Motif ID: CDX1,2,4.p2

Z-value: 1.476


Transcription factors associated with CDX1,2,4.p2:

Gene SymbolEntrez IDGene Name
CDX1 1044 caudal type homeobox 1
CDX2 1045 caudal type homeobox 2
CDX4 1046 caudal type homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CDX2chr13_-_274414230.322.4e-01Click!
CDX1chr5_+_1495265330.253.7e-01Click!
CDX4chrX_+_72583814-0.029.3e-01Click!


Activity profile for motif CDX1,2,4.p2.

activity profile for motif CDX1,2,4.p2


Sorted Z-values histogram for motif CDX1,2,4.p2

Sorted Z-values for motif CDX1,2,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDX1,2,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_10173947 2.748 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_-_155834357 2.438 NM_031282
FCRL4
Fc receptor-like 4
chr8_+_24207524 2.366 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr1_-_165326148 2.299 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr9_-_139047112 2.059 NM_004479
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr22_+_21384862 1.980 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr3_-_171070314 1.906 NM_024727
LRRC31
leucine rich repeat containing 31
chr5_+_141326620 1.890 NM_183399
RNF14
ring finger protein 14
chr14_-_30927931 1.823 NM_015473
HEATR5A
HEAT repeat containing 5A
chr6_-_137536412 1.780 NM_052962
NM_181309
NM_181310
IL22RA2


interleukin 22 receptor, alpha 2


chr2_+_38009405 1.673 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr18_+_59726183 1.647 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr2_-_32344192 1.628 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr16_+_20328355 1.618 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr1_-_181889070 1.604 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr3_-_184756101 1.598 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr10_+_91488704 1.567 KIF20B
kinesin family member 20B
chr17_-_5078773 1.549 NM_207103
C17orf87
chromosome 17 open reading frame 87
chr1_-_155788775 1.431 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr10_-_95231933 1.391 NM_013451
NM_133337
MYOF

myoferlin

chr1_+_158975662 1.361 NM_021181
SLAMF7
SLAM family member 7
chr12_+_111375382 1.337 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr12_+_9033403 1.326 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_-_20318578 1.307 NM_012400
PLA2G2D
phospholipase A2, group IID
chr19_+_14554895 1.231 NM_207390
CLEC17A
C-type lectin domain family 17, member A
chr22_-_16080265 1.225 CECR1
cat eye syndrome chromosome region, candidate 1
chr3_-_152403636 1.204 NM_013308
GPR171
G protein-coupled receptor 171
chr12_-_101115677 1.199 NM_002674
PMCH
pro-melanin-concentrating hormone
chr4_-_160175782 1.193 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr11_-_104411065 1.171 NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CASP1




caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr19_+_40895669 1.166 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr8_-_27997306 1.112 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr10_-_69125932 1.089 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr12_+_8499788 1.072 NM_001007033
CLEC6A
C-type lectin domain family 6, member A
chr14_-_106249999 1.069 IGHA1
immunoglobulin heavy constant alpha 1
chr4_-_77176163 1.052 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_-_130585650 1.049 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr18_-_46068689 1.048 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr6_-_133120587 1.043 NM_004665
VNN2
vanin 2
chr7_+_73826244 1.036 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr1_-_245120900 1.027 AHCTF1
AT hook containing transcription factor 1
chr3_+_46258875 1.020 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr1_+_190811479 1.013 NM_002922
RGS1
regulator of G-protein signaling 1
chr16_-_70168449 1.011 NM_000353
TAT
tyrosine aminotransferase
chr1_+_246635918 1.007 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr13_-_98708549 1.006 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr7_+_150077756 1.006 NM_001162367
LOC100128542
hypothetical protein LOC100128542
chr1_+_246195157 1.003 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr3_-_191321367 1.002 LEPREL1
leprecan-like 1
chr12_+_91620749 0.992 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr12_+_9713472 0.990 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr19_+_46762872 0.987 CEACAM21
carcinoembryonic antigen-related cell adhesion molecule 21
chr17_+_63338500 0.976 BPTF
bromodomain PHD finger transcription factor
chr20_+_62158882 0.975 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr6_+_30238961 0.975 NM_033229
TRIM15
tripartite motif containing 15
chr12_-_8656705 0.974 NM_020661
AICDA
activation-induced cytidine deaminase
chr16_+_27346079 0.972 NM_021798
IL21R
interleukin 21 receptor
chr15_-_48192804 0.969 ATP8B4
ATPase, class I, type 8B, member 4
chr10_+_15125900 0.963 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr11_-_59707074 0.960 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr1_-_205210567 0.953 NM_001122979
NM_001170631
NM_032029
FCAMR


Fc receptor, IgA, IgM, high affinity


chr17_-_6924227 0.953 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr19_-_55539769 0.936 NAPSB
napsin B aspartic peptidase pseudogene
chr9_-_21067804 0.934 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr14_+_87541220 0.932 NM_003608
GPR65
G protein-coupled receptor 65
chr13_+_45174446 0.929 NM_152719
SPERT
spermatid associated
chr11_-_104421240 0.922 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr16_-_28425632 0.917 NM_145659
IL27
interleukin 27
chr11_-_104274606 0.910 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr1_+_67404756 0.905 NM_144701
IL23R
interleukin 23 receptor
chr8_-_42742729 0.903 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr10_+_35466715 0.879 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr19_-_16111695 0.877


chr2_+_204279624 0.872 CD28
CD28 molecule
chr1_+_50348052 0.867 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_-_16111594 0.856


chr4_-_77163609 0.855 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_+_245647973 0.852 NM_001127462
NM_004895
NM_183395
NLRP3


NLR family, pyrin domain containing 3


chr2_+_161701711 0.828 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr2_-_127817143 0.827 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr1_-_197173159 0.827 LOC100131234
familial acute myelogenous leukemia related factor
chr9_+_139047441 0.818 C9orf139
chromosome 9 open reading frame 139
chr1_+_181421796 0.812 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_-_70099964 0.812 NM_001115152
CD300LD
CD300 molecule-like family member d
chr4_-_103464491 0.808 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_-_31441390 0.800 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr22_+_36008511 0.798 CYTH4
cytohesin 4
chr12_+_102859354 0.788 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr5_+_156628929 0.788 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr11_+_59038961 0.785 NM_001004711
OR4D9
olfactory receptor, family 4, subfamily D, member 9
chr3_+_110024234 0.779 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr1_-_24112345 0.776 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr19_-_45141473 0.773 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr12_+_8216416 0.771 NM_001004328
ZNF705A
zinc finger protein 705A
chr7_+_37689903 0.768


chr6_+_53043729 0.765 NM_012347
FBXO9
F-box protein 9
chr5_+_94752803 0.764 NM_152548
FAM81B
family with sequence similarity 81, member B
chr11_-_129268113 0.758 NM_006165
NFRKB
nuclear factor related to kappaB binding protein
chr5_+_49997489 0.756 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr20_-_33658823 0.753 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr2_-_45648608 0.752 SRBD1
S1 RNA binding domain 1
chr9_-_116732403 0.745 NM_001244
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr6_+_64289585 0.742 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_15637521 0.741 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr12_+_53178834 0.737 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr12_-_7709734 0.718 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr16_-_88604029 0.716 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr6_+_10629550 0.716 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr5_-_66528330 0.712 NM_005582
CD180
CD180 molecule
chr14_-_105523735 0.706 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr8_-_7207899 0.702 NM_001164457
ZNF705G
zinc finger protein 705G
chr11_-_17147863 0.697 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr4_-_164754106 0.695 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr11_-_58032153 0.688 NM_001005218
OR5B21
olfactory receptor, family 5, subfamily B, member 21
chr22_+_42900168 0.684 NM_001137605
PARVG
parvin, gamma
chr22_-_22426551 0.683 NM_013378
VPREB3
pre-B lymphocyte 3
chr8_-_110411283 0.680 NM_001128211
NUDCD1
NudC domain containing 1
chr8_+_39890484 0.678 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr5_+_76470829 0.676


chr10_+_5976354 0.672 NM_032807
FBXO18
F-box protein, helicase, 18
chr19_-_56612653 0.655 NM_001171156
NM_001171157
NM_001171158
NM_001171159
NM_001171160
NM_001171161
NM_033130
SIGLEC10






sialic acid binding Ig-like lectin 10






chr9_-_21472311 0.651 NM_176891
IFNE
interferon, epsilon
chr2_+_204279442 0.647 NM_006139
CD28
CD28 molecule
chr5_-_36277441 0.644 C5orf33
chromosome 5 open reading frame 33
chr22_+_36008465 0.643 CYTH4
cytohesin 4
chr2_-_151052391 0.641 NM_005168
RND3
Rho family GTPase 3
chr16_+_55950195 0.635 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr21_-_14840506 0.628 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_36992221 0.627 NM_130442
ELMO1
engulfment and cell motility 1
chr19_-_6621078 0.627 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr12_-_55042793 0.625 NM_001638
APOF
apolipoprotein F
chr16_+_73810383 0.619 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr12_-_8110268 0.614 C3AR1
complement component 3a receptor 1
chr1_+_169549996 0.614 NM_002022
FMO4
flavin containing monooxygenase 4
chr3_+_179759181 0.613 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr1_-_156013487 0.611 NM_030764
FCRL2
Fc receptor-like 2
chr12_-_12740387 0.605 NM_006143
GPR19
G protein-coupled receptor 19
chr5_-_88155360 0.603 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr9_-_21375258 0.603 NM_000605
IFNA2
interferon, alpha 2
chr7_+_101810018 0.600


chr12_+_63510481 0.597


chr14_-_22354851 0.592 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7

chr10_+_114125003 0.589 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_+_6415259 0.586 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr2_+_68815416 0.581 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr16_+_3499894 0.571 NM_024793
CLUAP1
clusterin associated protein 1
chr1_-_77457664 0.571 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr16_+_30391609 0.563


chr7_-_107930170 0.559 PNPLA8
patatin-like phospholipase domain containing 8
chr3_-_122862391 0.559 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr8_-_6783193 0.555 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr17_-_35975227 0.554 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr4_-_47678187 0.554 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr6_+_3022030 0.553 NM_003804
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr3_-_113701073 0.553 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr1_+_178232379 0.551 CEP350
centrosomal protein 350kDa
chr2_+_102345528 0.551 NM_003855
IL18R1
interleukin 18 receptor 1
chr10_-_98280299 0.551 TM9SF3
transmembrane 9 superfamily member 3
chr13_+_96726197 0.551 MBNL2
muscleblind-like 2 (Drosophila)
chr3_-_122862447 0.550 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr5_-_180175146 0.549 MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr2_-_152538694 0.548 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr12_+_9925354 0.548 NM_001190765
KLRF2
killer cell lectin-like receptor subfamily F, member 2
chr10_-_85921703 0.546 LOC642934
hypothetical LOC642934
chr1_-_181826633 0.544 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr12_-_8110196 0.543 NM_004054
C3AR1
complement component 3a receptor 1
chr8_-_87824996 0.539 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr6_+_26609427 0.539 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr22_+_36008369 0.536 NM_013385
CYTH4
cytohesin 4
chr18_+_59705918 0.534 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr14_-_94677807 0.533 NM_030621
DICER1
dicer 1, ribonuclease type III
chr19_-_14646626 0.532 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_+_73864823 0.532 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr6_-_31242593 0.531 NM_001173531
NM_203289
POU5F1

POU class 5 homeobox 1

chr19_+_13999959 0.526 NM_080864
RLN3
relaxin 3
chr5_-_70356696 0.526 NM_004536
NM_022892
NAIP

NLR family, apoptosis inhibitory protein

chr12_+_111829121 0.525 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr1_+_207944807 0.522 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_-_202726068 0.521 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr15_-_96875133 0.515 NM_182562
FAM169B
family with sequence similarity 169, member B
chr17_-_64823368 0.515 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr9_+_78305368 0.511 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr16_+_31312097 0.508 NM_005353
ITGAD
integrin, alpha D
chr19_-_11550765 0.507 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr4_+_147316284 0.503 NM_007080
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_153541468 0.500 NM_001123228
TMEM14E
transmembrane protein 14E
chr10_-_6144119 0.499 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr2_-_179623030 0.498 NM_173648
CCDC141
coiled-coil domain containing 141
chr7_+_137411717 0.494 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr17_-_59825221 0.493


chr11_-_104477367 0.491 NM_001007232
CARD17
caspase recruitment domain family, member 17
chr19_-_53444733 0.489 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr10_+_90511142 0.487 NM_001102469
LIPN
lipase, family member N
chr1_+_160868822 0.487 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr9_+_139758336 0.487 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr2_-_242205556 0.486 NM_001164356
THAP4
THAP domain containing 4
chr20_+_56912146 0.484 GNAS
GNAS complex locus
chrX_+_1361570 0.483 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr4_+_89519004 0.481 HERC6
hect domain and RLD 6
chr12_+_10348311 0.480 NM_001114396
KLRD1
killer cell lectin-like receptor subfamily D, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 4.97e-05 GO:0006952 defense response
1.50 4.99e-05 GO:0002376 immune system process
2.46 2.21e-04 GO:0009615 response to virus
1.64 4.29e-04 GO:0002682 regulation of immune system process
1.59 9.51e-04 GO:0006955 immune response
1.79 2.80e-03 GO:0051707 response to other organism
1.68 7.41e-03 GO:0009607 response to biotic stimulus
1.72 8.07e-03 GO:0050776 regulation of immune response
1.69 1.93e-02 GO:0002684 positive regulation of immune system process
2.10 2.18e-02 GO:0002696 positive regulation of leukocyte activation
2.13 2.54e-02 GO:0051251 positive regulation of lymphocyte activation
2.06 3.29e-02 GO:0050867 positive regulation of cell activation

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.64 3.40e-03 GO:0003823 antigen binding
7.29 1.93e-02 GO:0005132 interferon-alpha/beta receptor binding