Motif ID: ATF2.p2

Z-value: 1.530


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_175741096-0.572.5e-02Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_23500706 2.411 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_-_127822227 2.173 NM_014702
KIAA0408
KIAA0408
chr8_+_134272463 2.085 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr20_+_32610161 2.053 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr22_+_40286957 2.010 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr7_+_28415495 1.967 LOC401317
hypothetical LOC401317
chr10_+_95838801 1.779 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr6_+_42896771 1.753 NM_015349
KIAA0240
KIAA0240
chr6_+_39868116 1.751


chr17_-_13445942 1.731 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr17_+_36515166 1.695 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr2_-_240613357 1.662 NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr2_-_73170290 1.623 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr14_+_95792299 1.601 NM_000710
BDKRB1
bradykinin receptor B1
chr14_+_95740916 1.547 BDKRB2
bradykinin receptor B2
chr6_+_39868126 1.516 DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_134042500 1.511 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr3_+_141136691 1.451 NM_022131
CLSTN2
calsyntenin 2
chr3_+_42107711 1.438 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr13_+_75232797 1.406 NM_015842
LMO7
LIM domain 7
chr5_-_158690047 1.400 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr1_+_99502655 1.378 LPPR4
lipid phosphate phosphatase-related protein type 4
chr16_+_27320983 1.369 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr3_-_64186151 1.350 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr19_-_56919032 1.345 NM_001523
HAS1
hyaluronan synthase 1
chr2_-_31491102 1.343 NM_000379
XDH
xanthine dehydrogenase
chr11_+_116575249 1.313 NM_001001522
NM_003186
TAGLN

transgelin

chr2_-_31491057 1.289 XDH
xanthine dehydrogenase
chr8_+_70567581 1.284 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr13_-_27967215 1.246 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr1_-_151614681 1.243 NM_005621
S100A12
S100 calcium binding protein A12
chr8_+_70567634 1.237 SULF1
sulfatase 1
chr17_-_19592178 1.237 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr22_-_42589543 1.235 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr17_+_36493927 1.232 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr1_+_66570363 1.230 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr7_-_45095017 1.218 NM_001146334
NACAD
NAC alpha domain containing
chr12_+_70119785 1.198 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr17_-_36528113 1.190 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr8_-_142446546 1.187 NM_005293
GPR20
G protein-coupled receptor 20
chr17_+_7402788 1.145 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr7_+_2524022 1.140 NM_002304
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_95740768 1.116 NM_000623
BDKRB2
bradykinin receptor B2
chr1_+_182040837 1.111 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr5_+_14493905 1.104 TRIO
triple functional domain (PTPRF interacting)
chr8_+_67096344 1.092 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr6_-_46401174 1.082 RCAN2
regulator of calcineurin 2
chr1_+_66570683 1.059 PDE4B
phosphodiesterase 4B, cAMP-specific
chr2_-_238861830 1.056 NM_022817
PER2
period homolog 2 (Drosophila)
chr11_-_62213946 1.048 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr2_+_220117009 1.047 TMEM198
transmembrane protein 198
chr10_-_90957028 1.045 NM_003956
CH25H
cholesterol 25-hydroxylase
chrX_-_83644054 1.036 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr9_+_17568952 1.035 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr5_-_147266257 1.035 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr8_-_67253234 1.029 NM_000756
CRH
corticotropin releasing hormone
chr11_-_62213577 1.027 LRRN4CL
LRRN4 C-terminal like
chr9_-_112139908 1.023 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr11_-_31796061 1.017 NM_001127612
PAX6
paired box 6
chr19_+_40716153 1.002 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr4_+_145786622 0.996 NM_022475
HHIP
hedgehog interacting protein
chr15_-_81037554 0.991 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr6_-_46401363 0.981 NM_005822
RCAN2
regulator of calcineurin 2
chr9_-_128924819 0.976 NM_012098
ANGPTL2
angiopoietin-like 2
chr3_-_21767819 0.955 NM_024697
ZNF385D
zinc finger protein 385D
chr6_+_108593907 0.952 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr9_-_32991518 0.952 NM_001195249
NM_001195254
NM_001195248
NM_001195250
NM_001195251
NM_001195252
NM_175069
NM_175073
APTX







aprataxin







chr14_+_62740878 0.951 NM_020663
RHOJ
ras homolog gene family, member J
chr2_+_220116986 0.948 NM_001005209
TMEM198
transmembrane protein 198
chr21_-_42060334 0.938 RIPK4
receptor-interacting serine-threonine kinase 4
chr22_+_39404940 0.936 NM_005297
MCHR1
melanin-concentrating hormone receptor 1
chr5_-_176760242 0.925 NM_001029886
PFN3
profilin 3
chr17_+_38250122 0.922 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr8_+_22909305 0.916 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr11_+_122936145 0.916 GRAMD1B
GRAM domain containing 1B
chr3_-_56784634 0.910 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr5_+_32747194 0.907 NM_000908
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr12_-_90029328 0.888 LUM
lumican
chr5_+_159276317 0.879 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr19_-_5291700 0.864 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr5_-_138238891 0.857 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr2_-_240613480 0.855 NM_004544
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr20_-_33489383 0.851 NM_000557
GDF5
growth differentiation factor 5
chr1_+_99502435 0.851 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr14_-_79748273 0.845 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr1_+_207944807 0.842 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_-_54317102 0.831 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr12_-_121753795 0.831 NM_177551
GPR109A
G protein-coupled receptor 109A
chr16_+_86561124 0.826 NM_001173543
BANP
BTG3 associated nuclear protein
chr21_-_42060266 0.825 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr6_+_139497933 0.823 NM_016217
HECA
headcase homolog (Drosophila)
chr10_+_123913094 0.822 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr17_-_39340414 0.821 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr5_-_138238877 0.819 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr6_+_136214495 0.819 NM_018945
PDE7B
phosphodiesterase 7B
chr4_+_120276386 0.818 NM_016599
MYOZ2
myozenin 2
chr11_+_122936246 0.814 GRAMD1B
GRAM domain containing 1B
chr1_+_165330710 0.811 NM_001080426
DUSP27
dual specificity phosphatase 27 (putative)
chr10_+_24023680 0.807 NM_001098500
KIAA1217
KIAA1217
chr2_-_133895795 0.805 NCKAP5
NCK-associated protein 5
chr17_-_46479127 0.796 SPAG9
sperm associated antigen 9
chr2_+_219453487 0.790 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr4_-_24641404 0.789 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr3_+_63928459 0.787 NM_001128149
ATXN7
ataxin 7
chr20_+_9236446 0.786 NM_000933
PLCB4
phospholipase C, beta 4
chr1_-_177106702 0.784 NM_004673
ANGPTL1
angiopoietin-like 1
chr3_+_189354167 0.767 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr12_-_90029672 0.764 NM_002345
LUM
lumican
chr3_+_50272648 0.760


chr11_-_35397675 0.756 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr20_-_38751289 0.756 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr2_+_10969513 0.753 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr11_-_85108030 0.746 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr5_-_139992621 0.744 NM_000591
CD14
CD14 molecule
chr4_+_113958652 0.741 NM_001127493
ANK2
ankyrin 2, neuronal
chr2_+_54638957 0.728 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_-_49076658 0.720 NM_001145475
FAM186A
family with sequence similarity 186, member A
chrX_-_10605726 0.717 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr17_-_7106497 0.710 CLDN7
claudin 7
chr2_-_27384617 0.701 NM_003353
UCN
urocortin
chr17_-_77824849 0.694 NM_001893
NM_139062
CSNK1D

casein kinase 1, delta

chr8_-_95343716 0.693 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr4_-_142273881 0.687 NM_020724
RNF150
ring finger protein 150
chr6_-_46566969 0.683 RCAN2
regulator of calcineurin 2
chr12_+_110328126 0.676 NM_005475
SH2B3
SH2B adaptor protein 3
chr2_-_206790871 0.671 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr9_-_128924782 0.670 ANGPTL2
angiopoietin-like 2
chr2_-_241408296 0.665 NM_004321
KIF1A
kinesin family member 1A
chr17_-_36507900 0.662 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr10_-_99780336 0.661 CRTAC1
cartilage acidic protein 1
chr11_-_8849485 0.660 ST5
suppression of tumorigenicity 5
chr1_-_1283770 0.653 NM_032348
MXRA8
matrix-remodelling associated 8
chr17_+_55098280 0.653 CLTC
clathrin, heavy chain (Hc)
chr10_+_63803921 0.652 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr12_-_7935010 0.650 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr12_+_79625538 0.649 NM_002469
MYF6
myogenic factor 6 (herculin)
chr3_+_89239363 0.642 NM_005233
NM_182644
EPHA3

EPH receptor A3

chr4_+_3341521 0.642 NM_198227
RGS12
regulator of G-protein signaling 12
chr7_+_89681069 0.638 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr10_+_95507555 0.637 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr14_+_103165244 0.637 NM_001130107
NM_005552
NM_182923
KLC1


kinesin light chain 1


chr22_-_37211467 0.634 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr3_+_89239494 0.634 EPHA3
EPH receptor A3
chr7_+_73080362 0.632 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr11_+_108798084 0.629 C11orf87
chromosome 11 open reading frame 87
chr12_-_123568781 0.622


chr19_+_49147219 0.608 NM_013359
ZNF221
zinc finger protein 221
chr22_+_23309717 0.606 NM_013430
GGT1
gamma-glutamyltransferase 1
chr8_+_40130143 0.605 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr5_+_112877251 0.601 NM_022828
YTHDC2
YTH domain containing 2
chr10_-_5035967 0.596 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chrX_+_117992603 0.592 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr15_-_81412354 0.592 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr15_-_61461127 0.591 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr15_+_69626594 0.591 THSD4
thrombospondin, type I, domain containing 4
chr2_-_152664056 0.591 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chrX_-_131918905 0.583 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chrX_+_110226030 0.582 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr7_+_73080387 0.581 ELN
elastin
chr14_-_76958984 0.581 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr5_-_1935764 0.577 NM_016358
IRX4
iroquois homeobox 4
chr15_-_61460967 0.575 CA12
carbonic anhydrase XII
chr20_-_44034346 0.574 ZNF335
zinc finger protein 335
chr3_+_62279707 0.570 C3orf14
chromosome 3 open reading frame 14
chr2_-_133145539 0.569 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr11_+_7574992 0.566 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr20_+_5839973 0.565 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr6_-_87861492 0.563 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr3_-_188870799 0.562 NM_001048
SST
somatostatin
chr19_+_8361260 0.562 RAB11B
RAB11B, member RAS oncogene family
chr15_-_75259714 0.561 PEAK1
NKF3 kinase family member
chr11_-_85107569 0.561 NM_206929
SYTL2
synaptotagmin-like 2
chr2_+_3683660 0.561 NM_018436
ALLC
allantoicase
chr11_-_57947358 0.557 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr5_-_32424444 0.554 ZFR
zinc finger RNA binding protein
chr8_-_117837224 0.553 EIF3H
eukaryotic translation initiation factor 3, subunit H
chr8_-_95343696 0.550 GEM
GTP binding protein overexpressed in skeletal muscle
chr10_-_95350949 0.550 NM_006744
RBP4
retinol binding protein 4, plasma
chr5_-_138238953 0.547 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr14_+_100362204 0.545 MEG3
maternally expressed 3 (non-protein coding)
chr11_+_35596310 0.544 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr2_-_20886293 0.543 NM_021925
C2orf43
chromosome 2 open reading frame 43
chr2_+_5750229 0.540 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr5_-_32424352 0.536 ZFR
zinc finger RNA binding protein
chr9_-_32542550 0.535 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr22_+_49272078 0.534 NM_017584
MIOX
myo-inositol oxygenase
chr19_+_8361243 0.533 RAB11B
RAB11B, member RAS oncogene family
chr9_+_71009746 0.532 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr3_+_129690735 0.527


chr21_-_43671355 0.524 NM_173354
SIK1
salt-inducible kinase 1
chr7_-_37923040 0.519 NM_003014
SFRP4
secreted frizzled-related protein 4
chr1_+_11171967 0.515 NM_021146
ANGPTL7
angiopoietin-like 7
chr2_-_197883569 0.513 ANKRD44
ankyrin repeat domain 44
chr17_-_36792161 0.513 NM_021013
KRT34
keratin 34
chr3_+_141136896 0.513 CLSTN2
calsyntenin 2
chr17_+_7096545 0.512 C17orf81
chromosome 17 open reading frame 81
chr1_-_17180659 0.511 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr5_+_140747586 0.510 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr4_+_85723080 0.509 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr6_+_134800533 0.508 LOC154092
hypothetical LOC154092

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 2.60e-07 GO:0032502 developmental process
1.47 6.17e-07 GO:0048856 anatomical structure development
1.48 3.84e-06 GO:0048731 system development
1.42 5.17e-06 GO:0007275 multicellular organismal development
1.27 4.16e-04 GO:0032501 multicellular organismal process
1.58 7.03e-03 GO:0051239 regulation of multicellular organismal process
1.44 7.64e-03 GO:0030154 cell differentiation
1.43 8.80e-03 GO:0048869 cellular developmental process
1.51 1.36e-02 GO:0009653 anatomical structure morphogenesis
1.16 1.40e-02 GO:0065007 biological regulation
1.17 3.42e-02 GO:0050789 regulation of biological process

Nothing significant found in compartment category.

Nothing significant found in function category.