Motif ID: TCF4_dimer.p2

Z-value: 3.637


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_512198800.468.2e-02Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_41641881 8.061 NM_001142445
NM_020478
NM_020480
 ANK1


ankyrin 1, erythrocytic


chr9_+_135389698 4.885 NM_014694
 ADAMTSL2
ADAMTS-like 2
chr1_+_46151845 4.699 MAST2
microtubule associated serine/threonine kinase 2
chr4_+_114190233 4.320 NM_001148
NM_020977
 ANK2

ankyrin 2, neuronal

chr3_-_39209075 3.947 NM_194293
NM_001198621
 XIRP1

xin actin-binding repeat containing 1

chr17_-_36451189 3.891 NM_030967
 KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr1_-_154205675 3.887 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr11_-_47427263 3.753 NM_005055
NM_032645
 RAPSN

receptor-associated protein of the synapse

chr20_+_29870836 3.721 NM_033118
 MYLK2
myosin light chain kinase 2
chr22_+_21094094 3.608


chr1_-_16217871 3.588 NM_014424
 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr12_-_47679176 3.586 NM_015086
 DDN
dendrin
chr2_+_219991342 3.558 NM_001927
 DES
desmin
chr2_+_233099113 3.515 NM_000751
 CHRND
cholinergic receptor, nicotinic, delta
chr1_-_39871226 3.499 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr11_+_384238 3.452 PKP3
plakophilin 3
chr3_-_52844274 3.357 NM_205853
 MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr22_-_35011703 3.185 MYH9
myosin, heavy chain 9, non-muscle
chr4_+_54660954 3.171 NM_133267
 GSX2
GS homeobox 2
chr17_+_36493927 3.167 NM_033061
 KRTAP4-7
keratin associated protein 4-7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
2.53 9.79e-03 GO:0030199 collagen fibril organization
2.31 2.10e-02 GO:0051153 regulation of striated muscle cell differentiation
1.89 4.97e-02 GO:0051147 regulation of muscle cell differentiation
1.84 2.03e-02 GO:0008016 regulation of heart contraction
1.75 6.68e-06 GO:0003012 muscle system process
1.73 6.79e-05 GO:0006936 muscle contraction
1.68 9.77e-03 GO:0042692 muscle cell differentiation
1.60 2.02e-03 GO:0007517 muscle organ development
1.58 2.17e-05 GO:0061061 muscle structure development
1.47 9.84e-04 GO:0007411 axon guidance
1.47 1.03e-03 GO:0044057 regulation of system process
1.46 3.72e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.43 5.84e-04 GO:0009968 negative regulation of signal transduction
1.41 1.12e-03 GO:0023057 negative regulation of signaling
1.40 1.36e-03 GO:0010648 negative regulation of cell communication
1.40 2.38e-03 GO:0007409 axonogenesis
1.38 1.12e-03 GO:0000904 cell morphogenesis involved in differentiation
1.38 4.72e-03 GO:0048812 neuron projection morphogenesis
1.38 6.38e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.37 2.27e-03 GO:0048585 negative regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
1.81 2.69e-05 GO:0043292 contractile fiber
1.80 8.81e-05 GO:0030016 myofibril
1.76 5.18e-04 GO:0044449 contractile fiber part
1.74 3.68e-03 GO:0030017 sarcomere
1.54 2.55e-02 GO:0005912 adherens junction
1.46 6.43e-03 GO:0016323 basolateral plasma membrane
1.38 2.44e-03 GO:0031012 extracellular matrix
1.32 8.54e-04 GO:0030054 cell junction
1.26 6.70e-03 GO:0031988 membrane-bounded vesicle
1.25 1.26e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 2.36e-02 GO:0031982 vesicle
1.23 2.54e-02 GO:0031410 cytoplasmic vesicle
1.14 8.99e-03 GO:0044459 plasma membrane part
1.07 2.58e-05 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.80 1.56e-02 GO:0005201 extracellular matrix structural constituent
1.36 4.59e-02 GO:0003779 actin binding
1.34 1.26e-03 GO:0008092 cytoskeletal protein binding
1.08 4.87e-04 GO:0005515 protein binding