_66705407 0.634 NM_001011645
AR
androgen receptor
chr4_-_68432293 0.631 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr10_+_95507555 0.627 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr4_+_68995761 0.625 NM_014058
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_221168388 0.625 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr3_-_101316038 0.623 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr4_-_21308415 0.622 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr20_-_49747397 0.621 ATP9A
ATPase, class II, type 9A
chr2_+_113542017 0.620 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr4_-_83566045 0.619


chr12_+_79362256 0.617 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr10_+_102113410 0.614


chr7_+_18501876 0.614 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr6_+_71192862 0.612 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr12_-_14024187 0.611 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr12_+_9871343 0.611 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr2_+_161980865 0.609 NM_006593
TBR1
T-box, brain, 1
chr15_-_59308770 0.605 NM_134261
RORA
RAR-related orphan receptor A
chr15_+_75074743 0.601 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr10_+_80743769 0.597 ZMIZ1
zinc finger, MIZ-type containing 1
chr3_-_11598829 0.596 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr16_+_20682812 0.595 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr1_+_185064654 0.594 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr6_-_52882419 0.594 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr3_-_110155237 0.592 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr15_-_53996597 0.592 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr16_+_22432344 0.585 NM_001135865
LOC100132247
NPIPL3
nuclear pore complex interacting protein related gene
nuclear pore complex interacting protein-like 3
chr11_-_117305277 0.581 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr15_+_38849450 0.579 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr1_-_57057956 0.575 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr21_-_42219849 0.561 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_90552466 0.561 NM_001128215
LIPM
lipase, family member M
chr3_+_63928459 0.551 NM_001128149
ATXN7
ataxin 7
chrX_+_105823723 0.549 NM_024539
RNF128
ring finger protein 128
chr9_-_33455191 0.545 NOL6
nucleolar protein family 6 (RNA-associated)
chr12_-_10173947 0.544 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr5_-_39255335 0.543 NM_001465
NM_199335
FYB

FYN binding protein

chr10_-_105427898 0.540 SH3PXD2A
SH3 and PX domains 2A
chr4_-_57242492 0.539 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr10_+_24795446 0.534 KIAA1217
KIAA1217
chr12_+_39372456 0.532 NM_001843
NM_175038
CNTN1

contactin 1

chr12_+_8866416 0.532 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr20_-_33489383 0.531 NM_000557
GDF5
growth differentiation factor 5
chrX_-_133620103 0.524 NM_021796
PLAC1
placenta-specific 1
chr17_+_56843893 0.524 NM_203425
C17orf82
chromosome 17 open reading frame 82
chr17_-_19290745 0.523


chr3_+_2528272 0.521 CNTN4
contactin 4
chr19_+_42689881 0.519 ZNF793
zinc finger protein 793
chr3_+_101316463 0.519 NM_001167924
C3orf26
chromosome 3 open reading frame 26
chr7_-_112513379 0.518 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr4_-_83566246 0.517 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_27133163 0.516 NM_153631
HOXA3
homeobox A3
chr20_-_62052922 0.515 NM_001193379
UCKL1
uridine-cytidine kinase 1-like 1
chr3_+_160269734 0.514 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr1_-_155336223 0.512 NM_001004341
ETV3L
ets variant 3-like
chr11_+_117452995 0.510 TMPRSS4
transmembrane protease, serine 4
chr4_-_116254381 0.506 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr21_-_38955487 0.500 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_-_19703371 0.500 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr18_-_26996742 0.500 NM_004948
NM_024421
DSC1

desmocollin 1

chr20_+_9236446 0.499 NM_000933
PLCB4
phospholipase C, beta 4
chr2_-_40593074 0.496 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chrX_+_111005934 0.496 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr7_+_80113903 0.494 CD36
CD36 molecule (thrombospondin receptor)
chr4_-_176970895 0.493 GPM6A
glycoprotein M6A
chr21_-_35343331 0.491 RUNX1
runt-related transcription factor 1
chr4_-_176971175 0.490 NM_201591
GPM6A
glycoprotein M6A
chr14_+_51397134 0.488 GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr8_-_110689396 0.488 SYBU
syntabulin (syntaxin-interacting)
chr11_+_126378507 0.486 NCRNA00288
non-protein coding RNA 288
chrX_-_43717864 0.486 NM_000266
NDP
Norrie disease (pseudoglioma)
chr1_-_42156913 0.484


chr8_-_102872614 0.477 NM_032041
NCALD
neurocalcin delta
chr12_-_6354650 0.476 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_42165740 0.475 TRAK1
trafficking protein, kinesin binding 1
chr3_+_42165829 0.471 TRAK1
trafficking protein, kinesin binding 1
chr5_+_140772691 0.470 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr8_-_67253234 0.468 NM_000756
CRH
corticotropin releasing hormone
chr7_-_87694218 0.466 NM_198901
SRI
sorcin
chr17_+_71232370 0.463 NM_001005619
ITGB4
integrin, beta 4
chr12_+_28301399 0.462 NM_018318
CCDC91
coiled-coil domain containing 91
chr18_+_18989786 0.462 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_+_54400417 0.462 NM_002905
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr1_+_50342168 0.451 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.49e-09 GO:0032501 multicellular organismal process
1.39 9.98e-06 GO:0032502 developmental process
1.38 1.96e-04 GO:0007275 multicellular organismal development
1.52 2.46e-04 GO:0030154 cell differentiation
1.41 6.07e-04 GO:0048731 system development
1.38 8.60e-04 GO:0048856 anatomical structure development
1.48 1.34e-03 GO:0048869 cellular developmental process
1.79 1.74e-03 GO:0009888 tissue development
1.52 2.83e-03 GO:0003008 system process
3.11 7.57e-03 GO:0034329 cell junction assembly
1.79 9.41e-03 GO:0007155 cell adhesion
1.79 9.41e-03 GO:0022610 biological adhesion
1.21 1.18e-02 GO:0050896 response to stimulus
2.94 1.19e-02 GO:0034330 cell junction organization
3.02 1.26e-02 GO:0007156 homophilic cell adhesion
3.02 1.26e-02 GO:0048589 developmental growth
1.78 1.32e-02 GO:2000026 regulation of multicellular organismal development
2.69 1.42e-02 GO:0030855 epithelial cell differentiation
1.46 1.49e-02 GO:0048513 organ development
2.02 1.64e-02 GO:0051094 positive regulation of developmental process
1.29 2.12e-02 GO:0023052 signaling
2.42 2.30e-02 GO:0040007 growth
1.55 3.14e-02 GO:0051239 regulation of multicellular organismal process
1.78 3.55e-02 GO:0045595 regulation of cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 2.42e-06 GO:0005886 plasma membrane
1.35 2.77e-06 GO:0071944 cell periphery
1.43 1.27e-03 GO:0005576 extracellular region
1.39 4.63e-03 GO:0044459 plasma membrane part
1.75 1.78e-02 GO:0030054 cell junction
1.17 3.71e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.58 1.70e-03 GO:0004888 transmembrane receptor activity
1.47 3.64e-03 GO:0004872 receptor activity
1.41 6.03e-03 GO:0004871 signal transducer activity
1.41 6.03e-03 GO:0060089 molecular transducer activity