Motif ID: LHX3,4.p2

Z-value: 0.778


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
LHX3chr9_-_138236775-0.401.4e-01Click!
LHX4chr1_+_178466064-0.136.4e-01Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_166516901 2.084 NM_005149
TBX19
T-box 19
chr19_-_56612653 1.989 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr20_+_56919233 1.830 GNAS
GNAS complex locus
chr5_-_88155360 1.786 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr17_+_19917420 1.712 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_154120170 1.671 SYT11
synaptotagmin XI
chr10_-_50066386 1.119 NM_001010863
C10orf128
chromosome 10 open reading frame 128
chr1_+_117345894 0.950 NM_004258
CD101
CD101 molecule
chr3_-_57209319 0.943 NM_003865
HESX1
HESX homeobox 1
chr10_+_35466715 0.881 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr12_+_52697160 0.875 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_75794919 0.864 YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr3_-_158704056 0.857 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr10_+_91488704 0.840 KIF20B
kinesin family member 20B
chr3_+_69895651 0.781 NM_006722
MITF
microphthalmia-associated transcription factor
chr21_+_29374743 0.771 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr1_-_149681265 0.768 NM_207171
POGZ
pogo transposable element with ZNF domain
chr10_+_126620681 0.743 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr12_-_101396459 0.728 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr3_+_153074118 0.700 NM_033050
SUCNR1
succinate receptor 1
chr11_+_33306652 0.700 HIPK3
homeodomain interacting protein kinase 3
chr4_+_71806538 0.690 NM_001037442
NM_014961
RUFY3

RUN and FYVE domain containing 3

chr9_+_124173049 0.679 NM_000962
NM_080591
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr7_+_110518297 0.675 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr7_-_86433139 0.674 NM_152748
KIAA1324L
KIAA1324-like
chr7_+_77307382 0.672 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr11_+_123600553 0.661 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr1_-_143708467 0.652 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr7_-_13992351 0.646 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr7_-_107667728 0.646 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr7_-_25234582 0.641 NM_022150
NPVF
neuropeptide VF precursor
chr9_+_124173143 0.640 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_52281050 0.630 NM_001130059
ATF7
activating transcription factor 7
chr7_+_37689903 0.627


chr5_+_6799100 0.618 NM_001171806
PAPD7
PAP associated domain containing 7
chr3_+_46386636 0.603 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr4_-_176970372 0.600 GPM6A
glycoprotein M6A
chr13_+_112349358 0.588 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr7_-_132371208 0.580 EEF1G
eukaryotic translation elongation factor 1 gamma
chr1_+_242283129 0.576 NM_006352
ZNF238
zinc finger protein 238
chr5_+_67622242 0.549 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_122627235 0.544 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr3_+_45902999 0.528 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr22_+_38627031 0.524 NM_004810
GRAP2
GRB2-related adaptor protein 2
chr4_+_123311207 0.512 NM_015312
KIAA1109
KIAA1109
chr9_-_205892 0.510 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr4_+_72423633 0.505 NM_003759
SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr7_-_92615593 0.499 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr12_-_101036407 0.496 NM_024057
NUP37
nucleoporin 37kDa
chr12_+_52696908 0.495 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr17_-_64568641 0.487 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chrX_-_55074125 0.486 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr22_+_38627129 0.484 GRAP2
GRB2-related adaptor protein 2
chr21_-_35153664 0.482 RUNX1
runt-related transcription factor 1
chr6_+_53043729 0.480 NM_012347
FBXO9
F-box protein 9
chr12_+_54700955 0.480 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr12_+_9871343 0.476 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr17_-_1195096 0.474 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr1_+_61320213 0.460 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr4_+_38740246 0.459 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr12_-_101398429 0.458 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_176970895 0.455 GPM6A
glycoprotein M6A
chr4_-_185921384 0.453 ACSL1
acyl-CoA synthetase long-chain family member 1
chr3_-_54937001 0.450 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr14_+_74968589 0.450 NM_001135049
JDP2
Jun dimerization protein 2
chr3_-_25654659 0.449 TOP2B
topoisomerase (DNA) II beta 180kDa
chr2_-_175170674 0.444 WIPF1
WAS/WASL interacting protein family, member 1
chr13_+_48923688 0.443 NM_001160308
SETDB2
SET domain, bifurcated 2
chr3_-_143201878 0.443 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_130004404 0.443 NM_198827
GPR133
G protein-coupled receptor 133
chr4_-_176970407 0.425 GPM6A
glycoprotein M6A
chr2_+_68815416 0.421 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr7_-_135263737 0.416 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr1_+_196874839 0.416 PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_152394215 0.415 NM_001159484
NM_207308
NUP210L

nucleoporin 210kDa-like

chr13_-_98708549 0.413 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_153186602 0.411 NM_001145934
TKTL1
transketolase-like 1
chr7_+_90177082 0.411 CDK14
cyclin-dependent kinase 14
chr11_-_58032153 0.409 NM_001005218
OR5B21
olfactory receptor, family 5, subfamily B, member 21
chr1_+_172683834 0.409 NM_005684
GPR52
G protein-coupled receptor 52
chr1_+_173111306 0.404 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr4_-_177353707 0.403 NM_144644
SPATA4
spermatogenesis associated 4
chr8_-_82536312 0.401 NM_001080526
FABP9
fatty acid binding protein 9, testis
chr1_-_158815895 0.399 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr5_+_156628929 0.394 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr3_+_63928459 0.393 NM_001128149
ATXN7
ataxin 7
chr3_+_152934393 0.389 NM_207365
AADACL2
arylacetamide deacetylase-like 2
chr22_-_38619739 0.388 NM_152512
ENTHD1
ENTH domain containing 1
chr16_+_2749934 0.387


chr18_+_3443771 0.387 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr2_-_80384454 0.387 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr19_-_53841064 0.384 NM_001217
CA11
carbonic anhydrase XI
chr4_+_88748704 0.382 NM_014208
DSPP
dentin sialophosphoprotein
chr17_-_9863929 0.381 GAS7
growth arrest-specific 7
chr13_+_47948586 0.380 RB1
retinoblastoma 1
chr15_+_32048380 0.377 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr6_+_73133152 0.376 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr7_+_128802719 0.375 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr10_+_18589589 0.372 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr11_-_5279750 0.372 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr3_+_99733432 0.371 NM_005290
GPR15
G protein-coupled receptor 15
chr11_-_102081654 0.369 NM_022122
MMP27
matrix metallopeptidase 27
chr3_-_114047479 0.362 NM_001008784
CD200R1L
CD200 receptor 1-like
chr3_+_179759181 0.361 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr5_-_160211623 0.359 NM_025153
ATP10B
ATPase, class V, type 10B
chr10_+_17310475 0.358 VIM
vimentin
chr8_-_7207899 0.357 NM_001164457
ZNF705G
zinc finger protein 705G
chr1_+_40635058 0.356 NM_001198980
SMAP2
small ArfGAP2
chr5_+_76470829 0.351


chr12_-_41269679 0.349 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr15_-_70350609 0.347 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr16_-_79811475 0.344 NM_001076780
NM_052892
PKD1L2

polycystic kidney disease 1-like 2

chr14_-_106249999 0.340 IGHA1
immunoglobulin heavy constant alpha 1
chr15_-_48345453 0.338 NM_002112
HDC
histidine decarboxylase
chr11_-_35235325 0.337 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_74478405 0.337 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr3_-_158703821 0.337 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr2_+_182558795 0.334 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr4_+_160408447 0.331 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_+_132037271 0.330 NM_000589
NM_172348
IL4

interleukin 4

chr11_-_114593838 0.329 CADM1
cell adhesion molecule 1
chr4_-_122357104 0.329 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr18_+_70352649 0.328 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr1_+_242582559 0.324 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr12_-_52939636 0.323 NM_001127321
CBX5
chromobox homolog 5
chr8_-_108579270 0.320 NM_001146
ANGPT1
angiopoietin 1
chr9_+_124172644 0.319 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr13_-_34948758 0.318 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr16_+_11966464 0.318 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_+_59580630 0.317 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr6_-_76022565 0.317 TMEM30A
transmembrane protein 30A
chr8_+_107807415 0.316 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr3_-_143230124 0.315 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr6_+_152053323 0.311 NM_001122742
ESR1
estrogen receptor 1
chr1_-_114215768 0.310 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr19_+_14554895 0.310 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr11_+_59979857 0.310 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_+_31661934 0.308 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr2_-_207291364 0.306 NM_001093730
DYTN
dystrotelin
chr12_-_16652202 0.305 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_152517204 0.302 NM_023915
GPR87
G protein-coupled receptor 87
chr3_+_120799411 0.302 NM_015900
PLA1A
phospholipase A1 member A
chr1_+_246682699 0.301 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr18_+_70352779 0.299 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr12_-_25041639 0.298 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr1_+_61642287 0.297 NFIA
nuclear factor I/A
chr11_+_59580705 0.297 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr11_-_47472648 0.295 NM_198700
CELF1
CUGBP, Elav-like family member 1
chr12_-_52939584 0.294 NM_001127322
CBX5
chromobox homolog 5
chr12_-_101398288 0.286 IGF1
insulin-like growth factor 1 (somatomedin C)
chr6_-_133076873 0.286 NM_004666
VNN1
vanin 1
chr8_-_134156437 0.285 SLA
Src-like-adaptor
chrX_+_84145487 0.283 NM_198450
APOOL
apolipoprotein O-like
chr19_-_21985560 0.279 NM_007153
ZNF208
zinc finger protein 208
chr12_-_101398503 0.277 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr17_-_1211263 0.275 YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_+_188222337 0.274 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr2_+_37282516 0.273 LOC100505876
hypothetical LOC100505876
chr1_-_157014048 0.272 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr3_-_127810087 0.268 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr12_-_101398470 0.268 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_-_51476047 0.268 NM_057088
KRT3
keratin 3
chr4_+_2853434 0.267 ADD1
adducin 1 (alpha)
chr9_+_124172606 0.266 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_-_151549790 0.263 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr11_-_89181390 0.263 NM_020358
TRIM49
tripartite motif containing 49
chr1_+_242281199 0.260 ZNF238
zinc finger protein 238
chr16_+_2672527 0.258 KCTD5
potassium channel tetramerisation domain containing 5
chr18_+_28023984 0.257 NM_005925
MEP1B
meprin A, beta
chr12_-_51887266 0.256 NM_000889
ITGB7
integrin, beta 7
chr2_-_158008763 0.255 NM_004288
CYTIP
cytohesin 1 interacting protein
chr5_+_140772691 0.254 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr16_+_68284252 0.252 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr7_+_96583840 0.251 NM_020186
ACN9
ACN9 homolog (S. cerevisiae)
chr1_-_152445432 0.248 NM_001010979
C1orf189
chromosome 1 open reading frame 189
chr9_+_123369219 0.246 NM_032552
DAB2IP
DAB2 interacting protein
chr12_-_51887318 0.244 ITGB7
integrin, beta 7
chr2_+_216695062 0.242 XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr11_+_44026106 0.241 NM_001031854
ACCSL
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
chr14_-_105997732 0.241 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_50026689 0.240 NM_001971
CELA1
chymotrypsin-like elastase family, member 1
chr12_-_101398451 0.239 IGF1
insulin-like growth factor 1 (somatomedin C)
chrX_+_78313124 0.235 NM_032553
GPR174
G protein-coupled receptor 174
chr17_-_36209672 0.235 NM_181535
KRT28
keratin 28
chr6_-_136829705 0.234 NM_001198615
MAP7
microtubule-associated protein 7
chr15_+_100175888 0.234 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr10_-_33264491 0.233 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr16_-_66075216 0.232 NM_001138
AGRP
agouti related protein homolog (mouse)
chr1_+_157067729 0.230 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr2_+_73864823 0.230 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr16_-_3783475 0.229 CREBBP
CREB binding protein
chr6_+_167445284 0.229 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr7_+_129057152 0.228 NM_001040110
NRF1
nuclear respiratory factor 1
chr2_+_170074457 0.228 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr11_+_59612712 0.227 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr6_+_43097352 0.226 NM_033112
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr12_+_8499788 0.223 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr22_+_21817512 0.222 NM_004914
RAB36
RAB36, member RAS oncogene family
chr3_+_123779122 0.222 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr13_-_102517196 0.218 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 6.47e-06 GO:0050896 response to stimulus
2.46 3.19e-05 GO:0007608 sensory perception of smell
1.29 2.44e-04 GO:0032501 multicellular organismal process
1.72 2.61e-04 GO:0002376 immune system process
2.25 3.49e-04 GO:0007606 sensory perception of chemical stimulus
1.55 1.99e-03 GO:0003008 system process
1.20 1.16e-02 GO:0050794 regulation of cellular process
4.06 1.32e-02 GO:0042113 B cell activation
1.76 1.39e-02 GO:0007600 sensory perception
1.96 1.62e-02 GO:0007186 G-protein coupled receptor protein signaling pathway
1.17 2.14e-02 GO:0065007 biological regulation
1.74 2.69e-02 GO:0006952 defense response
1.53 4.90e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 6.22e-06 GO:0071944 cell periphery
1.35 9.90e-06 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.20 3.31e-09 GO:0004930 G-protein coupled receptor activity
2.52 4.87e-06 GO:0004984 olfactory receptor activity
1.65 4.95e-06 GO:0004872 receptor activity
1.56 8.33e-06 GO:0004871 signal transducer activity
1.56 8.33e-06 GO:0060089 molecular transducer activity
1.75 8.69e-06 GO:0004888 transmembrane receptor activity
8.35 4.64e-05 GO:0001608 nucleotide receptor activity, G-protein coupled
8.35 4.64e-05 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
6.52 6.76e-04 GO:0001614 purinergic nucleotide receptor activity
6.52 6.76e-04 GO:0016502 nucleotide receptor activity
5.80 2.24e-03 GO:0035586 purinergic receptor activity
1.77 1.19e-02 GO:0043565 sequence-specific DNA binding
1.61 1.86e-02 GO:0001071 nucleic acid binding transcription factor activity
1.61 1.86e-02 GO:0003700 sequence-specific DNA binding transcription factor activity