Motif ID: ESRRA.p2

Z-value: 1.416


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_63829616-0.116.9e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_44726635 2.948 NM_001123376
TMEM72
transmembrane protein 72
chr19_-_4486202 2.750 NM_001013706
PLIN5
perilipin 5
chr6_+_44076281 2.546 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr19_-_44518465 2.359 GMFG
glia maturation factor, gamma
chr1_-_143706265 2.293 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_29086206 2.254 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr19_-_44518516 2.204 NM_004877
GMFG
glia maturation factor, gamma
chr1_+_29086156 2.167 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr14_+_87560646 2.162 LOC283587
hypothetical protein LOC283587
chr20_+_41621119 1.887 SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_41621079 1.844 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_172153087 1.843 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr20_+_36867708 1.801 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr1_-_143706196 1.796 PDE4DIP
phosphodiesterase 4D interacting protein
chr6_+_31662454 1.687 NM_205837
LST1
leukocyte specific transcript 1
chr1_-_172153024 1.663 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr12_+_50592379 1.638 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr2_-_175754366 1.626 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr1_-_152431175 1.602 NM_152263
TPM3
tropomyosin 3
chr1_+_181028016 1.550 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr1_+_55237193 1.454 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr1_+_32489426 1.342 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr11_-_64284762 1.320 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr9_-_130006309 1.314 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr3_-_49701085 1.295 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr17_-_39500512 1.273 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr17_+_37247568 1.268 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr19_+_7734034 1.266 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr11_-_60379998 1.243 NM_004778
GPR44
G protein-coupled receptor 44
chr19_+_62434188 1.178 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr19_-_60360768 1.152 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr1_-_56750235 1.109 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_21631992 1.101


chr11_-_59369501 1.067 NM_005142
GIF
gastric intrinsic factor (vitamin B synthesis)
chr12_-_107257205 1.049 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr17_-_77386212 1.016 NM_001007533
DYSFIP1
dysferlin interacting protein 1
chr17_-_77386156 1.010 DYSFIP1
dysferlin interacting protein 1
chr19_+_17923110 0.981 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr1_-_35097922 0.971 NM_001164825
NM_138428
C1orf212

chromosome 1 open reading frame 212

chrX_-_153397566 0.965 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chrX_-_47374187 0.963 NM_001145252
CFP
complement factor properdin
chr10_+_80777265 0.961 PPIF
peptidylprolyl isomerase F
chr10_-_97190885 0.954 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr21_-_42659671 0.953 NM_003225
TFF1
trefoil factor 1
chr19_-_62759536 0.945 NM_001039654
ZNF550
zinc finger protein 550
chr7_+_150413814 0.945 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr7_+_128795280 0.933 AHCYL2
adenosylhomocysteinase-like 2
chr7_+_128795178 0.914 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr8_-_131097856 0.913 FAM49B
family with sequence similarity 49, member B
chr7_-_38355949 0.897


chr9_+_130005429 0.894 NM_001005336
NM_004408
DNM1

dynamin 1

chr6_-_135312899 0.893 NM_001193480
NM_022568
NM_170771
ALDH8A1


aldehyde dehydrogenase 8 family, member A1


chr6_+_34314545 0.891 NM_145905
HMGA1
high mobility group AT-hook 1
chr19_-_3013880 0.886 NM_198969
AES
amino-terminal enhancer of split
chr1_-_199259447 0.884 NM_017596
KIF21B
kinesin family member 21B
chr9_+_130005489 0.868 DNM1
dynamin 1
chr17_-_31332568 0.860 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr17_+_35075124 0.859 NM_003673
TCAP
titin-cap (telethonin)
chr15_-_89276657 0.857 NM_198527
HDDC3
HD domain containing 3
chr9_+_130005487 0.855 DNM1
dynamin 1
chr1_-_45224784 0.845 EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr19_+_1199548 0.840 NM_177401
MIDN
midnolin
chr14_-_20572783 0.831 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr4_-_40212670 0.831 NM_019027
RBM47
RNA binding motif protein 47
chr10_+_80777248 0.823 PPIF
peptidylprolyl isomerase F
chr7_-_158304062 0.820 ESYT2
extended synaptotagmin-like protein 2
chr7_+_116238309 0.813 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr9_-_14858974 0.806 FREM1
FRAS1 related extracellular matrix 1
chr22_+_19651446 0.805 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr11_-_64459910 0.797 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr7_-_38356100 0.785 TRGV5
T cell receptor gamma variable 5
chrX_+_65152004 0.767


chr17_-_34014390 0.762 SRCIN1
SRC kinase signaling inhibitor 1
chr16_+_31274020 0.755 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chrX_+_48505097 0.754 NM_001080489
GLOD5
glyoxalase domain containing 5
chr16_-_4794749 0.750 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr8_-_131097828 0.742 FAM49B
family with sequence similarity 49, member B
chr6_+_43257883 0.734 NM_015089
CUL9
cullin 9
chr3_-_198839026 0.728 LOC220729
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene
chr14_-_74400288 0.724 NM_001080408
PROX2
prospero homeobox 2
chr16_+_31273969 0.722 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr19_-_3013768 0.711 AES
amino-terminal enhancer of split
chr16_+_4614959 0.708 MGRN1
mahogunin, ring finger 1
chr7_-_100630912 0.708 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr1_-_27353987 0.700 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr1_-_1679940 0.698 NM_001198995
NADK
NAD kinase
chr16_+_31274030 0.690 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_+_163867057 0.688 NM_004528
MGST3
microsomal glutathione S-transferase 3
chr6_+_44418374 0.676 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chr5_-_148014282 0.675 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr6_-_41811323 0.674 TFEB
transcription factor EB
chr1_+_29113589 0.673 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_-_143706300 0.670 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr19_+_12941431 0.667 NM_152654
DAND5
DAN domain family, member 5
chr17_+_7474177 0.665 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr2_-_105421661 0.662 NM_201557
FHL2
four and a half LIM domains 2
chr1_+_204924903 0.651 NM_004759
NM_032960
MAPKAPK2

mitogen-activated protein kinase-activated protein kinase 2

chr5_+_138920893 0.646 NM_003339
NM_181838
UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

chr19_+_59796858 0.646 NM_006863
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chrX_-_47374647 0.642 NM_002621
CFP
complement factor properdin
chr17_+_71586857 0.641 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr17_-_40839082 0.637 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr20_-_44713466 0.637 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr9_-_99994704 0.632 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr2_+_119905812 0.631 NM_183240
TMEM37
transmembrane protein 37
chr6_-_31789824 0.630


chr11_-_64582568 0.630 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr1_+_46413335 0.629 NM_005727
TSPAN1
tetraspanin 1
chr19_-_14771947 0.629 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr6_-_108252200 0.627 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr4_+_24406336 0.615 SOD3
superoxide dismutase 3, extracellular
chr3_+_46423682 0.607 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr1_+_226337425 0.605 NM_001024227
NM_001024228
ARF1

ADP-ribosylation factor 1

chr6_+_36773605 0.603 RAB44
RAB44, member RAS oncogene family
chr16_-_65984836 0.597 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr12_+_56462794 0.589 NM_001172695
NM_001172696
NM_001172697
NM_005726
TSFM



Ts translation elongation factor, mitochondrial



chr13_-_79810972 0.588 SPRY2
sprouty homolog 2 (Drosophila)
chr4_+_24406238 0.583 SOD3
superoxide dismutase 3, extracellular
chr21_+_43903803 0.580 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr3_+_187917791 0.578 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr4_+_24406301 0.576 SOD3
superoxide dismutase 3, extracellular
chr4_+_24406182 0.574 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr11_-_18704294 0.573 NM_173588
IGSF22
immunoglobulin superfamily, member 22
chr6_+_31662954 0.567 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr18_-_44730706 0.565 SMAD7
SMAD family member 7
chr16_+_66121040 0.565 NM_001193523
FAM65A
family with sequence similarity 65, member A
chr20_+_31541565 0.564 NM_001032999
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr20_+_30061905 0.559 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr12_-_642786 0.557 NM_016533
NINJ2
ninjurin 2
chr1_-_150065176 0.556 NM_001001523
RORC
RAR-related orphan receptor C
chr1_-_38243747 0.552 NM_004468
FHL3
four and a half LIM domains 3
chr22_-_29290875 0.552 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr4_+_24406283 0.547 SOD3
superoxide dismutase 3, extracellular
chr10_+_80777234 0.546 PPIF
peptidylprolyl isomerase F
chr11_+_268569 0.542 NM_138329
NLRP6
NLR family, pyrin domain containing 6
chr5_+_138921041 0.540 UBE2D2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr2_-_30883775 0.529 NM_144575
CAPN13
calpain 13
chr6_-_30236667 0.528 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr12_-_116021473 0.525 NM_001168325
NM_017899
TESC

tescalcin

chr1_-_27689129 0.523 WASF2
WAS protein family, member 2
chr3_+_10265357 0.520 TATDN2
TatD DNase domain containing 2
chr9_+_102229283 0.519 NM_001198807
NM_080655
NM_001198805
C9orf30


chromosome 9 open reading frame 30


chr16_-_28843955 0.517 NM_024816
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr9_-_37894331 0.512 NM_033412
MCART1
mitochondrial carrier triple repeat 1
chr16_+_55456619 0.511 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr10_+_80777199 0.507 NM_005729
PPIF
peptidylprolyl isomerase F
chr5_-_148013908 0.505 NM_000870
HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr2_-_32344192 0.502 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr11_-_780065 0.500 CEND1
cell cycle exit and neuronal differentiation 1
chr19_+_50141068 0.497 NM_000483
APOC2
apolipoprotein C-II
chr2_-_96667710 0.495 KIAA1310
KIAA1310
chr20_+_1132097 0.495 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr20_+_30329096 0.492 NM_004798
KIF3B
kinesin family member 3B
chr17_+_40580466 0.492 NM_006460
HEXIM1
hexamethylene bis-acetamide inducible 1
chr16_-_56886380 0.491 NM_001080492
PRSS54
protease, serine, 54
chr12_-_55042793 0.489 NM_001638
APOF
apolipoprotein F
chr22_+_18485145 0.485 RANBP1
RAN binding protein 1
chr1_-_19089971 0.484 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr1_-_27689254 0.483 NM_006990
WASF2
WAS protein family, member 2
chr1_-_203985932 0.477


chr19_-_56582997 0.477 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr12_-_119038941 0.475 RAB35
RAB35, member RAS oncogene family
chr6_+_43257903 0.475 CUL9
cullin 9
chr6_+_37081387 0.474 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr15_+_41597097 0.470 NM_002373
MAP1A
microtubule-associated protein 1A
chr8_-_131098015 0.468 FAM49B
family with sequence similarity 49, member B
chr2_-_96667787 0.468 KIAA1310
KIAA1310
chrX_-_149817720 0.465 CD99L2
CD99 molecule-like 2
chr11_+_77577505 0.463 NM_020798
USP35
ubiquitin specific peptidase 35
chr7_-_64088848 0.461 NM_015852
ZNF117
zinc finger protein 117
chrX_+_152682772 0.458 NM_001163257
NM_005393
PLXNB3

plexin B3

chr1_+_204924931 0.457 MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
chr16_+_24475129 0.456 RBBP6
retinoblastoma binding protein 6
chr1_-_27582368 0.455 NM_207397
CD164L2
CD164 sialomucin-like 2
chr19_+_1358750 0.455 DAZAP1
DAZ associated protein 1
chr7_+_128099581 0.451 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr1_+_24701886 0.448 NM_013441
RCAN3
RCAN family member 3
chr16_+_4614820 0.447 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr6_-_11219932 0.446 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr13_+_112349358 0.445 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr6_+_10629550 0.443 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_-_24628348 0.441 C12orf67
chromosome 12 open reading frame 67
chr20_-_581808 0.440 SRXN1
sulfiredoxin 1
chr15_+_76644882 0.440 NM_000745
CHRNA5
cholinergic receptor, nicotinic, alpha 5
chr11_-_780103 0.439 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr18_+_53967544 0.438 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr7_+_37926687 0.437 NM_017549
EPDR1
ependymin related protein 1 (zebrafish)
chr1_+_157441133 0.436 NM_002036
DARC
Duffy blood group, chemokine receptor
chr2_-_172675873 0.435 DLX2
distal-less homeobox 2
chr10_-_75304225 0.435 NM_001222
NM_172169
NM_172171
NM_172173
NM_172170
CAMK2G




calcium/calmodulin-dependent protein kinase II gamma




chr19_+_1358664 0.429 DAZAP1
DAZ associated protein 1
chr12_-_119038934 0.427 RAB35
RAB35, member RAS oncogene family
chr19_+_19183763 0.426 NM_004386
NCAN
neurocan
chr7_-_92686773 0.425 NM_198151
HEPACAM2
HEPACAM family member 2
chr17_-_70430839 0.424 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr1_-_202726068 0.422 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr1_+_16242833 0.419 NM_000085
CLCNKB
chloride channel Kb
chr1_+_177261798 0.417 FAM20B
family with sequence similarity 20, member B
chr8_-_100975417 0.414 NM_004374
COX6C
cytochrome c oxidase subunit VIc
chr20_+_31541441 0.414 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.92 7.15e-07 GO:0045333 cellular respiration
4.27 4.60e-06 GO:0022904 respiratory electron transport chain
1.42 2.68e-05 GO:0006810 transport
3.47 4.69e-05 GO:0022900 electron transport chain
2.31 8.10e-05 GO:0006091 generation of precursor metabolites and energy
1.40 9.65e-05 GO:0051234 establishment of localization
2.48 6.72e-04 GO:0015980 energy derivation by oxidation of organic compounds
1.31 4.14e-03 GO:0051179 localization
1.64 2.16e-02 GO:0055114 oxidation-reduction process
5.18 2.71e-02 GO:0009060 aerobic respiration

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.14 5.57e-12 GO:0005743 mitochondrial inner membrane
2.98 1.79e-11 GO:0019866 organelle inner membrane
2.30 7.19e-11 GO:0044429 mitochondrial part
2.62 2.00e-10 GO:0031966 mitochondrial membrane
2.54 5.03e-10 GO:0005740 mitochondrial envelope
1.80 4.08e-09 GO:0005739 mitochondrion
1.27 2.86e-07 GO:0044444 cytoplasmic part
2.02 3.33e-07 GO:0031967 organelle envelope
2.01 3.33e-07 GO:0031975 envelope
1.20 7.83e-07 GO:0005737 cytoplasm
3.64 2.60e-06 GO:0044455 mitochondrial membrane part
4.40 5.74e-05 GO:0070469 respiratory chain
4.48 1.01e-04 GO:0005746 mitochondrial respiratory chain
1.36 1.12e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.74 2.61e-03 GO:0016491 oxidoreductase activity
3.11 9.03e-03 GO:0015078 hydrogen ion transmembrane transporter activity
5.69 2.46e-02 GO:0004129 cytochrome-c oxidase activity
5.69 2.46e-02 GO:0015002 heme-copper terminal oxidase activity
5.69 2.46e-02 GO:0016675 oxidoreductase activity, acting on a heme group of donors
5.69 2.46e-02 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
2.18 2.83e-02 GO:0022890 inorganic cation transmembrane transporter activity
1.15 3.56e-02 GO:0005515 protein binding
4.27 4.43e-02 GO:0003823 antigen binding